Clinical trials: Growth Modification
Uveitis, Macular Edema
Effects of Conbercept in Refractory Uveitic Macular Edema and VEGF
As a primary exploratory study, this study aims to evaluate the short-term effectiveness of intravitreal Conbercept injection in UME, and to explore the correlation between inflammatory factors like VEGF and the responsiveness to…
- Conditions
- Uveitis, Macular Edema, Vascular Endothelial Growth Factor, Effect of Drugs
- Trial name
- NCT04296838
- Testing
- intravitreal injection of Conbercept
- Where
- China
- Volunteers
- 5 people
- Sponsor
- Peking Union Medical College Hospital
Anemia, Growth Retardation
Creating Homestead Agriculture for Nutrition and Gender Equity (CHANGE) in Burkina Faso
The purpose of this study is to assess the long-term impact of the Enhanced Homestead Food Production Program implemented by HKI on household food security and nutritional status, as well as the impact on including additional…
- Trial name
- CHANGE (NCT02236468)
- Testing
- Enhanced-Homestead Food Production Program (old), WASH/malaria behavior change, LNS distribution
- Where
- Burkina Faso
- Volunteers
- 2,747 people, healthy volunteers welcome
- Sponsor
- International Food Policy Research Institute
Intraocular Pressure
Intraocular Pressure Change Following Intravitreal Injection of Anti-vascular Endothelial Growth Factor Agent
The introduction of additional fluid into the vitreous cavity by intravitreal therapy would be expected to cause an immediate rise in the intraocular pressure.
- Trial name
- NCT02474225
- Testing
- Intravitreal injection (bevacizumab or ranibizumab)
- Where
- Thailand
- Volunteers
- 70 people
- Sponsor
- Prince of Songkla University
Silicosis
Safety Study of Autologous Bone Marrow Stromal Cells With Modification by Hepatocyte Growth Factor to Treat Silicosis
The aim of this study was to analyze the safety, pulmonary function, and imaging changes of patients with silicosis treated with autologous bone marrow stromal cells with modification by hepatocyte growth factor.
- Trial name
- NCT01977131
- Testing
- Cells
- Volunteers
- 10 people
- Sponsor
- Wei Yu
Rheumatoid Arthritis, Healthy
The Role of Cytokines on Growth Hormone Suppression in Premenopausal Women With Rheumatoid Arthritis and the Effect of Treatment With Etanercept
This study has two phases. Phase 1 will examine the role of inflammatory mediators called cytokines on growth hormone levels in women with rheumatoid arthritis (RA).
- Trial name
- NCT00034060
- Testing
- Etanercept
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Hypoglycemia Non-Diabetic, Gastric Bypass Status Complicating Pregnancy, Birth, or Puerperium
Bariatric Surgery and Consequences for Mother and Baby in Pregnancy
Background Roux-en-Y gastric bypass (RYGB) is a well-established treatment of obesity, most often performed in women during their reproductive years. Adverse events related to RYGB include hypoglycemia.
- Trial name
- BAMBI (NCT03713060)
- Testing
- Mixed meal test
- Where
- 2 sites in Denmark
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University of Southern Denmark
Myopia
Study Comparing Eye Growth Over Time in Children Using Two Myopia Control Lenses
The goal of this clinical trial is to investigate the short-term changes in the eye structure while wearing two types of lenslet-based myopia control lenses over a period of 6 months in children aged 6 to 13 years with myopia.
- Trial name
- NCT07253064
- Testing
- MCL 1, MCL 2
- Where
- Singapore
- Volunteers
- 20 people
- Sponsor
- Essilor International
Kidney Transplant; Complications, Glomerular Disease
Effect of Moderate Caloric Restriction on Glomerular Growth After Kidney Transplantation
One possible reason that weight gain after transplant may interfere with new kidney function is due to the enlargement of a kidney structure called the glomerulus.
- Conditions
- Kidney Transplant; Complications, Glomerular Disease, Weight Gain, Kidney Transplant
- Trial name
- NCT03607500
- Testing
- caloric intake reduction
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Michigan
NSCLC
A Study of REGN5093 in Adult Patients With Mesenchymal Epithelial Transition Factor (MET)-Altered Advanced Non-Small Cell Lung Cancer
This study will evaluate REGN5093 for the treatment of Non-Small Cell Lung Cancer (NSCLC) with MET alteration. The main purpose of this study is to determine the safety, tolerability, and effectiveness of REGN5093.
- Trial name
- NCT04077099
- Testing
- REGN5093
- Where
- 29 sites in United States, France and 1 more
- Volunteers
- 95 people
- Sponsor
- Regeneron Pharmaceuticals
Infant Malnutrition, Cognitive Change
Integrating Infant Feeding Counselling With Psychosocial Stimulation to Improve Child Growth and Development in Urban Slum of Bangladesh
Undernutrition and poor cognitive development affect many children under 5 in developing countries, who are exposed to multiple risk factors including poverty, malnutrition, poor health, and unstimulating home environments.
- Trial name
- NCT03040375
- Testing
- Peer counselling
- Volunteers
- 365 people, healthy volunteers welcome
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Temporomandibular Joint Disorders
Cytokine and Growth Factor Changes and Correlation With Clinical Outcomes Following Acupuncture for TMD
Purpose: 1) To investigate differences in pro-inflammatory and anti-inflammatory cytokines and growth factors in the circulating blood (and cytokine levels only in saliva) of patients with chronic temporomandibular disorder (TMD)…
- Trial name
- NCT02324712
- Testing
- Acupuncture
- Sponsor
- University of North Carolina, Chapel Hill
Benign Prostatic Hyperplasia
The Changes of Urine Growth Factors Level
The Changes of Urine Growth Factors Level in Patients With Benigh Prostate Hyperplasia after medical treatment.
- Trial name
- NCT06282731
- Testing
- Silodosin
- Where
- Taiwan
- Volunteers
- 74 people
- Sponsor
- En Chu Kong Hospital
Ovarian Cancer, Endometrial Cancer
Targeted Disruption to Cancer Metabolism and Growth Through Dietary Macronutrient Modification
The objective of this investigation is to examine the effects of 12 weeks of usual care plus a ketogenic diet (KD) or usual care plus dietary recommendations endorsed by the Academy of Nutrition and Dietetics (AND) in women with…
- Trial name
- NCT03171506
- Testing
- Ketogenic diet, AND diet
- Volunteers
- 57 people
- Sponsor
- University of Alabama at Birmingham
Osteoarthritis (Knee), Metabolic Syndrome (MetS)
Effect of Resistance Exercises on Serum IGF-1 Levels in Knee Osteoarthritis
The goal of this clinical trial is to evaluate the effects of a resistance exercise program on serum Insulin-like Growth Factor 1 (IGF-1) levels in patients with knee osteoarthritis.
- Trial name
- NCT07890155
- Testing
- Resistance Exercise Program
- Where
- Turkey (Türkiye)
- Volunteers
- 86 people
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
Stunting, Underweight
Spirulina Supplementation and Infant Growth, Morbidity and Motor Development
Background: In developing countries, micronutrient deficiency in infants is associated with growth faltering, morbidity, and delayed motor development.
- Conditions
- Stunting, Underweight, Pneumonia, Pneumocystis, Cough
- Trial name
- NCT03523182
- Testing
- Spirulina, Control
- Where
- Zambia
- Volunteers
- 501 people, healthy volunteers welcome
- Sponsor
- Programme Against Malnutrition
Height, Cognitive Function
A Study to Evaluate the Effects of a Dietary Supplement on Children's Health and Development Outcomes.
A 6-month virtual two-armed randomized double-blind placebo-controlled clinical trial. Participants will take NuBest Tall Growth Protein Powder or a placebo daily.
- Conditions
- Height, Cognitive Function, Weight Gain
- Trial name
- NCT06704178
- Testing
- NuBest Tall Growth Protein Powder
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- NuBest
Very Low Birth Weight Infant, Weight Gain
Effect of Milk Warming on the Very Low Birth Weight Infant
This study will compare if using a continuous milk warmer to warm breast milk compared to the standard method of warming breast milk in a hot water bath improves weight gain and feeding tolerance in infants born at 32 weeks…
- Conditions
- Very Low Birth Weight Infant, Weight Gain, Feeding Disorder Neonatal
- Trial name
- VLBW (NCT04282655)
- Testing
- Treatment Guardian Milk Warmer (Medela TM), Control
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Diarrhea, Infantile, Infection Gastrointestinal
PAthogen Transmission and Health Outcome Models of Enteric Disease
The objective of the PATHOME study is to (1) develop statistical and computational methods for examining a complex disease system of interactions between and amongst children, animals, the environment, and enteric pathogens and…
- Conditions
- Diarrhea, Infantile, Infection Gastrointestinal, Stunting, Wasting
- Trial name
- PATHOME (NCT05322655)
- Where
- Kenya
- Volunteers
- 286 people
- Sponsor
- State University of New York at Buffalo
Recurrent Chronic Lymphocytic Leukemia, Recurrent Diffuse Large B-Cell Lymphoma
Genetically Engineered Cells (EGFRt/19-28z/IL-12 CAR T Cells) for the Treatment of Relapsed or Refractory CD19+ Hematologic Malignancies
This phase I trial tests the safety, side effects, and best dose of genetically engineered cells called EGFRt/19-28z/IL-12 CAR T cells, and to see how they work in treating patients with hematologic malignancies that makes a…
- Conditions
- Recurrent Chronic Lymphocytic Leukemia, Recurrent Diffuse Large B-Cell Lymphoma, Recurrent Follicular Lymphoma, Recurrent High Grade B-Cell Lymphoma
- Trial name
- NCT06343376
- Testing
- Biopsy, Biospecimen Collection, Bone Marrow Aspiration
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Roswell Park Cancer Institute
Diarrhea, Malnutrition
Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development
Malnutrition is considered one of the most prevalent risk factors for morbidity and mortality in children under five. An estimated 20% of children in the developing world are malnourished [1] and poor nutrition is linked to more…
- Conditions
- Diarrhea, Malnutrition, Stunting, Wasting
- Trial name
- MAL-ED (NCT02441426)
- Where
- 8 sites in Bangladesh, Brazil and 6 more
- Volunteers
- 1,796 people, healthy volunteers welcome
- Sponsor
- Foundation for the National Institutes of Health