Clinical trials: Gulf War Illness
Gulf War Illness
Research Examining Gulf War Illness in Our Nations Service Members
At least 1 in 4 of the 700,000 U.S. Veterans who served in the 1990-1991 Gulf War suffer from Gulf War Illness (GWI). Despite considerable research, effective treatments remain elusive.
- Trial name
- REGIONS (NCT01846182)
- Testing
- Duloxetine, Pregabalin
- Where
- 2 sites in United States
- Volunteers
- 112 people
- Sponsor
- VA Office of Research and Development
Pain, Migraine
Vagus Nerve Stimulation: Treatment for Gulf Veterans With Gulf War Illness
The researchers propose studying Gulf veterans with Gulf War Illness (GWI), characterized by a problem with widespread pain. Besides their pain, the researchers will also assess the effect of vagus nerve stimulation (VNS) in…
- Trial name
- NCT02791893
- Testing
- VNS device, Inactive device
- Where
- 4 sites in United States
- Volunteers
- 27 people
- Sponsor
- Benjamin Natelson
Gulf War Syndrome
Pycnogenol (French Maritime Pine Bark) for the Treatment of Gulf War Illness
The purpose of this research study is to determine how pycnogenol may reduce Gulf War Illness (GWI) symptom severity. The study will also examine the safety of this treatment and determine the optimal dosage.
- Trial name
- NCT07266571
- Testing
- Pycnogenol, 100mg, Pycnogenol, 200mg, Pycnogenol, 400mg
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Alabama at Birmingham
Gulf War Syndrome, Headache
Alleviating Headache and Pain in GWI With Neuronavigation Guided rTMS
This study aims to assess the effect of repetitive transcranial magnetic stimulation (rTMS) on Gulf War illness related headaches and pain.
- Trial name
- NCT03030794
- Testing
- Repetitive transcranial magnetic stimulation
- Where
- 2 sites in United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Veterans Medical Research Foundation
Persian Gulf Syndrome, Chronic Sinusitis
Gulf War Illness Nasal Irrigation Study
The purpose of this study is to determine whether nasal irrigation with Xylitol or saline are effective in the treatment of chronic rhinosinusitis and fatigue symptoms associated with Gulf War Illness.
- Conditions
- Persian Gulf Syndrome, Chronic Sinusitis, Fatigue, Acute Sinusitis
- Trial name
- GWINIS (NCT01700725)
- Testing
- Nasal Irrigation - Saline, Nasal Irrigation - Xylitol
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Wisconsin, Madison
Gulf War Illness, Headache
Machine Learning in Guiding rTMS Treatment for GWI-Related Headaches and Body Pain
The goal of this clinical trial is to create a machine learning algorithm to improve active repetitive transcranial magnetic stimulation (rTMS) treatments for veterans and/or active military personnel by alleviating Gulf War…
- Conditions
- Gulf War Illness, Headache, Muscle and Joint Pain
- Trial name
- SVM - GWI (NCT07325513)
- Testing
- Active Repetitive Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- Veterans Medical Research Foundation
Gulf War Illness, Persian Gulf Syndrome
Understanding GWI: Integrative Modeling
The investigator proposes to perform a Phase I study assessing safety, efficacy, and biomarker response to the therapeutic interventions of Etanercept followed by mifepristone for veterans with Gulf War Illness.
- Conditions
- Gulf War Illness, Persian Gulf Syndrome, Occupational Diseases
- Trial name
- NCT04255498
- Testing
- Etanercept, Mifepristone
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- South Florida Veterans Affairs Foundation for Research and Education
Gulf War Illness, Depression
rTMS in Alleviating Pain and Co-Morbid Symptoms in Gulf War Veterans Illness (GWVI)
This study aims to look at the effectiveness of using repetitive transcranial magnetic stimulation (rTMS) in relieving pain and other co-morbid symptoms of Gulf War Illness.
- Trial name
- NCT04046536
- Testing
- Transcranial Magnetic Stimulation
- Where
- 3 sites in United States
- Volunteers
- 204 people
- Sponsor
- VA Office of Research and Development
Gulf War Syndrome
Ketamine in Veterans With Gulf War Illness
Up to one third of the 700,000 U.S. military veterans of the 1990-91 Gulf War have Gulf War Illness (GWI), a symptom complex characterized by a combination of chronic pain, cognitive impairment, debilitating fatigue…
- Trial name
- NCT04712071
- Testing
- Ketamine Hydrochloride
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Baylor College of Medicine
Persian Gulf Syndrome, Gulf War Syndrome
Confirming the Effects of Acupuncture Treatments to Relieve Symptoms of Gulf War Illness
This unblinded Phase II clinical trial will test the effects of individualized acupuncture treatments offered in extant acupuncture practices in the community; practitioners will have had at least 5 years of experience plus…
- Conditions
- Persian Gulf Syndrome, Gulf War Syndrome, Multiple Chronic Illnesses, Occupational Diseases
- Trial name
- CARE (NCT06716411)
- Testing
- Acupuncture
- Where
- 10 sites in United States
- Volunteers
- 200 people
- Sponsor
- University of Utah
Gulf War Illness, Chronic Fatigue
Ca-Mg Butyrate in Gulf War Illness
The primary objective of this clinical trial is to determine if treatment with Butyrate formulation that consists of butyric acid as calcium and magnesium derivatives (Ca-Mg Butyrate) improves the physical function of men and…
- Conditions
- Gulf War Illness, Chronic Fatigue, Neurocognitive Dysfunction
- Trial name
- Butyrate (NCT05367245)
- Testing
- Cal-Mag Butyrate
- Where
- 3 sites in United States
- Volunteers
- 120 people
- Sponsor
- VA Office of Research and Development
Gulf War Illness
D-cycloserine: A Novel Treatment for Gulf War Illness (GWDCS)
The purpose of this study is to investigate the efficacy of d-cycloserine (DCS) treatment for Gulf War Illness (GWI). Gulf War veterans with Gulf War Illness experience numerous chronic health symptoms, including cognition and…
- Trial name
- GWDCS (NCT02983734)
- Testing
- D-cycloserine
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Boston University Charles River Campus
Gulf War Syndrome
Cranial Electrotherapy Stimulation and Brain Imaging for Gulf War Syndrome
The main goal of the proposed study is to critically evaluate a nonpharmacological and readily available therapy, cranial electrical stimulation (CES) using Alpha-Stim™, and to discover the brain function mechanisms underlying…
- Trial name
- NCT07151248
- Testing
- Cranial electrical/electrotherapy stimulation (CES)
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Emory University
Gulf War Illness
Trial of Naltrexone and Dextromethorphan for Gulf War Illness
Veterans of the 1991 Gulf War who developed Gulf War Illness are being studied. Treatments with FDA approved generic drugs are being administered to see if they help with the symptoms of Gulf War Illness, such as chronic fatigue…
- Trial name
- GWI Treatment (NCT02206490)
- Testing
- naltrexone, Dextromethorphan
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- East Carolina University
Persian Gulf Syndrome
Treatment Study of Carnosine Versus Placebo in Gulf War Illness (GWI)
The purpose of this study is to perform a randomized double-blind, placebo-controlled, 12 week study of the effects of carnosine on cognitive, psychometric, autonomic, and muscle strength outcomes in 100 GWI subjects.
- Trial name
- NCT00810368
- Testing
- Carnosine
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Georgetown University