Clinical trials: Gum Disease
Gingival Diseases
A Study to Measure the Effect of Two Fluoride Toothpastes on Gingival Health Over a Six Month Period
This study is a double-blind, randomised, parallel group efficacy study. A minimum of 240 healthy female and male participants aged over 18 years will participate. The participants will be randomised into two groups.
- Trial name
- NCT03027908
- Testing
- Fluoride Toothpaste 1, Fluoride Toothpaste 2
- Volunteers
- 239 people, healthy volunteers welcome
- Sponsor
- Unilever R&D
Gingivitis, Gingival Diseases
NOVOSYN® Quick Versus MONOSYN® Quick Suture Material in Resective Periodontal Surgery
The aim of this study is to prove that Novosyn Quick and Monosyn Quick are equivalent in early wound healing in adult patients undergoing resective periodontal surgery.
- Conditions
- Gingivitis, Gingival Diseases, Periodontal Diseases
- Trial name
- NOQMOQS (NCT05813236)
- Testing
- Novosyn® in resective periodontal surgery, Monosyn® in resective periodontal surgery
- Where
- Spain
- Volunteers
- 84 people
- Sponsor
- Aesculap AG
Gingivitis
A Study of the C3 Complement Inhibitor AMY-101 in Adults With Gingivitis
A Phase 2a Clinical Trial to Assess the Safety and Efficacy of Complement 3 Inhibitor Analog, AMY-101, in Adults with gingivitis.
- Trial name
- NCT03694444
- Testing
- AMY-101, Water for injection
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Amyndas Pharmaceuticals S.A.
Tobacco Dependence
Evaluation of the Safety Profile, Quit and Reduction Rate After Nicorette® Gum and Patch Treatment
To evaluate the safety, smoking cessation and reduction rate during 3 months of active nicotine replacement therapy (NRT) and a follow-up period of 3 months in smoking hospital physicians and staff who are motivated to quit
- Trial name
- NCT00749463
- Testing
- Nicotine Gum, Nicotine Patch
- Where
- 6 sites in China
- Volunteers
- 300 people
- Sponsor
- McNeil AB
Heart Failure With Preserved Ejection Fraction
Single-Ascending Dose Study of JK07 in Subjects With HFpEF
A phase 1, randomized, double-blind, placebo-controlled single-ascending dose study to assess JK07 in adult subjects with heart failure with preserved ejection fraction.
- Trial name
- NCT05322616
- Testing
- JK07
- Where
- 7 sites in United States
- Sponsor
- Salubris Biotherapeutics Inc
Periodontitis, Alveolar Bone Loss
Phase 3 Clinical Trial of Periodontal Tissue Regeneration Using Fibroblast Growth Factor-2(Trafermin)
This study aims to verify the effectiveness of Trafermin (recombinant human basic fibroblast growth factor) in stimulating regeneration of periodontal tissue lost by periodontitis and to evaluate the safety of such stimulation.
- Conditions
- Periodontitis, Alveolar Bone Loss, Periodontal Attachment Loss
- Trial name
- NCT00734708
- Testing
- Trafermin (genetical recombination)
- Where
- 21 sites in Japan
- Volunteers
- 328 people
- Sponsor
- Kaken Pharmaceutical
Periodontal Disease
Comparison Between Different Interdental Brushes in Adults With Periodontal Disease.
The aim of this exploratory study is to evaluate the efficacy of the tested interdental brush versus comparative interdental brushes in adults with periodontal disease, over a 4-week period.
- Trial name
- NCT07575997
- Testing
- Test interdental brush, Comparative interdental brush
- Where
- Belgium
- Volunteers
- 88 people
- Sponsor
- Pierre Fabre Dermo Cosmetique
Gingivitis
Potential of Stannous Fluoride Toothpaste to Reduce Gum Disease
This will be a single-center, 12 week, examiner-blind, randomized, stratified (gender and baseline mean whole mouth MGI score), two-treatment, parallel group, clinical study in healthy adult volunteers with moderate gingivitis.
- Trial name
- NCT02750943
- Testing
- Stannous Fluoride, Sodium Monofluorophosphate
- Where
- United States
- Volunteers
- 253 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Gingivitis
Meta-analysis of Stannous Fluoride and the Effects on Gingival Health
The aim of this 18 study analysis was to compare the effect of bioavailable stannous fluoride (SnF2) dentifrices when used up to 3 months on gingivitis relative to a positive or negative control dentifrice.
- Trial name
- NCT03970759
- Testing
- Stannous Fluoride Dentifrice, Positive control dentifrice, Negative control dentifrice
- Where
- United States
- Volunteers
- 2,890 people, healthy volunteers welcome
- Sponsor
- Procter and Gamble
Periodontitis, Plaque, Dental
Impact of Regular Home Use of Lumoral Dual-light Photodynamic Therapy on Plaque Control and Gingival Health
This early-stage study is designed to determine the efficacy of the CE-approved, antibacterial, dual-light Lumoral method in periodontitis patients.
- Conditions
- Periodontitis, Plaque, Dental, Plaque Induced Gingivitis
- Trial name
- NCT05361590
- Testing
- Lumoral device
- Where
- Finland
- Volunteers
- 40 people
- Sponsor
- Koite Health Oy
Plaque, Dental, Gingivitis
Clinical Investigation to Assess the Efficacy of Manual Toothbrushes in the Reduction of Plaque and Gingivitis.
Qualified subjects will be enrolled and randomized to one of the two study groups based on their initial Plaque and Gingivitis scores. Subjects will be instructed to use the products according to the instructions provided.
- Trial name
- NCT06565897
- Testing
- Test regimen, Control regimen
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Gingival Inflammation in Diabetic Patients
Herbal Periodontal Patch (THPP) for Gingival Inflammation in Diabetics
Diabetes increases the incidence and severity of periodontal inflammation and disease, and periodontal disease causes an increase in the severity of diabetes by worsening glycemic control and increasing insulin resistance.The…
- Trial name
- NCT00731432
- Testing
- Transmucosal Herbal Periodontal Patch (THPP)
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Izun Pharma Ltd
Gingivitis
A Clinical Study Investigating the Effects of a Dentifrice Containing 0.454% Stannous Fluoride on Gingivitis Treatment and Plaque Reduction When Used Twice Daily for 12 Weeks
The purpose of this clinical study is to investigate the efficacy of a dentifrice containing 0.454 percent (%) weight by weight (w/w) stannous fluoride (SnF2), on gingivitis treatment and plaque reduction, compared to a regular…
- Trial name
- NCT06143670
- Testing
- Stannous fluoride toothpaste, Sodium fluoride toothpaste
- Where
- United States
- Volunteers
- 159 people
- Sponsor
- HALEON
Dental Plaque, Dental Plaque Induced Gingivitis
Clinical Efficacy of the Combined Effect of Oral Irrigator and Chemicals (0.075% CPC)
This is an experimental gingivitis clinical study to evaluate gum health efficacy from the combination effect of water flosser and chemistry (0.075% CPC) compared to water flosser and water and to no oral hygiene regimen with a…
- Conditions
- Dental Plaque, Dental Plaque Induced Gingivitis, Dental Plaque and Gingivitis, Gingivitis
- Trial name
- WFPOC (NCT06607172)
- Testing
- oral irrigator, Cetylpyridinium Chloride (CPC)
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Gingival Diseases
Compare the Clinical Efficacy of Prototype Toothpastes.
Evaluate clinical efficacy of a prototype toothpaste on control of dental plaque gingival inflammation
- Trial name
- NCT00761930
- Testing
- Fluoride, Triclosan and fluoride, Herbal Ingredient and fluoride
- Where
- United States
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Gingival Inflammation, Gingival Bleeding
Evaluation of a Toothpaste Containing a Gum Health Active in Participants With Gingival Problem
The primary objective of this clinical study is to evaluate the impact on gingival health when participants switch to a fluoride toothpaste without gum-health actives for 4 weeks after using a proven gum-health toothpaste for 13…
- Conditions
- Gingival Inflammation, Gingival Bleeding, Dental Plaque
- Trial name
- NCT07415733
- Testing
- Test Toothpaste, Control Toothpaste
- Where
- Indonesia
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Unilever R&D
Bleeding Gum, Gingivitis
Clinical Investigation of Bleeding Reduction Efficacy on Toothpaste Containing 1.05% Chitosan
The purpose of this study is to assess the bleeding reduction efficacy of toothpaste containing 1.05% Chitosan compared to a regular fluoride toothpaste, and compared to a toothpaste containing 67% bicarbonate.
- Trial name
- NCT06955871
- Testing
- Toothpaste containing 1.05% Chitosan, Silica-based NaF Toothpaste, Toothpaste with 67% bicarbonate
- Where
- China
- Volunteers
- 134 people
- Sponsor
- Colgate Palmolive
Esophagitis, Gastro Oesophageal Reflux Disease
Clinical Investigation to Assess the Acid Neutralisation Activity of a Calcite Chewing Gum
This investigation is designed to evaluate the acid neutralisation action of a new test product versus unmatched placebo.
- Trial name
- NCT05129670
- Testing
- Calcite chewing gum
- Where
- Ireland
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Reckitt Benckiser Healthcare (UK) Limited
Periodontitis
Study of Scaling and Root Planing With PerioWave Versus Scaling and Root Planing Alone in Chronic Periodontitis
This study is to determine whether scaling and root planing (SRP) followed by photodynamic disinfection results in improved outcomes that persist over time in adults with chronic periodontitis when compared with subjects with SRP…
- Trial name
- NCT00297531
- Testing
- PerioWave, Scaling and Root Planing
- Where
- 4 sites in Canada
- Volunteers
- 120 people
- Sponsor
- Ondine Research Laboratories
Gingivitis
Comparative Efficacy of a Toothpaste That Reduces Plaque and Gingivitis
The objective of this study is to evaluate the performance of two toothpastes in controlling established gingivitis and dental plaque in adults.
- Trial name
- NCT00926328
- Testing
- Triclosan, fluoride, Fluoride
- Where
- Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive