Clinical trials: Gum Disease
Periodontal Disease
The Effect of Periodontal Treatment and the Use of Dentifrice on Glycaemic Control in Diabetics
To test effectiveness of dentifrice in maintaining periodontal health.
- Trial name
- NCT00763256
- Testing
- Triclosan, Fluoride, Fluoride
- Where
- Australia
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Inflamed Gums, Dryness Oral
Regular Antibacterial Photodynamic Therapy on Oral Hygiene in the Elderly 24-hour Care
This study aims to determine the effectiveness of the Lumoral device on oral hygiene, inflammatory load, and dryness of mouth in elderly 24-hour care residents.
- Conditions
- Inflamed Gums, Dryness Oral, Plaque
- Trial name
- NCT05720104
- Testing
- Lumoral Treatment, Standard oral hygiene instructions
- Where
- Sweden
- Sponsor
- Koite Health Oy
Periodontal Diseases, Gingivitis
Randomized Trial of a Gum Health Formulation
The purpose of this study is to evaluate the safety and efficacy of a newly formulated foaming gel product on gingivitis and/or moderate periodontitis when used with or without the GLO Science accelerating device (GLO Device)…
- Conditions
- Periodontal Diseases, Gingivitis, Periodontitis, Halitosis
- Trial name
- NCT03196648
- Testing
- Gingival health formulation in an accelerating device, Gingival health formulation on a toothbrush, OTC fluoride toothpaste
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Glo Science, Inc.
Gingival Inflammation and Bleeding, Dental Plaque
Clinical Efficacy Evaluation of Three Dentifrices
Clinical study to evaluate and compare the efficacy of two baking soda containing dentifrices, containing 20% and 35% baking soda, to a non-baking soda dentifrice for their ability to reduce gingivitis and plaque following…
- Trial name
- NCT03988374
- Testing
- Dentifrices
- Where
- Canada
- Volunteers
- 319 people
- Sponsor
- Church & Dwight Company, Inc.
Gingivitis, Plaque
Measuring Efficacy of an Oral-Irrigator After Three Weeks of Use
The primary objective of this exploratory study is to evaluate the efficacy of an Oral Irrigator in the reduction of gingivitis compared to a negative control over a 3 week period by using the Modified Gingival Index and the…
- Trial name
- NCT04899440
- Testing
- Water Flosser, Control
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Procter and Gamble
Regurgitation, Gastric, Diarrhea
To Assess the Safety and Tolerance of Infant Formula With Locust Bean Gum in Infants With Regurgitation
A randomized, controlled study to evaluate the safety and tolerance of an infant formula with locust bean gum in infants with regurgitation. (Solar)
- Trial name
- Solar (NCT04042454)
- Testing
- milk based anti-regurgitation infant formula, Milk based infant formula
- Where
- 16 sites in Italy, Poland and 1 more
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Nutricia Research
Periodontitis
PerioWave Re-Treatment Protocol Compared to Scaling and Root Planing (SRP) and a Single Treatment With PerioWave
This is a pivotal, prospective, randomized, blinded, multicenter study to evaluate two treatments of photodynamic disinfection in adults with chronic periodontal disease.
- Trial name
- NCT00336661
- Testing
- PerioWave
- Where
- 2 sites in China
- Volunteers
- 105 people
- Sponsor
- Ondine Research Laboratories
Oral Hygiene, Toothbrushing
Open-label Trial Evaluating Four Oral Hygiene Regimens Using a Manual Toothbrush, Toothpaste, and Mouthwash
The purpose of this open-label, randomized controlled clinical trial, is to provide preliminary clinical data (efficacy on plaque and gingival sensitivity, and safety and tolerability of two types of toothpaste, a mouthwash, and…
- Conditions
- Oral Hygiene, Toothbrushing, Dental Plaque
- Trial name
- NCT05999175
- Testing
- the toothpaste is used with a standard toothbrush without any claims 3 times a day after the main meals for 28 days., the mint toothpaste and mouthwash are used with the scalar toothbrush 33 medium with antibacterial " Spazzolino tau-marin®" 3 times a day after the main meals for 28 days., subjects of this group will use their routine oral hygiene products.
- Where
- 2 sites in Italy
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Biokosmes Srl
Gingivitis
A Clinical Study to Assess the Gingivitis Effects of Various Dentifrices
The objective of this learning clinical study is to assess the gingivitis effects of four different dentifrices over a 3-month period.
- Trial name
- NCT06140771
- Testing
- 0.76% Sodium Monofluorophosphate Dentifrice, 1.15% Sodium Monofluorophosphate Dentifrice, 0.454% Stannous Fluoride Dentifrice
- Where
- United States
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Procter and Gamble
Gingival Recession
A Pilot Study of CelTx(TM) (Apligraf®) in the Treatment of Gingival Recession Requiring Root Coverage
The purpose of this study is to evaluate CelTx as an alternative to tissue from the palate in the treatment of subjects with Miller Class I or II recession defects who desire root coverage.
- Trial name
- NCT00679081
- Testing
- CelTx, Autologous sub-epithelial connective tissue graft
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Organogenesis
Gingivitis
Assessing Gingivitis and Plaque From a Marketed Toothpaste
The primary objective of this study is to evaluate the effect of two 0.454% stannous fluoride dentifrices on gingivitis relative to a negative control (Colgate® Cavity Protection toothpaste) and the comparative anti-gingivitis…
- Trial name
- NCT07158112
- Testing
- Stannous Fluoride Dentifrice, Test Stannous Fluoride Dentifrice, Sodium monofluorophosphate dentifrice
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Procter and Gamble
Periodontitis, Periodontal Pocket
Treatment of Advanced Periodontitis With a Chitosan Brush and a Chitosan Gel
In the here suggested study, the aim is to test non-surgical treatment of advanced periodontal disease with a chitosan brush with or without chitosan gel in patients with advanced periodontal disease having responded poorly to a…
- Conditions
- Periodontitis, Periodontal Pocket, Periodontal Diseases, Periodontal Inflammation
- Trial name
- Chitosangel (NCT05773911)
- Testing
- 4% chitosan gel (pH 3.48)., Reciprocal Chitosan brush
- Where
- Norway
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Caspar Wohlfahrt
Periodontal Diseases, Periodontitis
Home Use of Dual-light Photodynamic Therapy for Chronic Periodontitis
This early-stage research is designed to determine the efficacy of the Lumoral method in chronic periodontitis patients. Improved supragingival plaque control can help to also sustain the subgingival plaque management in the long…
- Conditions
- Periodontal Diseases, Periodontitis, Plaque, Dental, Plaque Induced Gingivitis
- Trial name
- NCT05425784
- Testing
- Lumoral treatment, Standard oral hygiene self care
- Where
- 3 sites in Finland
- Volunteers
- 41 people
- Sponsor
- Koite Health Oy
Osteoarthritis, Knee
FiH Safety and Feasibility Study Assessing Intra-articular Administration of aeGF in Patients With Knee Osteoarthritis
The company funding this study has developed an advanced therapy medicinal product (a cell therapy) from human donor cells which it wants to assess as a possible treatment for knee osteoarthritis (OA).
- Trial name
- NCT06690710
- Testing
- allogeneic engineered Gingival Fibroblasts (aeGF)
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- Scarcell Therapeutics S.A.S.
Gingivitis
Stannous Fluoride and Gingivitis
8-week study using stannous fluoride toothpaste on subjects with gingivitis ("unhealthy") and without gingivitis ("healthy"). Gingivitis index will be performed at BL, Week 4 and Week 8.
- Trial name
- NCT05326373
- Testing
- Stannous fluoride
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Procter and Gamble
Gingivitis
Curved Soft-Picks on Plaque Accumulation on Patients With Gingivitis
The aim of this study is to evaluate the efficacy of a new interdental cleaning device (Soft-Picks Advanced), as compared to a leading brand floss; and, how ease of use can promote the establishment of a hygienic routine of…
- Trial name
- NCT02883244
- Testing
- Soft-Picks Advanced, Floss
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Sunstar Americas
Gingivitis, Plaque
Clinical Study of Toothpaste Containing Zinc Lactate as Compared to Colgate Cavity Protection Toothpaste.
The objective of this six-month clinical research study is to evaluate the clinical efficacy of two dentifrices - Toothpaste containing zinc lactate and Colgate Cavity Protection Toothpaste in reducing gingivitis and dental…
- Trial name
- NCT06563518
- Testing
- Meridol, Colgate Cavity Protection
- Where
- Thailand
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Gingivitis, Plaque
Clinical Research Study to Assess the Efficacy of Two Brushing Regimens in the Reduction of Established Dental Plaque and Gingivitis.
Qualified subjects will be enrolled and randomized to one of the two study groups based on their initial Plaque and Gingivitis scores. Subjects will be instructed to use the products according to the instructions provided.
- Trial name
- NCT06244303
- Testing
- manual Tooth Brush + Colgate Total TP (0.454% SnF, 1100 ppm F), manual toothbrush + Colgate dental cream
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Gingivitis, Dental Plaque
A Meta-analysis Comparing Toothbrushes on Plaque Removal and Gingival Health
The aim of this analysis was to compare gingivitis- and plaque-reduction efficacy from randomized controlled trials (RCTs) up to six months long evaluating oscillating-rotating, sonic, and manual toothbrushes
- Trial name
- NCT05594004
- Testing
- Oscillating-rotating electric toothbrush, Sonic electric toothbrush, Manual toothbrush
- Where
- United States
- Volunteers
- 2,929 people, healthy volunteers welcome
- Sponsor
- Procter and Gamble
Dental Plaque, Gingivitis
A Clinical Study Investigating the Efficacy of an Experimental Toothpaste Containing Stannous Fluoride in Improving Gingival Health
The aim of this study is to evaluate the ability of an experimental toothpaste, containing 0.454 percent (%) Stannous Fluoride (SnF2) to improve gingival health and reduce plaque accumulation compared to a regular fluoride…
- Trial name
- NCT07169188
- Testing
- Test Fluoride Toothpaste, Colgate Cavity Protection Toothpaste
- Where
- Canada
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- HALEON