Clinical trials: Gut
Irritable Bowel Syndrome (IBS)
Synbiotic Supplement With Botanical Extracts for Gut Microbiota Balance in Irritable Bowel Syndrome
The goal of this clinical trial is to evaluate whether a synbiotic dietary supplement containing botanical extracts and multiple probiotic strains can improve gastrointestinal symptoms and modulate gut microbiota composition in…
- Trial name
- NCT07475299
- Testing
- Synbiotic supplement containing probiotic strains, botanical extracts, magnesium, vitamin B1, and L-theanine designed to support gut microbiota balance.
- Where
- Romania
- Volunteers
- 8 people
- Sponsor
- Iuliu Hatieganu University of Medicine and Pharmacy
Colorectal Cancer
Study of Oxaliplatin, Capecitabine and Bevacizumab as First Line Treatment for Patients With Advanced Colorectal Cancer
This study is for people with colorectal cancer, who have tumors that cannot be completely removed by surgery. This study is being done to find out how long it takes tumors to grow after patients receive the drugs capecitabine…
- Trial name
- NCT00159432
- Testing
- Oxaliplatin, Bevacizumab, Capecitabine
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- University of Southern California
Bodily Distress Disorder Moderate, Bodily Distress Disorder Severe
Internet-based Treatment for Patients Suffering From Severe Functional Somatic Disorders
The aim of this multi-center, two-armed, randomized controlled trial is to assess the effect of a novel internet-based therapist-assisted treatment program "One step at a time" designed for the treatment of patients with moderate…
- Conditions
- Bodily Distress Disorder Moderate, Bodily Distress Disorder Severe, Fibromyalgia, Chronic Fatigue Syndrome
- Trial name
- OneSTEP (NCT05525598)
- Testing
- "One step at a time", "Get started"
- Where
- Denmark
- Volunteers
- 166 people
- Sponsor
- University of Aarhus
Cancer Diagnosis, LungCancer
Prospective Screening and Differentiating Common Cancers Using Peripheral Blood Cell-Free DNA Sequencing
The goal of this observational study is to screen and differentiate common cancers in participants with or without suspicious lesions.
- Conditions
- Cancer Diagnosis, LungCancer, Gastric Cancer, Liver Cancer
- Trial name
- NCT06036563
- Where
- 8 sites in China
- Volunteers
- 3,200 people, healthy volunteers welcome
- Sponsor
- Air Force Military Medical University, China
Unresectable Colorectal Liver Metastases
Local Immunomodulation After Radiofrequency of Unresectable Colorectal Liver Metastases
The main objective of this trial is to determine feasibility and tolerance of the human body to RFA associated with local immunomodulation carried out using a thermoreversible hydrogel combined with 2 immunomodulators, GMCSF and…
- Trial name
- LICoRN-01 (NCT04062721)
- Testing
- Chemotherapy, Radiofrequency ablation (RFA), In situ immunotherapy
- Where
- France
- Volunteers
- 12 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Inflammatory Bowel Disease
The Altitude Inflammatory Bowel Disease Study
This is a prospective, controlled and observational study. Participants underwent a 3-hour exposure to hypoxic conditions simulating an altitude of 4,000 meters above sea level (m.a.s.l.) in a hypobaric pressure chamber.
- Trial name
- NCT02849821
- Testing
- hypobaric pressure chamber, Sigmoidoscopy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Pancreatic Neoplasms, Biliary Tract Neoplasms
Nonstented Stump-closed vs Duct-to-Mucosa Pancreaticojejunostomy After Pancreaticoduodenectomy
Pancreaticojejunostomy is the key procedure of pancreaticoduodenectomy. The aim of our study is to investigate a new pancreaticojejunal (PJ) anastomosis procedure named "nonstented stump-closed pancreaticojejunostomy" in…
- Conditions
- Pancreatic Neoplasms, Biliary Tract Neoplasms, Pancreatitis, Chronic, Duodenal Neoplasms
- Trial name
- NCT01731821
- Testing
- pancreaticojejunostomy
- Where
- China
- Volunteers
- 308 people
- Sponsor
- Fudan University
Cancer of Head and Neck, Nutrition Aspect of Cancer
The Gut Microbiome As an Indicator of Readiness for Head & Neck Cancer Surgery
The purpose of this study is to understand how a pre-operative nutritional intervention alters the gut microbiome and improves outcomes after major head and neck cancer surgery.
- Trial name
- NCT05061316
- Testing
- Nestlé Impact Advanced Recovery
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Alabama at Birmingham
Gastroesophageal Reflux Disease, Obesity
The Effect of PPI Therapy on Weight, Gut Microbiome, and Expression of GPR41 and GPR43
The investigators long-term goal is to understand how PPIs influence energy balance in both obese and normal-weight individuals.
- Trial name
- NCT02457104
- Testing
- Colonoscopy, Weight and diet questionnaire
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Appendicitis
Open Versus Laparoscopic Appendectomy
The aim of this prospective randomized trial is to compare the feasibility of open with laparoscopic appendectomy in suspected acute appendicitis.
- Trial name
- NCT00908804
- Testing
- open appendectomy, laparoscopic appendectomy
- Where
- Finland
- Sponsor
- North Karelia Central Hospital
Colorectal Cancer, Colorectal Neoplasm
A Stool DNA Test for Detection of Advanced Colorectal Neoplasia in Asymptomatic Chinese Community Population
to determine screening value of stool-based SDC2 DNA methylation test for advanced colorectal neoplasia in the asymptomatic Chinese community population.
- Conditions
- Colorectal Cancer, Colorectal Neoplasm, Advanced Adenoma, Adenoma
- Trial name
- NCT04786704
- Testing
- Stool-based SDC2 DNA methylation test, quantitative Fecal immunochemical test
- Where
- China
- Volunteers
- 12,106 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Post-induction Hypotension, Intestinal Obstruction
SV and IVC Collapsibility Index to Predict Postinduction Hypotension
Postinduction hypotension (PIH) is a frequent complication during general anesthesia. This study aims to compare the predictive effectiveness and diagnostic accuracy of stroke volume (SV) measured via left ventricular outflow…
- Trial name
- NCT07742904
- Volunteers
- 75 people
- Sponsor
- Ain Shams University
Healthy
The Effects of Lactobacillus Rhamnosus (JB-1) on Stress and Cognition
Emerging evidence suggests that microorganisms acting via the Brain-Gut axis may have potential benefits for the management of stress-related conditions. The majority of studies have focused on animal models.
- Trial name
- NCT03160066
- Testing
- Lactobacillus Rhamnosus (JB-1)
- Where
- Ireland
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University College Cork
Colorectal Cancer
Safety Study of Transumbilical Single Incision Versus Conventional Laparoscopic Surgery for Colorectal Cancer
Compared with traditional open colectomy, laparoscopic surgery is associated with less pain, earlier recovery, and better cosmetic outcome, and its short- and long-term oncologic outcomes have been demonstrated.
- Trial name
- NCT02117557
- Testing
- Single incision laparoscopic surgery, Conventional laparoscopic surgery
- Where
- China
- Volunteers
- 198 people
- Sponsor
- Guoxin Li
Adenocarcinoma of the Gastroesophageal Junction, Diffuse Gastric Adenocarcinoma
Akt Inhibitor MK2206 in Treating Patients With Advanced Gastric or Gastroesophageal Junction Cancer
This phase II clinical trial studies how well Akt inhibitor MK2206 works in treating patients with advanced gastric or gastroesophageal junction cancer.
- Conditions
- Adenocarcinoma of the Gastroesophageal Junction, Diffuse Gastric Adenocarcinoma, Gastric Intestinal Type Adenocarcinoma, Gastric Mixed Adenocarcinoma
- Trial name
- NCT01260701
- Testing
- Akt Inhibitor MK2206
- Where
- 187 sites in United States, Canada
- Volunteers
- 75 people
- Sponsor
- National Cancer Institute (NCI)
Crohn's Disease
Nutritional Therapy Study in Pediatric Crohn's Disease
The investigators are doing this research study to answer questions about a nutritional therapy called the Specific Carbohydrate Diet (SCD) for children with active Crohn's Disease (CD).
- Trial name
- NCT02610101
- Testing
- Traditional SCD Diet, Modified SCD Diet, Whole foods diet
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Seattle Children's Hospital
Colorectal Cancer, Functional Status
Functional and Respiratory Predictors of Early Postoperative Outcomes
Functional status is a fundamental indicator reflecting a patient's ability to perform activities of daily living and is closely associated with early postoperative outcomes.
- Conditions
- Colorectal Cancer, Functional Status, Respiratory Parameters, Clinical Outcomes
- Trial name
- NCT07529301
- Testing
- Preoperative Assessments, Postoperative Assessments (Daily from Postoperative Day 1 Until Discharge)
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Müşerref Ebru YALÇIN
Crohn's Disease
CD INFORM: Investigating Natalizumab Through Further Observational Research and Monitoring
The primary objective of the study is to determine the incidence and pattern of serious and/or clinically significant infections, malignancies, and other serious adverse event (SAE) in participants with Crohn's Disease (CD)…
- Trial name
- INFORM (NCT00707512)
- Testing
- natalizumab
- Where
- 36 sites in United States, Puerto Rico
- Volunteers
- 87 people
- Sponsor
- Biogen
Inflammatory Bowel Disease
Fecal Transplantation for Inflammatory Bowel Disease
Fecal microbial treatment (FMT) is a treatment that utilizes the microbiota of a healthy intestine as a probiotic preparation. The feces of a healthy individual is fluidized and than inserted into the intestinal tract of a sick…
- Trial name
- FMT IBD (NCT02391012)
- Testing
- Fecal microbial l transplantation
- Where
- 2 sites in Israel
- Volunteers
- 9 people
- Sponsor
- Meir Medical Center
Inflammatory Bowel Diseases
Folic Acid in Pediatric Inflammatory Bowel Disease
Inflammatory bowel disease often requires immunomodulators, such as methotrexate, to maintain disease remission. This medication is administered as one dose weekly.
- Trial name
- NCT03860012
- Testing
- Folic Acid
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Le Bonheur Children's Hospital
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