Clinical trials: Gut Dysbiosis
Crohn Disease (CD)
The Microbial Impact on Intestinal Fibrosis and the Associated Immune Microenvironment in Crohn's Disease
The goal of this study is to find out if there is a direct connection between an imbalance of gut bacteria and the development of scar tissue in the gut by identifying important bacterial proteins found in scarred gut tissue.
- Trial name
- NCT06720961
- Testing
- Collection of surgical specimen, Collection of stool sample
- Where
- Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Dysbiosis, Cardiometabolic Health Indicators
Pulse Education and Children
This parallel-arm, randomized controlled trial will evaluate the effectiveness of a 6-week pulse-focused nutrition intervention in school-aged children (6-13 years).
- Conditions
- Dysbiosis, Cardiometabolic Health Indicators, Education on Feeding and Health Status, Gut Motility
- Trial name
- NCT07648446
- Testing
- Education Only, Education + Pulse Provision, Cooking Class
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Florida State University
Intestinal Infections, Dysbacteriosis
Study of the Safety and Tolerability of the Broad-spectrum Probiotic Medicine "AS-Probionorm"
The subject of this clinical trial is the medicine "AS-Probionorm". Pharmacological group - Antidiarrheal drugs. Antidiarrheal microorganisms. Microorganisms that produce lactic acid.
- Trial name
- NCT06252831
- Testing
- "AS-Probionorm"
- Where
- Kazakhstan
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Industrial Microbiology LLP
Diminished Ovarian Reserve
Characterization of Gut and Tongue Coating Microbiota in Patients With Diminished Ovarian Reserve
The goal of this observational study is to investigate the distinct tongue manifestation characteristics in patients with diminished ovarian reserve (DOR) compared to healthy individuals, and to clarify the features of tongue…
- Trial name
- CGTCMPDOR (NCT07124260)
- Testing
- gut microbiota, tongue coating microbiota, tongue picture
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University
Crohn Disease
PMA-Zeolite-Clinoptilolite Effects in Crohn Disease
This pilot study aims to evaluate the safety and efficacy of PMA-zeolite when used in patients with uncontrolled CD (Crohn´s disease).
- Trial name
- NCT04370535
- Testing
- cellulose, PMA-zeolite
- Where
- 3 sites in Slovenia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ciim Plus, d.o.o.
Gut Dysbiosis
A Clinical Study to Assess the Safety and Effectiveness of Test Product in Healthy Adult Human Subjects Having Symptoms of Gut Dysbiosis (Heart Burn, Bloating, Constipation and Gut Immunity).
This is prospective, open-label, single-arm, proof of science, clinical safety and efficacy study of MetProUltima in healthy adult human subjects having symptoms of Gut Dysbiosis (heart burn, bloating, constipation).
- Trial name
- NCT06572358
- Testing
- MetProUltima
- Where
- India
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- NovoBliss Research Pvt Ltd
Microscopic Colitis, Colorectal Cancer
Mucosa Adherent Intestinal Microbiome in Microscopic Colitis and Colorectal Cancer
Microscopic colitis (MC) is an inflammatory bowel disease characterized by chronic non-bloody watery diarrhoea and a macroscopically normal colonic mucosa upon endoscopic exploration (colonoscopy).
- Conditions
- Microscopic Colitis, Colorectal Cancer, Colon Adenoma
- Trial name
- CMBACT (NCT06172647)
- Testing
- Colonoscopy
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hospital Mutua de Terrassa
Gastrointestinal Disorder, Functional
PHAGE Study: Bacteriophages as Novel Prebiotics
The PHAGE study is designed to determine if a commercial prebiotic product can change the composition of bacteria in the gut for improved intestinal health.
- Trial name
- NCT03269617
- Testing
- Bacteriophage mixture
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Colorado State University
Microbiome Dysbiosis, Gut Health
Colon-delivered Riboflavin and Gut Microbiota Composition
Recent studies suggest B-vitamins such as riboflavin to possess prebiotic-like effects. However, there is still a lack of understanding of the exact host health benefits vs. conventional systemically available vitamin forms.
- Trial name
- CONCOL (NCT07093463)
- Testing
- Colon-delivered riboflavin, Conventional riboflavin, Microcrystalline Cellulose
- Where
- Germany
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- dsm-firmenich Switzerland AG
Anorexia Nervosa, Dysbiosis
Alteration of Symbiosis Intestinal Microbiota on Patients With Anorexia Nervosa
The purpose of this study will be to study the association between the level of psychic symptomatic of anorexia nervosa (AN) (intensity of food restriction, symptoms of anxiety and depression) and alteration of host environment…
- Conditions
- Anorexia Nervosa, Dysbiosis, Anxious Depression
- Trial name
- INT-METAVOSA (NCT05632497)
- Testing
- Stool and blood samples
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Irritable Bowel Syndrome, Dysbiosis
Fecal Microbiota Transplantation and ACHIM for Manipulating Gut Microbiota in IBS Patients
The double-blinded placebo-controlled study compares the effect of fecal microbiota transplantation vs. Anaerobically Cultivated Human Intestinal Microbiota (ACHIM) or placebo (own feces) on manipulating the gut microbiota in…
- Trial name
- NCT05088434
- Testing
- Anaerobically Cultivated Human Intestinal Microbiota (ACHIM), Donor fecal microbiota transplantation
- Where
- Norway
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Haukeland University Hospital
Arterial Stiffness, Blood Pressure
Prebiotic Effects of California Grapes on Gut Health and Cardiometabolic Health in Overweight Men and Women
The goal of this clinical trial is to assess the impact of table grape consumption on gut microbiome, intestinal permeability, systemic inflammation, and vascular function in healthy overweight men and women aged 45-70 years.
- Conditions
- Arterial Stiffness, Blood Pressure, Dysbiosis, Inflammation
- Trial name
- CALGRAM (NCT06544954)
- Testing
- Freeze-dried grape powder
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Crohn's Disease, Genetic Predisposition
Abnormal Fecal Microbiota in Healthy Subjects at High Risk for Crohn's Disease
Transversal multicentric French study on the microbiota in patients with Crohn's disease and their first degree healthy relatives The primary objective is the comparison of microbiota between patients with CD, healthy controls…
- Trial name
- MAGIC (NCT02826330)
- Testing
- biomarkers
- Where
- 10 sites in France
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Microbial Colonization, Irritable Bowel Syndrome
Probiotic Supplementation in the Dysbiosis of Bowel Preparation
Significant changes in gut microbiota was noted after the high-volume bowel preparation with PEG before colonoscopy. The dynamic changes were found to be short-term.
- Conditions
- Microbial Colonization, Irritable Bowel Syndrome, Metabolic Syndrome
- Trial name
- NCT04774042
- Testing
- Infloran probiotic, HAC probiotic
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Microbiome
Effect of a Probiotic or Postbiotic on Gut Microbiome During Antibiotic Treatment
This study assesses the effects of a probiotic or postbiotic on gut microbiome during antibiotic treatment.
- Trial name
- POTATO-2 (NCT07594860)
- Testing
- Probiotic, Postbiotic
- Where
- Greece
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- The Archer-Daniels-Midland Company
Irritable Bowel Syndrome, Crohn Disease
Evaluation of the SIMBA Capsule for Small Intestinal Dysbiosis
The SIMBA Capsule is a small, single-use, ingestible capsule that allows for the non-invasive sampling of small bowel contents using purely mechanical means.
- Conditions
- Irritable Bowel Syndrome, Crohn Disease, Celiac Disease, Ulcerative Colitis
- Trial name
- NCT05633706
- Testing
- fluid biopsy capsule
- Where
- Canada
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Nimble Science Ltd.
Boswellia Serrata, Irritable Bowel Syndrome
Positive Outcomes of the Supplementation With Lecithin-based Delivery Form of Curcuma Longa and of Boswellia Serrata in IBS
Small bowel dysbiosis (SBD), is a frequent finding in subjects with irritable bowel syndrome (IBS). The formula-tion in sunflower lecithin (Phytosome) of Curcuma longa and Boswellia serrata demonstrated beneficial effects on…
- Trial name
- NCT06407609
- Testing
- Curcuma and boswellia extracts plus low fodmap diet, Low Foodmap diet
- Where
- Italy
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Azienda di Servizi alla Persona di Pavia
Overweight and Obesity, Insulin Resistance
Carbohydrate-induced Resilience of the Gut Microbiome After Antibiotics Use
The gut microbiome is a complex ecosystem with a wide range of functions, and it is thought that it can influence multiple processes in the human body.
- Conditions
- Overweight and Obesity, Insulin Resistance, Dysbiosis
- Trial name
- CARMA (NCT04561284)
- Testing
- Indigestible fiber (classified)
- Where
- Netherlands
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Metabolic Syndrome, Dysbiosis
Almonds to Improve Gut Health and Decrease Inflammation
Almonds are a good source of beneficial compounds. This study will investigate if eating almonds everyday for 12 weeks can affect gut health and inflammation in persons with metabolic syndrome.
- Conditions
- Metabolic Syndrome, Dysbiosis, Inflammation
- Trial name
- NCT05790564
- Testing
- Almond, Crackers
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Oregon State University
Mental Disorder
Microbiome and the Gut-Brain Axis
This research study will examine the relationship interconnecting medical body health, mental health, and microbes of the digestive tract in persons living with serious mental illnesses,as compared to persons without such…
- Trial name
- NCT02693327
- Testing
- Biological Sample, Blood Sample
- Where
- 2 sites in United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of Florida