Clinical trials: Gut Metabolites
Graft Vs Host Disease
Alterations in Intestinal Microbiota, Metabolites, and Immune Cells in Allo-HSCT
This research project delves into the critical role of gut immunity in the occurrence and progression of acute graft-versus-host disease (aGVHD) post allogeneic hematopoietic stem cell transplantation (allo-HSCT).
- Trial name
- NCT06143501
- Testing
- Blood Sample, Stool Sample, Urine Sample
- Where
- China
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Soochow University
Healthy
Effect of Diets on the Gut Microbiota Composition and Cardiometabolic Wellbeing
The project will characterize human gut microbiome response to two different diets and the possible physiological and biochemical implications of such response on cardiometabolic risk factors.
- Trial name
- NCT03539666
- Testing
- diet
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- South Dakota State University
Obesity, Healthy
Gastrointestinal Tolerability to Agavins and Impact on Host-gut Microbiota-metabolism Interactions Modulation
Agavins are branched neo-fructans and prebiotic fiber found in Agave plants. In preclinical studies, agavins have demonstrated an effect in reversing metabolic disorders associated to overweight and obesity through the modulation…
- Trial name
- NCT04555447
- Testing
- Agavins (prebiotic fiber)
- Where
- 2 sites in Mexico
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Centro De Investigación Y De Estudios Avanzados Del Instituto Politécnico Nacional-Unidad Irapuato
Executive Function
The Effects of Short-Chain Fatty Acids in Psychosocial Stress-Induced Impairment on Core Executive Functions
The aim of the present trial is to examine core executive functions (EFs) as a functional outcome of attenuating the cortisol response to acute laboratory stress through colonic delivery of an Short Chain Fatty Acids (SCFAs) mix…
- Trial name
- GUTSIE (NCT06286943)
- Testing
- Short Chain Fatty Acids (SCFAs)., Maastricht Acute Stress Task, No-stress control task
- Where
- Belgium
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Rhinitis, Allergic
Study on the Mechanism of ZhenQiFuZheng in the Treatment of Allergic Rhinitis Based on Intestinal Flora and Metabolites
ZhenQi FuZheng granules has been used to improve the immune function of human body, protect the bone marrow and adrenal cortex function and promote the recovery of positive function in traditional Chinese medicine care…
- Trial name
- NCT06427577
- Testing
- ZhenQi FuZheng granules (ShiDaiYangGuang)
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Cognitive Function, Urinary Metabolites
Effects of Consumption of Nut Components on Cognitive Function, Intestinal Microbial Communities and Markers of Health
Tree nuts (for example brazil nuts, almonds, hazelnuts, walnuts, cashew nuts etc) contain a wide variety of nutrients including fatty acids, polyphenols and micronutrients.
- Conditions
- Cognitive Function, Urinary Metabolites, Intestinal Microbiota
- Trial name
- NCT03500601
- Testing
- Nut components
- Where
- United Kingdom
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Fecal Incontinence
Diet and Stool Metabolites in Fecal Incontinence
Fecal Incontinence (FI) is a debilitating and common condition with a prevalence ranging from 7-15% in community dwelling women.
- Trial name
- NCT02485522
- Testing
- No Intervention
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Exercised Induced Asthma, Asthma
The Effects of Prebiotics on Gut Bacterial Parameters, Immune Function & Exercise-Induced Airway Inflammation.
The current study aims to explore the role of prebiotic supplementation in adults with and without Asthma/Exercise-Induced Bronchoconstriction (A/EIB).
- Trial name
- NCT02872675
- Testing
- HOST-DM059, Maltodextrin
- Where
- United Kingdom
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Nottingham Trent University
Breast Milk Collection, Human Milk/Breastfeeding
Human Milk and Its Effect on Infant's Metabolism and Infant Gut Microbiome
This protocol explains the MAINHEALTH cohort. The study examine the influence of maternal health parameters on human breast milk composition and integrates milk phenotype with infant metabolism and infant gut microbial content…
- Conditions
- Breast Milk Collection, Human Milk/Breastfeeding, Human Milk Microbiome, Infant Gut Microbiome
- Trial name
- MAINHEALTH (NCT05111990)
- Where
- Denmark
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Healthy
The Effect of Vaccinium Myrtillus L. Extract Intake on Human Metabolism
Advanced glycation end-products (AGEs) has been linked to ageing, and many metabolic diseases. The findings of previous experiments suggested that the extracts from polyphenol-rich bilberry might inhibit the formation of AGEs.
- Trial name
- NCT03316612
- Testing
- Vaccinium Myrtillus L. extract
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Huazhong University of Science and Technology
Anxiety, Microbiome
Microbiome, Anxiety and Cognitive Orientation Study
Mounting evidence shows that the gut microbiome plays an important role in communication within the gut-brain axis. However, the relationship between gut microbiota and their influence on anxiety is still not fully understood.
- Conditions
- Anxiety, Microbiome, Mood Disorders, Neurodegeneration
- Trial name
- MACO (NCT05388630)
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Endominance
Inflammatory Bowel Diseases
Characterization of Disease Related Changes in Inflammatory Bowel Disease Using Fecal Metabolite Profiling
The purpose of the study is to evaluate fecal metabolites profiles of Inflammatory Bowel Disease(IBD) patients versus healthy controls (HC).
- Trial name
- NCT01666717
- Where
- Belgium
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Psyllium, Inulin
Exploring Mechanism of Action of Dietary Fibre on the Gut Microbiota and Metabolites
Cancer patients receiving pelvic radiotherapy suffer side effects to the intestine, including diarrhoea and occasionally rectal bleeding, often worsened by chemoradiation.
- Trial name
- MERLIN (NCT05906589)
- Testing
- Inulin, Psyllium, Maltodextrin
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Aberdeen
HFpEF - Heart Failure With Preserved Ejection Fraction
The Gut Microbiota and Metabolites in HFpEF
Heart failure (HF) with preserved ejection fraction (HFpEF) has emerged as a critical public health concern. The annual mortality rate for HFpEF is approximately 15%, accompanied by a re-hospitalization rate of nearly 80%.
- Trial name
- NCT06645535
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Chronic Kidney Diseases
Impact of Dapagliflozin on Intestinal Microbiota Composition and on the Metabolites Derived From the Intestinal Microbiota in Non-diabetic Chronic Renal Failure Patients
Chronic kidney disease (CKD) is a common disease affecting 10-12% of the adult population and characterize with high-risk cardiovascular morbidity and mortality with progression of CKD.
- Trial name
- DAPA-GUT (NCT05965440)
- Testing
- impact of Dapagliflozin on Intestinal Microbiota on chronic renal failure patients
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Inflammatory Bowel Disease, Crohn's Disease
The Impact of 6MP Metabolite Levels on Infliximab Pharmacokinetics and Anti-infliximab Antibodies in Crohn's Disease
In this research proposal, the investigators will focus on methods to optimize the therapeutic response to anti-TNF antibodies, by determining a correlation of 6-mp metabolite levels with IFX trough levels, anti-IFX antibody…
- Trial name
- NCT02453607
- Testing
- Infliximab, thiopurine
- Where
- Canada
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- Ernest Seidman
Multiple Sclerosis, Ulcerative Colitis
Determine PK Profiles of Ozanimod and Its' Major Metabolites in Healthy Subjects
The goal of this clinical trial is to learn how Ozanimod drug can be administered to the healthy subjects via transdermal delivery system (TDS, patch) to achieve better drug absorption and delivery than via oral capsules…
- Trial name
- NCT06528665
- Testing
- ZEPOSIA® indicated for the treatment of: Relapsing forms of multiple sclerosis, and active ulcerative colitis in adults
- Where
- Malaysia
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Corium Innovations, Inc.
Metabolite Concentration, Gut Permeability
Tributyrin: Time Course & Efficacy to Improve Health & Performance
The purpose of this study is to determine if tributyrin supplementation improves metabolite concentrations, overall health biomarkers, and performance in sedentary men and women.
- Conditions
- Metabolite Concentration, Gut Permeability, Inflammation, Sleep
- Trial name
- CoreBiome (NCT06501898)
- Testing
- CoreBiome
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Florida State University
Metabolic Diseases, Immune System Disorder
Study on the Effects of Wheat and Corn Germ Blend Oil on Antioxidation and Immune Regulation of Dyslipidemia Population
The goal of this clinical trial is to explore the role of wheat and corn germ blended oils in regulating oxidative stress and immunomodulation in dyslipidaemic populations, to explore their effects on intestinal flora…
- Conditions
- Metabolic Diseases, Immune System Disorder, Dyslipidemias, Fatty Acid Metabolism Disorder
- Trial name
- NCT06060509
- Testing
- Phytosterol-rich Wheat and Corn Germ Blended Oil, Peanut oil
- Where
- China
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Southeast University, China
Hypercholesterolemia, Flatulence
Fabulous Fibre Study - Effect of Wheat Bran Extract on Gut and General Health in Healthy Aging Subjects (FFS)
This is a placebo controlled, cross-over, randomized, double blinded study. The intervention food products will be taken as diet prebiotic supplements: 1.
- Conditions
- Hypercholesterolemia, Flatulence, Intestinal Diseases
- Trial name
- FFS (NCT02693782)
- Testing
- Fibre supplement
- Where
- United Kingdom
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Aberdeen