Clinical trials: Gut Microbiomes
Breast Cancer
Breast Cancer and Its Relationship With the Microbiota
Breast cancer ranks first in women, and is the second cause of death in this gender. In addition to genetics, the environment contributes to the development of the disease, although the factors involved are not well known.
- Trial name
- MICROMA (NCT03885648)
- Where
- Spain
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Universidad de Granada
Melanoma Stage Iv, Unresectable Stage III Melanoma
Fecal Microbiota Transplantation (FMT) in Metastatic Melanoma Patients Who Failed Immunotherapy
Altering the Gut Microbiota of Melanoma Patients Who Failed Immunotherapy Using Fecal Microbiota Transplantation (FMT) From Responding Patients. FMT includes both colonoscopy and stool capsules.
- Trial name
- NCT03353402
- Testing
- Fecal Microbiota Transplant (FMT)
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Sheba Medical Center
Obese Patients With Bariatric Surgery
Role of the Microbiota in Obesity: Effect After Bariatric Surgery
Several studies have demonstrated that bariatric surgery is effective for inducing weight loss in obese patients. In addition, the effects of this surgery on multiple associated alterations are well known, including changes in…
- Trial name
- MICROOBAR (NCT07277465)
- Testing
- Bariatric surgery
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Celia Bañuls
Gut Microbiota, Gastrointestinal Symptoms
Mother-Infant Cohort Study in Malaysia and China
This mother-infant cohort study aims to determine the geographic differences in the microbial profiles in breast milk from mothers living in Malaysia and China that are potentially important determinants of infant development.
- Conditions
- Gut Microbiota, Gastrointestinal Symptoms, Temperament, Eczema
- Trial name
- NCT04919265
- Testing
- No intervention - mother-infant cohort study
- Where
- Malaysia
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Universiti Putra Malaysia
Athlete
To Explore the Effects of Different Training Periods and Dietary Pattern on the Gut Microbiota, Metabolites and Protein Expression Levels of Strength and Endurance Athletes and to Find Relevant Biological Indicators.
The gastrointestinal tract contains hundreds of millions of microorganisms, collectively called the intestinal flora, which plays an important role in the health of the host.
- Trial name
- NCT04710667
- Where
- Taiwan
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- National Taiwan Sport University
Obesity
Investigation of the Gut Microbiota in Regulating Nutrient Absorption in Humans
We propose to study both stool and urine energy loss in 24 individuals on two experimental diets (50% increased and 50% reduced nutrient load relative to body size) in a random cross-over design.
- Trial name
- NCT02037295
- Testing
- Vancomycin, Overfeeding diet (OF), Underfeeding diet (UF)
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
End Stage Renal Disease, Gut Microbiome Dysbiosis
Prebiotics in Peritoneal Dialysis
The Prebiotics in Peritoneal Dialysis trial is a non-randomized, open-label, crossover study of p-inulin for patients with end-stage renal disease treated with peritoneal dialysis.
- Trial name
- NCT03265639
- Testing
- P-inulin
- Where
- 2 sites in United States
- Volunteers
- 9 people
- Sponsor
- Ali Ramezani
Healthy Participants, Infants
First Complementary Foods and the Infant Gastrointestinal Microbiota
This study evaluates the effect of different complementary foods on the gastrointestinal microbiota of exclusively human milk fed infants.
- Conditions
- Healthy Participants, Infants, Gastrointestinal Microbiota
- Trial name
- NCT05492253
- Testing
- Infant fruit, Infant vegetable, Infant meat
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of Delaware
Sedentary
Comparison of Gut Microbiota in Sedentary and Active Women
Gut microbiota comparison of active and sedentary women
- Trial name
- NCT02901912
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universidad Europea de Madrid
Gastrointestinal Microbiome, Immunoglobulin A
The Effect of Maternal Dadiah Supplementation During Pregnancy on Child Growth and Gastrointestinal Health Outcomes
The aim of our study is to assess the effect of giving dadiah as a supplement to pregnant women on improving the growth and digestive health of children.
- Conditions
- Gastrointestinal Microbiome, Immunoglobulin A, Growth; Stunting, Nutritional
- Trial name
- NCT05140928
- Testing
- Dadiah Pudding, Pudding without Dadiah
- Where
- Indonesia
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Andalas University
Aging
Can Synbiotic Use Effect Gut Bacteria and the Immune Response in Older People
The objectives of this study are to use a nutritional change in the diet to improve gut health in older people. Ageing can result in major changes in the composition and activities of the bacteria in your gut, leading to a higher…
- Trial name
- NCT01226212
- Testing
- Synbiotic (Synergy 1/B. longum)
- Where
- United Kingdom
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University of Dundee
Inflammatory Bowel Diseases
Biobank - Investigating the Gut Microbiota, Genetics, Epigenetics and Metabolites
Inflammatory bowel disease (IBD) affects 1 in 500 to 1,000 people in the West. Previously a disease predominantly of the West, there is now a marked increase in the incidence of ulcerative colitis (UC) and Crohn's disease (CD) in…
- Trial name
- NCT03855657
- Where
- Hong Kong
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Metastatic Testicular Cancer
Impact of a Physical Activity Program to Reduce Long-term Cancer-related Fatigue in Metastatic Testicular Germ Cell Tumor Patients
Testicular germ cell tumor (TGCT) is the most common malignancy in men between 15 and 40 years. Although TCGT survivors have a good survival prognosis, they suffer from short- and long-term sequelae such as chronic fatigue…
- Trial name
- STARTER (NCT05588700)
- Testing
- Physical activity recommendations, Connected activity tracker, Physical Activity (PA) Intervention
- Where
- 12 sites in France
- Volunteers
- 236 people
- Sponsor
- Centre Leon Berard
Hematological Malignancies, Chimeric Antigen Receptor T-cell Therapy
Correlation Between Gut Microbiota and Clinical Response to CAR-T Treatment for Hematological Malignancies
The purpose of this prospective and observational study is to evaluate the correlation between gut microbiota and clinical response to CAR-T treatment for hematological malignancies
- Trial name
- NCT06041815
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The First Affiliated Hospital of Soochow University
Atopic Dermatitis (Eczema), Atopic Dermatitis, Probiotics
Prebiotic Effects of Mulberry Fruit in Children and Adolescents With Atopic Dermatitis
This project proposes a randomized controlled human study to explore the prebiotic effects of consuming mulberry juice on atopic dermatitis in children and adolescents.
- Trial name
- NCT06636240
- Testing
- Mulberry fruit juice, Mometasone furoate 0.1% cream
- Where
- 2 sites in Taiwan
- Volunteers
- 120 people
- Sponsor
- Taipei Medical University Shuang Ho Hospital
Microbiota
Gut Microbiota in Chronic GI Diseases
The study involves characterizing the microbiota of patients with IBS, functional diarrhea, IBD, severe motility disorders and celiac disease.
- Trial name
- ChronicGI (NCT06532110)
- Testing
- Endoscopy/Colonoscopy
- Where
- Canada
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- McMaster University
Prebiotics, Metagenomic Next Generation Sequencing
Assessing Changes in the Gut Microbiome of Non-Gastrointestinal Disordered Subjects Before and After Oral Prebiotic Supplementation Using the SIMBA Capsule
This is a randomized, double-blind, placebo-controlled, parallel-group clinical study. The primary objective is to assess the changes in the small intestinal (SI) metagenomic profile of healthy participants without any known…
- Conditions
- Prebiotics, Metagenomic Next Generation Sequencing, Microbiome, Small Intestine
- Trial name
- NCT07788924
- Testing
- FiberSmart
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Anderson Advanced Ingredients
Intestinal Disease
Outcomes of Outpatients in an Gut Microbiota Clinic
The gut microbiota plays a crucial role in human health, influencing metabolism, immunity, and pathogen resistance. Research has linked microbiome dysbiosis to various intestinal and extra-intestinal disorders, prompting interest…
- Trial name
- Microfec (NCT06845527)
- Testing
- Microbiome testing and Cytokine profiling
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Stroke
Effects of Bifidobacterium Longum OLP-01 Supplement on Cognitive Function, Exercise Performance, Nutritional Status and Gut Microbiota in Stroke Patients
Stroke is a syndrome of acute, focal neurological deficit attributed to vascular injury of the central nervous system. It was the 2nd leading cause of death worldwide and accompanied by high disability rate also increases the…
- Trial name
- NCT05477732
- Testing
- Bifidobacterium longum OLP-01
- Where
- 3 sites in Taiwan
- Volunteers
- 120 people
- Sponsor
- Taipei Medical University
Overweight and Obesity, Weight Loss
Personalized Obesity Management - Matching Dietary Fibers and Microbial Enterotype
The overall aim of this 12-week randomized controlled trial is to investigate if a dietary fiber supplement rich in arabinoxylans (AX) affects weight loss success differently according to baseline gut microbiota composition in…
- Trial name
- POMFAME (NCT05260762)
- Testing
- Arabinoxylan, Control
- Where
- Denmark
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen