Clinical trials: Gut Microbiota
Healthy
The Role of Synbiotics in Modulating Host Physiology Via the Gut Microbiome
The current study is a proof of concept mechanistic study that will utilise a combination of prebiotic and probiotic (synbiotic) supplements.
- Trial name
- NCT06480812
- Testing
- Synbiotic
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Elizabeth Simpson
Overweight, Obesity
Dietary Fibre and Chromium Picolinate Efficacy in Overweight and Obese Women
Obesity is one of the greatest causes of preventable morbidity and mortality worldwide with the main treatments requiring significant changes to lifestyle, particularly dieting and physical exercise.
- Trial name
- DFCP (NCT04250831)
- Testing
- agglomerated glucomannan, oligofructose and chromium mixture
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Roehampton
Intestinal Health
Fiber Fermentation Study
The aim of the study is to better understand the interplay between the intake of dietary fiber and intestinal bacteria, their metabolic activity and the effect on the intestinal barrier.
- Trial name
- NCT04570137
- Testing
- Dietary fiber supplementation
- Where
- Germany
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Hohenheim
Fatigue, Stress, Job
Effects of Probiotics on Gut Microbiota, Endocannabinoid and Immune Activation and Symptoms of Fatigue in Dancers
The aim of the planned research is to assess the dynamics of changes in the elements of the gut-brain axis (GBA), the cytokine profile and the endocannabinoid system markers, after dietary supplementation with probiotics…
- Trial name
- NCT05567653
- Testing
- Lactobacillus helveticus Rosell-52 and Bifidobacterium longum Rosell-175 (Sanprobi Stress)
- Where
- Poland
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Poznan University of Physical Education
Healthy
Gut Microbiome Pill
The purpose of this study is to evaluate the safety and efficacy of a 3D-printed ingestible pill designed to sample microbiota from the GI tract, focusing on the ability to collect data also from the small intestine.
- Trial name
- NCT07243756
- Testing
- 3D-printed ingestible pill
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Human Gut Microbiome Development
Phages Dynamics and Influences During Human Gut Microbiome Establishment
Microbial communities are key components of human environment. Consequently, human gut microbiome have been extensively studied providing a better understanding of the relations between bacterial populations and host physiology.
- Trial name
- METAKIDS (NCT03296631)
- Testing
- collection of diapers with fresh stools
- Where
- 2 sites in France
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur
Intestinal Diseases
The Prebiotic Effect of Daily Intake of Orange Juice Affects the Bioavailability of Flavanones?
This study aimed investigate the chronic effect of orange juice consumption on gut microbiota and in the bioavailability of flavanones and metabolites by feces, blood and urine analysis.
- Trial name
- NCT03032861
- Testing
- Orange juice
- Where
- Brazil
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- São Paulo State University
HIV, Immune Cells (Mucosal and Systemic)
Quantification of Immune Cells in Women Using Contraception (CHIC II)
This study is being done to understand if using birth control causes changes in the immune cells within the reproductive tract (including the cervix and the lining of the uterus) of healthy women.
- Conditions
- HIV, Immune Cells (Mucosal and Systemic), Contraception
- Trial name
- CHIC-II (NCT01873170)
- Testing
- levonorgestrel exposure, DMPA exposure, etonogestrel exposure
- Where
- United States
- Volunteers
- 326 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Vitamin B 12 Deficiency
The Impact of Vitamin B12 Deficiency on Infant Gut Microbiota
Vitamin B12 plays important roles in DNA synthesis and neurological functions. Vitamin B12 deficiency is one of the most common micronutrient deficiencies and it has become increasingly more frequent in infants.
- Trial name
- NCT03365583
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Marmara University
Diminished Ovarian Reserve
Characterization of Gut and Tongue Coating Microbiota in Patients With Diminished Ovarian Reserve
The goal of this observational study is to investigate the distinct tongue manifestation characteristics in patients with diminished ovarian reserve (DOR) compared to healthy individuals, and to clarify the features of tongue…
- Trial name
- CGTCMPDOR (NCT07124260)
- Testing
- gut microbiota, tongue coating microbiota, tongue picture
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University
Healthy
Healthy Volunteer Short Chain Fatty Acid Study
The purpose of this study is to evaluate the production of short chain fatty acids (fatty acids are part of your diet) in stool through the measurement of fecal inulin after a one-time ingestion of 10-gram dose of inulin among…
- Trial name
- NCT05254340
- Testing
- Inulin
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Indiana University
Crohn Disease
Effects of Enteral Nutrition and Corticosteroid on Intestinal Flora in Induction Remission of Crohn Disease in Adult
The pathogenesis of Crohn Disease (CD) is unknown, but there is evidence show that the inadequate immune response or overreaction of the immune system against food antigens or components of the commensal flora involve it.
- Trial name
- EN (NCT02056418)
- Testing
- enteral nutrition, corticosteroid
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Jinling Hospital, China
Healthy
Intestinal Microbiota: Immunity, Recovery and Metabolic Health
The aim of this intervention study is to investigate the effect of a specific postbiotic (Lacticaseibacillus rhamnosus GG = LGG) and whey protein on immunity, recovery, and weight management in young adults.
- Trial name
- VAR-MIKRO (NCT06355089)
- Testing
- Whey protein hydrolysate milk product, Postbiotic and whey protein hydrolysate milk product
- Where
- Finland
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Turku
Gastrointestinal Health
Colostrum and Gut Health
The primary objective of this study is to evaluate changes in participant-reported gastrointestinal function over a 16-week intervention period and a 4-week non-supplementation period (20 weeks total) following daily consumption…
- Trial name
- NCT07856979
- Testing
- Bovine Colostrum - Lower Dose, Bovine Colostrum - Higher Dose
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Bovita Labs, LLC
Metabolic Syndrome, Obesity
Genistein Stimulates Insulin Sensitivity Through Gut Microbiota
There is evidence that genistein present in soy can improve insulin resistance in rodents and humans with metabolic syndrome (MetS). However, it is not known if this improvement is associated with changes in the gut microbiota.
- Trial name
- GENISTEIN (NCT04105023)
- Testing
- genistein
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Healthy Volunteers
The Effect of Wheat Germ on Gastrointestinal Discomfort, Blood Cholesterol and Postprandial Glycaemic Response
Wheat germ is a by-product of the wheat-milling industry with high nutritional value and therefore could be used as a raw source for the preparation of food products such as bread, cookies, muffins, etc.
- Trial name
- NCT02405507
- Testing
- wheat bread with wheat germ, wheat bread without wheat germ
- Where
- 2 sites in Portugal
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Universidade do Porto
Obesity, Intestinal Bacteria Flora Disturbance
Study on Dietary Nutrition Intervention Techniques for Children Obesity
With the rapid development of society and economy, children's simple obesity is the rising in the world and has become a chronic disease which is one of the biggest public health challenges in the world.
- Conditions
- Obesity, Intestinal Bacteria Flora Disturbance, Body Weight
- Trial name
- NCT02539836
- Testing
- Dietary nutrition based on plant fermentation extract, MRI in quantifying liver fat with MRS
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Chinese Academy of Sciences
Stress Physiology
Prebiotic and Probiotic Modulation of the Gut Microbiota-gut-brain Axis During Acute Stress
Emerging evidence supports the existence of a microbiota-gut-brain axis through which gut microbes influence cognition, mood and behavior.
- Trial name
- NCT05392556
- Testing
- Probiotic, Prebiotic
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
A03 - Digestive System, B03 - Bacteria
Fermented Dairy Product and Bifidobacterium Diversity (ThreeBees)
Bifidobacterium strains with potential health benefits can contribute to the gastrointestinal wellbeing. However, the ability of these strains to survive gastro-intestinal tract stress and their impact on gut microbiome remains…
- Trial name
- ThreeB (TB) (NCT06799364)
- Testing
- 28-days consumption of Product A in 45 to 60-year-old healthy subjects., 28-days consumption of Product B in 45 to 60-year-old healthy subjects., 28-days consumption of Control product in 45 to 60-year-old healthy subjects.
- Where
- 3 sites in France
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- Danone Global Research & Innovation Center
Intestinal Bacteria Flora Disturbance
Allium Extracts on the Intestinal Microbiota in Healthy Resident Volunteers.
To evaluate the effect of daily consumption of a combination of garlic and onion extracts on the intestinal microbiota and the production of short chain fatty acids in elderly healthy volunteers living in a residence.
- Trial name
- NCT05016999
- Testing
- Garlic and onion concentrate
- Where
- Spain
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- DOMCA S.A.
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