Clinical trials: Gut Microbiota Diversity and Composition
Glucose Intolerance, Glucose and Insulin Response
Sucralose and Glucose Metabolism in Young Healthy Adults
This study aimed to investigate the effects of a three-week consumption of sucralose-sweetened beverages (low-calorie sweetener) on postprandial glycemic responses in healthy adults, compared with sugar-sweetened beverages under…
- Conditions
- Glucose Intolerance, Glucose and Insulin Response, Glucose Homeostasis, Low-grade Inflammation
- Trial name
- NARELO (NCT07194772)
- Testing
- Low-calorie sweeteners (LCS), Refined sugars (SSB), Natural sugars (FJ)
- Where
- Canada
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Growth Retardation, Infant Morbidity
Prebiotics and Microbiota Composition and Functionality in Rural Burkinabe Infants
The purpose of this study is to assess the effect of a mixture of prebiotics included in a food supplement on microbiota diversity and functionality, and to explore its subsequent effects on linear growth velocity and morbidity.
- Trial name
- NCT02716935
- Testing
- Fortified lipid based nutrient supplement, lipid based nutrient supplement
- Where
- Burkina Faso
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- University Ghent
Gut Epithelial Permeability, Gut Microbiota Composition and Diversity
Impact of Dairy Integration Into Canadian Food Guide on Gut Health
The primary objective is to investigate the impact of milk, fermented milk, and soy beverages, incorporated in a diet reflecting adherence to Canadian food guide recommendations on food choices on gut microbiota in middle-aged…
- Conditions
- Gut Epithelial Permeability, Gut Microbiota Composition and Diversity, Gut and Circulating Inflammatory Markers, Milk and Digestion
- Trial name
- GutMilk (NCT07257913)
- Testing
- Milk, Fermented milk, Soy beverage
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Laval University
Short Chain Fatty Acids Concentration in Stools, Gut Microbiota Diversity and Composition
The Effect of Vitamin C Supplementation on Gut Microbiota Composition and Function in Healthy Adults
The aim of this dietary intervention study is to explore how vitamin C affects the bacteria that live in our gut. Vitamins are essential nutrients found in fruits and vegetables.
- Trial name
- VitaGut (NCT07388121)
- Testing
- Moderate Vitamin C dose (200 mg), High-dose vitamin C supplementation (1000 mg), Habitual diet (run in period)
- Where
- United Kingdom
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Glasgow
Nutrition, Ketogenic Diet
Dietary Macronutrients and Gut Microbiota, Inflammation, and Metabolic Markers
This 12-week randomized controlled trial will investigate the effects of dietary patterns with different macronutrient compositions on gut microbiota, intestinal inflammation, gene expression, and metabolic health in healthy…
- Conditions
- Nutrition, Ketogenic Diet, Gene Expression, Diet
- Trial name
- DIETMICRO (NCT07672691)
- Testing
- Ketogenic Diet (KD), Vegetarian Diet (VD), Control Diet (CD)
- Where
- 2 sites in Poland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- The Jerzy Kukuczka Academy of Physical Education in Katowice
HIV Infections
Gut Microbiota Changes of HIV Patients Before and After One Year of ART
HIV infection leads to destruction of CD4+T cells in the gut-associated lymphoid tissue (GALT) and promotes a decline in mechanical barrier functions of the gut mucosa, and the subsequent translocation of microbial products from…
- Trial name
- NCT04297501
- Testing
- Antiretroviral Therapy
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Peking Union Medical College Hospital
Temperament, Sleep
GUTLINK4KIDS Intervention
This study aims to investigate the chronic effects of prebiotic consumption on cognitive, behavioural and gut microbiome outcomes in children aged 3-5 years.
- Conditions
- Temperament, Sleep, Cognition, Emotion Regulation
- Trial name
- GUTLINK4KIDS (NCT07401212)
- Testing
- Prebiotic powder
- Where
- United Kingdom
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- University of Reading
Premature, Gut Microbiota Diversity and Composition
Effect of Rectal Administration of Breast Milk on Gut Microbiota in Preterm Infants
This study aims to evaluate the effect of rectal administration of maternal breast milk on gut microbiota development in preterm infants.
- Conditions
- Premature, Gut Microbiota Diversity and Composition, NEC - Necrotizing Enterocolitis
- Trial name
- premic (NCT07558499)
- Testing
- Rectal irrigation with maternal breast milk, Rectal irrigation with salin
- Volunteers
- 60 people
- Sponsor
- Zekai Tahir Burak Women's Health Research and Education Hospital
Biomarkers of B-vitamin Status and Gut Microbiome Composition
Effect of a Food Intervention With a Prebiotic Alone or Combined With B-vitamins on Gut Microbiota Diversity, Inflammation and Mental Health Outcomes in Older Adults (GutFood)
Ageing is associated with changes in gut microbiota composition, increased inflammation, and a greater risk of poor mental health outcomes.
- Trial name
- NCT07592975
- Testing
- Inulin and B-vitamins, Inulin
- Where
- United Kingdom
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of Ulster
Short Chain Fatty Acids Concentration in Stools, Gut Microbiota Diversity and Composition
Effects Of Dietary Fats on Gut Microbiota Composition and Metabolic Activity in Healthy Adults
This study will investigate how adding a specific type of dietary fat to daily meals for two weeks affects the gut bacteria and their activity.
- Conditions
- Short Chain Fatty Acids Concentration in Stools, Gut Microbiota Diversity and Composition, Blood Lipid Profiles, Inflammation Biomarkers
- Trial name
- NCT07550023
- Testing
- Butter, Coconut oil, Extra Virgin Olive Oil
- Where
- United Kingdom
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Glasgow
Colonization, Asymptomatic, Probiotic Intervention
Probiotic in Fruit Snack
The aim of this study is to investigate whether a fruit snack containing probiotic ''Lactobacillus rhamnosus'' can survive and establish itself more effectively in the gut when it is protected inside a natural plant-protein…
- Conditions
- Colonization, Asymptomatic, Probiotic Intervention, Gut Microbiota Diversity and Composition, Gut-brain Axis
- Trial name
- Probiotics (NCT07679490)
- Testing
- Microencapsulated Lactobacillus rhamnosus Fruit Snack
- Where
- Ireland
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University College Dublin
Severely Burned Patients, Gut Microbiota Diversity and Composition
Monitoring the Clinical and Immunological Effects of Microbiome Changes Following Severe Burn Injury
The aim of this study is to longitudinally monitor dynamic changes in the gut microbiome following severe burn injury using fecal samples.
- Conditions
- Severely Burned Patients, Gut Microbiota Diversity and Composition, Inflammatory Responses
- Trial name
- microbiome (NCT07329595)
- Where
- Hungary
- Volunteers
- 30 people
- Sponsor
- Tamas Vegh, MD
Gut Microbiota Diversity and Composition, Gut Microbiota Modulation
Effects of Barley and Kefir on Gut Microbiota in Physically Active Adults
The purpose of this randomized controlled clinical trial is to investigate whether a four-week dietary intervention consisting of a daily meal with barley and kefir can influence gut microbiota diversity and composition in…
- Conditions
- Gut Microbiota Diversity and Composition, Gut Microbiota Modulation, Probiotic, Prebiotic
- Trial name
- GUTS (NCT07864779)
- Testing
- Barley, Kefir
- Where
- Norway
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Western Norway University of Applied Sciences
Gut Microbiota Diversity and Composition, Athletic Performance
Kefir, Gut Microbiota, and Athletic Performance in Soccer Players
This research work is a clinical trial that will assess the impact of kefir consumption on the gut microbiota profile and athletic performance of female soccer players of age 18-29 years.
- Conditions
- Gut Microbiota Diversity and Composition, Athletic Performance, Functional Food Intervention (Kefir), Body Composition
- Trial name
- KEFIR-SPORT (NCT06753422)
- Testing
- Kefir
- Where
- Turkey (Türkiye)
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Acibadem University
Appendicitis, Appendicitis Acute
Clinical Study of PEG Bowel Preparation in Appendectomy Patients
Colonoscopy is a necessary item of physical examination for colorectal cancer. For high-risk groups, annual physical examination is the most effective way of early prevention; At present, a large amount of polyethylene glycol…
- Trial name
- NCT07478029
- Testing
- Bowel Preparation with Polyethylene Glycol (PEG) Laxatives
- Where
- China
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Huaping Xie