Clinical trials: Gut Microbiota Modulation
Gastrointestinal Microbiome (Focus), Gastrointestinal Symptoms
The Effect of a Synbiotic on Intestinal Barrier Function and Microbiota Modulation in Middle-aged to Elderly Individuals With Excessive Body Weight
The study is a single-center, randomized, double-blind, placebo-controlled study in middle-aged to elderly adults with excessive body weight. The study includes an 8-week intervention period followed by a 2-week follow-up period.
- Trial name
- myBIOM (NCT07453823)
- Testing
- Synbiotic
- Where
- Ireland
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Chr Hansen - part of Novonesis
Healthy, Healthy Nutrition
The BEGIN Study Bifidobacterium Infantis to Newborns: Effects of Modulating the Gut Microbial Composition on Growth, Immune Function and Inflammatory Conditions - a Randomized Placebo-controlled Double-blinded Intervention Trial
The goal of The BEGIN Study, a randomized controlled double-blinded intervention trial, is to learn if probiotics, with Bifidobacterium longum subspecies infantis Bifin02 (B.
- Trial name
- BEGIN (NCT06452199)
- Testing
- B. infantis
- Where
- 2 sites in Denmark
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Stress Physiology
Prebiotic and Probiotic Modulation of the Gut Microbiota-gut-brain Axis During Acute Stress
Emerging evidence supports the existence of a microbiota-gut-brain axis through which gut microbes influence cognition, mood and behavior.
- Trial name
- NCT05392556
- Testing
- Probiotic, Prebiotic
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Microtia
The Effect of Prebiotics on Endurance Performance
The aim of this study is to investigate the effect of a six-week period personalised food intervention with prebiotic supplementation on intense exercise performance in healthy, recreationally active adults.
- Trial name
- NCT04946578
- Testing
- Prebiotic
- Where
- Netherlands
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Maastricht University
Obesity, Gut Microbiota Modulation
ESAN III - Energy Sensing in Depression
The purpose of this study is to assess the effects of carotenoids from natural carrot juice on the immune system. Therefore, the study aims to distinguish the effects of natural juices that are rich in phytonutrients such as…
- Conditions
- Obesity, Gut Microbiota Modulation, Immunomodulation
- Trial name
- NCT06985381
- Testing
- Carotenoid-rich juice, Control
- Where
- Austria
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Healthy, Overweight (BMI > 25)
Effect of Probiotics on Appetite Regulation in Adults With Overweight/Obesity
The goal of this 16-week randomised, placebo-controlled parallel study is to investigate the effect of a newly formed probiotic supplement on satiety and gut microbiota composition in healthy men and women with overweight or…
- Conditions
- Healthy, Overweight (BMI > 25), Overweight , Obesity, Male
- Trial name
- ProBiSat (NCT07715955)
- Testing
- Probiotic supplementation
- Where
- Netherlands
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Healthy Volunteers
Effect of Nutrition Ingredients on Microbiota Modulation
The objective of this study is to evaluate in healthy volunteers the time-dependent effect of daily consumption for four weeks of six different nutrition ingredients on relative abundance of microbial taxa in fecal samples.
- Trial name
- VitaGut (NCT03668964)
- Testing
- Vitamin B2, Vitamin C, Vitamin B2 + C
- Where
- Ireland
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- dsm-firmenich Switzerland AG
Healthy Diet
Impact of Whole Grain Rye Bread on Health
This randomized controlled trial aims to study how a high intake of a fibre-rich bread affects the composition and functioning of the gut microbiota in healthy subjects, and how this, in turn, impacts on the release of gut…
- Trial name
- FBS (NCT06333717)
- Testing
- Whole grain bread, Control bread
- Where
- Sweden
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Örebro University, Sweden
Obesity
Modulation of the Intestinal Microbiome by a High Protein Diet
The objective of this study is to test and determine whether a high protein diet induces weight loss by modulating the composition and function of the intestinal microbiome in obesity.
- Trial name
- HPD (NCT04812964)
- Testing
- Protein powder supplement, standard dosage based on 0.5 gram protein per pound of subject's lean body mass, Protein powder supplement, High Level Protein, based on 1 gram of protein per pound of lean body mass: 25% protein and 45% carbohydrate
- Where
- United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Glucose Intolerance, Glucose and Insulin Response
Sucralose and Glucose Metabolism in Young Healthy Adults
This study aimed to investigate the effects of a three-week consumption of sucralose-sweetened beverages (low-calorie sweetener) on postprandial glycemic responses in healthy adults, compared with sugar-sweetened beverages under…
- Conditions
- Glucose Intolerance, Glucose and Insulin Response, Glucose Homeostasis, Low-grade Inflammation
- Trial name
- NARELO (NCT07194772)
- Testing
- Low-calorie sweeteners (LCS), Refined sugars (SSB), Natural sugars (FJ)
- Where
- Canada
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Diet, Healthy, Systemic Inflammatory Response
Effect of Pectin and Inulin Fibre Supplementation on Glucose and ANS Modulation
The study involves intake of dietary supplements, which are commonly found in the UK diet (not pharmacological agents) to test their effects on inflammation in the body and gut microbiome composition.
- Trial name
- NCT06480799
- Testing
- Fibre intervention
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Elizabeth Simpson
Microbiota
Benefits of Almond Consumption in Modulation of Intestinal Microbiome and Novel Disease Risk Biomarkers
The overall goal is to assess the health benefits of almond consumption on gut microbiome patterns and their association with circulating disease risk biomarkers, as well as the processes that control those pathways.
- Trial name
- NCT03327441
- Testing
- Almonds, Omelette
- Where
- Canada
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Obesity & Overweight, Circadian Rhythm Disorders
Effects of Akkermansia Muciniphila and Berberine Supplementation on Insulin Sensitivity in Night-shift Workers
Night shift work is associated with an increased risk of obesity, insulin resistance, and cardiometabolic disorders, largely due to circadian misalignment, disrupted sleep, and altered eating patterns.
- Conditions
- Obesity & Overweight, Circadian Rhythm Disorders, Gut Microbiota Modulation, Prediabetes (Insulin Resistance, Impaired Glucose Tolerance)
- Trial name
- Shift2Health (NCT07440147)
- Testing
- Verum (A)
- Where
- Austria
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- FH Joanneum Gesellschaft mbH
Functional Gastrointestinal Disorders (FGIDs), Weight Loss
Effects of Multi-strain Bacillus Spore Probiotics on Growth, Digestive Function, and Gut Microbiota in Cesarean-Delivered Neonates
Infants born by cesarean section commonly show early weight loss and slower recovery of birth weight, together with characteristic patterns of gut microbiota dysbiosis marked by reduced Bifidobacterium and Bacteroides and…
- Trial name
- NCT07320287
- Testing
- RO water, LiveSpo PREG-MOM, LiveSpo CONSY
- Where
- Vietnam
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Anabio R&D
Changes in Human Gut Microbiome in Healthy Adults
Prospective Randomized Controlled Pilot Study of Gut Microbiome Modulation by Nigella Sativa Seed Oil and Thymoquinone Metabolism in Healthy Volunteers
For many patients, the additive use of dietary supplements without side effects is motivating for therapy and enhances quality of life.
- Trial name
- NCT07450807
- Testing
- Intake of Thymoquinone (TQ) containing Nigella Sativa Seed Oil (NSSO) capsules
- Where
- Germany
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Aysun Tekbaş
Healthy Adults
Probiotic LR08 Improves Gut and Metabolism
Evaluate the efficacy and safety of LR08 as a dietary supplement compared to a placebo in enhancing intestinal health and immune function in healthy adults.
- Trial name
- NCT06875362
- Testing
- Probiotic
- Where
- China
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Wecare Probiotics Co., Ltd.
Pulmonary Inflammation, Cystic Fibrosis
Modulation of Intestinal and Pulmonary Inflammation by Lactobacillus Diet Supplementation in Pediatric Cystic Fibrosis
Pulmonary inflammation is an independent risk factor for disease progression in cystic fibrosis patients (CF). Yet, no effective treatment is known to reduce this detrimental inflammation.
- Conditions
- Pulmonary Inflammation, Cystic Fibrosis, Microbiota
- Trial name
- MoHuM-1 (NCT01837355)
- Testing
- Lactobacillus rhamnosus
- Where
- Switzerland
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Cantonal Hospital of St. Gallen
Constipation, Gastrointestinal Discomfort
Clinical Evaluation of the Effects of EpiCor on Digestive Comfort
Previous in vitro studies suggest that EpiCor is well fermented in the colon and has prebiotic potential. The repeated long-term administration of low doses of EpiCor in the Simulator of the Human Intestinal Microbial Ecosystem…
- Trial name
- NCT03051399
- Testing
- EpiCor
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- ProDigest
HELICOBACTER PYLORI INFECTIONS, Metabolic Syndrome
Eradication of Helicobacter Pylori Improves Metabolic Syndrome Through Modulation of Gut Microbiota.
The Role of Gut Microbiota in the Mechanism of Helicobacter pylori Eradication-Induced Amelioration of Metabolic Syndrome-Related Parameters Study Sponsor: Nanjing First Hospital Principal Investigator: Dr.
- Trial name
- NCT07306988
- Testing
- Vonoprazan-Amoxicillin Dual Therapy, Vonoprazan-Amoxicillin with Bifidobacterium tetravaccae, Vonoprazan-Amoxicillin with Berberine
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Gestational Diabetes Mellitus in Pregnancy, Diet- Controlled, Exercise Addiction
Modulation of the Intestinal Flora With the Probiotic VIVOMIXX™ in Pregnant Women at Risk of Metabolic Complications
The investigators aimed at evaluating the effectiveness of probiotics ingestion in changing maternal microbiota and preventing gestational diabetes in overweight and obese women.
- Conditions
- Gestational Diabetes Mellitus in Pregnancy, Diet- Controlled, Exercise Addiction, High-Risk Pregnancy, Dietary Modification
- Trial name
- NCT02768818
- Testing
- Probiotic VIVOMIXX™
- Where
- Italy
- Volunteers
- 205 people, healthy volunteers welcome
- Sponsor
- University of Modena and Reggio Emilia