Clinical trials: Gut-Brain Disorders
Major Depressive Disorder, Bipolar Disorder, Mixed
Chinese Longitudinal and Systematic Study of Bioplar Disorder
Affective disorders (mainly including major depressive disorder and bipolar disorder) are common, chronic and highly disabling mental disorders, which lack of objective biological markers.
- Conditions
- Major Depressive Disorder, Bipolar Disorder, Mixed, Affective; Disorder, Organic
- Trial name
- CLASS-BD (NCT05480150)
- Testing
- Escitalopram Oxalate Tablets, Quetiapine Fumarate Tablets, Lurasidone
- Where
- China
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Zhejiang University
Sleep, Gut Microbiome
Impact of Nutritional Supplementation on Sleep Quality and Gut Microbiome Composition in Older Adults
The aim of this study is to assess the impact of 5-hydroxytryptophan (5-HTP) supplementation on sleep quality and gut microbiome composition in older adults with normal cognition vs.
- Trial name
- NCT04078724
- Testing
- 5-HTP, Without 5-HTP
- Where
- 2 sites in Singapore
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Healthy, Cognitive Function 1, Social
Active Gains in Brain Using Exercise During Aging
AGUEDA (Active Gains in brain using Exercise During Aging) is a randomized controlled trial designed to examine the effects of a 24-week resistance exercise program on brain health in cognitively normal adults between 65-80 years…
- Trial name
- AGUEDA (NCT05186090)
- Testing
- 24-week resistance exercise program
- Where
- Spain
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Universidad de Granada
Adrenal Cortical Cancer, Brain Cancer
Spectroscopy With Surface Coils and Decoupling
The purpose of this study is to obtain chemical information from part of your body without a biopsy. This is done using a technique called magnetic resonance spectroscopy (MRS) which is similar to magnetic resonance imaging (MRI)…
- Conditions
- Adrenal Cortical Cancer, Brain Cancer, Breast Cancer, CNS Cancer
- Trial name
- NCT00581815
- Testing
- Proton-decoupled 31P MRS at 1.5T, 1H Spectroscopy at 1.5T and 3T
- Where
- United States
- Volunteers
- 582 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Obesity, Stress
Brain-Gut Interactions in Overweight and Normal Weight Patients With Chronic Abdominal Pain
About 15 to 20 percent of individuals living in the United States have chronic abdominal pain, often of unknown origin, which is often difficult to diagnose and treat.
- Conditions
- Obesity, Stress, Irritable Bowel Syndrome, Women
- Trial name
- NCT00824941
- Where
- United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- National Institute of Nursing Research (NINR)
Mental Disorder
Microbiome and the Gut-Brain Axis
This research study will examine the relationship interconnecting medical body health, mental health, and microbes of the digestive tract in persons living with serious mental illnesses,as compared to persons without such…
- Trial name
- NCT02693327
- Testing
- Biological Sample, Blood Sample
- Where
- 2 sites in United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of Florida
Parkinson Disease
Levodopa Response and Gut Microbiome in Patients With Parkinson's Disease
Levodopa (LD) is an effective treatment to control symptoms of Parkinson's disease (PD). However, the response to (the effectiveness) LD changes over time and patients require higher and more frequent LD doses for treatment.
- Trial name
- NCT04956939
- Testing
- Low dose levodopa, High dose levodopa
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Sleep Disturbance, Mood Disturbance
Enhancement of Sleep Quality and Mood Following Supplementation With Lemon Balm in an Adult Population (Lemslp)
This study aims to investigate the effect of a 4-week dietary intervention of 300mg encapsulated aqueous lemon balm extract on measures of sleep quality, mood and well-being, alongside relevant biomarkers of circadian rhythms in…
- Trial name
- NCT05422599
- Testing
- Lemon balm
- Where
- United Kingdom
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- University of Reading
Ulcerative Colitis (UC), Crohn's Diseases
Cardiovascular Risk in Patients With IBD
In this study the Research Hospital San Donato Policlinic ask the participation with the aim to evaluate the risk of cardiovascular complication (i.e. stroke, myocardial infarction) in patients with inflammatory bowel disease.
- Conditions
- Ulcerative Colitis (UC), Crohn's Diseases, Cardiovascular Risk
- Trial name
- DICOM-IBD (NCT07663201)
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- IRCCS Policlinico S. Donato
Functional Gastrointestinal Disorders (FGIDs), Cyclic Vomiting Syndrome
Autonomic Reactivity and Personalized Neurostimulation
Disorders of gut-brain interaction (DGBI) affect up to 25% of U.S. children. Patients often suffer from disabling, multisystem comorbidities that suggest a common root (sleep disturbances, fatigue, anxiety, etc).
- Conditions
- Functional Gastrointestinal Disorders (FGIDs), Cyclic Vomiting Syndrome, Functional Dyspepsia, Dysautonomia
- Trial name
- NCT06863207
- Testing
- Percutaneous electrical nerve field stimulation, Hypnotherapy
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Meconium Obstruction of Prematurity
Saline Enema Administration in Meconium Obstruction of Prematurity and Impact on the Resolution, Feeds, Microbiome, and Gut-brain Axis.
The goal of this clinical trial is to study the effect of twice-daily saline enema (SE) in the treatment obstruction of prematurity (MOP) in infants with the birth weight ≤1.25kg.
- Trial name
- NCT06048614
- Testing
- Saline Enema (SE), Glycerin Suppository
- Where
- 2 sites in Singapore
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- KK Women's and Children's Hospital
Healthy, Irritable Bowel Syndrome
Effect of Serotonergic Stimulation on the Gut-brain Axis
Selective serotonin reuptake inhibitors increase the level of serotonin. This study will use functional magnetic resonance imaging to examine how subjects with, and without, irritable bowel syndrome patients respond to…
- Trial name
- NCT03920410
- Testing
- serotonergic stimulation, no serotonergic stimulation
- Where
- Sweden
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Örebro University, Sweden
Brain Injuries
The Gut-Brain Axis During Neurorehabilitation; Prebiotic Treatment to Alter the Gut Microbiome and Neurologic Symptoms
The aim of this study is to characterize the microbiome of patients undergoing post-acute residential neurorehabilitation compared to community controls and to determine if a dietary fiber, Inulin, can create a shift in the…
- Trial name
- NCT06607523
- Testing
- Inulin
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Long COVID, Brain Fog
Effect of Probiotic Strain Lactobacillus Paracasei PS23 on Brain Fog in People With Long COVID
The goal of this clinical trial is to test whether the intervention of probiotics supplement can improve symptoms of long covid syndrome. Participants will be given probiotics or placebo capsules for two month.
- Conditions
- Long COVID, Brain Fog, Cognitive Change
- Trial name
- COVID-19 (NCT06348212)
- Testing
- Lactobacillus paracasei PS23, microcrystalline cellulose
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Gut Microbiome, Gastrointestinal Microbiome
A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Disease
This study seeks to correlate microbiome sequencing data with information provided by patients and their medical records.
- Conditions
- Gut Microbiome, Gastrointestinal Microbiome, Autism, Autism Spectrum Disorder
- Trial name
- NCT04031469
- Testing
- There is no intervention in this study
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- ProgenaBiome
Dyspepsia, Functioanl Dyspepsia
Effect of Digestive Enzymes as Add on Therapy on Patients With Functional Dyspepsia.
The goal of this clinical trial is to assess the effect of digestive enzymes in improving dyspeptic symptoms in patients with functional dyspepsia.
- Conditions
- Dyspepsia, Functioanl Dyspepsia, Epigastric Pain Syndrome, Epigastric Fullness
- Trial name
- NCT07578402
- Testing
- Digestive enzyme 325mg, PPI 20 mg + Domperidone 10 mg
- Where
- Bangladesh
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Rakibul Mostafa
Irritable Bowel Syndrome, Colonic Diseases, Functional
fMRI and Visceral Perception Upon Capsaicin Infusion
Brain imaging has shown abnormal brain activations in response to visceral stimulation in patients with the Irritable Bowel Syndrome (IBS) and Functional Dyspepsia (FD).
- Conditions
- Irritable Bowel Syndrome, Colonic Diseases, Functional, Dyspepsia, Gastrointestinal Diseases
- Trial name
- NCT02551029
- Testing
- Capsaicin
- Where
- Netherlands
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Diabetes, Chronic Kidney Diseases
Benchtop NMR Spectroscopy for Assessment of Clinical Human Pathologies (BRANCH-P STUDY)
This research programme seeks to combine the resources of NHS primary care, with the leading spectroscopic work in low-magnetic fields of the Wilson Group (Nottingham Trent University) to demonstrate the potential for benchtop…
- Conditions
- Diabetes, Chronic Kidney Diseases, Cancer, Bowel Disease
- Trial name
- BRANCH-P (NCT05473325)
- Where
- United Kingdom
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Willows Health
Multiple Sclerosis
Retrospective Study on the Role of SCFA Modulation in Multiple Sclerosis
Recent studies show that gut microbiota strongly influences multiple sclerosis. These data suggest that the microbiota could have a direct effect on MS pathogenesis, although the mechanisms through which it modulates central…
- Trial name
- NCT06746896
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Prof. Massimo Filippi
PTSD - Post Traumatic Stress Disorder
Rapid Recovery: Gut Microbiome Correction for PTSD
This cohort clinical trial (RAPID RECOVERY) investigates the role of gut microbiome in mental health and the effectiveness of personalized microbiome correction in individuals with post-traumatic stress disorder (PTSD).
- Trial name
- RAPID RECOVERY (NCT07623967)
- Testing
- Investigational Probiotic Preparation
- Where
- Ukraine
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Uzhhorod National University