Clinical trials: Gynaecological Cancers
Ovarian Cancer, Ovarian Cancer Stage III
Prehabilitation in Gynaecological Cancer Patients
Prehabilitation refers to interventions aiming to improve patients' resilience and functional capacity before a known stressful event, e.g., scheduled surgery.
- Conditions
- Ovarian Cancer, Ovarian Cancer Stage III, Ovarian Cancer Stage IV, Endometrial Cancer
- Trial name
- PHOCUS (NCT04789694)
- Testing
- Physiological intervention, Psychological intervention, Nutritional intervention
- Where
- Czechia
- Volunteers
- 64 people
- Sponsor
- Charles University, Czech Republic
Gynecological Cancer
Low-Intensity CBT for Gynaecological Cancer Survivors
There are 21,500 gynaecological cancers diagnosed in the UK each year. These are often diagnosed later than common cancers, which is predictive of low survival and high psychological distress.
- Trial name
- EPELIT (NCT03553784)
- Testing
- Group delivered Low Intensity Cognitive Behavioural Therapy
- Where
- United Kingdom
- Volunteers
- 32 people
- Sponsor
- University of Chester
Cervix Cancer, Endometrium Cancer
Probe-based and Needle-based Confocal Laser Endomicroscopy During Gynaecological Procedures.
The protocol aims at demonstrating the technical feasibility and safety of doing endomicroscopic imaging (both probe-based confocal laser endomicroscopy (pCLE) and needle-based confocal laser endomicroscopy, nCLE) during…
- Conditions
- Cervix Cancer, Endometrium Cancer, Ovarian Cancer, Carcinoma in Situ of Fallopian Tube
- Trial name
- NCT02221076
- Testing
- Confocal Laser Endomicroscopy (CLE)
- Where
- France
- Volunteers
- 16 people
- Sponsor
- Mauna Kea Technologies
Cervix Cancer, Endometrial Cancer
Opioid Free Anaesthesia in Oncologic Gynaecological Surgery: Is There Any Benefit?
Opioid Free Anesthesia (OFA) is a multimodal anesthesia and emerging technique that spares the use of opioids and involve other adjuvant anesthetics, which have demonstrated in vitro influence on immunologic and inflammatory…
- Conditions
- Cervix Cancer, Endometrial Cancer, Ovarian Cancer, Breast Cancer
- Trial name
- NCT05448586
- Testing
- Opioid
- Where
- Spain
- Volunteers
- 132 people
- Sponsor
- Instituto de Investigación Hospital Universitario La Paz
Cervical Cancer
Fat Grafting for Vaginal Stenosis in Gynaelogical Cancer
The GRASS study looks at performing a technique called "Fat Tissue Grafting" to assess whether it can reduce the side effects of vaginal stenosis effects and improve the sexual function of participants who wish to preserve…
- Trial name
- GRASS (NCT06015360)
- Testing
- Fat Graft
- Where
- United Kingdom
- Volunteers
- 8 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Cancer of Endometrium, Carcinoma of Endometrium
LUDEC Study - Pilot Study of the Lavage of the Uterine Cavity for the Diagnosis of Endometrial Carcinoma
The current pilot study aims at answering the scientific question, whether exfoliated cells from Endometrium Carcinoma (EC) can be detected in the lavage fluid from the uterine cavity and proximal fallopian tubes with the same…
- Conditions
- Cancer of Endometrium, Carcinoma of Endometrium, Endometrial Neoplasms
- Trial name
- LUDEC (NCT02387645)
- Testing
- Lavage of the Uterus
- Where
- Austria
- Volunteers
- 80 people
- Sponsor
- Medical University of Vienna
Gynecologic Cancers
Geriatric Patients Undergoing Gynaecological Cancer Surgery
Sınce old age includes variables such as genetics, chronic diseases, lifestyle, aging can be classified as chronological, social, physiological and psychological.
- Trial name
- NCT07077629
- Testing
- morbidity and mortality
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Lymphocele
Efficacy of a Fibrin Sealant for the Prevention of Lymphocele After Lymphadenectomy
Objective: Lymphocele (LC) is a potential complication of lymph node removal. The objective of this study was to assess the efficacy of the Tissucol Duo® (Baxter AG Industriestrasse 67 A-1221 Vienna, Austria) fibrin sealant in…
- Trial name
- NCT03914963
- Testing
- Fibrin sealant hemipelvis, Control hemipelvis
- Volunteers
- 82 people
- Sponsor
- IBON JAUNARENA
Endometrial Cancer, High Grade Serous Adenocarcinoma of Ovary
First in Human Study of IMGN151 in Recurrent Gynaecological Cancers
IIMGN151-1001 is a Phase 1, first in human, open-label dose-escalation, optimization, and expansion study designed to characterize the safety, tolerability, pharmacokinetics (PK), immunogenicity, and preliminary antitumor…
- Conditions
- Endometrial Cancer, High Grade Serous Adenocarcinoma of Ovary, Primary Peritoneal Carcinoma, Fallopian Tube Cancer
- Trial name
- NCT05527184
- Testing
- IMGN151
- Where
- 58 sites in United States, Australia and 8 more
- Volunteers
- 256 people
- Sponsor
- AbbVie
Peritoneal Carcinomatosis
Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) and Electrostatic PIPAC (ePIPAC) With Paclitaxel In Patients With Peritoneal Carcinomatosis
Peritoneal carcinomatosis (PC) is a miserable disease with poor treatment outcome. Intraperitoneal administration of anticancer drugs enables an extremely high concentration of drugs to directly contact the target cancer lesions…
- Trial name
- NCT05395910
- Testing
- Paclitaxel
- Where
- Singapore
- Volunteers
- 36 people
- Sponsor
- National University Hospital, Singapore
Breast Cancer, Multiple Myeloma
Standard Care Alone or With Acupuncture for CIPN in Breast Cancer and Multiple Myeloma
The purpose of this study is to determine whether the addition of acupuncture to standard treatment reduces the level of chemotherapy induced peripheral neuropathy experienced by patients with breast cancer, multiple myeloma…
- Conditions
- Breast Cancer, Multiple Myeloma, Gastrointestinal Cancer, Gynaecological Cancer
- Trial name
- ACUFOCIN (NCT02275403)
- Testing
- Acupuncture, Medication taken to manage the symptom burden of CIPN
- Where
- 2 sites in United Kingdom
- Volunteers
- 120 people
- Sponsor
- The Christie NHS Foundation Trust
Gynaecological Oncology, Gynaecological Malignancies
Laparotomy vs Laparoscopy in Endometrial Cancer Staging
Endometrial cancer is one of the most common gynecological malignancies worldwide. Surgical staging is the cornerstone of management and traditionally performed via laparotomy.
- Conditions
- Gynaecological Oncology, Gynaecological Malignancies, Laparoscopic
- Trial name
- NCT07546825
- Testing
- laparoscopic surgical staging, open surgical staging
- Where
- Egypt
- Volunteers
- 48 people
- Sponsor
- Assiut University
Infections, Papillomavirus
Gynaecological Follow-up of a Subset of HPV-015 (NCT00294047) Study Subjects
This study is intended to provide up to a maximum of four years of annual oncogenic human papillomavirus (HPV) DNA testing and cervical cytology examination for NCT00294047 study subjects who displayed normal cervical cytology…
- Trial name
- NCT01190176
- Testing
- Gynaecological follow-up, Cervarix
- Where
- 20 sites in United States, Canada and 5 more
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Quality of Life, Gynaecological Cancer
Side Effects Screening and Early Intervention to Impact in Quality of Life of Gynaecological Cancer Patients
The goal of this randomized study is to assess the impact on self-perceived quality of life (QoL) of systematic screening and early treatment of aftereffects in patients with gynaecological cancers.
- Conditions
- Quality of Life, Gynaecological Cancer, Lymphedema, Lower Limb, Sexual Dysfunction
- Trial name
- HALIS (NCT05918770)
- Testing
- systematic screening and early treatment
- Volunteers
- 168 people
- Sponsor
- Hospital Universitario 12 de Octubre
Hysterectomy, Minimal Invasive Surgery
Comparative Study of LAVH and Minilaparotomy Hysterectomy
Minilaparotomy hysterectomy (MLH) relies on the simplicity of traditional open technique of abdominal hysterectomy, imparts cosmesis and faster recovery of laparoscopic hysterectomy yet avoids the long learning curve, cost of…
- Conditions
- Hysterectomy, Minimal Invasive Surgery, Benign Gynecologic Neoplasm
- Trial name
- LAVH (NCT03548831)
- Volunteers
- 52 people
- Sponsor
- Manipal University
Gynaecological Cancers
ATr Inhibitor in Combination With Olaparib/Durvalumab (MEDI4736) in Gynaecological Cancers With ARId1A Loss or no Loss
ATARI trial tests the ATR inhibitor drug ceralasertib (AZD6738) alone and in combination with either a PARP inhibitor drug called olaparib, or an anti-PD-L1 immunotherapy called durvalumab (MEDI4736) in patients with relapsed…
- Trial name
- ATARI (NCT04065269)
- Testing
- Ceralasertib, Olaparib, Durvalumab
- Where
- 9 sites in Canada, United Kingdom
- Volunteers
- 174 people
- Sponsor
- Institute of Cancer Research, United Kingdom
Cancer
Skin Incision Study - Closure of Skin Incisions in Gynecological Cancer Surgery
The Skin Incision Study evaluates the efficacy of skin closure methods: skin staples and subcuticular sutures at 6 weeks and at 3 months following the operation by measuring cosmesis and pain.
- Trial name
- NCT00107627
- Testing
- Caprosyn subcuticular sutures., Monocryl subcuticular sutures., Skin staples;
- Where
- 2 sites in Australia
- Volunteers
- 90 people
- Sponsor
- Queensland Centre for Gynaecological Cancer
Ovarian Cancer
Individualised Versus Conventional Medical Follow-up for Women After Primary Treatment for Ovarian Cancer.
The purpose of this study in women who have completed primary treatment for ovarian cancer is to investigate the effects of individualised follow-up care delivered by a nurse compared to conventional medical follow-up on quality…
- Trial name
- NCT02298855
- Testing
- Individualised follow-up
- Where
- 3 sites in United Kingdom
- Volunteers
- 113 people
- Sponsor
- University College, London
Adenomyosis of Uterus
Association of Ultrasound Features of the Myometrium Suggestive of Adenomyosis and Clinical Symptoms
The goal of this study/research is to assess the relationship between ultrasound features of the myometrium suggestive of adenomyosis and clinical symptoms of adenomyosis and to establish a reporting system for adenomyosis…
- Trial name
- MUSA3 (NCT07397715)
- Where
- 5 sites in Belgium, Poland and 2 more
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Swiss GO Trial Group
Neoplasms, Gynaecological Oncology
Impact of Pharmacy Services on Gynaecology Chemotherapy Safety
What was studied? We wanted to see whether having pharmacists closely involved in cancer care improves medication safety and reduces severe side effects for patients with gynecologic cancers (like ovarian or uterine cancer)…
- Trial name
- NCT06826950
- Testing
- comprehensive pharmaceutical care, Routine pharmaceutical services
- Where
- China
- Volunteers
- 629 people
- Sponsor
- Peking University First Hospital