Clinical trials: Gynecologic Cancer
Breast Cancer, Gynecologic Cancer
Psychosexual Educational Partners Program (PEPP)
The purpose of this study is to compare two Psychosexual Educational programs for women who have completed treatment for breast or gynecological cancer and their partners in preparation for a well-powered phase III study.
- Conditions
- Breast Cancer, Gynecologic Cancer, Sexual Dysfunction, Partner Communication
- Trial name
- PEPP (NCT06253182)
- Testing
- Self-Guided PEPP Intervention Workbook, Self-Guided PEPP Education Workbook
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- The University of Tennessee, Knoxville
Gynecologic Cancer, Endometriosis
Urinary Procedures Performed by Gynecologists, Results and Learning Curves.
Urinary procedures such as placing a JJ catheter, performing a psoic bladder, a Bricker technique or even a partial cystectomy are relatively frequent procedures in the context of the surgical management of gynecological cancer…
- Trial name
- URINA (NCT05150262)
- Where
- France
- Volunteers
- 96 people
- Sponsor
- University Hospital, Strasbourg, France
Gynecologic Cancer
Psychological Interventions for Gynecologic Cancer
Subjects that have received medical treatment for ovarian cancer can be both physically and emotionally demanding for patients. The purpose of this study is to determine whether two common pyschological interventions…
- Trial name
- NCT01951807
- Testing
- Psychotherapy
- Where
- 9 sites in United States
- Volunteers
- 375 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Gynecologic Cancer, Immunotherapy
Gut Microbiome and Treatment for Gynecological Cancer Patients Receiving Immunotherapy
30 participants with advanced or recurrent gynecological cancer from are enrolled for this study. Eligible participants then provide fecal specimen, blood, vaginal swab, oral mucosal swab and receive food dietary recommendation.
- Conditions
- Gynecologic Cancer, Immunotherapy, Gut Microbiome
- Trial name
- NCT04957511
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Viome
Neoplasms, Ovarian
Efficacy and Safety of Pazopanib Monotherapy After First-line Chemotherapy in Ovarian, Fallopian Tube, or Primary Peritoneal Cancer in Asian Women
This is a study to determine whether therapy with pazopanib is effective and safe in Asian women with epithelial ovarian, fallopian tube or primary peritoneal cancer whose cancer has not progressed on first-line chemotherapy.
- Trial name
- NCT01227928
- Testing
- Pazopanib
- Where
- 15 sites in China, Hong Kong and 2 more
- Volunteers
- 145 people
- Sponsor
- GlaxoSmithKline
Lung Cancer, Adult Soft Tissue Sarcoma
Vaccine Therapy in Treating Patients With Metastatic Cancer
RATIONALE: Vaccines made from a peptide may make the body build an immune response and kill tumor cells. PURPOSE: Randomized phase I trial to study the effectiveness of vaccine therapy in treating patients who have metastatic…
- Conditions
- Lung Cancer, Adult Soft Tissue Sarcoma, Colorectal Cancer, Bone Cancer
- Trial name
- NCT00020267
- Testing
- interleukin-2, MAGE-12 peptide vaccine, Montanide ISA-51
- Where
- United States
- Sponsor
- National Cancer Institute (NCI)
Gynecologic Cancer
Novel Imaging Technique to Assess Gynecologic Cancer
This study will test a new type of DCE (dynamic contrast-enhanced) MRI (magnetic resonance imaging) to see whether, compared with traditional MRI, it produces better images that provide more information about tumors, which may…
- Trial name
- NCT04893434
- Testing
- Gadobutrol, MRI
- Where
- 3 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Breast Cancer, Gynecologic Cancer
Opening the Conversation Study
Young adult survivors of breast and gynecologic cancer face a number of challenges, including interrupted life plans. As many as two-thirds of these young survivors experience negative effects of cancer and cancer treatment on…
- Trial name
- NCT04806724
- Testing
- Opening the Conversation, Side by Side
- Where
- United States
- Volunteers
- 158 people
- Sponsor
- Oregon State University
Metastatic Malignant Female Reproductive System Neoplasm, Platinum-Resistant Malignant Female Reproductive System Neoplasm
Brachytherapy With Durvalumab or Tremelimumab for the Treatment of Patients With Platinum-Resistant, Refractory, Recurrent, or Metastatic Gynecological Malignancies
This phase II trial studies the side effects and how well brachytherapy with durvalumab or tremelimumab work for the treatment of gynecological malignancies that is resistant to platinum therapy (platinum-resistant), does not…
- Conditions
- Metastatic Malignant Female Reproductive System Neoplasm, Platinum-Resistant Malignant Female Reproductive System Neoplasm, Recurrent Malignant Female Reproductive System Neoplasm, Refractory Malignant Female Reproductive System Neoplasm
- Trial name
- NCT04395079
- Testing
- Durvalumab, Internal Radiation Therapy, Tremelimumab
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Gynecologic Cancer
OCRA Distress & Unmet Needs
This study is a prospective longitudinal cohort study with an embedded intervention. It follows participants with gynecologic malignancies and their informal caregivers over a 6-month period to assess caregiver distress, NMDOH…
- Trial name
- NCT07591623
- Testing
- Surveys
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- M.D. Anderson Cancer Center
Persistent Isolated Chemotherapy-Induced Thrombocytopenia, Chemotherapy-Induced Thrombocytopenia
Romiplostim N01 Plus ATRA for Persistent Isolated Chemotherapy-Induced Thrombocytopenia After Complete Remission of Gynecologic, Breast, or Lung Solid Tumors
This is a prospective, randomized, open-label, active-controlled study to evaluate the efficacy and safety of Romiplostim N01 plus all-trans retinoic acid (ATRA) compared with Romiplostim N01 alone in adults with persistent…
- Conditions
- Persistent Isolated Chemotherapy-Induced Thrombocytopenia, Chemotherapy-Induced Thrombocytopenia, Gynecologic Cancers, Ovarian Cancer
- Trial name
- N01-A-PICIT-GT (NCT07586826)
- Testing
- Romiplostim N01, All-trans retinoic acid
- Where
- China
- Volunteers
- 220 people
- Sponsor
- Peking University People's Hospital
Gastrointestinal Toxicity, Gynecologic Cancer
Probiotics in Radiation-treated Gynecologic Cancer
The aim of the current Project is to study the efficacy of a probiotic Product in reducing the symptoms of gastrointestinal toxicity linked to the irradiation of gynecologic cancer.
- Trial name
- ProRad (NCT02351089)
- Testing
- Capsules probiotic powder and corn starch
- Where
- Sweden
- Volunteers
- 97 people
- Sponsor
- Probi AB
Endometrial Cancer, Papillary Serous
Vaginal Cuff Brachytherapy Followed by Chemotherapy in Endometrial Cancer
The purpose of this study is to determine the feasibility of treatment in patients with high risk endometrial cancer treated by vaginal cuff brachytherapy followed by 3 cycles of dose dense paclitaxel and carboplatin chemotherapy.
- Conditions
- Endometrial Cancer, Papillary Serous, Clear Cell Endometrial Cancer
- Trial name
- NCT03189446
- Testing
- Vaginal Cuff Brachytherapy, Carboplatin, Paclitaxel
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- University of Oklahoma
Endometrium Cancer, Sentinel Lymph Node
Multimedia Aid Gynecologic Counseling and Consent
This is an interventional trial to introduce two short animated videos into preoperative counseling/consent and to compare patient comprehension and satisfaction with a multimedia approach compared to standard of care currently.
- Conditions
- Endometrium Cancer, Sentinel Lymph Node, Perioperative/Postoperative Complications
- Trial name
- NCT03899441
- Testing
- Video
- Where
- United States
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Malignant Female Reproductive System Neoplasm, Stage III Cervical Cancer AJCC v8
e-Health Intervention (Day-by-Day) for the Management of Fear of Progression in Women With Stage III or IV Gynecologic Cancer: A Pilot Study
This clinical trial studies how well an electronic (e)-health intervention (day-by-day) woks in managing fears or worries about cancer growing, spreading, or getting worse (progression) in patients with stage III or IV…
- Conditions
- Malignant Female Reproductive System Neoplasm, Stage III Cervical Cancer AJCC v8, Stage III Ovarian Cancer AJCC v8, Stage III Uterine Corpus Cancer AJCC v8
- Trial name
- NCT05786456
- Testing
- Discussion, Informational Intervention, Media Intervention
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- City of Hope Medical Center
Thoracic Cancer, Gynecologic Cancer
Real World Study of Four PD-1 Agents in China
Consecutive patients treated with PD-1 therapy in Qingdao City were included in our study. The effecy and safety of the four PD-1 agents according to clinical outcomes in real world will be studied.
- Conditions
- Thoracic Cancer, Gynecologic Cancer, Abdomen Tumors, Malignant Melanoma
- Trial name
- NCT03966456
- Testing
- Chemotherapy
- Where
- China
- Volunteers
- 500 people
- Sponsor
- The Affiliated Hospital of Qingdao University
Sleep Disturbance, Gynecologic Cancer
Improving Sleep in Gynecologic Cancer Survivors
This purpose of this study is to learn about how to provide treatment to gynecologic cancer survivors who have difficulty sleeping.
- Trial name
- NCT05044975
- Testing
- Sleep restriction, Stimulus control, Systematic light exposure
- Where
- 2 sites in United States
- Volunteers
- 78 people
- Sponsor
- University of Arizona
Breast Cancer, Gynecologic Cancer
Mobile App Postoperative Home Monitoring After Enhanced Recovery Oncologic Surgery
This study will assess whether the implementation of a combination of ERAS (Enhanced Recovery After Surgery) protocols and postoperative followup via a smartphone app can offer 1) improved patient satisfaction, 2) virtual patient…
- Trial name
- ERAS-OncoRe (NCT03456167)
- Testing
- RecoverWell mobile app for follow-up care
- Where
- Canada
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Alberta Health Services, Calgary
Gynecologic Cancer
A Trial Comparing Acute Toxicity in Patients With Gynecological Cancer Treated With VMAT
This is a randomized, controlled, open-label, prospective and longitudinal clinical trial. Rectal, intestinal and bladder EBRT-related toxicity will be assessed according to RTOG / EORTC scales at the first day of EBRT, during…
- Trial name
- ATGCRT (NCT03899376)
- Testing
- Volumetric modulated arc therapy, conventional radiotherapy
- Where
- Mexico
- Volunteers
- 80 people
- Sponsor
- National Institute of Cancerología
Gynecologic Disease, Gynecologic Cancer
Enhanced Recovery After Surgery (ERAS) in Gynecological Surgery (ERASGS-01)
Enhanced recovery programs are composed of preoperative, intraoperative and postoperative strategies combined to form a multi-modal pathway.
- Trial name
- ERAS (NCT03629626)
- Testing
- ERAS protocol
- Where
- China
- Volunteers
- 540 people
- Sponsor
- Shandong University