Clinical trials: Gynecologic Disorders
Breast Cancer, Head and Neck Cancer
Radiomic Analysis for Predicting Treatment Response and Clinical Outcomes in Malignancies
In this study, the investigators aim to undertake a retrospective analysis of CT and MRI scans for patients undergoing radiation treatment to develop radiomic signatures to predict treatment response and clinical outcomes.
- Conditions
- Breast Cancer, Head and Neck Cancer, Brain Cancer, Gynecologic Cancer
- Trial name
- NCT05170087
- Where
- Canada
- Volunteers
- 1,200 people
- Sponsor
- Sunnybrook Health Sciences Centre
Gastrointestinal Cancer, Urologic Cancer
Palliative Radiotherapy in Symptomatic Pelvic Soft Tissue Tumors
PALLSOFT is a randomized, open-label, non-inferiority phase III, multicenter, national trial that will investigate whether the patient-reported symptomatic effect of palliative radiotherapy delivered in 1-2 fractions is…
- Conditions
- Gastrointestinal Cancer, Urologic Cancer, Gynecologic Cancer
- Trial name
- PALLSOFT (NCT06398314)
- Testing
- Palliative radiotherapy
- Where
- 11 sites in Norway
- Volunteers
- 200 people
- Sponsor
- Sykehuset Telemark
Gynecologic Disease
The Comparison of Effectiveness Between Epidural Combined Bilateral US TAP Block Versus Epidural Alone for Gynaecology Operation.
The goal of this clinical trial is to compare effectiveness between epidural combined with TAP block versus epidural alone in gynaecology operation participant .The main question[s] it aims to answer are: what is the pain score…
- Trial name
- NCT06425484
- Testing
- Bilateral US TAP block
- Where
- Malaysia
- Volunteers
- 46 people
- Sponsor
- Universiti Sains Malaysia
Ovarian Cancer
Data and Specimen Bank of Patients Diagnosed With, and at High-risk for, Gynecologic Cancers
The purpose of this project is to establish a bank at UVa of tampon samples, cervical swabs, blood, associated tumor specimens that would otherwise be discarded, and relevant medical data from consenting patients that have…
- Trial name
- NCT04170712
- Testing
- Tampons
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Other Cancer, Gastrointestinal Cancer
Symptom Management Implementation of Patient Reported Outcomes in Oncology
Deficits in the management of common symptoms cause substantial morbidity for cancer patients.Because the health care delivery system is structured to be reactive and not proactive, there are missed opportunities to optimize…
- Conditions
- Other Cancer, Gastrointestinal Cancer, Thoracic Cancer, Gynecologic Cancer
- Trial name
- SIMPRO (NCT03850912)
- Testing
- Stakeholder Survey (Control Period), Stakeholder Survey (Intervention Period), Qualitative Interview
- Where
- 6 sites in United States
- Volunteers
- 42,808 people
- Sponsor
- Dana-Farber Cancer Institute
Gynecologic Disease, Adnexal Mass
Assessment of Women's Sexual Quality of Life After Benign Adnexal Surgery Using vNOTES Approach
Transvaginal Natural Orifice Transluminal Endoscopic Surgery (vNOTES) is a recent innovation in minimally invasive surgery which has already proven its non-inferiority to conventional abdominal laparoscopy (CAL) for hysterectomy…
- Conditions
- Gynecologic Disease, Adnexal Mass, Adnexal Cyst, Sexuality
- Trial name
- NCT05761275
- Testing
- Elective cystectomy, Elective oophorectomy, Elective salpingectomy
- Where
- Switzerland
- Volunteers
- 62 people
- Sponsor
- Jean Dubuisson
Cervical Cancer, Uterine Cancer
PROton Therapy for Post Surgical Treatment of GYNecologic Cancer
This is a single institution, multi-center, Phase II, single-arm study, using Whole Pelvis (WP) Pencil Beam Scanning Proton Radiation (PBS PRT) in the post-surgical, adjuvant setting for definitive treatment of gynecologic…
- Conditions
- Cervical Cancer, Uterine Cancer, Endometrial Cancer
- Trial name
- PROPS GYN (NCT05758688)
- Testing
- Whole Pelvis (WP) Pencil Beam Scanning Proton Radiation (PBS PRT)
- Where
- 3 sites in United States
- Volunteers
- 25 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Gynaecological Disease, Vitamin D Deficiency
Association Between Vitamin D and the Risk of Uterine Fibroids
The aim of this randomised clinical trial study is to evaluate whether supplementation with vitamin D could reduce the risk of uterine fibroids in reproductive stage women.
- Conditions
- Gynaecological Disease, Vitamin D Deficiency, Uterine Fibroids
- Trial name
- ABVDATROUF (NCT03586947)
- Testing
- Vitamin D3 400 UNT Oral Capsule
- Where
- China
- Volunteers
- 1,160 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
GYN Disorders
GENERATE - Next GENERATion of GynEcological Surgery - Robotic Assisted Surgery in Gynecological Indications
GENERATE - Next GENERATion of GynEcological Surgery - Robotic Assisted Surgery in Gynecological Indications Generate real-world evidence in the use of the da Vinci Surgical Systems for gynecological indications within the German…
- Trial name
- GENERATE (NCT05867927)
- Testing
- Robotic-assisted surgery (da Vinci), Non-da Vinci Surgery
- Where
- 15 sites in Germany
- Volunteers
- 1,250 people
- Sponsor
- Intuitive Surgical
Gynecologic Cancer, Gynecologic Disease
Molecular and Cellular Profiling of Uterine Lavage Collected During Gynecologic Surgery
This study is a designed as a to test the clinical and technical feasibility of using this novel uterine lavage collection catheter to collected UL samples from up to 50 individuals undergoing gynecologic surgery and to describe…
- Conditions
- Gynecologic Cancer, Gynecologic Disease, Gynecological Surgery, Uterine Cancer
- Trial name
- NCT07044505
- Testing
- Uterine Lavage
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Stanford University
Urinary Incontinence, Urinary Stress Incontinence
Pregnancy After Tension-free Vaginal Tape and Other Mid-urethral Sling Procedures
The purpose of this study is to determine the interactions between pregnancy and urinary stress incontinence in women with a mid-urethral sling (MUS).
- Conditions
- Urinary Incontinence, Urinary Stress Incontinence, Pregnancy Complications
- Trial name
- PregnanT (NCT02999347)
- Where
- Norway
- Volunteers
- 80 people
- Sponsor
- Oslo University Hospital
Quality, Prostate Cancer
Assessments of Genetic Counseling Augmented With an Educational Video or Pamphlet Versus Traditional Counseling
The purpose of this research study is to understand the impact of an educational video or pamphlet on the patient experience in a hereditary cancer genetic counseling program.
- Conditions
- Quality, Prostate Cancer, Gastrointestinal Cancer, Gynecologic Cancer
- Trial name
- NCT05132868
- Testing
- Educational video and pamphlet, Traditional genetic counseling
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- Stanford University
Alopecia, Chemotherapy-induced Alopecia
A Pilot Study to Evaluate the Use of the AMMA Portable Scalp Cooling System From Cooler Heads
Eligible patients will be recruited prior to initiation of chemotherapy for any stage breast or gynecologic cancer. Patients will undergo training in the use of the AMMA Portable Scalp Cooling System and will use the device…
- Conditions
- Alopecia, Chemotherapy-induced Alopecia, Hair Loss, Breast Cancer
- Trial name
- NCT05365243
- Testing
- AMMA Portalbe Scalp Cooling System
- Where
- United States
- Sponsor
- Cooler Heads Care Inc.
Cancer, Food Deprivation
The Florida ASCENT Study
The goal of this clinical trial is to adapt, implement, and evaluate MyCarePulse and ASCENT patient navigator to overcome barriers to care among patients with cancer.
- Conditions
- Cancer, Food Deprivation, Food Habits, Food Selection
- Trial name
- NCT07042243
- Testing
- MyCarePulse and ASCENT PN
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Florida
Cervical Cancer, Endometrial Cancer
Evaluation of Clinical and Molecular Biomarkers in Immunotherapy Treatment in Gynecologic Cancer
Background: Immunotherapy has changed the therapeutic approach for gynecologic gynecological malignancies such us endometrial and cervical cancer.
- Trial name
- Immuno-Gyn (NCT06737640)
- Where
- Italy
- Volunteers
- 90 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Gynecologic Disease, Inflammation
Inflammatory Markers in Natural Orifice Hysterectomies
The authors aimed to detect inflammatory marker changes in two natural orifice hysterectomies: single-port laparoscopic hysterectomy (SLH) and vaginal hysterectomy (VH).
- Trial name
- NCT04221308
- Testing
- Single port laparoscopic systems
- Where
- Turkey (Türkiye)
- Volunteers
- 134 people
- Sponsor
- Derince Training and Research Hospital
Breast Cancer, Gynecologic Cancer
Avanzando Juntas: Adapting an Evidence Based Weight Loss Program for Hispanic Breast Cancer Survivors
This study examine the feasibility and efficacy of Avanzando Juntas, a four-month community-based lifestyle intervention rooted in the evidence-based Moving Forward lifestyle intervention developed with and for AA breast cancer…
- Trial name
- NCT04321135
- Testing
- Guided Lifestyle Program Intervention, Self-Guided Lifestyle Program (Control Arm)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Medical College of Wisconsin
Gynecologic Cancers
Assessing Whole-body Metabolism in Gynecologic Cancers in Response to a Single Chemotherapy Cycle and/ or Immunotherapy
It is well established that cancer cells have fundamentally altered metabolism, which contributes to tumorigenicity and malignancy.
- Trial name
- NCT07393633
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- University of Tennessee Graduate School of Medicine
Female
Dostarlimab, Cisplatin and Etoposide in Combination With Radiotherapy in Sandwich Sequence for Small Cell Neuroendocrine Cervical Carcinoma
Add-on dostarlimab to chemoradiation with etoposide and cisplatin and radiotherapy can improve progression-free survival (PFS) compared with historical controls who were treated with chemoradiation alone in SCNECC
- Trial name
- NCT07336147
- Testing
- Dostarlimab
- Where
- Taiwan
- Volunteers
- 45 people
- Sponsor
- Chang Gung Memorial Hospital
Genital Neoplasms, Female
A Phase I Study of CCI-779 (Temsirolimus) in Combination With Topotecan in Patients With Gynecologic Malignancies
The aim of the trial is to determine the recommended phase II dose of weekly intravenous topotecan in combination with a fixed dose (25 mg or 15 mg) of weekly intravenous temsirolimus in patients with and without prior pelvic…
- Trial name
- NCT00523432
- Testing
- Topotecan, CCI-779 (temsirolimus)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Chicago