Clinical trials: Gynecologic Disorders, open to volunteers
Ovarian Cancer
Peer Ambassador in Gyn Onc Trials
The goal of this study is to learn if peer ambassador support will increase clinical trial enrollment in patients with ovarian cancer.
- Trial name
- NCT07915336
- Testing
- Mentee encounters
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Breast Cancer, Sarcoma
Riluzole For Preventing Cognitive Dysfunction in Ca Pts Receiving Chemo (REFOCUS): Pilot Trial
This is a phase II single-arm, Phase 2a, randomized, double-blinded, placebo-controlled pilot clinical trial determining efficacy of riluzole in preventing cognitive dysfunction in subjects with cancer, who are receiving…
- Conditions
- Breast Cancer, Sarcoma, Gastric (Stomach) Cancer, Lung Cancer
- Trial name
- NCT07447050
- Testing
- Riluzole
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of California, Irvine
Female
Dostarlimab, Cisplatin and Etoposide in Combination With Radiotherapy in Sandwich Sequence for Small Cell Neuroendocrine Cervical Carcinoma
Add-on dostarlimab to chemoradiation with etoposide and cisplatin and radiotherapy can improve progression-free survival (PFS) compared with historical controls who were treated with chemoradiation alone in SCNECC
- Trial name
- NCT07336147
- Testing
- Dostarlimab
- Where
- Taiwan
- Volunteers
- 45 people
- Sponsor
- Chang Gung Memorial Hospital
Gynecologic Cancer, Hereditary Cancer Syndrome
Chatbot to Maximize Hereditary Cancer Genetic Risk Assessment
In this study, the investigators aim to compare a mobile health platform, known as a 'chatbot,' that leverages artificial intelligence and natural language processing to scale communication, to 'usual care' that patients would…
- Trial name
- NCT05562778
- Testing
- Chatbot
- Where
- 4 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Gynecologic Cancers, Anxiety
Brief Title- Virtual Reality Glasses in Gynecologic Cancer
It was planned to determine the effect of virtual reality glasses used in female patients diagnosed with gynecological cancer and receiving chemotherapy on treatment compliance and anxiety level.
- Trial name
- NCT06760689
- Testing
- virtual reality glasses, scale
- Where
- Turkey (Türkiye)
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Çankırı Karatekin University
Gynecological Disease
Network Pharmacology Was Applied to Explore the Mechanism of Remimazolam Applied in General Anesthesia for Gynecological Surgeries
To explore the related mechanisms by which remimazolam regulates hemodynamic stability, inflammatory factors and the immune system in patients undergoing general anesthesia for gynecological surgeries.
- Trial name
- NCT06990763
- Testing
- Remimazolam, propofol
- Volunteers
- 40 people
- Sponsor
- Second Hospital of Shanxi Medical University
Acute Kidney Injury, Subclinical Acute Kidney Injury
Early Kidney Injury Biomarkers in Gynecologic Laparoscopic Surgery
This prospective observational study aims to evaluate early subclinical acute kidney injury associated with pneumoperitoneum and Trendelenburg positioning during gynecological laparoscopic surgery.
- Trial name
- NCT07704242
- Testing
- Pneumoperitoneum and Trendelenburg Positioning
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Medipol University
Malignant Female Reproductive System Neoplasm, Gynecologic Cancer
PROmOting Gynecologic Cancer Patients With Frailty to Achieve Functional Recovery
This study seeks to understand how frailty, a term that describes people who are more vulnerable stressors such as a new medical problem, affects the outcomes and quality of life in adult patients with gynecologic cancer.
- Conditions
- Malignant Female Reproductive System Neoplasm, Gynecologic Cancer, Gynecologic Neoplasm
- Trial name
- PROOF (NCT06089083)
- Testing
- Physical function assessment, Self-reported Assessments and Questionnaires, Surgery (Standard of Care, Non-Interventional)
- Where
- 2 sites in United States
- Volunteers
- 500 people
- Sponsor
- University of California, San Francisco
Gynecologic Cancer
High-frequency Ultrasound for Intraoperative Lymph Node Assessment in Gynecological Cancer: From Surgery to Radiomics
Lymph node assessment is crucial in gynecological cancers (ovarian, endometrial, cervical, and vulvar), as nodal involvement significantly impacts prognosis and treatment.
- Trial name
- RHINOCERUS (NCT06906705)
- Where
- Italy
- Volunteers
- 160 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Endometrial Cancer, Ovarian Cancer
Study Evaluating the Safety and Efficacy of HWK-007, a PTK7-directed Antibody Drug Conjugate in Participants With Advanced Solid Tumors
HWK-007-101 is a multicenter, open-label, first-in-human (FIH) Phase 1 study evaluating HWK-007, a protein tyrosine kinase 7 (PTK7)-targeted antibody drug conjugate (ADC), in adult participants with advanced or metastatic solid…
- Conditions
- Endometrial Cancer, Ovarian Cancer, Ovarian Cancer Metastatic, Ovarian Cancer Metastatic Recurrent
- Trial name
- NCT07444814
- Testing
- HWK-007
- Where
- 12 sites in United States
- Volunteers
- 226 people
- Sponsor
- Whitehawk Therapeutics, Inc.
Venous Thromboembolism, Bleeding
Avoiding Risks of Thrombosis and Bleeding in Surgery (ARTS) Trial
Avoiding Risks of Thrombosis and bleeding in Surgery (ARTS) trial is a pragmatic, international, multicenter, randomized controlled open label trial comparing a direct oral anticoagulant (DOAC) - oral factor Xa inhibitor apixaban…
- Trial name
- ARTS (NCT06523959)
- Testing
- Apixaban 2.5 MG
- Where
- Finland
- Volunteers
- 5,436 people
- Sponsor
- Clinical Urology and Epidemiology Working Group
Genital Neoplasms, Female, Uterine Cervical Neoplasms
Patient Journey in Advanced Gynecologic Cancers
This is a mixed-methods survey study including a 2-phased sequential-explanatory design. This study is to understand the patient journey in conventional therapy for newly diagnosed stage III or IV CC or EC in China, including…
- Conditions
- Genital Neoplasms, Female, Uterine Cervical Neoplasms, Endometrial Carcinoma
- Trial name
- NCT07015593
- Testing
- interview
- Where
- 4 sites in China
- Volunteers
- 780 people
- Sponsor
- Tongji Hospital
Gynaecologic Cancer
Improving Sexual Health in Gynecological Cancer Patients
The goal of this clinical trial is to test whether a nurse-led program can improve screening and referral rates for sexual dysfunction and improve sexual health care in individuals with gynecological cancer.
- Trial name
- NCT07144566
- Testing
- Nurse Led Sexual Health Clinical Program Intervention
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Cedars-Sinai Medical Center
Endometrial Cancer
Low-Residue Diet Versus Rectal Enema Before Laparoscopic Surgery for Endometrial Cancer
The goal of this clinical trial is to compare a standardized 3-day bowel preparation protocol with a rectal enema before laparoscopic surgery for endometrial cancer.
- Trial name
- NCT07702799
- Testing
- Low-Residue Diet, Sodium Phosphate Rectal Enema
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Mahmut Yassa
Cervical Cancers, Vaginal Cancers
Minimally Invasive Pelvic Exenteration in Vaginal or Cervical Cancer Recurrence
The aim of this clinical trial is to assess the oncologic safety of minimally invasive pelvic exenteration in patients with recurrence or persistence of cervical or vaginal cancer with pelvic location, suitable for pelvic…
- Trial name
- MIPEX (NCT06867445)
- Testing
- Minimally invasive pelvic exenteration
- Where
- Italy
- Volunteers
- 64 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
CNS Cancer, Head and Neck Cancer
Prospective Evaluation of Pencil Beam Scanning Proton Therapy for Previously Irradiated Tumors
The goal of this clinical research trial is to study the use of differing investigational doses and scheduling for Proton Therapy for tumors previously treated with radiation therapy.
- Conditions
- CNS Cancer, Head and Neck Cancer, GI Cancer, Gynecologic Cancer
- Trial name
- ReRT (NCT05313191)
- Testing
- Pencil Beam Scanning Proton Therapy
- Where
- United States
- Volunteers
- 1,800 people
- Sponsor
- The New York Proton Center
Cancer, Cancer Diagnosis
Avera Cancer Sequencing and Analytics Protocol (ASAP)
The purpose of this study is to characterize the breadth of molecular features present in participants receiving care within a large, integrated, community-based healthcare system.
- Conditions
- Cancer, Cancer Diagnosis, Early Detection of Cancer, Breast Cancer
- Trial name
- ASAP (NCT05142033)
- Where
- 6 sites in United States
- Volunteers
- 25,000 people
- Sponsor
- Avera McKennan Hospital & University Health Center
Gynecologic Cancer, Prostate Cancer
CARE Tool Study Aim 3
This study is a multi-site randomized trial to study the implementation of the CARE Tool and evaluate the CARE Tool. The CARE Tool is a web-based tool that gives people information about cancer care costs, health insurance, and…
- Conditions
- Gynecologic Cancer, Prostate Cancer, Lung Cancer, Colorectal Cancer
- Trial name
- NCT07296887
- Testing
- Financial education information, CARE Tool, CARE Tool Training
- Where
- 3 sites in United States
- Volunteers
- 430 people
- Sponsor
- Washington University School of Medicine
Adenomyosis of Uterus, Uterine Diseases
Multicenter Observational Cohort Study on the Epidemiology of Therapeutic Strategies in Patients Affected by Adenomyosis
The primary objective of this multicenter observational cohort study is to evaluate the current medical approach to the management of adenomyosis in women, with particular focus on treatment selection and treatment persistence.
- Conditions
- Adenomyosis of Uterus, Uterine Diseases, Gynecologic Diseases, Menorrhagia, Dysmenorrhea
- Trial name
- Adenomyosis (NCT07478614)
- Testing
- This is a non-interventional study. Treatment allocation will not be influenced by the study protocol.
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- SCHETTINI SERGIO
Endometrial Hyperplasia, Endometrial Cancer
Fertility Sparing Management of EndomeTrial Cancer and Hyperplasia
This study protocol evaluates the use of hysteroscopic endomyometrial resection in women diagnosed with atypical endometrial hyperplasia or grade I endometrial cancer who have not responded to anti-hormone therapy.
- Conditions
- Endometrial Hyperplasia, Endometrial Cancer, Gynecologic Cancer
- Trial name
- FETCH (NCT04362046)
- Testing
- Hysteroscopic uterine resection
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Vancouver Coastal Health Research Institute