Clinical trials: Gynecologic Disorders
Gynecologic Neoplasm, Healthy Women
The Effect of Dimenhydrinate on Postoperative Nausea and Vomiting After Abdominal Hysterectomy: Randomized-controlled Trial
The aim of this clinical trial is to learn if Dimenhydrinate works to prevent postoperative nausea-vomiting in adult women who undergoing abdominal hysterectomy.
- Trial name
- NCT06395064
- Testing
- Dimenhydrinate
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Preeyaporn Jirakittidul
Gynecological Imaging, Ultrasound Diagnostics
Ultrasound Image Bank: Advancing Medical Research and Diagnostics
The study titled "Ultrasound Image Bank: Advancing Medical Research and Diagnostics", sponsored by the Fondazione Policlinico Universitario A.
- Conditions
- Gynecological Imaging, Ultrasound Diagnostics, Gynecologic Disease
- Trial name
- Ultra-Bank (NCT07031921)
- Where
- Italy
- Volunteers
- 25,000 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Breast Cancer, Lung Cancer
Investigating the Effects of Atezolizumab in People Whose Tumour DNA or RNA Indicates Possible Sensitivity
This study will investigate the effects of atezolizumab on select cancer types in people whose analysis of tumour DNA and RNA indicates they may be sensitive to atezolizumab.
- Conditions
- Breast Cancer, Lung Cancer, Gastrointestinal Cancer, Genitourinary Cancer
- Trial name
- CAPTIV-8 (NCT04273061)
- Testing
- Atezolizumab
- Where
- 2 sites in Canada
- Volunteers
- 50 people
- Sponsor
- British Columbia Cancer Agency
Adjuvant Chemotherapy, Ovarian Neoplasms
Efficacy and Safety of PEG-rhG-CSF Secondary Prophylaxis vs. Therapeutic Administration in Patients With Ovarian Cancer
This study is a multicenter, open-label, randomized clinical trial. Patients with ovarian cancer receiving postoperative adjuvant chemotherapy were eligible to enroll in this study.
- Conditions
- Adjuvant Chemotherapy, Ovarian Neoplasms, Ovarian Cancer
- Trial name
- NCT03858166
- Testing
- PEG-rhG-CSF
- Where
- China
- Volunteers
- 68 people
- Sponsor
- Shandong University
Cervical Dysplasia, Cervical Cancer
Circulating Human Papilloma Virus (HPV) DNA for the Screening and Surveillance of Gynecologic Cancers
Human papilloma virus-related gynecologic malignancies affect over 20,000 women in the United States, and over half a million women globally each year.
- Trial name
- NCT05606133
- Testing
- NavDx(R)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Northwell Health
Pelvic Pain, Infertility
Effect of the Bioheat Patch on Pain Following the HyFoSy Procedure
This randomized controlled trial (RCT) evaluates the efficacy of Bioheat thermal patches in reducing post-procedural pain following Hysterosalpingo Foam Sonography (HyFoSy).
- Conditions
- Pelvic Pain, Infertility, Pain Management, Gynecologic Procedures
- Trial name
- B-HyP (NCT07081971)
- Testing
- Bioheat Patch
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assaf-Harofeh Medical Center
Colon Disease, Gynecologic Disease
Optic Nerve Sheath Diameter in Laparoscopic Surgeries During Trendelenburg Position
It is difficult to measure the several levels of intracranial pressure during abdominal surgery, and direct monitoring with intracranial devices is often impossible.
- Trial name
- NCT04428229
- Testing
- Optic nerve sheath diameter
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Medipol University
Infertility, Female, Recurrent Miscarriage
Immune Cell Populations in the Endometrium
Specialized immunological studies in the diagnostics of idiopathic infertility and recurrent miscarriages have limited applicability, as the role of the immune system in these conditions is not thoroughly understood.
- Conditions
- Infertility, Female, Recurrent Miscarriage, Gynecologic Disease
- Trial name
- NCT06826365
- Testing
- Percentage distribution of immune system cells in peripheral blood, Percentage distribution of immune system cells in endometrium
- Where
- Poland
- Volunteers
- 50 people
- Sponsor
- Jagiellonian University
Endometrial Hyperplasia
Comparison of Dilatation & Curettage and Endometrial Aspiration Biopsy Accuracy in Patients Treated With Progestin for Endometrial Hyperplasia: A Korean Gynecologic Oncology Group Study
A prospective multicenter trial has been started in Korea to evaluate the diagnostic accuracy of endometrial aspiration biopsy compared with D\&C in patients treated with progestin for endometrial hyperplasia (EH).
- Trial name
- NCT02412072
- Where
- South Korea
- Volunteers
- 75 people
- Sponsor
- Korean Gynecologic Oncology Group
Endometrial Cancer, Ovarian Cancer
Quality of Life in Survivors of Gynecologic Cancer
RATIONALE: Quality-of-life assessment in cancer survivors may help determine the long-term effects of having had gynecologic cancer and may help improve the quality of life for future cancer survivors.
- Trial name
- NCT00003795
- Testing
- quality-of-life assessment
- Where
- 44 sites in United States, Canada
- Volunteers
- 311 people
- Sponsor
- Gynecologic Oncology Group
Ovarian Cancer, Fallopian Tube Cancer
A Pilot Study Investigating the Effect of Chemotherapy on the Tumoral Immunoprofile of Gynecologic Cancers
The investigators propose to collect biologic samples (i.e. tumor tissue, ascites, and/or blood), from patients undergoing standard of care therapy for a gynecologic malignancy.
- Conditions
- Ovarian Cancer, Fallopian Tube Cancer, Peritoneal Cancer, Uterine Endometrial Cancer
- Trial name
- NCT02824328
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Duke University
Gynecologic Cancer, Cancer Metastatic
Study of AK112 in the Treatment of Advanced Gynecological Tumors
A phase II study to evaluate the efficacy and safety of AK112 in subjects with advanced gynecological tumors.
- Conditions
- Gynecologic Cancer, Cancer Metastatic, Ovarian Neoplasms, Cervical Neoplasm
- Trial name
- NCT04870177
- Testing
- AK112
- Where
- 2 sites in China
- Volunteers
- 53 people
- Sponsor
- Akeso
Gynecologic Cancer, Ovarian Cancer
Role of the ATP7A Transporter in Ovarian Cancer
Ovarian cancer has the highest mortality rate among all gynecologic cancers, with most patients presenting with advanced stage tumors.
- Conditions
- Gynecologic Cancer, Ovarian Cancer, High Grade Serous Carcinoma, Chemotherapy Effect
- Trial name
- ATHOC (NCT05490407)
- Testing
- Carboplatin
- Where
- 2 sites in Slovenia
- Volunteers
- 40 people
- Sponsor
- University Medical Centre Ljubljana
Cancer, Breast Cancer
Mind Over Matter for Black and African American Women: A Single Arm Trial Examining Feasibility and Acceptability of a Supportive Intervention
The goal of this study is to learn if the Mind Over Matter (MOM) Intervention, a 5-week group program, can help Black and African American women deal with the fears, worries and sadness that often accompany cancer diagnosis and…
- Conditions
- Cancer, Breast Cancer, Brain Cancer, Central Nervous System Cancer
- Trial name
- MOM (NCT06168825)
- Testing
- Mind Over Matter (MOM)
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Inova Health Care Services
Gynecologic Diseases
AirSeal®Insufflation Trocar/CO2 Absorption Study
The purpose of this study is to compare carbon dioxide (CO2) absorption during gynecologic laparoscopy using the AirSeal® valveless trocar system versus standard insufflation trocars at intra-abdominal pressures of 10 and 15…
- Trial name
- NCT02654808
- Testing
- AirSeal trocar, Standard trocar
- Where
- United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Columbia University
Endometrial Cancer
Molecular Staging of Endometrial Cancer
This study, sponsored by NCI and the Gynecologic Oncology Group (GOG), will collect tissue samples from women with cancer of the endometrium (lining of the uterus).
- Trial name
- NCT00340808
- Where
- United States
- Volunteers
- 5,492 people
- Sponsor
- National Cancer Institute (NCI)
Fallopian Tube Cancer, Female Reproductive Cancer
Ziv-aflibercept in Treating Patients With Locally Advanced, Unresectable, or Metastatic Gynecologic Soft Tissue Sarcoma
This phase II trial is studying how well ziv-aflibercept works in treating patients with locally advanced, unresectable or metastatic gynecologic soft tissue sarcoma.
- Conditions
- Fallopian Tube Cancer, Female Reproductive Cancer, Ovarian Carcinosarcoma, Ovarian Sarcoma
- Trial name
- NCT00390234
- Testing
- ziv-aflibercept
- Where
- 16 sites in United States, Canada
- Volunteers
- 63 people
- Sponsor
- National Cancer Institute (NCI)
Advanced Solid Tumor, Gynecologic Cancer
A Study to Evaluate Lucitanib in Combination With Nivolumab in Patients With a Solid Tumor
This is an open-label, Phase 1b/2 study to determine the recommended dose of lucitanib in combination with nivolumab in patients with an advanced solid tumor (Phase 1b); followed by evaluation of the safety and efficacy of…
- Trial name
- NCT04042116
- Testing
- Lucitanib, Nivolumab
- Where
- 27 sites in United States, Austria and 4 more
- Volunteers
- 227 people
- Sponsor
- Clovis Oncology, Inc.
Gynecologic Condition, Scheduled for a Total Laparoscopic or Robotic-assisted Hysterectomy
Trial of YUMI Uterine Manipulator
The purpose of this study is to test the feasibility and safety of using a new device called Yukio's Uterine Manipulating Instrument (YUMI). The YUMI is a type of uterine manipulator.
- Trial name
- NCT02923544
- Testing
- YUMI manipulator
- Where
- 7 sites in United States
- Volunteers
- 11 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Alopecia, Chemotherapy-induced Alopecia
A Pilot Study to Evaluate the Use of the AMMA Portable Scalp Cooling System From Cooler Heads
Eligible patients will be recruited prior to initiation of chemotherapy for any stage breast or gynecologic cancer. Patients will undergo training in the use of the AMMA Portable Scalp Cooling System and will use the device…
- Conditions
- Alopecia, Chemotherapy-induced Alopecia, Hair Loss, Breast Cancer
- Trial name
- NCT05365243
- Testing
- AMMA Portalbe Scalp Cooling System
- Where
- United States
- Sponsor
- Cooler Heads Care Inc.