Clinical trials: Gynecologic Disorders
Breast Cancer, Ovarian Cancer
Evaluation of the Safety and Tolerability of Niraparib With Everolimus in Advanced Gynecologic Malignancies and Breast
Open-label, cohort study to determine the feasibility and tolerability of the combination of daily niraparib and daily or thrice weekly everolimus for one 28-day cycle in patients with advanced ovarian and breast cancer.
- Trial name
- NCT03154281
- Testing
- niraparib, everolimus
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Avera McKennan Hospital & University Health Center
Gynecologic Nursing, Training Group, Sensitivity
Improving Gynecological Examination Skills with the Use of a Model
Vaginal, abdominal, and breast examinations are among the essential gynecological examination skills for midwifery students and are crucial steps that need to be learned.
- Conditions
- Gynecologic Nursing, Training Group, Sensitivity, Gynecologic Disease
- Trial name
- NCT06536192
- Testing
- Model group
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Karabuk University
Breast Cancer
Large Language Models to Aid Gynecological Oncology Treatment
This trial aims to assess the impact of providing medical students with access to large language models, in comparison to treatment guideline pdfs, on treatment concordance with a conventional multidisciplinary tumor board
- Trial name
- EASING (NCT06865534)
- Testing
- Local language model, Guideline pdf
- Where
- Germany
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Philipps University Marburg
Cervical Dysplasia, Cervical Cancer
Circulating Human Papilloma Virus (HPV) DNA for the Screening and Surveillance of Gynecologic Cancers
Human papilloma virus-related gynecologic malignancies affect over 20,000 women in the United States, and over half a million women globally each year.
- Trial name
- NCT05606133
- Testing
- NavDx(R)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Northwell Health
Gynecologic Disease
Ultrasound-guided Bilateral Rectus Sheath Block for Robotic Single-port Gynecologic Surgery
Rectus sheath block (RSB) is a kind of anterior abdominal wall block. It has postoperative analgesic effect for abdominal surgery with midline incision.
- Trial name
- NCT02450084
- Testing
- Rectus sheath block, Ropivacaine, Bandage
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Ewha Womans University Mokdong Hospital
Endometrial Hyperplasia
Comparison of Dilatation & Curettage and Endometrial Aspiration Biopsy Accuracy in Patients Treated With Progestin for Endometrial Hyperplasia: A Korean Gynecologic Oncology Group Study
A prospective multicenter trial has been started in Korea to evaluate the diagnostic accuracy of endometrial aspiration biopsy compared with D\&C in patients treated with progestin for endometrial hyperplasia (EH).
- Trial name
- NCT02412072
- Where
- South Korea
- Volunteers
- 75 people
- Sponsor
- Korean Gynecologic Oncology Group
Breast Cancer, Peripheral Neuropathy
Yoga for Symptoms of Nerve Damage Caused by Chemotherapy
Some types of chemotherapy used to treat breast cancer can cause damage to nerves with symptoms like tingling, numbness, muscle weakness, and pain in the hands and feet that can last and can affect functioning.
- Conditions
- Breast Cancer, Peripheral Neuropathy, Gynecologic Cancer
- Trial name
- NCT03292328
- Testing
- Yoga, Wait List Control
- Where
- 2 sites in United States
- Volunteers
- 51 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Ovarian Cancer
A Novel Method of Screening for Ovarian Cancer Using Gynecologic Fluids and Mucus
Ovarian cancer is deadly and generally diagnosed at late stage when the chances of survival are low. There is a current belief that this cancer starts in the fallopian tubes and progresses towards the ovaries, spreading to the…
- Trial name
- NCT01787656
- Where
- United States
- Volunteers
- 438 people
- Sponsor
- University of South Alabama
Gynecologic Cancers, Advanced Breast Cancer
Phase II, Prospective, Randomized, Proof-of-concept Study to Evaluate the Effects of a Personalized Dietary Intervention in Women With Advanced Gynecologic or Breast Tumors Treated With Antibody-Drug Conjugates (ADCs).
The objective of the study is to evaluate the effect of a personalized dietary intervention (cohort A), compared with a standard nutritional intervention based on general recommendations for following a Mediterranean diet (cohort…
- Trial name
- LUMInova (NCT07406789)
- Testing
- Personalised dietary intervention., General recommendations
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- TNC Nutrición Terapéutica S.L.
Uterine Cervical Neoplasms, Locally Advanced Cervical Cancer
US Radiomics in Advanced Cervical Cancer
This is a retrospective, multicenter observational study aimed at evaluating the role of ultrasound-based radiomics in patients with locally advanced cervical cancer (LACC).
- Conditions
- Uterine Cervical Neoplasms, Locally Advanced Cervical Cancer, Radiomics, Ultrasound Imaging
- Trial name
- RU-LACC (NCT06984289)
- Testing
- Radiomic Analysis of Ultrasound Images
- Where
- Italy
- Volunteers
- 220 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Cancer of the Cervix, Cervical Neoplasms
Integrated Dose Escalation for Advanced, Localized Gynecologic Cancer (The IDEAL - GYN Trial)
The purpose of this study is to determine the maximum tolerated dose of integrated boost radiation therapy when given with concurrent chemotherapy (cisplatin).
- Trial name
- IDEAL (NCT01627288)
- Testing
- Boost radiation
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Duke University
Breast Cancer, Sarcoma
Riluzole For Preventing Cognitive Dysfunction in Ca Pts Receiving Chemo (REFOCUS): Pilot Trial
This is a phase II single-arm, Phase 2a, randomized, double-blinded, placebo-controlled pilot clinical trial determining efficacy of riluzole in preventing cognitive dysfunction in subjects with cancer, who are receiving…
- Conditions
- Breast Cancer, Sarcoma, Gastric (Stomach) Cancer, Lung Cancer
- Trial name
- NCT07447050
- Testing
- Riluzole
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of California, Irvine
Cervical Cancer, Endometrial Cancer
Fondaparinux in Preventing Blood Clots in Patients Undergoing Surgery for Gynecologic Cancer
RATIONALE: Fondaparinux may help prevent blood clots from forming in patients who are undergoing surgery for gynecologic cancer.
- Conditions
- Cervical Cancer, Endometrial Cancer, Fallopian Tube Cancer, Ovarian Cancer
- Trial name
- NCT00381888
- Testing
- fondaparinux sodium
- Where
- 2 sites in United States
- Volunteers
- 44 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Gynecologic Cancers, Platinum-Sensitive Ovarian Cancer
A Study to Assess Change in Disease Activity and Adverse Events in Adult Participants With Gynecologic Cancers Receiving Intravenous Infusion of IMGN151 as Monotherapy or in Combination With Other Therapies
Cancer is a condition where cells in a specific part of body grow and reproduce uncontrollably. The purpose of this study is to assess safety and tolerability of IMGN151 when given as monotherapy and in combination with other…
- Conditions
- Gynecologic Cancers, Platinum-Sensitive Ovarian Cancer, Fallopian Tube Cancer, Primary Peritoneal Cancer (PSOC)
- Trial name
- NCT07024784
- Testing
- IMGN151, Carboplatin, Bevacizumab
- Where
- 21 sites in United States, Israel and 1 more
- Volunteers
- 377 people
- Sponsor
- AbbVie
Gynecologic Cancer, Cervical Cancer
A Pilot Study of Quantitative Tumor Oxygen Measurements in Cervical Cancer
This research is studying the level of oxygen in tumors during the brachytherapy procedure.
- Trial name
- NCT03970083
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Brigham and Women's Hospital
Gynecologic Disease
Comparison of Two Ventilation Modes With Laryngeal Mask Airway Guardian
The purpose of this study is to compare volume- and pressure- controlled ventilation with laryngeal mask airway Guardian in obese patients undergoing laparoscopic gynecologic surgery in terms of ventilatory efficacy, airway leak…
- Trial name
- wang002 (NCT02097628)
- Testing
- tidal volume, peak airway pressure
- Volunteers
- 40 people
- Sponsor
- Haiyun Wang
Shoulder Pain
A Simple Clinical Maneuver to Reduce Laparoscopy Induced Shoulder Pain
A pulmonary recruitment maneuver at the end of surgery reduced shoulder pain as well as nausea and vomiting after laparoscopic surgery.
- Trial name
- NCT00575237
- Testing
- Recruitment manouver
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Phelps, Paul, M.D.
Gynecologic Cancer, Adjustment
Yoga for Psychological Distress in Gynecologic, Gastrointestinal, or Thoracic Cancer
This study will test the feasibility and acceptability of a yoga program for women with gynecologic, gastrointestinal (GI), or thoracic malignancies.
- Conditions
- Gynecologic Cancer, Adjustment, Gastrointestinal Cancer, Thoracic Cancer
- Trial name
- NCT03385577
- Testing
- Stilling the Waters of Uncertainty: A yoga program for women with gynecologic, gastrointestinal (GI), or thoracic cancer
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- University of Florida
Surgical Procedure, Unspecified
Development and Pilot Test of an Elective Bilateral Salpingo-Oophorectomy (BSO) Decision Support Guide
The investigators propose to conduct formative research to gain an understanding of patients' needs and desires regarding elective Bilateral Salpingo-Oophorectomy (BSO) decision making, and to develop and pilot test a BSO…
- Trial name
- BSO (NCT01369654)
- Testing
- Computerized decision aid with 1 type of value clarification
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Gynecologic Disease
Clinical Study to Evaluate Efficacy of Cabergoline to Coasting in Reducing the Incidence of Ovarian Hyperstimulation Syndrome
Ovarian hyperstimulation syndrome (OHSS) is a serious iatrogenic complication of controlled ovarian stimulation of gonadotrophin-Stimulated ovarian cycles.
- Trial name
- NCT07043322
- Testing
- Coasting, Cabergoline
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Tanta University