Clinical trials: H Pylori Infection
Helicobacter Pylori Infection
Compare Sequential and Quadruple Therapy for the Eradication of Helicobacter Pylori in Korea
1. To compare 10-day sequential therapy and 14-day modified bismuth quadruple therapy and to establish more effective first-line regimen for the eradication of Helicobacter pylori in Korea. 2. To evaluate the effect of H.
- Trial name
- NCT02159976
- Testing
- Pantoprazole, Amoxicillin, Clarithromycin
- Where
- South Korea
- Volunteers
- 390 people
- Sponsor
- Seoul National University Bundang Hospital
Dyspepsia
UBT as a Diagnostic Tool for HP Prevalance
The prevalence of H. pylori infection in Pakistan is unknown and investigators want to assess it in dyspeptic patients utilizing UBT.
- Trial name
- NCT02570776
- Where
- Pakistan
- Volunteers
- 200 people
- Sponsor
- National Institute of Liver & GI Diseases, Pakistan
Helicobacter Pylori Infection
Bismuth Quadruple Therapy in Helicobacter Pylori Rescue Therapy of Different Tetracycline Doses and Frequencies.
The researchers collect H.pylori-positive patients who need rescue therapy from the outpatient clinic. The subjects were randomized to receive a dose and frequency of tetracycline 500mg tid or qid of bismuth quadruple eradication…
- Trial name
- NCT05802888
- Testing
- Tetracycline 500mg tid, Tetracycline 500mg qid
- Where
- China
- Volunteers
- 260 people
- Sponsor
- Shandong University
Helicobacter Pylori Infection
Efficacy of 10-day Concomitant Regimen Versus High Dose Dual Therapy in Anti-Helicobacter Pylori Rescue Therapy
Currently, a 10-day concomitant therapy has been reported to be equally effective and safe to the 10-day sequential therapy for 1st-line anti-Helicobacter pylori(H. pylori) therapy.
- Trial name
- NCT01265069
- Testing
- high dose dual therapy, concomitant therapy
- Where
- Taiwan
- Volunteers
- 204 people
- Sponsor
- National Taiwan University Hospital
Helicobacter Infections
Breath Ammonia Method for H. Pylori Detection: Phase II
The objective is to evaluate the utility of a breath ammonia sensing device. In this study we will assess the effect of H. pylori infection on breath ammonia levels by measuring whether there is a change in the pattern or…
- Trial name
- NCT00194688
- Testing
- H. pylori treatment
- Where
- United States
- Volunteers
- 278 people, healthy volunteers welcome
- Sponsor
- University of Washington
Helicobacter Pylori Infection
Comparison of Two Novel First-line Anti-Helicobacter Pylori Therapy
The Asian-Pacific Consensus Report has recommended that proton pump inhibitor (PPI)-clarithromycin-amoxicillin or metronidazole treatment for 7 to14 days is the first choice treatment for H pylori infection.
- Trial name
- NCT03383003
- Testing
- Nexium, Amolin, Klaricid
- Where
- Taiwan
- Volunteers
- 240 people
- Sponsor
- Chang Gung Memorial Hospital
H. Pylori Infection
Screening Strategy for Gastric Cancer Prevention
There are still some unsolved questions regarding population-based screening program for H. pylori infection to prevent gastric cancer, such as how to perform the optimal screening strategies.
- Trial name
- NCT05387005
- Testing
- UBT, HPSA, UBT and HPSA
- Where
- Taiwan
- Volunteers
- 4,403 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Therapeutic Duration, Helicobacter Pylori
Optimal Duration of Antimicrobial Susceptibility Test (AST) Guided Rescue Therapy for Helicobacter Pylori Infection
Strongly evidence supports that H. pylori eradication is an effective approach to reduce the incidence of those pathologies. However, due to the increasing resistance rates to antibiotics, failures of H.
- Conditions
- Therapeutic Duration, Helicobacter Pylori, Antimicrobial Susceptibility Test, Eradication
- Trial name
- NCT02934048
- Testing
- 7-day triple regimen guided by AST, 10-day triple regimen guided by AST, 14-day triple regimen guided by AST
- Volunteers
- 700 people
- Sponsor
- Shandong University
Helicobacter Pylori Infection, Traditional Chinese Medicine
Eradication of Helicobacter Pylori With Bismuth Agent Quadruple and Traditional Chinese Medicine
This study is a prospective randomized case-control study. Six hundred patients who were firstly diagnosed as Helicobacter pylori infection will be selected, and then randomly assigned into case group and control group.
- Conditions
- Helicobacter Pylori Infection, Traditional Chinese Medicine, Eradication
- Trial name
- NCT05586464
- Testing
- Ban xia xie xin Decoction and bismuth quadruplicate group, Bismuth quadruplicate group
- Volunteers
- 600 people
- Sponsor
- Liaocheng People's Hospital
Helicobacter Pylori Infection
Recurrence Rate Comparison Between Esomeprazole and Lansoprazole in Eradicating Helicobacter Pylori Infection Among Children
This study aims to compare the recurrence rates of Esomeprazole and Lansoprazole in triple combination therapy to eradicate H.pylori infection in children.
- Trial name
- NCT05861687
- Testing
- Esomeprazole, Lansoprazole, Amoxicillin
- Where
- 2 sites in Indonesia
- Volunteers
- 51 people
- Sponsor
- Finni Kollins
Helicobacter Infections, Gastritis
Tailored Treatment of H. Pylori Infection Based Polymorphisms of CYP2C19 and 23S rRNA of H. Pylori
The eradication rate of the standard H. pylori eradication therapy (such as the triple therapy with a proton pump inhibitor [PPI], amoxicillin and clarithromycin) depends on bacterial susceptibility to clarithromycin and…
- Conditions
- Helicobacter Infections, Gastritis, Gastric Ulcer, Duodenal Ulcer
- Trial name
- NCT00149084
- Testing
- Lansoprazole, clarithromycin, amoxicillin
- Where
- Japan
- Volunteers
- 296 people
- Sponsor
- Hamamatsu University
Helicobacter Pylori Infection
Efficacy of 7-day Versus 14-day Bismuth Quadruple Therapy for the Eradication of Helicobacter Pylori（SHARE2302)
Helicobacter pylori (H. pylori) infection is a common global infectious disease of the gastrointestinal tract. Helicobacter pylori eradication can effectively prevent the development of gastric cancer.The researchers collect…
- Trial name
- NCT05997433
- Testing
- 7days bismuth quadruple, 14 days bismuth quadruple
- Where
- China
- Volunteers
- 254 people
- Sponsor
- Shandong University
Gut Resistome
Effect of Probiotics on the Fecal Resistome During Helicobacter Pylori Eradication Therapy
Eradication therapy against Helicobacter pylori (Hp) carries adverse effects, such as altering the intestinal microbiota's structure and function and selecting commensals and pathogens resistant to antibiotics.
- Trial name
- NCT04786938
- Testing
- Saccharomyces Boulardii-Containing Product in Oral Dose Form
- Volunteers
- 72 people
- Sponsor
- Universidad San Francisco de Quito
HELICOBACTER PYLORI INFECTIONS
Gamma-Glutamyl Transpeptidase (GGT): A Potential Diagnostic Marker for Helicobacter Pylori Infections
The investigators hypothesis: Presence of anti-GGT (antibody against GGT) indicates H. pylori infection.
- Trial name
- NCT02123771
- Where
- Singapore
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Vonoprazan, Helicobacter Pylori Infection
A RCT of the Efficacy of Vonoprazan 20mg QD in the Treatment of Helicobacter Pylori Infection
The treatment of helicobacter pylori is very important. The routine treatment is quadruple therapy. In recent years, double therapy has appeared and the curative effect is fair.
- Conditions
- Vonoprazan, Helicobacter Pylori Infection, Proton Pump Inhibitor
- Trial name
- VATH-1 (NCT05590286)
- Testing
- Vonoprazan Tablets, Amoxicillin Capsules, Esomeprazole
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- First People's Hospital of Hangzhou
Helicobacter Pylori Infection
Feasibility Study of the Proposed Test-and-treat Screening Program in Younger Participants With H. Pylori Infection
This prospective non-interventional study is being conducted as part of the EU4Health project Eurohelican. The main goal of this pilot study is to evaluate the feasibility and acceptability of implementing the proposed…
- Trial name
- NCT06216639
- Testing
- Bismuth Subcitrate, Esomeprazole, Metronidazole
- Where
- Slovenia
- Volunteers
- 2,000 people
- Sponsor
- National Institute of Public Health, Slovenia
Duodenal Ulcer, Gastric Ulcer
Lymphocytic Subsets and Cytokine Production With H. Pylori Infection
The aims of this study are 1) to determine the cytokines produced by both Th1 and Th2 subsets in gastric antral biopsy specimens from Taiwanese patients before and after anti H.
- Conditions
- Duodenal Ulcer, Gastric Ulcer, Dyspepsia
- Trial name
- NCT00173953
- Testing
- immune response
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- National Taiwan University Hospital
Helicobacter Pylori Infection
H-pylori Infection With Disease Activity in Systemic Lupus Erythematosus and Rheumatoid Arthritis
To find the relation of Helicobacter pylori with disease activity in SLE and RA
- Trial name
- NCT06586567
- Testing
- Full history , clinical examination, assesment of disease activity ,Laboratory investigations ( CBC , ESR, CRP Serum creatinine and blood urea, Random plas
- Volunteers
- 150 people
- Sponsor
- Assiut University
Helicobacter Pylori Infection
Antibiotic Combination for H. Pylori Eradication in Penicillin-allergic Patients
This randomized controlled clinical trial will compare the eradication efficacy of bismuth quadruple therapy containing clarithromycin+metronidazole, clarithromycin+levofloxacin, or metronidazole+levofloxacin for Helicobacter…
- Trial name
- NCT05023577
- Testing
- Rabeprazole, Bismuth potassium citrate, Metronidazole
- Where
- China
- Volunteers
- 504 people
- Sponsor
- Shanghai Zhongshan Hospital
Helicobacter Pylori Infection
Tailored Juice-guided Eradication Therapy
In this study, the investigators aim to investigate the efficacy of tailored anti-microbial susceptibility guided-therapy via gastric juice PCR, compared with empirical standard triple therapy.
- Trial name
- HP (NCT04061447)
- Testing
- susceptibility-guided therapy, empirical clarithromycin-based triple therapy
- Where
- Taiwan
- Volunteers
- 182 people
- Sponsor
- Kaohsiung Medical University