Clinical trials: H Pylori Infection Eradication
Helicobacter Pylori Infection, Tegoprazan
Efficacy and Safety of Tegoprazan Dual Therapy and Furazolidone-based Bismuth Quadruple Therapy for Helicobacter Pylori Eradication: A Prospective, Multicenter, Open-label, Randomized Controlled Clinical Study
To compare the efficacy and safety of Tegoprazan-amoxicillin dual therapy and bismuth quadruple therapy based on furazolidone in the treatment of Helicobacter pylori eradication, the eradication rate, patient compliance, and…
- Conditions
- Helicobacter Pylori Infection, Tegoprazan, Furazolidone
- Trial name
- NCT06340334
- Testing
- Tegoprazan-amoxicillin dual therapy
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Helicobacter Pylori Infection
Standardize Communication With General Practitioner & Patient for Improved Eradication of Helicobacter Pylori
Patients who test Helicobacter pylori positive, are treated with antibiotics. However, due to a number of factors (such as unknown treatment compliance, no standardized follow-up, ...), a relative low eradication-percentage was…
- Trial name
- Helipro (NCT02873247)
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Algemeen Ziekenhuis Maria Middelares
Helicobacter Pylori Eradication
Efficacies of Tetracycline-levofloxacin, Standard Bismuth, Amoxicillin-levofloxacin Quadruple Therapy for H.p
1. Compare the efficacy of "Tetracycline combined with levofloxacin quadruple therapy", "standard tincture quadruple therapy" and "amoxicillin combined with levofloxacin quadruple therapy" on the second line of Helicobacter…
- Trial name
- NCT05850117
- Testing
- esomeprazole, tripotassium dicitrate bismuthate, tetracycline and levofloxacin, esomeprazole , tripotassium dicitrate bismuthate, tetracycline 500mg and metronidazole, esomeprazole, tripotassium dicitrate bismuthate , amoxicillin and levofloxacin
- Where
- Taiwan
- Volunteers
- 240 people
- Sponsor
- Kaohsiung Medical University
Helicobacter Pylori Infection, Resistant Infection
One Sequencing Find All for Helicobacter Pylori Infection
The aim of this study is to Identify antibiotic resistance gene mutations in Helicobacter pylori (HP) and genetic diversity of drug metabolism for antibiotics and proton pump inhibitors (PPIs) in patients with HP infection using…
- Trial name
- NCT03837990
- Testing
- Helicobacter Pylori eradication therapy
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Seoul National University Hospital
Helicobacter Pylori Infection, Helicobacter Pylori Infection, Susceptibility to
Eradication of H. Pylori Infection With Moxifloxacin
The main objective of the study is to compare the effectiveness of moxifloxacin triple therapy with levofloxacin-based sequential therapy in terms of eradication rate, safety, and patient compliance.
- Trial name
- RCT (NCT05863858)
- Testing
- Sequential Regimen: Levofloxacin 500 mg BID, Amoxicillin 1 gm BID, omeprazole 20 mg BID for first five days followed by Levofloxacin 500 mgBID, Tinidazole 500 mg BID, Omeprazole 20 mg BID, Triple Regimen: Moxifloxacin 400mg OD, Amoxicillin 1 gm BID, Omeprazole 20mgBID
- Where
- Pakistan
- Volunteers
- 162 people
- Sponsor
- Iyad Naeem Muhammad, PhD
Helicobacter Pylori Infection
Comparing Different Regimens for Eradication of Helicobacter Pylori in Kuwait
Eradication of H. pylori reduces morbidity in patients with chronic gastritis and can prevent gastric cancer. We aimed to evaluate the efficacy of clarithromycin-based triple therapy and non-bismuth based quadruple therapy for…
- Trial name
- NCT04617613
- Testing
- Omeprazole, Amoxicillin, Metronidazole and Clarithromycin, Omeprazole, Amoxicillin and Clarithromycin
- Volunteers
- 603 people
- Sponsor
- Al-Azhar University
Helicobacter Pylori Infection
Efficacy and Safety of Lacidofil® STRONG as an Adjuvant for Helicobacter Pylori Treatment in Non-ulcer Dyspepsia
Treatment for H. pylori eradication includes antibiotics. The treatment has decreased its efficiency (lower capability to eradicate the infection) due to increasing antibiotic resistance in the population.
- Trial name
- NCT04473079
- Testing
- Lacidofil
- Where
- Thailand
- Volunteers
- 90 people
- Sponsor
- Lallemand Health Solutions
Helicobacter Pylori Infection
Safety, Efficacy of Pylera BID Dosing in Eradication of H. Pylori
The purpose of this study is to evaluate the effect of Pylera when given twice a day. Pylera approved treatment schedule is 3 pills taken 4 times daily, in addition to omeprazole given twice daily.
- Trial name
- NCT00712413
- Testing
- OBMT
- Where
- 3 sites in United States, Canada
- Sponsor
- Forest Laboratories
Helicobacter Pylori
Optimized-dose Amoxicillin Versus Standard-dose Amoxicillin for Quadruple Therapy in Helicobacter Pylori Eradication
The goal of this prospective randomized clinical trial is to compare the rate of Helicobacter Pylori (HP) eradication after standard or dose-optimized amoxicillin quadritherapy in patients naïve to any anti-HP treatment and with…
- Trial name
- Helicomatri (NCT05635942)
- Testing
- optimized quadruple therapy, standard quadruple therapy
- Where
- Tunisia
- Volunteers
- 88 people
- Sponsor
- Les Laboratoires des Médicaments Stériles
Helicobacter Pylori Infection
Tailored Therapy for Helicobacter Pylori in Children
This study is designed to compare the eradication rates，safety and compliance of tailored therapy to those of standard triple therapy in children with H. pylori infection.
- Trial name
- NCT02635191
- Testing
- Tailored Group, Standard group
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Beijing Children's Hospital
Gastritis, Dyspepsia
Helicobacter Rescue Therapy With High-dose Esomeprazole and Amoxicillin Dual Therapy Versus Bismuth-containing Quadruple Therapy
This study aims at evaluating efficacy and safety of high-dose esomeprazole and amoxicillin dual therapy(esomeprazole and amoxicillin) versus bismuth-containing quadruple Therapy(bismuth，esomeprazole，tetracycline and…
- Conditions
- Gastritis, Dyspepsia, Helicobacter Pylori Infection, Gastric Cancer
- Trial name
- NCT04678492
- Testing
- Esomeprazole, Amoxicillin, Bismuth
- Where
- China
- Volunteers
- 658 people
- Sponsor
- Xijing Hospital of Digestive Diseases
H. Pylori Gastrointestinal Disease, H.Pylori Infection
CURE-H. Pylori: A Trial on the Combination of Anti-Ulcerants and Levofloxacin-Based Therapy for Helicobacter Pylori Eradication
This study, titled CURE-H. Pylori, is a three-arm, parallel-group, open-label, randomized controlled trial designed to evaluate the effectiveness of Dexlansoprazole, Lansoprazole, and Vonoprazan in combination with Levofloxacin…
- Conditions
- H. Pylori Gastrointestinal Disease, H.Pylori Infection, H.Pylori Eradication Rate
- Trial name
- CURE-H Pylori (NCT07344506)
- Testing
- Arm 1: Dexlansoprazole + Levofloxacin-Based Triple Therapy, Arm 2: Lansoprazole + Levofloxacin-Based Triple Therapy, Arm 3: Vonoprazan + Levofloxacin-Based Triple Therapy
- Where
- Pakistan
- Volunteers
- 942 people, healthy volunteers welcome
- Sponsor
- Dow University of Health Sciences
Helicobacter Pylori Infection
Efficacy and Safety of Vonoprazan as First-line Treatment for Helicobacter Pylori Eradication
This study aims to evaluate the efficacy of vonoprazan compared with esomeprazole as first-line treatment for Helicobacter Pylori(Hp) eradication, as well as the safety and economic benefits.
- Trial name
- NCT04907747
- Testing
- Vonoprazan, Esomeprazole, Colloidal bismuth pectin
- Where
- China
- Volunteers
- 234 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Bacterial Infection Due to Helicobacter Pylori (H. Pylori)
Rifaximin Associated With Classic Triple Therapy for the Eradication of Helicobacter Pylori Infection
Background: A progressive decrease in Helicobacter pylori eradication rates has been described over the years, so new combinations of antibiotics for treatment are needed.
- Trial name
- R+OCA (NCT03124199)
- Testing
- Rifaximin
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Fundación de Investigación Biomédica - Hospital Universitario de La Princesa
Helicobacter Pylori
The Situation of Re-infection of Helicobacter Pylori After Successful Eradication
The patients who accept the quadruple eradication program of the helicobacter pylori and success to eradicate helicobacter pylori will be followed-up to observe the situation of re-infection of helicobacter pylori.
- Trial name
- NCT04029493
- Where
- China
- Volunteers
- 1,800 people
- Sponsor
- Shandong University
Helicobacter Pylori Infection
Esomeprazole/Vonoprazan Combined With High-dose Amoxicillin Dual Therapy for Primary Eradication of Helicobacter Pylori Infection
This study intends to collect the clinical data of patients with Helicobacter pylori infection, and to observe and count the high-dose double therapy and the traditional quadruple / triple therapy ( i.e., esomeprazole +…
- Trial name
- NCT06250634
- Testing
- esomeprazole + amoxicillin, esomeprazole + amoxicillin + clarithromycin + colloidal bismuth tartrate agent, Vonoprazan + amoxicillin
- Where
- China
- Volunteers
- 806 people
- Sponsor
- The Third Xiangya Hospital of Central South University
Helicobacter Pylori Infection
Jinghua Weikang Capsule Containing Quadruple Therapy for IgAN With Helicobacter Pylori Infection
This study is to evaluate the efficacy and safety of the Jinghua Weikang Capsule (a Chinese patent medicine for peptic ulcer and gastritis) containing quadruple therapy (Jinghua Weikang Caplsule plus triple therpy) for…
- Trial name
- NCT05320133
- Testing
- JWC containing quadruple therapy, Bismuth-containing quadruple therapy
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Peking University First Hospital
Gastric Cancer Screening, Prevention and Control
Helicobacter Pylori Infection and Gastric Diseases in Lao PDR: First Community-Wide Population-Based Study
This study aims to determine the regional prevalence of Helicobacter pylori infection, bacterial strain differences, and the prevalence of gastric cancer in two provinces of Laos, a multi-ethnic country where these factors may…
- Conditions
- Gastric Cancer Screening, Prevention and Control, Helicobacter Eradication, Helicobacter Infections
- Trial name
- NCT07340593
- Where
- Laos
- Volunteers
- 1,251 people, healthy volunteers welcome
- Sponsor
- Zero Helicobacter IGAN Network
Helicobacter Pylori Infection Helicobacter Pylori Eradication Patient Education
Comparing the Efficacy of WeChat-based Patient Education and Conventional Patient Education in the Management of Helicobacter Pylori Eradication
we conducted a retrospective study to compare the efficacy of WeChat-based patient education and conventional patient education in the management of Helicobacter pylori eradication.
- Trial name
- NCT05186662
- Testing
- patient education
- Where
- China
- Volunteers
- 1,017 people, healthy volunteers welcome
- Sponsor
- Shandong University
Bacterial Infection Due to Helicobacter Pylori (H. Pylori)
High Dose Dual Therapy (HDDT) for Eradication of Helicobacter Pylori Infection
The investigators will performed a large-scale multi center trial to compare the efficacy of a high-dose dual therapy (HDDT) with that of standard therapies in treatment-naive (n = 300) patients with Hp infection.
- Trial name
- HDDT (NCT02553083)
- Testing
- Nexium 40 mg, amoxicillin 1.5 gr, doxycycline 200 mg
- Where
- Israel
- Volunteers
- 300 people
- Sponsor
- Rabin Medical Center