Clinical trials: HBP
Glaucoma, Ocular Hypertension
Efficacy and Tolerability of Xalatan in Patients
Efficacy data was not collected or analyzed. This study did assess safety and tolerability of Xalatan.
- Trial name
- A6111128 (NCT00950690)
- Testing
- Xalatan 0.005% eye drops
- Where
- 3 sites in Egypt, Saudi Arabia and 1 more
- Volunteers
- 1,289 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Pulmonary Hypertension
Study of Ambrisentan in Participants With Pulmonary Hypertension
The primary objective of this study is to monitor the long-term safety of ambrisentan in adult participants with pulmonary hypertension.
- Trial name
- ABS-LT (NCT00777920)
- Testing
- Ambrisentan
- Where
- 46 sites in United States, Argentina and 7 more
- Volunteers
- 140 people
- Sponsor
- Gilead Sciences
Hypertension, Blood Pressure
HIRREM for Stage 1 Primary Hypertension
The purpose of this study is to determine that effects of an intervention called High-resolution, relational, resonance-based, electroencephalic mirroring (HIRREM), on Stage 1 Primary Hypertension (systolic BP 130-139, and/or…
- Conditions
- Hypertension, Blood Pressure, Cardiovascular Diseases, Cardiovascular Risk Factor
- Trial name
- HIRREM (NCT03479697)
- Testing
- HIRREM, Continued Current Care
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Wake Forest University Health Sciences
Hypertension
Comparison of Bisoprolol With Metoprolol Succinate Sustained-release on Heart Rate and Blood Pressure in Hypertensive Patients
This is a multicentre, randomized, open-label parallel trial to demonstrate the superiority and/or non-inferiority of bisoprolol on metoprolol succinate sustained-release (SR) tablet in subjects with mild to moderate primary…
- Trial name
- CREATIVE (NCT01508325)
- Testing
- Bisoprolol, Metoprolol
- Where
- China
- Volunteers
- 186 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Pulmonary Arterial Hypertension
A Long-Term, Open-Label Study to Evaluate the Safety of Sitaxsentan Sodium Treatment in Patients With Pulmonary Arterial Hypertension
This is a multi-center, open-label study of sitaxsentan sodium 100 mg taken orally once daily by subjects with PAH until sitaxsentan, in a particular country or region, is commercially available for the treatment of PAH or the…
- Trial name
- STRIDE-3 (NCT00811018)
- Testing
- Sitaxsentan
- Where
- 91 sites in United States, Argentina and 14 more
- Volunteers
- 1,192 people
- Sponsor
- Pfizer
Glaucoma
Optical Coherence Tomography (OCT) Data Collection Study
Collect OCT data to evaluate the range and age trend of ocular measurements.
- Trial name
- NCT01641835
- Where
- Canada
- Volunteers
- 303 people, healthy volunteers welcome
- Sponsor
- Heidelberg Engineering GmbH
Brain Tumors
Nicardipine vs Esmolol Craniotomy Emergence
Emergence hypertension is a common occurrence in patients emerging from general anesthesia. This elevation of arterial pressure is particularly concerning in patients undergoing craniotomy due to increased risk of morbidity and…
- Trial name
- NCT01951950
- Testing
- Nicardipine, Esmolol
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Northwestern University
Normal Tension Glaucoma, Ocular Hypertension
Investigation of Intraocular Pressure (IOP) Reduction Efficacy of Travoprost Ophthalmic Solution in Patients With Normal Tension Glaucoma
The purpose of this study is to investigate IOP reduction efficacy of travoprost 0.004% ophthalmic solution (TRAVATAN Z®) in subjects with normal tension glaucoma.
- Trial name
- NCT01995136
- Testing
- Travoprost Ophthalmic Solution 0.004%
- Where
- Japan
- Volunteers
- 32 people
- Sponsor
- Alcon Research
Chronic Kidney Disease, Hypertension
Five, Plus Nuts and Beans for Kidneys
This Five, Plus Nuts and Beans for Kidneys Study is a single center, randomized controlled trial with 2 parallel arms testing the hypothesis that delivery of nutritional advice to adopt a Dietary Approaches to Stop Hypertension…
- Trial name
- NCT03299816
- Testing
- Coaching DASH group (C-DASH), Self-Shopping DASH group (S-DASH)
- Where
- United States
- Volunteers
- 142 people
- Sponsor
- Johns Hopkins University
Hypertension, Vascular Diseases
SPYRAL PIVOTAL - SPYRAL HTN-OFF MED Study
The purpose of this study is to test the hypothesis that renal denervation decreases blood pressure and is safe when studied in the absence of antihypertensive medications.
- Conditions
- Hypertension, Vascular Diseases, Cardiovascular Diseases
- Trial name
- NCT02439749
- Testing
- Symplicity Spyral™ multi-electrode renal denervation system
- Where
- 47 sites in United States, Australia and 7 more
- Volunteers
- 366 people
- Sponsor
- Medtronic Vascular
Open-Angle Glaucoma, Ocular Hypertension
Fixed Combination Brinzolamide 1%/Timolol 0.5% Versus Brinzolamide 1% + Timolol 0.5% in Open-Angle Glaucoma or Ocular Hypertension
The purpose of this study was to compare the intraocular pressure (IOP)-lowering efficacy and safety of AZARGA™ (Brinzolamide 1%/Timolol 0.5% Ophthalmic Suspension), dosed twice daily versus AZOPT® (Brinzolamide 1% Ophthalmic…
- Trial name
- NCT01357616
- Testing
- Brinzolamide 1% / Timolol 0.5% fixed combination ophthalmic suspension, Brinzolamide 1% ophthalmic suspension, Timolol 0.5% ophthalmic solution
- Volunteers
- 328 people
- Sponsor
- Alcon Research
Pulmonary Hypertension, Diastolic Left Ventricular Dysfunction
Study of Ranolazine in the Treatment of Pulmonary Hypertension Associated With Diastolic Left Ventricular Dysfunction
This is a single center, open-label trial designed to assess the safety and efficacy of ranolazine (Ranexa) in patients with pulmonary hypertension associated with left ventricular diastolic dysfunction.
- Trial name
- NCT02133352
- Testing
- Ranolazine
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Boston University
Pulmonary Hypertension
Special Investigation For Long-Term Use Of Sildenafil (Regulatory Post Marketing Commitment Plan)
The objective of this surveillance is to collect information about 1) adverse drug reaction not expected from the LPD (unknown adverse drug reaction), 2) the incidence of adverse drug reactions in this surveillance, and 3)factors…
- Trial name
- NCT00666198
- Testing
- SILDENAFIL
- Volunteers
- 3,337 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Hypertension
Pharmacokinetics of Sirolimus and Tacrolimus in Liver Transplant Recipients With Tacrolimus Toxicity
Pharmacokinetics of Tacrolimus and Sirolimus alone and in combination in liver transplant recipients.
- Trial name
- Sirolimus (NCT01709136)
- Testing
- Sirolimus
- Volunteers
- 3 people
- Sponsor
- University of Pittsburgh
Severe Pulmonary Arterial Hypertension
Open-label, Multi-center Protocol to Provide QTI571 to PAH Patients Who Participated in the Extension Study (A2301E1) in Japan
To provide continued treatment to Pulmonary Arterial Hypertension (PAH) patients who are benefitting from treatment with QTI571.
- Trial name
- NCT02042014
- Testing
- QTI571
- Where
- 3 sites in Japan
- Volunteers
- 8 people
- Sponsor
- Novartis Pharmaceuticals
Autosomal Dominant Polycystic Kidney, Hypertension
Effect of Beetroot Juice on Reducing Hypertension in Autosomal Dominant Polycystic Kidney Disease
People with autosomal dominant polycystic kidney disease (ADPKD) develop high blood pressure and kidney disease. Previous studies have shown that a commonly occurring chemical, nitric oxide (NO), is reduced in ADPKD, and may…
- Conditions
- Autosomal Dominant Polycystic Kidney, Hypertension, Endothelial Dysfunction
- Trial name
- BEET-PKD (NCT05401409)
- Testing
- Beetroot juice, Nitrate-depleted beetroot juice
- Where
- 2 sites in Australia
- Volunteers
- 60 people
- Sponsor
- Western Sydney Local Health District
Atherosclerosis
Aliskiren Effect on Aortic Plaque Progression
This study is being done to assess the effectiveness of short term (~9 months) Aliskiren/Placebo therapy to slow down the progression of atherosclerotic disease in thoracic and abdominal aorta.
- Trial name
- ALPINE (NCT01417104)
- Testing
- Aliskiren
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- Ohio State University
Obesity
Cardiometabolic Disease and Pulmonary Hypertension
This study will investigate if metformin can help people with obesity and high pressures inside their lung blood vessels. Metformin is approved by the U.S.
- Trial name
- NCT03349775
- Testing
- Metformin
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Massachusetts General Hospital
Open Angle Glaucoma, Ocular Hypertension
Phase 3 Trial of NCX 470 vs. Latanoprost in Subjects With Open-Angle Glaucoma or Ocular Hypertension
The objective of this clinical study is to evaluate the safety and efficacy of NCX 470 Ophthalmic Solution in lowering intraocular pressure (IOP) in patients with ocular hypertension or open-angle glaucoma.
- Trial name
- Mont Blanc (NCT04445519)
- Testing
- NCX 470 0.065% (initial phase of trial), Latanoprost 0.005% (initial phase of trial), NCX 470 0.1% (initial phase of trial)
- Where
- United States
- Volunteers
- 691 people
- Sponsor
- Nicox Ophthalmics, Inc.
Hypertension
Efficacy of Losartan + Amlodipine Compared to Amlodipine Alone in the Treatment of Uncontrolled High Blood Pressure (MK-0954F-399)
This study will determine whether using losartan and amlodipine together will be non-inferior in lowering blood pressure than amlodipine alone.
- Trial name
- NCT01277822
- Testing
- Losartan (+) amlodipine, Amlodipine camsylate
- Volunteers
- 334 people
- Sponsor
- Organon and Co
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