Clinical trials: HDL
Dyslipidemia
Effects of Niaspan™ on High-density Lipoprotein (HDL) in Healthy Male Subjects (0000-069)
This study will evaluate whether chronic dosing with Niaspan™ increases reverse cholesterol transport, high-density lipoprotein cholesterol (HDL-C) levels, and fecal excretion of cholesterol.
- Trial name
- NCT01071291
- Testing
- Niaspan
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Healthy, GEN1 Gene Mutation
SREBF1 Polymorphism and Egg Yolk on Cardiovascular Disease Risk in Healthy Young Adults: a Randomised, Two-period, Single Blinded, Crossover Trial
Our previous analysis showed that sterol regulatory element binding protein gene (SREBF1) rs2236513/rs2297508/rs4925119 polymorphism modulated the relation between dietary cholesterol and serum low density lipoprotein cholesterol…
- Trial name
- NCT04975048
- Testing
- Egg yolks, Macronutrients equivalent control
- Where
- China
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Shandong University
Cardiovascular Disease Prevention
Impact of a Nutritional Supplement on Metabolic Health
There are prevalent micronutrient and fiber deficiencies in a significant proportion of US population, particularly among the overweight or obese.
- Trial name
- CHORIBar (NCT02239198)
- Testing
- Nutrition bar
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- UCSF Benioff Children's Hospital Oakland
Type 1 Diabetes
Study of High Density Lipoprotein Function in Type 1 Diabetic Patients With Nephropathy
A number of arguments suggest that the deterioration in high density lipoproteins (HDL) functioning may worsen with the development of nephropathy during type 1 diabetes (T1D).
- Trial name
- DID&NEPHRO (NCT03512132)
- Testing
- Blood samples, Urine sample
- Where
- France
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Dijon
Metabolic Syndrome X
High Density Lipoprotein (HDL) Functionality in Metabolic Syndrome
The aim of the study is to examine the kinetic, anti-oxidant, anti-inflammatory and cellular cholesterol efflux properties of high-density lipoprotein (HDL) in subjects with the metabolic syndrome (MetS) and lean individuals.
- Trial name
- NCT00716300
- Where
- Australia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The University of Western Australia
Dyslipidemias, Hypertriglyceridemia
Effects of Phytoestrogen From Pueraria Mirifica in Improvement of Serum Lipid Parameters in Postmenopausal Women
The goal of this clinical trial is to learn about the effects of phytoestrogen from Pueraria Mirifica in improvement of serum lipid parameters.
- Conditions
- Dyslipidemias, Hypertriglyceridemia, Hypercholesterolemia, Hyper-LDL-cholesterolemia
- Trial name
- NCT06220266
- Testing
- Phytoestrogen, Diet control & life style modification
- Where
- Thailand
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Dhurakij Pundit University
HDL Cholesterol
Effect of Niaspan on Cholesterol in Men
To determine whether 8 weeks of Niaspan treatment increases cholesterol efflux in male subjects with low HDL-C cholesterol when compared to no treatment.
- Trial name
- NCT00765284
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- KineMed
Lipids
Effects of a Large Increase in Dietary Fats and Cholesterol on HDL Composition and Function in Healthy Subjects
In this study the investigators aimed at measuring the effect of a two-week high-fat/high-cholesterol (HFHC) normocaloric diet on HDL particles biochemical composition and HDL function compared to a two-week…
- Trial name
- NCT02549144
- Testing
- Low fat/cholesterol diet, High fat/cholesterol diet
- Where
- Italy
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliero, Universitaria Pisana
HDL Cholesterol
High-density Lipoprotein (HDL) Cholesterol in Women Taking Tibolone
Tibolone (Livial) has been shown in previous studies to lower HDL cholesterol by up to 40%. This study aims to study the effects of fenofibrate on HDL and subfractions in women taking tibolone.
- Trial name
- TibFen (NCT00809068)
- Testing
- fenofibrate and tibolone, tibolone
- Where
- Australia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Keogh Institute for Medical Research
Obesity, Hypercholesterolemia
Primary Prevention of Cardiovascular Diseases in Childhood and Adolescence: the Role of Physical Activity
This research project is about a physical activity intervention in pediatric outpatients to try control and prevent heart diseases such as hypertension, obesity, high cholesterol.
- Conditions
- Obesity, Hypercholesterolemia, High Blood Pressure, Sedentary Lifestyle
- Trial name
- NCT01580319
- Testing
- physical exercise
- Where
- Brazil
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Instituto de Cardiologia do Rio Grande do Sul
Diet Modification, HDL
Effects of Short-term Diet on HDL Composition and Function
The primary objective of this study is to generate preliminary data on the effects of a short-term diet of either fast food or Mediterranean type diet on HDL and microbiota composition and function in healthy subjects, which…
- Conditions
- Diet Modification, HDL, Inflammation
- Trial name
- NCT03205254
- Testing
- Mediterranean Diet, Fast food diet
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Cholesterol (Total and HDL), Exercise
Step-Aerobics Versus Core Exercise for Non-HDL Cholesterol Reduction in Sedentary/Obesity Women
This study investigated the effects of a step-aerobics program versus a core exercise program on serum non-HDL-C levels and other cardiometabolic parameters in sedentary women with overweight/obesity.
- Trial name
- NCT07703202
- Testing
- Intervention 1: Step-Aerobics Program, Intervention 2: Core Exercise Program
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Muğla Sıtkı Koçman University
Antioxidant Absorption
Evaluation of Obicetrapib on Antioxidant Levels in Plasma and HDL Particles of Healthy Volunteers
The goal of this clinical trial is to learn if Obicetrapib works to change antioxidant levels in HDL and plasma, as well as retinal tissue.
- Trial name
- VERMEER (NCT06982508)
- Testing
- Obicetrapib 10mg
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- NewAmsterdam Pharma
Obesity, Metabolic Syndrome
Lipoproteins and ImmunoMetabolism
Dietary interventions have been consistently proposed as a part of a comprehensive strategy to lower the incidence and severity of atherosclerosis and cardiovascular diseases (CVD).
- Conditions
- Obesity, Metabolic Syndrome, Metabolism Disorder, Inflammation
- Trial name
- NCT05746013
- Testing
- Lipid Emulsion
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Seville
Insulin Resistance, Hypertriglyceridemia
Comparing Tricor, Avandia, or Weight Loss to Lower Cardiovascular Risk Factors in People With High Triglycerides.
Approximately 1/4 of the US population has insulin resistance and the associated risk factors such as elevated lipid levels -triglycerides (type of fat from what we eat and what the liver produces and low HDL cholesterol which is…
- Trial name
- NCT00186537
- Testing
- Rosiglitazone, Fenofibrate, Weight Loss
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Stanford University
Lipoprotein (a)
Lipid Screening Study
The purpose of this pilot study is to estimate the prevalence of elevated Lipoprotein (a) in an adult primary care population and to describe the distribution of atherogenic lipid markers within this cohort.
- Trial name
- NCT07579325
- Testing
- Venipuncture
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Central Florida
Obesity (BMI Equal to or >30), Immune Function
Investigation of Egg Intake and the Relationship Between Gut Microbiome, Metabolic, and Immune Profiles
The purpose of this intervention study is to investigate the effects of daily egg intake on markers of gut health, high-density lipoprotein (HDL), metabolic, and immune cell profiles in adults with body mass indexes (BMI) in…
- Conditions
- Obesity (BMI Equal to or >30), Immune Function, HDL, Gut Microbiome
- Trial name
- NCT07844616
- Testing
- Egg whites, Whole eggs
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- University of Connecticut
HIV Infections, Dyslipidemia
Study of Niacin on Endothelial Function in HIV-infected Subjects With Low High Density Lipoprotein Cholesterol Levels
This study is a pilot study examining the effect of extended-release niacin (Niaspan ®) on flow-mediated vasodilation (FMD) of the brachial artery, among human immunodeficiency virus (HIV)-1 infected individuals with low high…
- Conditions
- HIV Infections, Dyslipidemia, Endothelial Dysfunction
- Trial name
- NCT00986986
- Testing
- extended release niacin
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Hawaii
Cardiovascular Diseases
Study of the Effectiveness and Safety of Niaspan ® in the Treatment of Lipid Abnormalities in Latin America
Post-Marketing Observational study of Niaspan® tablet in accordance with each country regulations. This study will be conducted in a prospective, single-arm, multi-center format.
- Trial name
- NCT01200160
- Testing
- Niacin
- Where
- 22 sites in Colombia, Mexico and 1 more
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Abbott
HIV Infections, Lipodystrophy
Observational Study of Changes in Fat Distribution and Blood Metabolites in HIV Infected Adults
The purpose of this study is to collect data on the body's breakdown of sugar and fat in HIV infected adults. Data from this study will make clearer the roles of HIV infection and anti-HIV drugs in the development of diabetes…
- Conditions
- HIV Infections, Lipodystrophy, Diabetes, Hyperlipidemia
- Trial name
- NCT00331448
- Volunteers
- 1,483 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)