Clinical trials: HEALTHY INDIVIDUALS
Health People, Physical Activity
The Effect of Auricular Vagus Nerve Stimulation and Controlled Breathing Exercises on Performance and Autonomic Nervous System
There are many studies in the literature on transcutaneous vagus nerve stimulation (VNS) and controlled breathing exercises (CBE), but there are limited studies examining the effects of both interventions on performance and the…
- Conditions
- Health People, Physical Activity, Autonomic Nerveus System, Vagus Nerve Stimulations
- Trial name
- NCT06796101
- Testing
- Vagus Nerve Stimulation, Controlled breathing exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Bahçeşehir University
Healthy Individuals (Controls)
Effects of Combined Exercise Training Modality
This study aims to investigate the effects of combined Inspiratory Muscle Training and aerobic exercise on diaphragm and pulmonary functions, respiratory muscle function, performance, and body composition
- Trial name
- NCT06742372
- Testing
- combined inspiratory and aerobic exercise training, aerobic exercise training
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Gazi University
Dietary Preferences, Sensory Evaluation
Sensory Evaluation of Chinese Specialty Foods
This project aims at college student consumers, recruiting a certain number of college student volunteers as sensory evaluators, and requiring them to evaluate samples of Babao Congee and deep-fried dough sticks.
- Conditions
- Dietary Preferences, Sensory Evaluation, Healthy Individuals
- Trial name
- NCT06736834
- Testing
- Babao Congee and Youtiao(deep-fried dough sticks) with different cooking conditions
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Zhejiang University
Healthy Volunteers
Neural Bases of Decision-making in Healthy Individuals
The goal of this single center non-interventional fMRI study is to assess the neural bases of decision-making and executive functioning in healthy individuals,and whether/how their responsiveness is modulated by ageing.
- Trial name
- NCT05774834
- Testing
- No intervention
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Central Auditory Disease, Auditory Processing Disorder, Central
taVNS Effect on Central Auditory Processing
The behavioral effects of vagus nerve stimulation (VNS) and observed activation in the auditory cortex with transcutaneous auricular VNS (taVNS) raise questions about their potential impact on auditory processing.
- Conditions
- Central Auditory Disease, Auditory Processing Disorder, Central, Auditory Processing Disorders, Vagus Nerve Stimulation
- Trial name
- NCT06970444
- Testing
- transcutaneous auricular vagus nerve stimulation (taVNS)
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Medipol University
Healthy
Observational Metabolic Health Study
The rationale for this study is to observe the effect of a consumer-grade commercially available product called Mimio Biomimetic Cell Care on metabolic health in overweight individuals.
- Trial name
- NCT06790407
- Testing
- Mimio Study Product
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Mimio Health, Inc.
Healthy Participants
A Phase 1 Study of Navlimetostat Tablet Formulations
This study aims to compare the PK of Navlimetostat after administration of a wet-granulation tablet versus the dry-granulation tablet formulation in healthy adult female
- Trial name
- NCT07544628
- Testing
- Navlimetostat
- Where
- 4 sites in United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Isolated Gastrocnemius Tightness, Healthy Adult Participants
Isolated Gastrocnemius Tightness and Tactile Sensitivity
Isolated gastrocnemius tightness is associated with various foot pathologies, particularly metatarsalgia and hallux valgus, and is also commonly observed in the general population.
- Trial name
- NCT07828392
- Testing
- Ankle Dorsiflexion Index
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Nigde Omer Halisdemir University
Depressive Disorder, Major, Persistent Depressive Disorder
Effectiveness of an Ecological Momentary Emotion Regulation Intervention
This two-armed randomized controlled trial aims to investigate the effectiveness of an emotion regulation intervention in individuals with and without depressive disorders.
- Conditions
- Depressive Disorder, Major, Persistent Depressive Disorder, Healthy
- Trial name
- NCT06311136
- Testing
- Valence-Specific Ecological Momentary Intervention
- Where
- Germany
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Heidelberg University
Prediabetes
PREPARE: "Prediabetes Research and Education Promoting Activity & Responsible Eating"
The purpose of this study is to determine if a 6-month community-based prediabetes lifestyle and behaviour change intervention (called, PREPARE) for middle and older adults with prediabetes will result in positive lifestyle…
- Trial name
- PREPARE (NCT01396772)
- Testing
- PREPARE education program, standard of care presentation
- Where
- Canada
- Volunteers
- 240 people
- Sponsor
- Brescia University College
Ketosis
Metabolomic Signature of Exogenous Ketosis
Ketone bodies are a fuel source and signaling molecule that are produced by your body during prolonged fasting or if you consistently eat at low-carbohydrate diet.
- Trial name
- KM (NCT05699707)
- Testing
- (R)-3-hydroxybutyl (R)-3-hydroxybutyrate ketone monoester
- Where
- Canada
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Microbiota Analysis in Healthy Subjects
Analysis of the Gut Microbiota Composition After Consumption of Probiotic Bacteria
The goal of this intervention study is to evaluate the beneficial effect of the probiotic bacterium Bacillus coagulans in healthy volunteers.
- Trial name
- NCT07046897
- Testing
- Consumption of probiotics strain 5, Consumption of probiotics strain 6
- Where
- Sweden
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Lund University
SARS-CoV-2 Infection, COVID-19
A Study to Learn About New COVID-19 RNA Vaccine Candidates in COVID-19 Vaccine-Experienced Healthy Individuals
The purpose of this clinical trial is to learn about the safety, tolerability and immunogenicity of BNT162b RNA-based SARS-CoV-2 vaccine candidates in adults to prevent COVID-19.
- Trial name
- NCT05472038
- Testing
- BNT162b5 Bivalent (WT/OMI BA.2), BNT162b2 Bivalent (WT/OMI BA.1), BNT162b2 Bivalent (WT/OMI BA.4/BA.5)
- Where
- 31 sites in United States
- Volunteers
- 1,453 people, healthy volunteers welcome
- Sponsor
- BioNTech SE
Gene Expression, Cardiometabolic Risk
Effects of Antioxidant Sugar vs Granulated Sugar on Metabolic Outcomes in Healthy and Cardio Metabolic Subjects
Study 1: To investigate the effects of antioxidant-rich sugar as alternative compared to granulated sugar on gene expression and other metabolic parameters in healthy subjects.
- Conditions
- Gene Expression, Cardiometabolic Risk, Metabolic Syndrome
- Trial name
- MSS (NCT04737044)
- Testing
- Study 1: MRBS, Study 2: White sugar & education module, Study 2: MRBS & education module
- Where
- Malaysia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universiti Putra Malaysia
Healthy
Exercising With a Surgical Mask in Both Athletic and Non-athletic Individuals
This study aimed to examine the impact of surgical masks on maximal and submaximal exercise in both athlete and non-athlete individuals.
- Trial name
- NCT05282472
- Testing
- CPET without mask, CPET with mask
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Şensu Dinçer
Healthy Participants
Evaluation of Methods for Measuring Gastrointestinal Transit and Food Reward in Healthy Individuals - The PRESET Study
The wireless motility capsule technology, SmartPill™, can be used to assess gastric emptying and gastrointestinal (GI) transit time.
- Trial name
- PRESET (NCT03894670)
- Testing
- Standard mixed breakfast meal, SmartBar™
- Where
- Denmark
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Kristine Færch
Healthy, Healthy Adult
Assessment of Lung Function (Lufu) at Sea Level LA vs. High Altitude HA in Healthy Individuals
To study the effect of a re-ascent to high altitude (Quito Ecuador: 2850m) after a one-week stay at sea level (after prior descent from 2850m) on lung function and pulmonary resistance/reactance in healthy individuals, who live…
- Conditions
- Healthy, Healthy Adult, High Altitude Effects, High Altitude
- Trial name
- NCT07804537
- Testing
- Re-ascent from sea level to 2850m
- Where
- Switzerland
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Silvia Ulrich Somaini
Healthy Individuals With no Periodontal Disease
The Effect of Nitrate Supplementation on Tongue Microbiome
The objective of this study is to investigate how the host environment influences microbiome structure. Specifically, the spatial organization of nitrate-metabolizing bacteria that will flourish in high and low salivary nitrate…
- Trial name
- NCT07865481
- Testing
- Nitrate-Supplemented Beet Juice, Nitrate-Depleted Beet Juice
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- The Forsyth Institute
Detection of Delayed-type Hypersensitivity Reactions to SARS-CoV-2 in Individuals Exposed to SARS-CoV-2
Assessment of Delayed-type Hypersensitivity Reactions to SARS-CoV-2 Peptide Antigens
This dose finding, multi-cohort study is designed to evaluate the safety and efficacy of intradermally-injectedTNX-2100, synthesized SARS-CoV-2 peptide antigens and assess the presence and magnitude of DTH reactions.
- Trial name
- COVID-19 DTH (NCT05216510)
- Testing
- TNX-2110, TNX-2120, TNX-2130
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Tonix Pharmaceuticals, Inc.
Allergy
Understanding Allergies and Sensitizations in Healthy and Allergic Individuals
The purpose of this study is to strengthen our ability to accurately diagnose allergies and understand cellular, humoral, genetic components and physiological changes in allergic disease
- Trial name
- NCT04828603
- Where
- United States
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Stanford University