Clinical trials: HEALTHY VOLUNTEERS
COVID-19; and High Infection Risk of SARS-CoV-2
Tolerability,Safety,Pharmacokinetic Profile and Immunogenicity of a Recombinant Humanized Anti-SARS-CoV-2 Monoclonal Antibody (JS016) for Injection in Chinese Health Subjects
This is a randomized, double-blind, placebo-controlled, phase I clinical study to evaluate the tolerability, safety, pharmacokinetic profile and immunogenicity of JS016 (anti-SARS-CoV-2 monoclonal antibody) injection in Chinese…
- Trial name
- NCT04441918
- Testing
- JS016 (anti-SARS-CoV-2 monoclonal antibody)
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Shanghai Junshi Bioscience Co., Ltd.
Altitude Hypoxia
Effect of Acetazolamide on Right Heart Function During Exercise in Lowlanders Older Than 40 Years at Altitude
Randomized, placebo controlled trial evaluating efficacy of acetazolamide on right heart function during exercise in lowlanders older than 40 years travelling from 760 m to 3'100 m.
- Trial name
- NCT03537924
- Testing
- ACETAZOLAMIDE oral capsule
- Where
- Kyrgyzstan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Healthy
Fed Study of Controlled-Release Oxycodone Hydrochloride 40 mg Tablets and OxyContin® 40 mg Tablets
The objective of this open-label, randomized, two-period, crossover study was to evaluate the oral bioavailability of the Mallinckrodt controlled-release test tablet formulation of oxycodone 40 mg compared to an equivalent oral…
- Trial name
- NCT00853268
- Testing
- Controlled-Release Oxycodone Hydrochloride 40 mg, OxyContin® 40 mg tablet
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Mallinckrodt
Chronic Obstructive Pulmonary Disease (COPD)
Validation of Structured Light Plethysmography - Health and Disease
Validation of Structured Light Plethysmography (SLP) in patients with conditions such as Chronic Obstructive Pulmonary Disease (COPD) that effect breathing and in healthy participants.
- Trial name
- SLP-RespDis (NCT02626468)
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Pneumacare Ltd
Healthy
Phase I Study to Investigate Safety, Tolerability, and Pharmacokinetics of VVZ-149 Injection
VVZ-149 is a novel analgesic drug candidate that shows a potential analgesic activity inhibiting GlyT2 and 5HT2A simultaneously.
- Trial name
- P1_VVZ149IV (NCT01905410)
- Testing
- VVZ-149 Injection
- Where
- South Korea
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Vivozon, Inc.
Healthy Volunteers
A Study to Detect Radioactivity of [14C]-OPC-167832 in Urine and Feces in Healthy Men
The purpose of this study is to determine the relative amounts of radioactivity excreted in urine and feces following a single oral dose of [14C]-OPC-167832 in healthy male participants.
- Trial name
- NCT07314320
- Testing
- [14C]-OPC-167832
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Satiety Response
The Effects of Whole Versus Processed Orange Consumption on Satiety
This is a human dietary intervention study that is randomized and crossover in design with 4 treatment arms consisting of control, orange juice,whole orange, and processed whole orange to investigate the satiety effects of the…
- Trial name
- NCT02288624
- Testing
- Processed orange juice
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Reading
In Development for Cystic Fibrosis
Study of VX-770 in Subjects With Moderate Hepatic Impairment and in Matched Healthy Subjects
The purpose of this study is to investigate the pharmacokinetics and safety of a single dose of VX-770 in subjects with moderate hepatic impairment.
- Trial name
- NCT01208285
- Testing
- VX-770
- Where
- 3 sites in Czechia, Slovakia
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Vertex Pharmaceuticals Incorporated
Attention Deficit Hyperactivity Disorder
A Bioequivalence (BE) Study in Healthy Subjects
To demonstrate the bioequivalence of 12.5 milliliters (mL) of atomoxetine oral solution (4 milligrams per milliliter [mg/mL]) compared with 2 capsules of atomoxetine (25 mg per capsule) in healthy adult male Japanese subjects.
- Trial name
- NCT01177943
- Testing
- Atomoxetine
- Where
- Japan
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Erectile Dysfunction
A Study of Semen Characteristics After 9 Months of Daily Tadalafil 20 mg
This is a multicenter, randomized, double-blind, placebo-controlled, fixed dose, parallel design study to evaluate effects on semen characteristics after 40 weeks of daily dosing with 20 mg tadalafil.
- Trial name
- NCT00382135
- Testing
- tadalafil
- Where
- United States
- Volunteers
- 282 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Postoperative Pain
Method Study: Bilateral TAP Block With 24 Hours Infusion
The purpose of this method study in healthy volunteers is to determine the extent of sensory block following Transversus Abdominis Plane (TAP) block with 24 hours infusion of ropivacaine versus infusion of saline.
- Trial name
- NCT01577940
- Testing
- Infusion of ropivacaine, Infusion of saline
- Where
- 2 sites in Denmark
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Glostrup University Hospital, Copenhagen
Healthy Volunteers
A Study To Evaluate the Safety, Tolerability, And Pharmacokinetics Of PF-06266047 In Healthy Adult Subjects
The purpose of this study is to evaluate the safety, tolerability, and pharmacokinetics of PF-06266047 after first-time administration to healthy adult subjects.
- Trial name
- NCT02539550
- Testing
- PF-06266047
- Where
- Belgium
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Pfizer
Healthy
Next-Day Residual Effects of Gabapentin, Diphenhydramine and Triazolam on Simulated Driving Performance in Normal Volunteers
This study will examine the next-day residual effects of a nighttime dose of gabapentin 250 mg, diphenhydramine citrate 76 mg and triazolam 0.5 mg compared to placebo and each other on simulated driving performance in normal…
- Trial name
- NCT01888497
- Testing
- Gabapentin, Diphenhydramine citrate, Triazolam
- Where
- 4 sites in United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Healthy Volunteers and Glaucoma Patients
Safety and Tolerability of MRZ-99030 Eye Drops in Healthy Volunteers and Glaucoma Patients
To assess the safety and tolerability of repeat dose topical administration of MRZ-99030 Ophthalmic Solution with ascending doses in healthy subjects (stage 1) and glaucoma subjects (stage 2).
- Trial name
- NCT01714960
- Testing
- MRZ-99030 eye drops 5mg/mL, MRZ-99030 eye drops 20mg/mL
- Where
- Germany
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Merz Pharmaceuticals GmbH
Healthy Volunteers
Absorption, Distribution, Metabolism and Excretion (ADME) Study With Single Oral Administration of [14C] NKTR-118
Study to Assess the Absorption, Metabolism and Excretion of [14C] NKTR-118 after a Single-Dose Oral Administration.
- Trial name
- NCT01348724
- Testing
- [14C] NKTR-118
- Where
- United Kingdom
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
COVID-19, Infection Viral
A Phase 1/2 Study to Determine Safety and Immunogenicity of Two COVID 19 Vaccines VB10.2129 (RBD Candidate) and VB10.2210 (T Cell Candidate) Previously Vaccinated in Healthy Adult Volunteers
An open label, dose escalation, and dose expansion study to evaluate the safety, reactogenicity and immunogenicity of two SARS-CoV-2 DNA plasmid vaccine candidates, VB10.2129 (C1) and VB10.2210 (C2).
- Conditions
- COVID-19, Infection Viral, Infections
- Trial name
- NCT05069623
- Testing
- VB10.2129, VB10.2210
- Where
- 2 sites in Norway
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Nykode Therapeutics ASA
Healthy
A Study in Healthy Men That Tests if Taking BI 1265162 by Mouth, Intravenously, or Inhaled Influences the Amount of BI 1265162 in the Blood
The main objective of this trial is to investigate the absolute bioavailability of BI 1265162 following administration of oral solution and inhaled (with and without charcoal) via Respimat.
- Trial name
- NCT03907280
- Testing
- BI 1265162 (T1), BI 1265162 (T2), BI 1265162 (R)
- Where
- Germany
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Healthy
A Clinical Study of BG136 Injection in Healthy Chinese Volunteers
This is a first-in-human, randomized, double-blind, placebo-controlled trial in healthy subjects. The trial consisted of two parts: part 1: single ascending dose (SAD) study and part 2: multiple ascending dose (MAD) study.
- Trial name
- NCT05984368
- Testing
- BG136
- Where
- China
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- The Affiliated Hospital of Qingdao University
Obesity
Role of Dopamine Transporter in Glucose Control
Healthy subjects will be enrolled in this study. Each subject will be scanned twice with F18-FP-CIT PET which is commercially available. F18-FP-CIT reflects dopamine transporter availability of striatum.
- Trial name
- NCT03466697
- Testing
- Glucose injection/Normal saline injection
- Where
- South Korea
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Pusan National University Hospital
Healthy
Dinner Time 2: Effect of Delayed Eating or Sleeping on Metabolism
This study examines the acute impact of eating an "early" versus "late" dinner. "Early" and "late" will be customized to individuals based on the individuals' own circadian rhythms.
- Trial name
- DT2 (NCT04671797)
- Testing
- Early dinner, Late Dinner, Late Dinner + Late Sleep
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
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