Clinical trials: HEALTHY VOLUNTEERS
Healthy Volunteers
Bioequivalence Study of Rotigotine Transdermal Patch With Two Different Formulations in Healthy Japanese Subjects
To investigate and compare the drug amount delivered to the body after each single administration of Rotigotine patch with 2 different formulations in healthy Japanese subjects.
- Trial name
- NCT01565018
- Testing
- Rotigotine PR 2.1.4, Rotigotine PR 2.2.1
- Where
- Germany
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- UCB Pharma
Healthy
Safety of Larazotide Acetate in Healthy Volunteers
To demonstrate the safety, tolerance and pharmacokinetics of multiple, oral doses of larazotide acetate.
- Trial name
- NCT00386490
- Testing
- larazotide acetate
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- 9 Meters Biopharma, Inc.
Effect of Food
A Food Effect Study of TS-142 in Healthy Subjects
This is a study to assess the food effect of TS-142 preliminary market formulation tablet in healthy subjects
- Trial name
- NCT05707897
- Testing
- TS-142 10 mg
- Where
- Japan
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Taisho Pharmaceutical Co., Ltd.
Healthy
Study in Healthy Subjects to Determine the Effect of Relacorilant on Exposure to Probe Substrates for Cytochrome P450s
This is an open-label, single-sequence, 3-period crossover study conducted in healthy subjects. Eligible subjects will participate in a single treatment period, in which they will receive the following treatments: Day 1, single…
- Trial name
- NCT03457597
- Testing
- Midazolam hydrochloride, Metoprolol tartrate, Pioglitazone hydrochloride
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Corcept Therapeutics
Healthy
Investigation of the Metabolism and Pharmacokinetics of 10 mg [14C] BI 1356 Administered Orally Compared to 5 mg [14C] BI 1356 Administered Intravenously in Healthy Male Volunteers
To determine the basic pharmacokinetics of BI 1356 BS, its metabolite CD 1750 XX and radioactivity including excretion mass balance, excretion pathways and metabolism following the intravenous and oral administration of [14C] BI…
- Trial name
- NCT02183610
- Testing
- [14C] BI 1356 as oral (p.o.) solution, [14C] BI 1356 solution for i.v. infusion
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Healthy
Evaluation of PK of AC-1204 Mixed in Water, AC-1202 Mixed in Water, and AC-1202 Mixed in Ensure® on Ketone Body Production
To compare serum ketone body (i.e., total ketones, β hydroxybutyrate, and estimate of acetoacetate) levels after single dose administration of AC-1204 mixed in water, AC-1202 mixed in water and AC-1202 mixed in Ensure®.
- Trial name
- NCT02959710
- Testing
- AC-1204 mixed in water, AC-1202 mixed in water, AC-1202 mixed in Ensure®
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Cerecin
Healthy
Safety and Pharmacokinetic Comparison of Exforge® and G-0081 in Healthy Male Volunteers
This study investigates safety and pharmacokinetic comparison of G-0081, a combination tablet of amlodipine and valsartan (test formulation), and Exforge®, a combination tablet of amlodipine and valsartan (reference formulation)…
- Trial name
- NCT01823913
- Testing
- Test formulation, Reference formulation
- Where
- South Korea
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Severance Hospital
Healthy
A Study of Single and Multiple Ascending Doses of TC-5214 in Japanese Healthy Elderly Male and Female Volunteers
The purpose of this study is to assess safety, tolerability and pharmacokinetics of TC-5214 in elderly healthy Japanese volunteers.
- Trial name
- NCT01392820
- Testing
- TC-5214
- Where
- Japan
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Healthy
Act Healthy! A Controlled Trial of Worksite Health Promotion
The purpose of this project is to determine if a worksite wellness intervention using a theoretically-based self-management model increases confidence for carrying out healthy behaviors and improves health practices of…
- Trial name
- NCT00924924
- Testing
- Act Healthy!, Delayed treatment control
- Where
- United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Fibrostenotic Crohn's Disease
A Study of PALI-2108 in Healthy Volunteers, Patients With Ulcerative Colitis, and Patients With Fibrostenosing Crohn's Disease
This is a Phase 1b, open-label, exploratory study designed to evaluate the pharmacodynamic effects of PALI-2108, a phosphodiesterase-4 (PDE4) inhibitor, in patients with fibrostenotic Crohn's disease (FSCD).
- Trial name
- NCT07428096
- Testing
- PALI-2108
- Where
- Canada
- Volunteers
- 6 people
- Sponsor
- Palisade Bio
Mountain Sickness
Safety Evaluation of Aminophylline and Methazolamide
This safety study is the first in a series of studies testing the application of the combination of aminophylline and methazolamide.
- Trial name
- NCT01587027
- Testing
- Aminophylline, Methazolamide, Aminophylline and Methazolamide
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Poudre Valley Health System
Pharmacokinetics and Pharmacodynamics in Healthy Volunteers
Pharmacokinetics, Pharmacodynamics, and Safety of NANOKINE Compared With Eprex 4000 U in Healthy Volunteers
This clinical trial aims to compare the pharmacokinetic (PK), pharmacodynamic (PD) parameters, and safety between Nanokine of Nanogen Pharmaceutical Joint Stock Company and Eprex® of Janssen Cilag Ltd on healthy male volunteers.
- Trial name
- NCT06919861
- Testing
- Erythropoietin alfa
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Nanogen Pharmaceutical Biotechnology Joint Stock Company
Healthy
Effects of Dimethyltryptamine in Healthy Subjects
N,N-dimethyltryptamine (DMT) is a naturally-occurring psychedelic substance widely used in recreational and spiritual settings. DMT can be used as a tool to induce an altered state of consciousness of interest in psychological…
- Trial name
- DMT (NCT04353024)
- Testing
- Dimethyltryptamine (DMT), Saline
- Where
- Switzerland
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Ehlers-Danlos Syndrome, Healthy Subjects
ABVN Phase 2 - EDS Wearable Device
The vagus nerve is a nerve that controls many bodily functions, including stomach function. Investigators hope that electrically stimulating the nerve around the external ear will also stimulate the internal vagus nerve.
- Trial name
- ABVN2 (NCT07856459)
- Testing
- ML1101 Stimulus Isolator, Cardiowatch Bracelet
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Indiana University
Healthy
Pharmacologic Effects of Darifenacin and Tolterodine on Cardiovascular Parameters in Healthy Subjects
This study will evaluate the pharmacologic effects of exposure to darifenacin and tolterodine on cardiovascular parameters in healthy subjects 50 years of age and older
- Trial name
- NCT00703703
- Testing
- Darifenacin, Tolterodine
- Where
- 21 sites in United States
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- Novartis
Drug Drug Interaction (DDI)
Study on the Drug Interaction Between Buagafuran and Voriconazole
This study is a non-randomized, open label trial aimed at evaluating the drug interaction between Buagafuran capsules and voriconazole tablets in Chinese adult healthy participants.The research period is 7 days in total.
- Trial name
- NCT07457203
- Testing
- Buagafuran, Voriconazole
- Where
- China
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Beijing Union Pharmaceutical Factory Ltd
Antibiotic Toxicity
A Pharmacokinetic Study of Polymyxin B in Healthy Subjects and Subjects With Renal Insufficiency
This is an open-label, single-center, single-dose, parallel-group study to evaluate the PK and safety profiles of polymyxin B administered by IV infusion in healthy subjects and subjects with renal insufficiency.
- Trial name
- NCT05359627
- Testing
- Polymyxin B
- Where
- Taiwan
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- TTY Biopharm
Cognition
A Healthy Volunteer Study to Evaluate Reversibility of Induced Impairment of Cognition
The purpose of this study is to determine if cognitive impairment induced by scopolamine is reversed using donepezil and/or AZD1446 as compared to placebo, as assessed by electroencephalogram (EEG) measures.
- Trial name
- NCT01044342
- Testing
- AZD1446, donepezil
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Healthy
A Pharmacokinetic Study Comparing EG12014 and Herceptin (Trastuzumab) in Healthy Male Volunteers
The primary objective of this trial is to assess the pharmacokinetic similarity of EG12014 (Test IMP) compared to reference products sourced from the European Union (Reference IMP 1: Herceptin® 150 mg powder for concentrate for…
- Trial name
- NCT03180242
- Testing
- EG12014, EU-sourced Herceptin, US-sourced Herceptin
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- EirGenix, Inc.
Healthy Volunteers
Comparison of Explicit, Implicit and no Values Clarification Decision Aids for Men Considering Prostate Cancer Screening
The investigators aim at comparing the perceived clarity of personal values in men considering PSA screening using decision aids with no VCM versus an implicit VCM versus an explicit VCM.
- Trial name
- NCT03988673
- Testing
- Decision aid with implicit values clarification method (booklet or website), Decision aid with explicit values clarification method (booklet or website)
- Volunteers
- 276 people, healthy volunteers welcome
- Sponsor
- Universidade do Porto
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