Clinical trials: HEART ARREST
Out-Of-Hospital Cardiac Arrest
Biochemical Makers for Outcome After Pediatric out-of Hospital Cardiac Arrest
This single-center study will validate serum, imaging and clinical markers to determine outcome of pediatric patients early after Out-of-Hospital cardiac arrest (OHCA).
- Trial name
- BIMOPECA (NCT03873662)
- Testing
- Blood sample
- Where
- Czechia
- Volunteers
- 4 people
- Sponsor
- Brno University Hospital
Cardiac Arrest, Sudden Death, Cardiac
Use of Public Access Defibrillators by Untrained Bystanders
Survival from out-of-hospital cardiac arrest is time critical and diminishes rapidly without appropriate intervention. Bystander CPR at least doubles the chances of survival and the additional use of a public access defibrillator…
- Trial name
- NCT03230773
- Testing
- Defibrillator model
- Volunteers
- healthy volunteers welcome
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Out-of-hospital Cardiac Arrest
Application of Mechanical Cardiopulmonary Resuscitation Devices and Their Value in Out-of-hospital Cardiac Arrest: A Retrospective Analysis of the German Resuscitation Registry
The aim of this study was to analyse a large CPR database, the German Resuscitation Registry, to evaluate potential benefits of mechanical CPR devices over manual CPR in adult cardiac arrest victims.
- Trial name
- NCT02932124
- Testing
- mechanical chest compression device
- Volunteers
- 19,609 people
- Sponsor
- German Resuscitation Registry
Cardiac Arrest, Brain Injury
Duration of Hypothermia for Neuroprotection After Pediatric Cardiac Arrest
In this study, children who survive cardiac arrest will be evaluated whether 24 or 72 hours of whole body hypothermia (cooling) during recovery is better to help prevent brain injury and improve outcome.
- Trial name
- NCT00797680
- Testing
- 72 hours hypothermia, 24 hours hypothermia
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University of Pittsburgh
Cardiomyopathy (Ischemic or Non-Ischemic)
Data Analysis and Evaluation of the Incidence of Life-threatening Ventricular Arrhythmias in Patients with Newly Diagnosed Cardiomyopathies of NICM or MI/CAD Origin PROTECTED from SCD by a WCD
SCD-PROTECT is an epidemiological, observational, multicenter study to assess the incidence of sudden cardiac arrest/death (SCA/SCD) in patients with newly diagnosed non-ischemic cardiomyopathy or with myocardial…
- Trial name
- SCD-PROTECT (NCT06883383)
- Where
- Germany
- Volunteers
- 19,598 people
- Sponsor
- Hannover Medical School
Heart Failure
Trial to Determine Imaging Parameters of LMI1195 in Heart Failure Patients at Low and High Risk of Defibrillator Firing
The purpose of this clinical study is to determine the optimal imaging parameters and assess the safety of LMI1195 -101 in Heart Failure subjects at Low and High Risk of cardiac events.
- Trial name
- LMI1195-201 (NCT01085175)
- Testing
- LMI 1195
- Where
- United States
- Sponsor
- Lantheus Medical Imaging
Heart Arrest, Targeted Temperature Management
Multi-channel aEEG in Cardiac Arrest Patients With Targeted Temperature Management
This study aims to examine the prognostic value of 18 channel amplitude-integrated EEG (aEEG) in comatose cardiac arrest patients The study design is a prospective observational study.
- Trial name
- MAEGIC (NCT03545828)
- Testing
- Multi-channel aEEG monitoring
- Where
- South Korea
- Volunteers
- 78 people
- Sponsor
- Sang Hoon Oh
Out-Of-Hospital Cardiac Arrest, Post Cardiac Arrest Syndrome
Pre-hospital Post ROSC Care: Are we Achieving Our Targets?
Rational: Out of hospital cardiac arrest is a devastating event with a high mortality. Survival rates have increased over the last years, with the availability of AED's and public BLS.
- Conditions
- Out-Of-Hospital Cardiac Arrest, Post Cardiac Arrest Syndrome, Emergency Medical Services
- Trial name
- POP-ROC (NCT04339257)
- Volunteers
- 175 people
- Sponsor
- University Medical Center Groningen
Cardiac Arrest
Esophageal Temperature Management After Cardiac Arrest
To control patient's body temperature remains of major importance especially after cardiac arrest (CA). Therapeutic hypothermia (TH) targeted to 32-34°C is now recommended for most unconscious CA patients.
- Trial name
- THE-COOL (NCT02327871)
- Testing
- Esophageal cooling device (and usual standard procedure)
- Where
- France
- Volunteers
- 15 people
- Sponsor
- IST cardiology
Cardiac Arrest, Post-Anoxic Coma
Evaluation of the "Pupillary Pain Index" in Neurological Prognosis After Cardiac Arrest
Two-thirds of patients admitted to the Intensive Care Unit after a cardiac arrest die in the context of treatment withdrawal after a multimodal evaluation that determines an unfavorable neurological outcome.
- Conditions
- Cardiac Arrest, Post-Anoxic Coma, Anoxic Brain Injury
- Trial name
- CAPPI (NCT04336930)
- Testing
- Pupillary pain index (PPI)
- Volunteers
- 60 people
- Sponsor
- Central Hospital, Nancy, France
Cardiac Arrest With Successful Resuscitation
Proteomic Profiling to Reveal Novel Prognostic Markers for Neurological Outcome Following Resuscitation
Background: Cardiac arrest is a life-threatening event. Intensivists are challenged with an increasing number of patients with uncertain neurological outcome following cardiopulmonary resuscitation (CPR).
- Trial name
- NCT01960699
- Where
- Austria
- Volunteers
- 96 people
- Sponsor
- Medical University of Vienna
Alpine Accident, Frostbite
10-years Nationwide Alpine Accidents in Austria
This observational study intends to analyze the characteristic of specific accidents happened in Austrian's mountainous regions.
- Conditions
- Alpine Accident, Frostbite, Cardiopulmonary Arrest With Successful Resuscitation, Lightning Injuries
- Trial name
- NCT03405467
- Testing
- general and specific data
- Where
- Austria
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Medical University Innsbruck
Asystole, Sinus Bradycardia
uPHI: Wireless Body Area Network Core Technology
The application scenario is shown in the figure below: the user utilizes an ECG-based wireless sensor (WiBoC Chipset), and transmit those signals to a mobile-phone device that has an embedded expert system integrated.
- Conditions
- Asystole, Sinus Bradycardia, Sinus Tachycardia, Sinus Arrhythmia
- Trial name
- uPHI (NCT01200667)
- Where
- Taiwan
- Volunteers
- 380 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University WanFang Hospital
Heart Arrest, Cardiac Arrest, Out-Of-Hospital
Synergy of Elevation of the Head and Thorax and REBOA During Out-of-Hospital Cardiac Arrest
Long-term neurological outcome after successful resuscitation of cardiac arrest remains poor, mainly due to cerebral hypoperfusion and severe hypoxic-ischemic brain injuries.
- Conditions
- Heart Arrest, Cardiac Arrest, Out-Of-Hospital, Cardiopulmonary Arrest, Cardiopulmonary Resuscitation
- Trial name
- GRAVITY2 (NCT06537492)
- Testing
- REBOA, Head-Up Cardiopulmonary Resuscitation (AHUP-CPR), Mechanical Chest Compression Device with Active Chest Decompression
- Where
- France
- Volunteers
- 35 people
- Sponsor
- University Hospital, Grenoble
Substance Use Disorder (SUD), Opioid Use Disorders
Recovery Management Checkup Scalability and Sustainability Hybrid Experiment
Individuals who are involved in the criminal-legal system (CLS) are at high risk of drug-related overdose; they also face significant barriers to engaging in substance use disorder (SUD) treatment and recovery support services.
- Conditions
- Substance Use Disorder (SUD), Opioid Use Disorders, Stimulant Overdose, Overdose Risk
- Trial name
- RMC-SS (NCT07873944)
- Testing
- Recovery Management Checkups (RMC) delivered by community-based agencies (RMC adopters), Recovery Management Checkups (RMC) delivered by staff under the research team (RMC by research staff)
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- Chestnut Health Systems
Cardiac Arrest
Evaluation of Perfusion Index as a Prognostication Tool for High Quality Cardiopulmonary Resuscitation
In order to monitor and improve cardiopulmonary resuscitation(CPR) quality, there is need for tools that provide real time feedback to responders.
- Trial name
- NCT06067464
- Where
- Egypt
- Volunteers
- 47 people
- Sponsor
- National Hepatology & Tropical Medicine Research Institute
Cardiac Arrest, Sudden Cardiac Death
Hemodynamic Efficiency of an Hemodialysis Treatment With High Permeability in Post-resuscitation Shock
Rationale: Despite spontaneous cardiac activity recovery, a shock occurs in more than half of patients after resuscitation for cardiac arrest.
- Conditions
- Cardiac Arrest, Sudden Cardiac Death, Shock
- Trial name
- Hyperdia (NCT00780299)
- Testing
- hemodialysis with high permeability (HDHP), CVVH
- Where
- France
- Volunteers
- 38 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
In-hospital Cardiac Arrest, Cardiopulmonary Resuscitation
Situation Awareness Incorporating Multidisciplinary Teams Reduce Arrests In the Pediatric ICU
The goal of this pragmatic prospective Type 1 Hybrid Implementation-Effectiveness Trial study is to learn if The Situation Awareness Incorporating Multidisciplinary Teams Reduce Arrests In (SAMURAI) the PICU Bundle can reduce…
- Trial name
- SAMURAI PICU (NCT06553534)
- Testing
- SAMURAI PICU Bundle
- Where
- 5 sites in United States
- Volunteers
- 5 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Hypoxic-Ischemic Encephalopathy, Cardiac Arrest
Propofol-induced EEG Changes in Hypoxic Brain Injury
PROPEA3 is a prospective observational study investigating the recovery of propofol-induced EEG slow-wave activity and its association with neurological outcome after cardiac arrest.
- Trial name
- PROPEA3 (NCT03485781)
- Where
- 2 sites in Finland
- Volunteers
- 102 people
- Sponsor
- University of Oulu
Cardiovascular Diseases, Coronary Disease
Natural History of Coronary Heart Disease
To examine the natural history of mortality due to coronary heart disease in post-myocardial infarction patients from the Beta-Blocker Heart Attack Trial (BHAT) and the Aspirin Myocardial Infarction Study (AMIS).
- Conditions
- Cardiovascular Diseases, Coronary Disease, Myocardial Infarction, Heart Diseases
- Trial name
- NCT00005265
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)