Clinical trials: HEART RATE, active
Healty Volunteers
Acute Effects of Thoracolumbar Fascia Myofascial Release on Cortical Activity
This study will examine the immediate (acute) effects of a single myofascial release technique applied to the thoracolumbar fascia on brain activity in healthy young adults aged 18-25.
- Trial name
- MFR-EEG (NCT07728617)
- Testing
- Thoracolumbar Fascia Myofascial Release (Pilat MIF Crossed-Hands Technique)
- Where
- Turkey (Türkiye)
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Hitit University
Community Based Study, Cardiovascular Disease
Heart Rate, Baroreflex Sensitivity and Cardiovascular Morbidity and Mortality in the Population
The aim of the present Paris Prospective Study III (PPS3) is (1) to assess the determinants of the regulation of heart rate and blood pressure variations and carotid properties (under different physiologic stimulations) and (2)…
- Conditions
- Community Based Study, Cardiovascular Disease, Sudden Death, Blood Pressure
- Trial name
- PPSIII (NCT00741728)
- Testing
- Spider flash ECG, high-precision carotid echo-tracking, step test
- Where
- France
- Volunteers
- 10,157 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Chronic Fatigue Syndrome (CFS)
Controlled Trial of Hydrogen Water as a Treatment for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
This is a 16-week controlled treatment trial of an over-the -counter supplement, hydrogen water, for individuals with ME/CFS patients. An active treatment condition will be compared to a placebo-control condition.
- Trial name
- ME/CFS (NCT07753122)
- Testing
- Molecular hydrogen produced by a metallic magnesium tablet, consumed 3x a day dissolved in water. Treatment duration is 16 weeks.
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Fred Friedberg
Cranial Neurosurgery
Heart Rate Variability and Processed EEG Features as Predictors of Postoperative Outcomes After Cranial Neurosurgery
Patients undergoing cranial neurosurgery face a high-risk postoperative period, particularly during emergence from anesthesia and early recovery in the post-anesthesia care unit (PACU).
- Trial name
- HERO-PACU (NCT07443072)
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Stress, Acute Stress
Neurophysiological and Autonomic Responses to Acute Physical and Emotional Stress: An EEG Study
This study aims to investigate neurophysiological, autonomic, and subjective responses to different acute physical and emotional stress-inducing conditions using a within-subject repeated-measures design.
- Trial name
- NCT07781670
- Testing
- Cold Pressor Test, Negative Autobiographical Memory Recall, Affective Picture-Viewing Task
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Pavia
Atrial Fibrillation (AF), Cardiomyopathy, Secondary
Patient Selection and Long-Term Outcomes of Pace & Ablate Strategy in Atrial Fibrillation
Atrioventricular node ablation with permanent pacing (the "pace-and-ablate" strategy) controls ventricular rate in atrial fibrillation that has not responded to drug therapy or catheter ablation.
- Conditions
- Atrial Fibrillation (AF), Cardiomyopathy, Secondary, Pacing-Induced Cardiomyopathy, Heart Failure
- Trial name
- REPACE (NCT07852221)
- Where
- 5 sites in Poland, Switzerland and 1 more
- Volunteers
- 2,600 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Sedentary Behavior, Frailty
Effects of Intermittent Hypoxia-Hyperoxia in Older Adults
The supply of oxygen is essential for energy production, recovery from efforts, and human life. Intermittent Hypoxia-Hyperoxia Exposure (IHHE) is a novel technique in which the subject is exposed to a respiratory environment with…
- Conditions
- Sedentary Behavior, Frailty, Older Adults
- Trial name
- NCT06686316
- Testing
- Device: Hypoxic Gas Mixture
- Volunteers
- 16 people
- Sponsor
- Sierra Varona SL
Well-Being, Psychological, Work Injury
Eastern Principles Acceptance and Commitment Therapy For Injury Prevention Among Nurses and Nursing Aides
This clinical trial will evaluate the effectivness of an Eastern Principles Acceptance and Commitment Therapy intervention (EPACT) relative to an estabished traditional Western-based Acceptance and Commitment Therapy intervention…
- Conditions
- Well-Being, Psychological, Work Injury, Musculoskeletal Pain, High Frequency Heart Rate Variability
- Trial name
- NCT06813495
- Testing
- Eastern Principles Acceptance and Commitment Therapy for Nurses and Nursing Aids (EPACT NNA), Acceptance and Commitment Therapy for Nurses and Nursing Aids (ACT NNA)
- Where
- United States
- Volunteers
- 255 people
- Sponsor
- Bowling Green State University
Cardiovascular Abnormalities, Arterial Blood Pressure
Multicenter Study on Cardiovascular and Metabolic Complications in Patients With Biochemically Silent Pheochromocytomas and Paragangliomas
The aim of the study is to characterise the cardiovascular and metabolic complications pre- and post-surgery of patients with biochemically negative PPGL and to compare them with normal individuals and patients with secreting…
- Conditions
- Cardiovascular Abnormalities, Arterial Blood Pressure, Heart Rate, Congestive Heart Failure Chronic
- Trial name
- NCT07316075
- Where
- Greece
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Laikο General Hospital, Athens
Stress, Stress and Burnout
Deep Relaxation Using Virtual Reality Intervention Before Surgery for Healthcare Professionals Working in the Operating Room
The goal of this clinical trials is to primary learn if deep relaxation using Virtual Reality (VR) compared to a low stimulus environment can lower perceived and measured stress in healthcare professionals working in the…
- Conditions
- Stress, Stress and Burnout, Stress Biomarkers
- Trial name
- DEEP_VR (NCT07470697)
- Testing
- Virtual Reality intervention, Low Stimulus Environment
- Where
- 2 sites in Denmark, Germany
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Depression, Treatment Resistant Depression
Neurocardiac Predictors of Treatment Response to RTMS in Depression
Heartbeat is controlled by the brain and is regular but flexible to change in response to environmental and internal stimuli. This feature is known as heart rate variability (HRV).
- Trial name
- NCP (NCT05139862)
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Where
- Canada
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Fibromyalgia Syndrome
Auricular Acupuncture for Autonomic Balance and Pain in Fibromyalgia
This longitudinal study evaluates the effects of semi-permanent auricular acupuncture on the Autonomic Nervous System (ANS) activity and pressure pain threshold in adult female patients (aged 35-64) diagnosed with Fibromyalgia…
- Trial name
- NCT07641374
- Testing
- The needles will be applied to specific auricular points: Point Zero, Shen Men, Thalamus, and Master Cerebral Point.
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Italian Association for the Research and the Scientific Update
Sepsis, Ivabradine
Effect of Heart Rate Control With Ivabradine on Hemodynamic in Patients With Sepsis
Sepsis, a life-threatening syndrome, is often accompanied by tachycardia in spite of adequate volume resuscitation to correct hypovolemia and vasopressor medication to correct hypotension.
- Conditions
- Sepsis, Ivabradine, Hemodynamics, Heart Rate Control
- Trial name
- NCT05882708
- Testing
- Ivabradine
- Where
- 3 sites in China
- Volunteers
- 172 people
- Sponsor
- Second Affiliated Hospital of Guangzhou Medical University
Ventilator Weaning, Airway Extubation
Can a Pain Monitor Predict When Postoperative Intensive Care Unit Patients Are Ready to Breathe on Their Own? A Pilot Study
The goal of this observational study is to learn if a chest monitor that tracks heart rhythm can help predict whether adults on a breathing machine after surgery will be able to breathe on their own once the breathing tube is…
- Conditions
- Ventilator Weaning, Airway Extubation, Respiration, Artificial
- Trial name
- NCT07771101
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Seoul National University Hospital
Fetal Distress With Antenatal Problem, Fetal Growth Retardation
Validation of Sensors for Long-term Non-Invasive Fetal Monitoring
A multidisciplinary team of a doctor and engineers have developed a new sensor that will be able to detect mothers' and babies' heartbeat and babies movements in late pregnancy.
- Trial name
- NCT06952777
- Testing
- Non-adhesive capacitively-coupled sensors
- Where
- United Kingdom
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Diabetic Nephropathies, Kidney Failure, Chronic
Sotagliflozin to Slow Kidney Function Decline in Persons With Type 1 Diabetes and Diabetic Kidney Disease
Powerful new drugs that can prevent or delay end stage kidney disease (ESKD) - so called sodium-glucose cotransporter-2 inhibitors (SGLT2i) - are now available for patients with type 2 diabetes.
- Conditions
- Diabetic Nephropathies, Kidney Failure, Chronic, Diabetes Mellitus Type 1, Heart Failure
- Trial name
- SUGARNSALT (NCT06217302)
- Testing
- Sotagliflozin
- Where
- 19 sites in United States, Canada
- Volunteers
- 150 people
- Sponsor
- Alessandro Doria
Postmenopausal, Menopausal Symptoms
Structured Combined Exercise Program in Postmenopausal Women: Effects on Heart Rate Variability and Menopausal Symptoms
The goal of this clinical trial is to learn whether a structured combined exercise program can improve heart health, menopausal symptoms, sleep quality, and quality of life in postmenopausal women aged 45 to 65 years.
- Conditions
- Postmenopausal, Menopausal Symptoms, Autonomic Nervous System Diseases, Sleep Wake Disorders
- Trial name
- NCT07615790
- Testing
- Structured Combined Exercise Program
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Fenerbahce University
Chronic Migraine, Headache
Comprehensive Approach to Lifestyle Modification in Chronic Migraine
Migraine is a highly prevalent neurological disorder and one of the leading causes of disability worldwide, substantially affecting quality of life and individuals during their most productive years.
- Trial name
- CALM-Migraine (NCT07802860)
- Testing
- Comprehensive Lifestyle Intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Hacettepe University
Defibrillators, Implantable, Electrodes, Implanted
Slew Rate As a Predictor for Optimal Lead Fixation
The goal of this observational study is to identify the most reliable electrical parameter measured at the time of implantation that can predict optimal lead fixation and long-term lead performance in patients undergoing…
- Conditions
- Defibrillators, Implantable, Electrodes, Implanted, Pacemaker, Artificial, Predictive Value of Tests
- Trial name
- SLEW REGISTRY (NCT06842940)
- Where
- Italy
- Volunteers
- 516 people
- Sponsor
- Paolo Pastori, MD
Total Thyroidectomy, Hyperthyroidism
Evaluation of Levothyroxine Replacement Therapy After Total Thyroidectomy Using a Smart Wristband
The goal of this observational study is to determine whether nighttime heart rate and heart rhythm data collected by a smart wristband can identify under- or over-replacement with levothyroxine before the routine 1-month thyroid…
- Conditions
- Total Thyroidectomy, Hyperthyroidism, Hypothyroidism
- Trial name
- SMART-THY (NCT07733375)
- Testing
- Xiomi Smart Band 10
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Yeditepe University Hospital