Clinical trials: HIV/AIDS, Medication Adherence
HIV Prevention, Pre-exposure Prophylaxis (PrEP)
A Study Evaluating An Integrated Pharmacy Digital Diary and Delivery Strategy to Increase PrEP Use Among MSM and TGW
The PrEP 3D randomized controlled trial (RCT) will study the effectiveness of the PrEP-3D app compared to standard of care for starting pre-exposure prophylaxis (PrEP), continuing PrEP, and adherence to PrEP.
- Conditions
- HIV Prevention, Pre-exposure Prophylaxis (PrEP), Risk Reduction, Adherence, Medication
- Trial name
- PrEP-3D RCT (NCT05474313)
- Testing
- PrEP-3D package, Standard of Care
- Where
- 2 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Public Health Foundation Enterprises, Inc.
HIV/AIDS, Adherence, Medication
Improving Engagement in HIV Care for High-risk Women
Transgender women (assigned 'male' at birth but who do not identify as male) are disproportionately impacted by HIV and have culturally unique barriers and facilitators to engagement in HIV care.
- Trial name
- NCT03081559
- Testing
- Healthy Divas
- Where
- 2 sites in United States
- Volunteers
- 278 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Acceptability of Health Care, Adherence, Medication
Project Engage: Oral PrEP Acceptability
This study is a two-arm open label acceptability study that will examine acceptability of, and adherence to, once daily dosing regimen of F/TDF (Truvada) and an investigational once daily dosing regimen of F/TAF (Descovy) under…
- Trial name
- NCT05458765
- Testing
- emtricitabine/tenofovir alafenamide, Emtricitabine / Tenofovir Disoproxil Oral Tablet
- Where
- 3 sites in South Africa, Zimbabwe
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- Eastern Virginia Medical School
HIV/AIDS
Video-Intervention to Inspire Treatment Adherence for Life for Adolescents
This a two-arm randomized controlled trial whose objective is to explore the impact of VITAL Start for Adolescents (VS4A), a video-based antiretroviral treatment (ART) adherence intervention, on a range of implementation and…
- Trial name
- VS4A (NCT07064785)
- Testing
- Video-based ART adherence counseling, Standard of Care (SOC)
- Where
- 32 sites in Malawi
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
HIV Infections, Contraception
Kuwa Free! - Live Free!
The study investigators are conducting foundational pharmacokinetic (PK) and qualitative studies, among 15-24 years old (inclusive) adolescent girls and young women living with HIV (AGYWLHIV) already on oral antiretroviral…
- Conditions
- HIV Infections, Contraception, Drug-drug Interaction
- Trial name
- NCT05044962
- Testing
- Cabotegravir/ Rilpivirine, Etonogestrel (ETG) implant, Intramuscular depo-medroxyprogesterone acetate (IM DMPA)
- Where
- Kenya
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Medication Adherence, HIV
Development of a Urine-Based Point-of-Care Test for Adherence to Antiretroviral Drugs
This is a single-center, open label study to identify adherence levels of commonly prescribed FDA-approved antiretroviral agents by tracking the decline of drug concentrations in plasma, urine and saliva following abrupt drug…
- Trial name
- APTAMER (NCT04302896)
- Testing
- dolutegravir oral tablet 50mg, emtricitabine/tenofovir alafenamide oral tablet 200mg/25mg, tenofovir disoproxil fumarate oral tablet 300mg
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Rhonda Brand
Adherence, Medication, Risk Behavior
DOT Diary Optimization Pilot: A Pilot Study to Optimize the DOT Diary App to Measure PrEP Adherence
The researchers are working with a technology company, AiCure, to develop a smartphone app, DOT Diary, which combines two drug adherence strategies.
- Conditions
- Adherence, Medication, Risk Behavior, Pre-Exposure Prophylaxis, HIV Prevention
- Trial name
- NCT03387462
- Testing
- Emtricitabine / Tenofovir Disoproxil Oral Tablet, DOT Diary mobile app
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Public Health Foundation Enterprises, Inc.
HIV Infections
Connecting Youth and Young Adults to Optimize ART Adherence: YouTHrive Efficacy Trial
YouTHrive (YT) is a two-arm randomized control trial (RCT) to test the efficacy of an adapted version of the Thrive With Me (TWM) intervention for youth living with HIV (YLWH).
- Trial name
- NCT03149757
- Testing
- YouTHrive, Information-only Control
- Where
- 7 sites in United States
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
HIV
The Tailored-Motivational Interviewing Project
The purpose of the Tailored Motivational Interviewing Project (TMI) is to develop an implementation intervention to increase evidence-based patient-provider communication strategies using a Motivational Interviewing (MI)…
- Trial name
- TMI Project (NCT03181022)
- Testing
- Motivational Interviewing
- Where
- 2 sites in United States
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Wayne State University
HIV Infections, Adherence, Medication
Testing a Real-time Electronic Antiretroviral Adherence Monitoring Intervention
The investigators propose using an electronic adherence device that is basically a pill container that can alert when it is not opened at a scheduled time.
- Trial name
- A-TEAM (NCT06550804)
- Testing
- A-TEAM
- Where
- United States
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago