Clinical trials: HIV/AIDS Prevention
HIV Infections
Improving Health Outcomes in Young Cisgender Men and Transgender Women (mLab App)
The mLab App combines HIV prevention information with push notifications/reminders to complete HIV testing and an automated image processing feature to provide real-time feedback on home-based HIV test results.
- Trial name
- NCT03803683
- Testing
- mLab App, HIV Prevention Information, HIV Home Tests
- Where
- 2 sites in United States
- Volunteers
- 525 people, healthy volunteers welcome
- Sponsor
- Rebecca Schnall, RN, MPH, PhD
HIV, Violence, Gender-Based
Supporting Trans Affirmation, Relationships, and Sex, Phase 3
The purpose of this clinical trial is to evaluate and test a newly developed gender-affirming intervention that addresses the dual and interconnected risks of HIV and intimate partner victimization (IPV) among transgender women…
- Conditions
- HIV, Violence, Gender-Based, Violence, Domestic, Risk Reduction Behavior
- Trial name
- STARS (NCT06001307)
- Testing
- Program STARS (Supporting Trans Affirmation, relationships, and Sex), Relaxation and Stress Reduction
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Brown University
HIV Infection
Renal, Endocrine, and Bone Changes in Response to FTC/TDF in Uninfected Young Men Who Have Sex With Men (YMSM).
This is a prospective observational cohort sub-study of subjects enrolled in the Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) 110 (NCT01772823) or ATN 113 (NCT01769456), which is a prospective…
- Trial name
- NCT01769469
- Testing
- FTC/TDF (Truvada®)
- Where
- 12 sites in United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
HIV Infections
Antiviral Responses to NNRTI-Based vs. PI-Based ARV Therapy in HIV Infected Infants Who Have or Have Not Received Single Dose NVP for Prevention of Mother-to-Child Transmission of HIV
A single dose of nevirapine (SD NVP) given to an HIV infected pregnant woman followed by a single dose to her infant has been shown to be an effective way of reducing the risk of mother-to-child transmission (MTCT) of HIV.
- Trial name
- P1060 (NCT00307151)
- Testing
- Lamivudine, Lopinavir/ritonavir, Nevirapine
- Where
- 10 sites in India, Malawi and 5 more
- Volunteers
- 452 people
- Sponsor
- International Maternal Pediatric Adolescent AIDS Clinical Trials Group
Hiv
HIV-Related Stigma Intervention for Malaysian Clinicians
Key populations at risk of HIV (including men who have sex with men, people who inject drugs, transgender women, and female sex workers) are more likely to be infected with HIV but less likely than members of the general…
- Trial name
- NCT05597787
- Testing
- HIV Connect, Project ECHO for HIV Prevention, Project ECHO for HIV Prevention and Stigma Reduction
- Where
- Malaysia
- Volunteers
- 78 people
- Sponsor
- University of Delaware
Substance Abuse, HIV
Electronic SBI(RT) for MSM in Argentina
The main goal of this pilot randomized controlled trial (RCT) with 200 participants is to establish the processes and procedures for a subsequent large-scale efficacy trial of an electronic-Screening, Brief Intervention, Referral…
- Trial name
- NCT05542914
- Testing
- electronic screening and brief intervention., Phase 2: Assessment Only
- Where
- Argentina
- Volunteers
- 274 people, healthy volunteers welcome
- Sponsor
- Florida State University
Male Circumcision
Phase 4 Field Trial of the Unicirc Instrument With Tissue Adhesive
This is a field trial of the Unicirc instrument to excise the foreskin, plus use of cyanoacrylate tissue adhesive to seal the wound.
- Trial name
- Unicirc003 (NCT02091726)
- Testing
- Unicirc instrument plus cyanoacrylate tissue adhesive
- Where
- South Africa
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Simunye Primary Health Care
HIV/AIDS
The PrEP (Pre-exposure Prophylaxis) SMART Study
The PrEP SMART study is testing a stepped model of scalable adherence support strategies in South African young women who initiate PrEP using a SMART (sequential multiple assignment randomized trial) design.
- Trial name
- NCT04038060
- Testing
- WhatsApp Group, 2-way SMS, Drug level feedback
- Where
- South Africa
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- University of Washington
HIV/AIDS
Developing a Patient Navigation Intervention for PrEP Continuum of Care Among Young Latino MSM (PrEParate)
This study aims to help young Latino gay and bisexual men access sexual health information, including PrEP. Participants will be randomly assigned to either the patient navigation or the usual care condition and followed for 6…
- Trial name
- NCT04048382
- Testing
- Patient Navigation, Usual Care
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- San Diego State University
HIV Infection, Alcohol Consumption
Boston ARCH 4F Intervention to Reduce Fall Risk in People With HIV and Alcohol Use
This study is being conducted to assess the acceptability and feasibility of a randomized trial of a 10 week virtual intervention to reduce fall risk in people with HIV who consume alcohol.
- Conditions
- HIV Infection, Alcohol Consumption, Falls, Accidental, Falls
- Trial name
- NCT04804579
- Testing
- Fall Prevention Intervention
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Boston University
Reduction in Heavy Drinking in Patients With HIV
Reducing Heavy Drinking to Optimize HIV/AIDS Treatment and Prevention
This is a double-blind placebo-controlled study to evaluate the effect of Naltrexone (NTX) and counseling on highly active antiretroviral treatment (HAART) medication adherence in a cohort of HIV-infected patients who report…
- Trial name
- DAWN (NCT01227044)
- Testing
- Naltrexone
- Where
- 2 sites in United States
- Volunteers
- 51 people
- Sponsor
- Yale University
Cardiovascular Diseases
The LEARN Study for CVD Prevention
The investigator is testing a virtual environment (VE) to address prevention of HIV-related comorbidities.
- Trial name
- LEARN (NCT05242952)
- Testing
- Gaming in a virtual environment
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Yale University
Self Efficacy, HIV Prevention
TAKE Steps: Motivational Interviewing to Prevent STIs
This study will consist of a randomized controlled trial of a motivational interviewing intervention for adolescents with diagnosed sexually transmitted infections (STIs).
- Conditions
- Self Efficacy, HIV Prevention, STI Prevention
- Trial name
- TAKE Steps (NCT05215262)
- Testing
- Treat Act Know Engage (T.A.K.E.) Steps, Standard or Care
- Where
- 5 sites in United States
- Volunteers
- 94 people
- Sponsor
- Children's Hospital of Philadelphia
HIV Infections
HealthMindr App to Increase Pre-exposure Prophylaxis (PrEP) Uptake and Retention Among Men Who Have Sex With Men (MSM)
This study is a randomized controlled clinical trial of a theoretically based mobile app, HealthMindr, to increase pre-exposure prophylaxis (PrEP) uptake among men who have sex with men (MSM) to prevent human immunodeficiency…
- Trial name
- NCT03763942
- Testing
- HealthMindr App, Control App
- Where
- 3 sites in United States
- Volunteers
- 658 people, healthy volunteers welcome
- Sponsor
- Emory University
HIV/AIDS, Sexually Transmitted Diseases
Innovative Tools to Expand HIV Self-Testing
The I-TEST study builds upon two participatory approaches, open challenge contests and entrepreneurship training. The study utilizes open challenge contest to generate youth-driven interventions on strategies to promote HIV…
- Trial name
- I-TEST (NCT04070287)
- Testing
- SMART Pack, Luv Box, Bili Vibes
- Where
- Nigeria
- Volunteers
- 388 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Adherence, Patient, Pre-Exposure Prophylaxis
mHealth Technologies to Enhance PrEP Adherence Among Thai MSM
This study aims to: 1) adapt the theory-based P3 (Prepared, Protected, emPowered) app designed to improve pre-exposure prophylaxis (PrEP) adherence, retention in PrEP clinical care, and PrEP persistence among young gay, bisexual…
- Conditions
- Adherence, Patient, Pre-Exposure Prophylaxis, HIV/AIDS
- Trial name
- P3-T (NCT04413708)
- Testing
- P3-T PrEP Adherence App
- Where
- Thailand
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Duke University
HIV Infections, HIV Primary Infection
A Couples-based Intervention for Transgender Women and Their Partners
This project seeks to test the efficacy of a couples-based HIV prevention program in large-scale randomized controlled trial (RCT) to reduce HIV risk among transgender woman and their partners.
- Trial name
- T2 (NCT04067661)
- Testing
- CHIP, Control
- Where
- United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Sexually Transmitted Infection (STI) Prevention, Unintended Pregnancy Prevention
Preventing Health Damaging Behaviors in Male and Female Army Recruits
Health damaging (risk) behaviors of young military personnel are reflections of health problems facing all young people in the U.S.
- Conditions
- Sexually Transmitted Infection (STI) Prevention, Unintended Pregnancy Prevention, Sexual Risk Reduction, Alcohol and Other Substance Use Prevention
- Trial name
- NCT01234103
- Testing
- Preventing Helath Damaging Health Behaviors in Male and Female Army Recruits
- Where
- United States
- Volunteers
- 933 people, healthy volunteers welcome
- Sponsor
- United States Department of Defense
HIV Infection
Integrated Care Centers to Improve HIV Outcomes in Vulnerable Indian Populations
This is a cluster randomized trial to evaluate the effectiveness of integrated care centers (ICC) to improve access to HIV testing, prevention services, and treatment among high-risk populations of injection drug users (IDU) and…
- Trial name
- NCT01686750
- Testing
- Integrated care centers
- Where
- India
- Volunteers
- 21,726 people
- Sponsor
- Johns Hopkins University
HIV
Comprehensive HIV Prevention Package for MSM in Southern Africa: Pilot Study (Sibanye Health Project)
The purpose of this study is to evaluate the acceptability and uptake of a combination package of biomedical, behavioral and community-level HIV prevention interventions and services for men who have sex with men (MSM) in South…
- Trial name
- NCT02043015
- Testing
- Condom choices, Condom-compatible lubricant choices, Couples HIV counseling and testing (CVCT)
- Where
- 3 sites in United States, South Africa
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Emory University