Clinical trials: HIV
HIV-1-infection, Adolescent Behavior
InTSHA: Interactive Transition Support for HIV-infected Adolescents Using Social Media
The goal of this study is to develop and evaluate a social media behavioral intervention based on the Social-ecological Model of Adolescent and Young Adult Readiness to Transition (SMART) to improve transition care for…
- Trial name
- InTSHA (NCT03624413)
- Testing
- Social Media Intervention, Standard of Care
- Where
- South Africa
- Volunteers
- 80 people
- Sponsor
- Emory University
Hypertension, HIV
Community Health Worker Optimization of Antihypertensive Care in HIV
To adapt and assess the implementation and preliminary effectiveness of an integrated COBRA and CHAMP multi-component community health worker-delivered hypertension intervention in improving blood pressure control among PLWH in…
- Trial name
- COACH (NCT06503991)
- Testing
- Community Health Worker (CHW)-delivered Hypertension Management Pilot (CHAMP), Control of Blood Pressure and Risk Attenuation (COBRA)
- Where
- Tanzania
- Volunteers
- 100 people
- Sponsor
- Duke University
AIDS
Efficacy and Safety of GSK Biologicals HIV Vaccine in Antiretroviral Therapy (ART)-naïve HIV-1 Infected Persons
This study is designed to determine whether administration of the GSK Biologicals HIV vaccine 732462 can lead to a reduction in viral load, and impact on the course of human immunodeficiency virus type 1 (HIV-1) infection.
- Trial name
- NCT01218113
- Testing
- GSK Biologicals HIV Vaccine 732462
- Where
- 42 sites in United States, France and 2 more
- Volunteers
- 191 people
- Sponsor
- GlaxoSmithKline
HIV/AIDS
A Randomized Controlled Trial of an Antiretroviral Treatment Adherence Intervention for HIV+ African Americans
Project Rise is a randomized controlled trial (RCT) of an innovative, culturally congruent treatment education (TE) intervention for African Americans with HIV that targets cultural and social issues contributing to health…
- Trial name
- NCT03331978
- Testing
- Rise - Treatment Education
- Where
- United States
- Volunteers
- 306 people
- Sponsor
- RAND
HIV-1-infection
ART First-line Treatment Durability in Russia
This study is a non-interventional retrospective study. Data from patients who signed informed consent form will be collected through retrospective chart or medical records review.
- Trial name
- NCT04253119
- Testing
- Antiretroviral/Anti HIV
- Where
- 4 sites in Russia
- Volunteers
- 536 people
- Sponsor
- MSD Pharmaceuticals LLC
Tuberculosis
A Phase I Study of Safety & Immunogenicity of AERAS-456 in HIV-Neg. Adults Treated for Drug-susceptible Pulmonary TB
This is a Phase I, double-blind, randomized, placebo-controlled safety and immunogenicity study in adults who have recently been successfully treated for drug-susceptible pulmonary Tuberculosis (TB).
- Trial name
- C-037-456 (NCT02375698)
- Testing
- H56:IC31
- Where
- 3 sites in South Africa
- Volunteers
- 22 people
- Sponsor
- Aeras
Human Immunodeficiency Virus-1
A Pilot Study Of A Novel Treatment Regimen, Maraviroc + Ritonavir Boosted Atazanavir, In Treatment Naive HIV-Infected Patients
This is a pilot study to examine if the novel treatment regimen maraviroc plus boosted atazanavir can be expected to be safe and efficacious in treatment naive HIV infected patients.
- Trial name
- NCT00827112
- Testing
- maraviroc
- Where
- 39 sites in United States, Germany and 1 more
- Volunteers
- 129 people
- Sponsor
- ViiV Healthcare
Substance Abuse
Evaluation of Treatments for Homeless Youths
Youth who leave home for the streets are at significantly more risk for a multitude of problems, yet little research is available to guide treatment intervention efforts with this population.
- Trial name
- NCT01143792
- Testing
- Community Reinforcement Approach (CRA) + HIV prevention, Case Management + HIV Prevention, Motivational Enhancement Therapy (MET) + HIV prevention
- Where
- United States
- Volunteers
- 270 people
- Sponsor
- Ohio State University
HIV-1-infection
INTERVAL: Varying Intervals of ART to Improve Outcomes in HIV
This is an unblinded cluster-randomized study to evaluate the effectiveness of two strategies for scripting/dispensing of antiretroviral therapy (ART) on retention, virologic suppression, and cost compared to the standard of…
- Trial name
- INTERVAL (NCT03101592)
- Testing
- Three-month ART dispensing, Six-month ART dispensing
- Where
- 2 sites in Malawi, Zambia
- Volunteers
- 9,118 people
- Sponsor
- University of California, Los Angeles
Harm Reduction, HIV Infections
Implementation of Onsite, Rapid ART Initiation Among People Who Inject Drugs Living With HIV at Syringe Services Program
The purpose of this study is to see if providing HIV medicine right away at the IDEA Syringe Services Program will help the participant start and remain in HIV care, including having no detectable HIV in the participant's blood.
- Conditions
- Harm Reduction, HIV Infections, Drug Use
- Trial name
- NCT04650269
- Testing
- Biktarvy 50Mg-200Mg-25Mg Tablet, HIV care
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of Miami
Smoking Cessation, HIV
Patch Study - Intervention for HIV Positive Smokers
The overall objective of the transdisciplinary team of Human Immunology Virus (HIV) and Tobacco funded researchers is to test if tailoring nicotine replacement doses to temper these excessive levels will enhance the efficacy of…
- Trial name
- NCT02982772
- Testing
- Combination Therapy, Standard Care Intervention
- Where
- United States
- Volunteers
- 488 people
- Sponsor
- dr. maria miguez
HIV-Associated Lipodystrophy Syndrome
Study of Reyataz in HIV-infected Patients With Lipodystrophy Syndrome
The purpose of this clinical research study is to learn if human immunodeficiency virus (HIV)-infected subjects with abdominal fat accumulation on their highly active antiretroviral treatment (HAART) regimen have better changes…
- Trial name
- NCT00135356
- Testing
- Atazanavir (ATV) + ritonavir (RTV), continuation of backbone 2 nucleoside reverse transcriptase inhibitor (NRTIs), continuation of current HAART (boosted protease inhibitor [PI] combination + 2 NRTIs)
- Where
- 30 sites in United States, Canada and 7 more
- Volunteers
- 219 people
- Sponsor
- Bristol-Myers Squibb
HIV-Associated Lipodystrophy Syndrome, Insulin Resistance
Growth Hormone and/or Rosiglitazone for HIV-Associated Increased Abdominal Fat and Insulin Resistance
The purpose of the study is to determine if the combination of recombinant human growth hormone plus rosiglitazone (an insulin-sensitizing drug) is safe and more effective than either drug alone (or no active therapy) for the…
- Conditions
- HIV-Associated Lipodystrophy Syndrome, Insulin Resistance, HIV Infections, Metabolic Syndrome X
- Trial name
- NCT00130286
- Testing
- Rosiglitazone, Recombinant human growth hormone + rosiglitazone
- Where
- 4 sites in United States
- Volunteers
- 77 people
- Sponsor
- Weill Medical College of Cornell University
HIV/AIDS, Methamphetamine Abuse
Depression Intervention Among Gay and Bisexual Men Receiving Treatment for Methamphetamine Use
This study is a single-arm, non-randomized pilot study. Eligible participants are newly enrolled participants in an outpatient methamphetamine treatment program, and study activities will take place contemporaneously with…
- Conditions
- HIV/AIDS, Methamphetamine Abuse, Depression
- Trial name
- NCT03864653
- Testing
- MoodGym
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Friends Research Institute, Inc.
Histoplasmosis, AIDS
Randomized Trial of Liposomal Amphotericin B for Histoplasmosis in AIDS Patients
Disseminated histoplasmosis (DH) is one of the major AIDS-defining infections responsible for high mortality rates in HIV-infected patients.
- Trial name
- NCT04059770
- Testing
- single dose of L-AmB, 2 doses of L-AmB, 2 weeks of L-AmB
- Where
- Brazil
- Volunteers
- 118 people
- Sponsor
- Alessandro Pasqualotto
HIV Infection
Evaluation of the Safety and Efficacy of Reformulated Raltegravir (MK-0518) 1200 mg Once Daily in Combination With TRUVADA™ in Human Immunodeficiency Virus (HIV)-1 Infected, Treatment-Naive Participants (MK-0518-292)
To evaluate the safety and efficacy of reformulated raltegravir (MK-0518) 1200 mg once daily in combination with TRUVADA™ versus raltegravir 400 mg twice daily in combination with TRUVADA™ in HIV-1 infected, treatment-naive…
- Trial name
- onceMRK (NCT02131233)
- Testing
- Reformulated Raltegravir, Raltegravir, TRUVADA™
- Volunteers
- 802 people
- Sponsor
- Merck Sharp & Dohme LLC
HIV
Antiretroviral Therapy for Advanced HIV Disease in South Africa
This study will determine how well four different antiretroviral drug therapies work in patients with advanced HIV disease. The trial is part of the South Africa-U.S.
- Trial name
- NCT00342355
- Testing
- Zidovudine, Stavudine, Didanosine
- Where
- 7 sites in South Africa
- Volunteers
- 1,771 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Contact Tracing
Enhancing Partner Services Among Men Who Have Sex With Men Living With HIV
Individuals will participate in a pilot randomized controlled trial (RCT) that implements and evaluates the feasibility, acceptability, and effectiveness of crowdsourced partner services (PS) or conventional PS among Chinese men…
- Trial name
- NCT04971967
- Testing
- Crowdsourced partner services intervention
- Where
- China
- Volunteers
- 121 people
- Sponsor
- University of North Carolina, Chapel Hill
HIV Infections
SPRING: Safety, Efficacy, Pharmacokinetics of tipRanavir/r IN Race/Gender HIV+ Patients Randomized to TDM or SoC
The primary purpose of this study is to: 1. Demonstrate the safety and efficacy of tipranavir/ritonavir (TPV/r) among a racially diverse HIV+ population (males and females) who are three-class (nucleoside reverse transcriptase…
- Trial name
- NCT00440271
- Testing
- tipranavir, ritonavir, Optimized Background Regimen (OBR)
- Where
- 30 sites in United States, Argentina and 5 more
- Volunteers
- 33 people
- Sponsor
- Boehringer Ingelheim
HIV-1 Infection
Endothelial Function, Lipoproteins, and Inflammation With Low HDL Cholesterol in HIV: ER Niacin Versus Fenofibrate
This study is being done with people with HIV infection who have low levels of HDL-C. HDL-C is a type of "good" cholesterol. People with low HDL-C have a higher risk of heart disease and may have problems with how their blood…
- Trial name
- NCT01426438
- Testing
- Niacin, Aspirin, Fenofibrate
- Where
- 14 sites in United States
- Volunteers
- 99 people
- Sponsor
- Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections