Clinical trials: HIV Chemoprophylaxis
HIV Infections
Evaluation of Three Regimens of Chemoprophylaxis for Tuberculosis in Patients co-Infected by HIV and Mycobacterium Tuberculosis
To evaluate adherence and safety of three regimens of chemoprophylaxis for tuberculosis (TB) in HIV-infected patients with positive tuberculin skin test.
- Trial name
- NCT00402454
- Testing
- isoniazid, rifampin + isoniazid or rifampin + pyrazinamide
- Where
- Spain
- Volunteers
- 300 people
- Sponsor
- Sociedad Andaluza de Enfermedades Infecciosas
HIV Infections, Anus Neoplasms
Chemoprevention of Anal Neoplasia Arising Secondary to Anogenital Human Papillomavirus Infection in Persons With HIV Infection.
PRIMARY: In Phase I, to define a broadly tolerable dose of isotretinoin that can be used in combination with interferon alfa-2a (IFN alfa-2a).
- Trial name
- NCT00000764
- Testing
- Isotretinoin, Interferon alfa-2a
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Malaria, Human Immunodeficiency Virus
Reducing the Burden of Malaria in HIV-Infected Pregnant Women and Their HIV-Exposed Children (PROMOTE-BC2)
This is a double-blinded, randomized controlled trial of 200 HIV-infected pregnant women living in Tororo, Uganda, an area of high malaria transmission.
- Trial name
- NCT02282293
- Testing
- Monthly dihydroartemisinin-piperaquine (DP) + daily trimethoprim/sulfamethoxazole (TS)
- Where
- Uganda
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
HIV Chemoprophylaxis, HIV Preexposure Prophylaxis
Sustainable Healthcenter Implementation PrEP Pilot Study
A health services implementation pilot study, conducted with an observational cohort of HIV-uninfected persons including men who have sex with men, heterosexual women and men, and injection drug users receiving daily oral…
- Trial name
- SHIPP (NCT02074891)
- Testing
- coformulated TDF/FTC
- Where
- 5 sites in United States
- Volunteers
- 1,420 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
HIV Infections
Emtricitabine/Tenofovir Disoproxil Fumarate for HIV Prevention in Men
The purpose of this study is to determine whether daily use of emtricitabine/tenofovir disoproxil fumarate (FTC/TDF) can prevent HIV infection in men who also receive HIV counseling, condoms, and treatment for other sexually…
- Trial name
- iPrEx (NCT00458393)
- Testing
- daily TDF/FTC
- Where
- 11 sites in United States, Brazil and 4 more
- Volunteers
- 2,499 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Malaria
Reducing the Burden of Malaria in HIV-uninfected Pregnant Women and Infants
This will be a double-blinded randomized controlled phase III trial of 300 HIV uninfected pregnant women and the children born to them. The study interventions will be divided into two phases.
- Trial name
- PROMOTE-BC1 (NCT02163447)
- Testing
- Monthly dihydroartemisinin-piperaquine (DP) for adult women during pregnancy, 3 dose dihydroartemisinin-piperaquine (DP) for adult women during pregnancy, 3 dose sulfadoxine-pyrimethamine (SP) for adult women during pregnancy
- Where
- Uganda
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Grant Dorsey, M.D, Ph.D.
Malaria
Prevention of Malaria in HIV-uninfected Pregnant Women and Infants
This will be a double-blinded randomized controlled phase III trial of 782 HIV uninfected pregnant women and the children born to them.
- Trial name
- PROMOTE-BC3 (NCT02793622)
- Testing
- Monthly Sulfadoxine-Pyrimethamine (SP) During Pregnancy, Monthly Dihydroartemisinin-Piperaquine (DP) During Pregnancy
- Where
- Uganda
- Volunteers
- 782 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Pregnancy; HIV; Malaria
Improving PRegnancy Outcomes With PReVEntive Therapy in Africa-2 (IMPROVE-2)
2.3.3 Short technical protocol summary Background: Pregnant women represent a vulnerable population for malaria. HIV-infected women are particularly at risk.
- Trial name
- IMPROVE-2 (NCT04158713)
- Testing
- Intermittent Preventive Therapy with Dihydroartemisinin-Piperaquine
- Where
- Kenya
- Volunteers
- 898 people, healthy volunteers welcome
- Sponsor
- Liverpool School of Tropical Medicine
HIV Infections, Tuberculosis
A Randomized Trial of Three Regimens to Prevent Tuberculosis in HIV-Infected Patients With Anergy
INTRODUCTION. To evaluate the efficacy of three regimens of prophylactic therapy for tuberculosis in HIV-infected patients with anergy. METHODS. Prospective, multi-center, randomized, comparative, and open clinical trial.
- Trial name
- NCT00402610
- Testing
- isoniazid, rifampin + isoniazid, rifampin + pyrazinamide or not treatment
- Where
- Spain
- Volunteers
- 332 people
- Sponsor
- Sociedad Andaluza de Enfermedades Infecciosas
Infection, HIV
A Pilot Study on Raltegravir, Tenofovir and Emtricitabine for Peri-exposure Prophylaxis for HIV Infection
This will be a pilot, open label study involving 65 participants. All participants will be followed until seroconversion or until the last enrolled participant completes one year of follow-up, whichever happens first.
- Trial name
- PERIEP (NCT01697046)
- Testing
- Truvada and Isentress
- Where
- Brazil
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Projeto Praça Onze
Prevention of HIV Infection, STI Prevention
Juntas Adelante: A Peer-Coaching Intervention to Promote Chemoprophylaxis for HIV Prevention Among Latina Transgender Women in the Washington DC Metropolitan Area.
The goal of this clinical trial is to evaluate the impact of the Juntas Adelante intervention on awareness and use of chemoprophylaxis for HIV prevention (Pre- and Post-Exposure prophylaxis, or PrEP and PEP) among Latina…
- Trial name
- NCT07808541
- Testing
- Juntas Adelante: A Peer coaching Intervention to Promote Chemoprophylaxis for HIV Prevention among Latina Transgender Women in the Washington DC Metropolitan Area.
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- George Washington University