Clinical trials: HIV Dementia
Depression, Stress, Psychological
Rural Dementia Caregiver Project
Rural caregivers face challenges of geographic isolation and lower health care access and quality. Many rural dementia caregivers experience serious health consequences due to caregiving responsibilities that can limit their…
- Conditions
- Depression, Stress, Psychological, Self Efficacy, Loneliness
- Trial name
- NCT04428112
- Testing
- Building Better Caregivers Workshop, Attention Control
- Where
- United States
- Volunteers
- 418 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Sexually Transmitted Diseases, Safe Sex
P3 (Prepared, Protected, emPowered)
P3 (Prepared, Protected, emPowered) is an interactive smartphone app for HIV-uninfected YMSM and YTW that utilizes social networking and game-based mechanics as well as a comprehensive understanding of what constitutes "best…
- Conditions
- Sexually Transmitted Diseases, Safe Sex, Adherence, Medication
- Trial name
- P3 (NCT03320512)
- Testing
- P3, P3+, Control
- Where
- 9 sites in United States
- Volunteers
- 246 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
AIDS Dementia Complex
Ferumoxytol-enhanced Imaging and Mapping in neuroAIDS
This project will investigate the ability of a novel MRI contrast agent to identify and quantitate ongoing monocyte/macrophage (M/MΦ)-mediated inflammation in the brains of HIV-infected individuals.
- Trial name
- NCT02678767
- Testing
- Ferumoxytol
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Beau Nakamoto
HIV-1-Associated Cognitive Motor Complex
The Prevalence of Neurocognitive Disorder in a Primary Care-based HIV Cohort Compared to a HIV-negative Control Cohort -
To determine the prevalence of HIV associated Neurological Disorder (HAND) in a population of HIV positive patients within a primary care setting compared with the HIV negative population.
- Trial name
- CNS HAND (NCT01434563)
- Volunteers
- 326 people, healthy volunteers welcome
- Sponsor
- Holdsworth House Medical Practice
All Diagnosed Health Conditions, ADD/ADHD
At-Home Research Study for Patients With Autoimmune, Inflammatory, Genetic, Hematological, Infectious, Neurological, CNS, Oncological, Respiratory, Metabolic Conditions
We are the missing link in clinical trials, connecting patients and researchers seamlessly and conveniently using a mobile health platform to advance medical research.
- Conditions
- All Diagnosed Health Conditions, ADD/ADHD, Alopecia Areata, Ankylosing Spondylitis
- Trial name
- NCT01931644
- Where
- United States
- Volunteers
- 17,667 people, healthy volunteers welcome
- Sponsor
- Sanguine Biosciences
HIV-Dementia, HIV-Associated Cognitive Motor Complex
PET Evaluation of Brain Peripheral Benzodiazepine Receptors Using [11C]PBR28 in HIV-Seropositive Patients With (MCMD)
The purpose of this protocol is to measure a receptor in the brain using positron emission tomography (PET) that is involved in inflammation.
- Conditions
- HIV-Dementia, HIV-Associated Cognitive Motor Complex, AIDS Encephalopathy, AIDS Dementia Complex
- Trial name
- NCT00459693
- Testing
- [11C]PBR28
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Depression, HIV Infections
PET Imaging of the Dopaminergic and Serotonergic Systems in Treated HIV Positive Subjects
Background: Human immunodeficiency virus (HIV) infection is a serious disease with no cure. Some people with HIV have depression and other mood problems. They can have problems with thinking and memory.
- Conditions
- Depression, HIV Infections, HIV-Associated Cognitive Motor Complex
- Trial name
- NCT03581305
- Testing
- 18F-FDOPA, 11C-DASB
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
HIV Infections
HIV-1 Specific Immune Responses in Thai Individuals With HIV Dementia
A total of 60 participants will be enrolled. They will be in 3 groups 1. ARV-naïve, HIV-positive ≥ 20 year of age with HAD (n=25) who intend to start ARV 2.
- Trial name
- NCT00777426
- Where
- Thailand
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- SEARCH Research Foundation
HIV-Associated Cognitive Motor Complex
Mild Neurocognitive Disorder in HIV Infection of the Brain
Background: Some people with human immunodeficiency virus (HIV) develop problems with thinking and concentration when the virus affects the brain. This is known as mild neurocognitive disorder (MND).
- Trial name
- NCT01547754
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Amyotrophic Lateral Sclerosis, ALS (Amyotrophic Lateral Sclerosis)
ALS Research Collaborative
The goal of this natural history study is to learn more about the biological and clinical aspects of amyotrophic lateral sclerosis (ALS).
- Conditions
- Amyotrophic Lateral Sclerosis, ALS (Amyotrophic Lateral Sclerosis), ALS With Frontotemporal Dementia (ALS/FTD), Motor Neuron Disease
- Trial name
- ARC (NCT06885918)
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- ALS Therapy Development Institute
HIV Associated Neurocognitive Disorder, HIV Dementia
SV2A & TSPO PET Imaging Measures to Reveal Mechanisms of HIV Neuropathogenesis During Antiretroviral Therapy
The purpose of this study is to longitudinally characterize and evaluate changes in synaptic density in the brain using novel positron-emission tomography (PET) scans; magnetic resonance imaging (MRI), and clinical laboratory…
- Conditions
- HIV Associated Neurocognitive Disorder, HIV Dementia, HIV Encephalitis, Healthy
- Trial name
- ART (NCT05586581)
- Testing
- SV2A PET, TSPO PET
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Yale University
HIV-1-infection, Aging, Premature
Mental Ability Challenge Study in Adults With and Without HIV
It is estimated that by 2016, nearly 50% of HIV-positive individuals in the US will be aged 50 or older, and up to 60% of those will experience some degree of cognitive impairment as they age.
- Conditions
- HIV-1-infection, Aging, Premature, Cognitive Impairment, Memory Impairment
- Trial name
- NCT03244488
- Testing
- Scopolamine Injectable Product, Mecamylamine Pill
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Ebola Virus Disease, Marburg Virus Disease
Evaluation of Safety, Tolerability and Immune Responses of Ebola-S and Marburg Vaccines in Healthy Adults
Primary Objective: To evaluate the safety and tolerability of cAd3-EBO-S and cAd3 Marburg vaccines when administered Intramuscular (IM) at a dose of 1 x 10^11 particle units (PU) to healthy adults.
- Trial name
- NCT04723602
- Testing
- cAd3-Marburg, cAd3-EBO-S
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Albert B. Sabin Vaccine Institute
Alzheimer Disease, HIV
F 18 T807 PET (Positron Emission Tomograph )Scan for HIV Infected & Uninfected
This project will collect quantitative pilot data that will allow the characterization of uptake and binding of 18F-AV-1451 (also known as F 18 T807, also known as T807, also known as…
- Trial name
- NCT03279523
- Testing
- F 18 T807
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Tammie L. S. Benzinger, MD, PhD
HIV Dementia
Exploring Racial Disparities in Sleep Health and Neurocognitive Function
Despite longer life expectancies due to combination antiretroviral therapy (cART), the prevalence of HIV-associated neurocognitive disorders (HAND) persists thus affecting 52% of the HIV population.
- Trial name
- NCT04015830
- Testing
- electroencephalography (EEG) and event related potentials (ERP)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Alabama, Tuscaloosa
Diabetes, Chronic Kidney Diseases
Benchtop NMR Spectroscopy for Assessment of Clinical Human Pathologies (BRANCH-P STUDY)
This research programme seeks to combine the resources of NHS primary care, with the leading spectroscopic work in low-magnetic fields of the Wilson Group (Nottingham Trent University) to demonstrate the potential for benchtop…
- Conditions
- Diabetes, Chronic Kidney Diseases, Cancer, Bowel Disease
- Trial name
- BRANCH-P (NCT05473325)
- Where
- United Kingdom
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Willows Health
HIV-ASSOCIATED NEUROCOGNITIVE DISORDER (HAND)
Prevalence of HIV-associated Neurocognitive Disorders (HAND) in a School of Medicine HIV/AIDS Outpatient Clinic
1. To determine, in the Quillen College of Medicine HIV+ outpatient clinic, the prevalence of NC (normal cognition ) ANI (asymptomatic neurocognitive impairment ) MCD (mild cognitive disorder ) HAD (HIV-associated dementia ) 2.
- Trial name
- HAND (NCT02187796)
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- East Tennessee State University
Encephalopathy, HIV-encephalopathy
SOLFAMU Study of Nasal Brushing Collected OLFActory MUcosa Samples in the Diagnosis of Human Encephalopathies
Encephalopathies are a group of central nervous system (CNS) affection with heterogeneous etiology. Several causes have been recognized including neurodegenerative, vascular, infectious, autoimmune, toxic or allergic affections…
- Conditions
- Encephalopathy, HIV-encephalopathy, Alzheimer Dementia
- Trial name
- NCT02951559
- Testing
- Nasal Brushing
- Where
- Italy
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of Turin, Italy