Clinical trials: HIV Infected Individuals
HIV-1 Infection
High Dose Vitamin D and Calcium for Bone Health in Individuals Initiating HAART
This study was done with people who were infected with HIV and needed to start treatment for their HIV disease. The purpose of this study is to see if taking vitamin D and calcium will help prevent the bone loss that sometimes…
- Trial name
- NCT01403051
- Testing
- EFV/FTC/TDF, Calcium Carbonate, Vitamin D3
- Where
- 39 sites in United States, Puerto Rico
- Volunteers
- 167 people
- Sponsor
- Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
Influenza, Human, Human Immunodeficiency Virus I Infection
Immune Response to Seasonal Influenza Vaccine in HIV Infected Individuals
Investigators in the Division of Infectious Diseases are carrying out a study to determine if human immunodeficiency virus (HIV)-seropositive patients receiving the Seasonal Influenza vaccination develop an adequate antibody…
- Trial name
- NCT01381029
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- George Washington University
HIV Infections
A Study of Thymic Humoral Factor (THF Gamma 2) in HIV-Infected Patients
To investigate the safety of thymic humoral factor (THF gamma 2), its effect on HIV load based on at least a 75 percent decrease in HIV quantitative PCR RNA copies/ml, and its persistence when administered in combination with an…
- Trial name
- NCT00002435
- Testing
- Thymic Humoral Factor, Zidovudine
- Where
- 10 sites in United States
- Sponsor
- Pharmacia
HIV
A Phase I Study to Evaluate the Immunologic Response and Virologic Impact of AGS-004
The purpose of this study is to: find out the intensity and duration of the immune response after multiple injections of the investigational study product AGS-004 made from one's own dendritic cells and one's own strain of HIV…
- Trial name
- NCT02042248
- Testing
- AGS-004
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Cynthia L Gay, MD
HIV Infections, Helminthiasis
Treatment of Helminth co-Infection: Short-Term Effects on HIV-1 Progression Markers and Immune Activation
Identifying methods to slow disease progression in patients with HIV-1 infection remains a top priority in many regions of the world.
- Trial name
- NCT00130910
- Testing
- Albendazole
- Where
- Kenya
- Volunteers
- 234 people
- Sponsor
- University of Washington
HIV Infections
Antiretroviral Therapy Intensification With Raltegravir or Addition of Hyper-immune Bovine Colostrum in HIV-1 Infected Patients With Suboptimal CD4+ T Cell Response
A research study to measure the effect on CD4 counts of adding to current anti-retroviral regimen raltegravir with or without hyper-immune bovine colostrum.
- Trial name
- CORAL (NCT00772590)
- Testing
- Raltegravir, Hyper-immune Bovine Colostrum, raltegravir and hyper-immune bovine colostrum
- Volunteers
- 75 people
- Sponsor
- Kirby Institute
HIV Infections
A Cluster-Randomized Intervention Trial to Improve Quality of Life for HIV-Infected Individuals in Anhui, China
The HIV epidemic in China has reached a phase of exponential growth; the number of new infections has been steadily increasing over the past decade.
- Trial name
- NCT00479141
- Testing
- HIV skills training, Popular Opinion Leaders training
- Where
- China
- Volunteers
- 3,199 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV-1
Fuzeon Viral Decay Pilot Study
In order to better understand the source(s) and the mechanism(s) of HIV persistence and to potentially lead to further suppression of HIV from viral reservoirs, we propose to examine the effect of co-administration of…
- Trial name
- NCT00334022
- Testing
- enfuvirtide
- Where
- Canada
- Volunteers
- 18 people
- Sponsor
- Canadian Immunodeficiency Research Collaborative
HIV Infections
The LATITUDE Study: Long-Acting Therapy to Improve Treatment SUccess in Daily LifE
The purpose of this study was to compare the efficacy, safety, and durability of two different strategies to treat participants with a history of sub-optimal adherence and control of their HIV infection: long-acting (LA)…
- Trial name
- NCT03635788
- Testing
- Standard of Care (SOC) Oral ART, Oral RPV, Oral CAB
- Where
- 33 sites in United States, Puerto Rico
- Volunteers
- 456 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Nonneoplastic Condition
Vaccine Therapy, Incomplete Freund's Adjuvant, and GM-CSF in Treating Patients With HIV
RATIONALE: Vaccines made from peptides may help the body build an effective immune response. Incomplete Freund's adjuvant may stimulate the immune system in different ways and may help the vaccine work better.
- Trial name
- NCT00381875
- Testing
- E1M184V peptide vaccine, incomplete Freund's adjuvant, sargramostim
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
HIV Infections
Effectiveness of a Telephone Intervention Program in Improving Depression, Coping, and Family Functioning in HIV-Infected Individuals and Caregivers
This study will evaluate the effectiveness of the Family Intervention: Telephone Tracking (FITT) program in improving depression, coping, and family functioning in HIV-infected individuals and their caregivers.
- Trial name
- NCT00183781
- Testing
- FITT: Family Intervention - Telephone Tracking
- Where
- United States
- Volunteers
- 270 people
- Sponsor
- Butler Hospital
HIV-1 Infection
Study to Evaluate Effects of Vorinostat and HXTC on Persistent HIV-1 Infection in HIV-Infected Subjects Started on Antiretroviral Therapy (ART)
This is a phase I, single-site, study to evaluate the effects of VOR and HIV-1 Antigen Expanded Specific T Cell Therapy (HXTC) on persistent HIV-1 Infection in HIV-infected individuals suppressed on ART.
- Trial name
- XTRA (NCT03212989)
- Testing
- Vorinostat, HXTC
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of North Carolina, Chapel Hill
HIV
Study to Evaluate the Safety and Effect of HIVconsv Vaccines in Combination With Histone Deacetylase Inhibitor Romidepsin on the Viral Rebound Kinetic After Treatment Interruption in Early Treated HIV-1 Infected Individuals
The BCN02-Romi study aims to evaluate a combined "kick and kill" strategy using the most immunogenic candidate vaccine available so far (HIVconsv) with the strongest latency reversal agent available at present time (romidepsin)…
- Trial name
- NCT02616874
- Testing
- MVA.HIVconsv vaccine, Romidepsin
- Where
- 2 sites in Spain
- Volunteers
- 15 people
- Sponsor
- IrsiCaixa
HIV-1-infection
ART First-line Treatment Durability in Russia
This study is a non-interventional retrospective study. Data from patients who signed informed consent form will be collected through retrospective chart or medical records review.
- Trial name
- NCT04253119
- Testing
- Antiretroviral/Anti HIV
- Where
- 4 sites in Russia
- Volunteers
- 536 people
- Sponsor
- MSD Pharmaceuticals LLC
HIV-infected Individuals
Safety and Immunogenicity of HPV Vaccine in HIV-infected
HPV can cause various cancers, including cervical cancer. HIV-infected individuals, due to immune deficiency or long-term immunosuppressive therapy, have significantly higher rates of HPV infection and associated lesion risks…
- Trial name
- NCT07797894
- Testing
- HPV vaccination
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Beijing 302 Hospital
HIV Infections
A Phase I/II Trial of Vaccine Therapy of HIV-1 Infected Individuals With 50-500 CD4 Cells/mm3
To examine the response of HIV-1 infected patients to vaccination with gp120/HIV-1MN antigen. To determine the effect of antiretroviral therapy on vaccine responsiveness.
- Trial name
- NCT00000755
- Testing
- rgp120/HIV-1MN, Zidovudine
- Where
- 10 sites in United States
- Volunteers
- 168 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections
Mefloquine Prophylaxis in HIV-1 Individuals: a Randomized Placebo-controlled Trial
This is a randomized placebo controlled trial. Malaria chemoprophylaxis with mefloquine in asymptomatic HIV-infected adults living in a malaria endemic region of Luanshya, Zambia will be compared to a placebo control group and…
- Trial name
- NCT00373048
- Testing
- mefloquine
- Where
- Zambia
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Institute of Tropical Medicine, Belgium
Malaria, HIV
In-Vivo Response of P. Falciparum to Antimalarial Treatment in HIV-Infected and HIV-Uninfected Adults
Plasmodium falciparum malaria and HIV are among the most important infectious diseases in sub-Saharan Africa. Approximately two-thirds of the estimated 35 million HIV infected persons live in sub-Saharan Africa.
- Conditions
- Malaria, HIV, AIDS
- Trial name
- NCT00144352
- Testing
- sulfadoxine-pyrimethamine
- Where
- Kenya
- Volunteers
- 540 people
- Sponsor
- Centers for Disease Control and Prevention
HIV/AIDS
Impact of Metformin on Immuno-virologic Parameters in HIV
Non-diabetic, aviremic HIV-infected individuals on antiretroviral therapy (ART) will be randomized to metformin therapy or to observation for 72 weeks.
- Trial name
- NCT04500678
- Testing
- Metformin
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- University of Hawaii
HIV Infections, Substance-Related Disorders
Zinc Therapy in HIV Infected Individuals Who Abuse Drugs
Zinc deficiency is prevalent in HIV infected individuals who abuse drugs. The purpose of this study is to determine if zinc therapy will prevent immune failure in HIV infected individuals who abuse drugs and have low plasma zinc…
- Trial name
- NCT00149552
- Testing
- zinc
- Where
- United States
- Volunteers
- 231 people
- Sponsor
- Florida International University