Clinical trials: HIV Infection, completed
HIV Infections
Safety and Immune Response to a Recombinant Adenovirus HIV-1 Vaccine in Healthy Adults
Successful control of the HIV epidemic will require a safe and effective vaccine to be developed. A successful vaccine will need to stimulate a widespread immune response.
- Trial name
- NCT00695877
- Testing
- Ad5.ENVA.48 HIV-1 vaccine
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV
Ibalizumab Plus Optimized Background Regimen in Patient With Multi-Drug Resistant HIV
This Phase 3, single arm, multicenter study will evaluate the safety and effectiveness of ibalizumab in treatment-experienced patients infected with multi-drug resistant HIV-1.
- Trial name
- NCT02475629
- Testing
- ibalizumab, Optimized Background Regimen (OBR)
- Where
- 30 sites in United States, Puerto Rico and 1 more
- Volunteers
- 40 people
- Sponsor
- TaiMed Biologics Inc.
HIV Infection
Partners Demonstration Project of PrEP and ART
The purpose of this protocol is to determine user preferences for antiretroviral therapy (ART) for HIV-1 infected partners and pre-exposure prophylaxis (PrEP) HIV-1 un-infected partners and to optimize targeted delivery and…
- Trial name
- NCT02775929
- Testing
- FTC-TDF PrEP, ART
- Where
- 4 sites in Kenya, Uganda
- Volunteers
- 1,013 people
- Sponsor
- University of Washington
HIV/AIDS, Tuberculosis
Dose Escalation Study to Determine the Pharmacokinetics of Atazanavir Administered With RIfampicin to HIV Positive Adults on sEcond-line ART Regimen With Suppressed HIV-1 Viral Load
The standard treatment for TB consists of rifampicin (RIF) as part of the regimen. However, due to drug-drug interactions (DDI), the bioavailability of PIs is greatly reduced when co-administered with RIF necessitating use of…
- Trial name
- DERIVE (NCT04121195)
- Testing
- Dose escalation
- Where
- Uganda
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Liverpool
HIV
Study to Evaluate the Dosage and Safety of Two Intramuscular Injections of an Investigational Clade B HIV Vaccine
This study aimed to evaluate the safety and reactogenicity of two intramuscular injections of two different dosages of an investigational clade B HIV vaccine.
- Trial name
- NCT01320176
- Testing
- Investigational HIV vaccine dose A, Investigational HIV vaccine dose B
- Where
- Belgium
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur
Tuberculosis, HIV
Start TB Patients on ART and Retain on Treatment (START Study)
The purpose of the START Study is to identify an effective, cost-effective, acceptable intervention that addresses programmatic, structural and psychosocial barriers to ART initiation and retention during TB treatment, with the…
- Trial name
- START (NCT01872390)
- Testing
- Combination Intervention Package, Standard of Care
- Where
- 12 sites in Lesotho
- Volunteers
- 415 people
- Sponsor
- Columbia University
HIV Seropositive
Study of Vitamin D Supplementation to Male HIV Sero-positive Patients
The investigators want to investigate if HIV sero-positive males benefit from vitamin D supplementation. The study runs in 16 weeks and the participants are treated with one of three placebo controlled regimes (tablets): 1.
- Trial name
- NCT00990678
- Testing
- Rocaltrol, Vitamin D, Calcium
- Where
- Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital
Pneumonia, Pneumocystis Carinii, HIV Infections
Escalating Multiple-Dose Safety and Tolerance of WR 6026 Hydrochloride in HIV-Infected Subjects
To determine the maximum tolerated dose (MTD) of WR 6026 in HIV-infected patients. To determine whether any unexpected toxicities are caused by WR 6026 in HIV-infected patients.
- Trial name
- NCT00000740
- Testing
- Sitamaquine
- Where
- 2 sites in United States
- Volunteers
- 44 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Cytomegalovirus Infections, HIV Infections
A Study of HIV and Cytomegalovirus (CMV) in HIV-Infected Patients
To define relationships between 1) HIV load and risk of CMV disease, 2) CMV load and the risk of developing CMV disease, and 3) CMV load and HIV load.
- Trial name
- NCT00001089
- Where
- 36 sites in United States
- Volunteers
- 400 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV, Contraception
Impact of Hormonal Contraception on HIV Acquisition and Transmission Risk
This is a prospective cohort study focusing on HIV negative women. The investigators want to learn how the contraceptive methods of depot medroxyprogesterone acetate (DMPA), etonogestrel implant (Eng-Implant), levonorgestrel…
- Trial name
- NCT02357368
- Testing
- Depot medroxyprogesterone acetate (DMPA), Etonogestrel implant (Eng-Implant), Levonorgestrel intrauterine device (Lng-IUD)
- Where
- 4 sites in United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Lisa Haddad
Bacterial Infections, HIV Infections
Risk-factors for Multidrug-resistant Bacteria Colonization Among Patients at High Risk of STIs
The aim of this study is to identify risk factors and prevalence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) bacteria colonization among patients at high risk of STIs
- Trial name
- BMR-IST (NCT03767374)
- Testing
- Inguinal swab sample, Anal swab sample, Fecal sample
- Where
- France
- Volunteers
- 2,186 people, healthy volunteers welcome
- Sponsor
- Institut de Médecine et d'Epidémiologie Appliquée - Fondation Internationale Léon M'Ba
Acquired Immunodeficiency Syndrome, Burning Mouth Syndrome
Thalidomide to Treat Oral Lesions in HIV-Infected Patients
This study will test the effectiveness of topical thalidomide in healing mouth sores in HIV infected patients. Oral (PO) thalidomide heals these sores at a dose of 200 mg per day.
- Conditions
- Acquired Immunodeficiency Syndrome, Burning Mouth Syndrome, HIV Infection
- Trial name
- NCT00001524
- Testing
- Thalidomide
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Acute HIV Infection, HIV CNS Involvement
Using Telmisartan With ART During Acute HIV Infection to Reduce the CNS Reservoirs of HIV and Lymph Node Fibrosis
Primary objective: To compare telmisartan therapy + antiretroviral therapy (ART) versus ART alone during acute Human Immunodeficiency Virus (HIV)a infection in reducing systemic immune activation and trafficking of activated and…
- Trial name
- NCT02750059
- Testing
- TDF/3TC/EFV + Telmisartan, TDF/3TC/EFV only
- Where
- Thailand
- Volunteers
- 21 people
- Sponsor
- SEARCH Research Foundation
HIV Infections
Interleukin-2 (IL-2) Treatment for HIV Infected Patients Who Have Interrupted Their Anti-HIV Drug Therapy
When an HIV infected person taking strong anti-HIV drugs temporarily stops taking them, viral load rises and the body's immune system is exposed to more HIV.
- Trial name
- NCT00038259
- Testing
- Aldesleukin
- Where
- 10 sites in United States
- Volunteers
- 21 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV/AIDS, Substance Use Disorders
HIV+ Substance Users Released From Jail
The long-term goal of this project is to improve HIV and substance use outcomes and reduce recidivism for HIV+ substance users released from jail.
- Trial name
- NCT03834779
- Testing
- DOORS-CHW Intervention
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Texas Southwestern Medical Center
HIV Infections, Peripheral Nervous System Disease
The Efficacy of a Standardized Acupuncture Regimen and Amitriptyline Compared With Placebo as a Treatment for Pain Caused by Peripheral Neuropathy in HIV-Infected Patients
To evaluate the separate and combined efficacy of a standardized acupuncture regimen and amitriptyline on the relief of pain due to peripheral neuropathy and on the quality of life of HIV-infected patients.
- Trial name
- NCT00000817
- Testing
- Amitriptyline hydrochloride, Point acupuncture
- Where
- 11 sites in United States
- Volunteers
- 260 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
AIDS
Study To Investigate The Hemodynamic Effects Of Single Dose Vardenafil In Subjects Receiving Maraviroc
The objective of this study was to estimate the effects of a single dose of vardenafil on the blood pressure (BP) in subjects receiving maraviroc (MVC) (dosed to steady-state) and to assess the safety and tolerability of MVC in…
- Trial name
- NCT00853840
- Testing
- Maraviroc, Vardenafil
- Where
- Belgium
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- ViiV Healthcare
HIV Infection, Pulmonary TB
Comparing Daily vs Intermittent Regimen of ATT in HIV With Pulmonary Tuberculosis
Acquired Rifampicin Resistance has emerged as an important issue in the treatment of HIV-TB patients. It has not been a major problem in HIV-negative individuals treated for TB treated with standard intermittent regimens.
- Trial name
- NCT00933790
- Testing
- ATT (Ethambutol, Pyrazinamide, INH, Rifampicin)
- Where
- 3 sites in India
- Volunteers
- 331 people
- Sponsor
- Tuberculosis Research Centre, India
Human Immunodeficiency Virus
HIV and Drug Use in Georgian Women
The purpose of this study is to determine how drug abuse treatment interventions can be integrated with established Human Immunodeficiency Virus prevention approaches to optimize their combined effectiveness.
- Trial name
- IMEDI (NCT01331460)
- Testing
- RBT, Case-Management
- Where
- Georgia
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Child Development
Zambia Infant Cohort Study - Brains Optimized for Surviving and Thriving
Children exposed to HIV in-utero but uninfected (CHEUs) number 14.8 million globally. In Zambia, an estimated 56,000 CHEUs are born annually, a staggering fraction of the national birth cohort.
- Trial name
- ZICS-BOOST (NCT05119959)
- Testing
- ECD intervention for CHEUs, Usual care for CHEUs
- Where
- 2 sites in United States, Zambia
- Volunteers
- 469 people
- Sponsor
- Boston University
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