Clinical trials: HIV Lipodystrophy
HIV-Associated Focal Segmental Glomerulosclerosis, HIV-Associated Collapsing Glomerulopathy
Evaluation of Albuminuria HIV-Infected Patients
This study will examine the following: 1) how common albuminuria and proteinuria are among HIV-positive patients, 2) what causes albuminuria or proteinuria in these patients and 3) whether the condition becomes more severe over…
- Conditions
- HIV-Associated Focal Segmental Glomerulosclerosis, HIV-Associated Collapsing Glomerulopathy, Proteinuria, Albuminuria
- Trial name
- NCT00524992
- Where
- 2 sites in United States
- Volunteers
- 252 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
HIV Infections, Healthy
Metabolism and Body Shape of Healthy Children and Children With Chronic Infections
Some HIV-infected adults develop lipodystrophy that includes significant changes in body shape, with fat losses in the face, arms and legs, and fat gain in the trunk.
- Conditions
- HIV Infections, Healthy, Hyperlipidemia, Lipodystrophy
- Trial name
- NCT00001142
- Where
- United States
- Volunteers
- 185 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
HIV
Eplerenone in HIV Associated Abdominal Fat Accumulation
The purpose of this study is to test the effects of a drug, eplerenone, along with lifestyle modification to affect sugar metabolism, body fat distribution, and cardiovascular health in HIV-infected individuals.
- Trial name
- NCT01405456
- Testing
- Eplerenone and lifestyle
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Massachusetts General Hospital
HIV Infections, HIV Lipodystrophy Syndrome
Study Evaluating the Impact on Fat Distribution of Nucleoside Reverse Transcriptase Inhibitor (NRTI)-Sparing Regimens in Antiretroviral Experienced Patients With Lipoatrophy
The aim of this trial is to evaluate the impact on fat distribution of switching to NRTI-sparing regimens in lipoatrophic antiretroviral experienced patients with complete viral suppression.
- Trial name
- NCT00122655
- Testing
- non-nucleoside reverse transcriptase inhibitors, nucleoside reverse transcriptase inhibitors, protease inhibitors
- Where
- France
- Volunteers
- 100 people
- Sponsor
- French National Agency for Research on AIDS and Viral Hepatitis
HAART-induced Lipodystrophy and Metabolic Syndrome
Randomized, Placebo-Controlled Study of Leptin for the Treatment of HIV Lipodystrophy and Metabolic Syndrome
The purpose of this study is to examine whether replacing leptin to normal levels can reverse the changes in fat distribution, lipid profile, and other metabolic problems associated with highly active antiretroviral therapy…
- Trial name
- NCT00140244
- Testing
- r-metHuLeptin
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Beth Israel Deaconess Medical Center
HIV Infections, Lipodystrophy
Raltegravir Therapy for Women With HIV and Fat Accumulation
Ritonavir-boosted protease inhibitor (PI) regimens have become a backbone for treatment of people with HIV. However, adverse drug effects, particularly lipodystrophy/lipoatrophy are closely associated with these regimens.
- Trial name
- NCT00656175
- Testing
- raltegravir
- Where
- 5 sites in United States, Canada
- Volunteers
- 39 people
- Sponsor
- University of California, Los Angeles
HIV Infections
Analysis of Changes in Adipose Tissue of Patients With Lipoatrophy HIV Infection Treated With Nucleoside Thymidine, After Switching to Monotherapy With Lopinavir / Ritonavir
The objective is to analyse the changes in the adipose tissue hystological features and the adipogenesis gene expression and related to inflammation after 48 and 96 weeks after the change from AZT+3TC+ABC (Trizivir®) to a…
- Trial name
- BIOKAL (NCT01031849)
- Testing
- Kaletra
- Where
- 2 sites in Spain
- Volunteers
- 7 people
- Sponsor
- Ines Perez
HIV Infections, Dyslipidemias
Seronegatives and Metabolic Abnormalities Protocol 2 (SAMA002): Study to Compare the Effect of Kaletra and Combivir® in HIV-Negative Healthy Subjects
This is a randomised study of the effect of treatment with Combivir (zidovudine [AZT] and lamivudine [3TC]) and Kaletra (lopinavir [LPVr]), alone and in combination, on the development of abnormalities in lipid and glucose…
- Conditions
- HIV Infections, Dyslipidemias, Glucose Metabolism Disorders, Metabolic Diseases
- Trial name
- NCT00192621
- Testing
- Combivir (zidovudine [AZT] / lamivudine [3TC]), Kaletra (lopinavir [LPVr])
- Where
- Australia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Kirby Institute
Lipodystrophy, Metabolic Syndrome
Prevalence of Lipodystrophy Syndrome and Its Role as Cause of Metabolic Disturbances
To evaluate the prevalence of lipodystrophy syndrome in patients receiving currently available antiretroviral drugs, and the prevalence of associated metabolic syndrome in HIV-infected patients with a previous diagnosis of…
- Trial name
- METALIP (NCT02614027)
- Testing
- Evaluation of metabolic syndrome, Evaluation of changes in fat by DXA while on current therapy
- Where
- Spain
- Volunteers
- 276 people
- Sponsor
- Asociacion para el Estudio de las Enfermedades Infecciosas
HIV Infections, Lipodystrophy
TH9507 in Patients With HIV-Associated Lipodystrophy
HIV lipodystrophy affects a significant proportion of patients treated with combination antiretroviral therapy (ART) and is characterized by excess visceral fat accumulation and loss of extremity and subcutaneous fat, in…
- Trial name
- NCT00123253
- Testing
- TH9507
- Where
- 42 sites in United States, Canada
- Volunteers
- 412 people
- Sponsor
- Theratechnologies
HIV Infections, HIV-Associated Lipodystrophy Syndrome
A Study of Physical and Metabolic Abnormalities in HIV Infected and Uninfected Children and Youth
The purpose of this study is to assess the prevalence of metabolic and physical abnormalities in HIV infected (via mother-to-child transmission) and uninfected children and youth.
- Conditions
- HIV Infections, HIV-Associated Lipodystrophy Syndrome, HIV Lipodystrophy Syndrome, Lipodystrophy
- Trial name
- NCT00069004
- Where
- 38 sites in United States, Puerto Rico
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV, AIDS
The Effects of Anabolic Steroids and Protease Inhibitors on People Living With HIV/AIDS
The main aim of the study is to investigate the combined effects of using anabolic steroids and protease inhibitors on fat metabolism and body composition of People Living with HIV/AIDS.
- Conditions
- HIV, AIDS, Lipodystrophy, Hyperlipidemia
- Trial name
- NCT00202241
- Testing
- testosterone injection
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Queen's University
HIV, Metabolic Diseases
Study of Lifestyle Modification in HIV Lipodystrophy
This study is designed to determine the effects of an intensive lifestyle modification program in patients with HIV and Metabolic Syndrome.
- Trial name
- NCT00111358
- Testing
- Lifestyle Modification, No lifestyle modification
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Massachusetts General Hospital
HIV/AIDS and Infections, Disorder Sleep
Quality of Life, Sleep, and Biomarkers in People With HIV/AIDS
Aim: Evaluate the influence of exercise, in different times, on quality of life, sleep and clinical parameters in people living with HIV/AIDS (PLHA). Methods: Intervention study, prospective.
- Conditions
- HIV/AIDS and Infections, Disorder Sleep, Lipodystrophy
- Trial name
- PLHA (NCT03445351)
- Testing
- Aerobic, resistance and concorrent.
- Volunteers
- 17 people
- Sponsor
- JULIANY DE SOUZA ARAUJO
HIV Infection
Pilot Study of Raltegravir Lipodystrophy IISP
The substitution of raltegravir for the NRTIs will result in some reversal of the long term adverse effect of lipodystrophy (specifically peripheral lipoatrophy) that is associated with the chronic use of NRTIs.
- Trial name
- NCT01164605
- Testing
- Raltegravir
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Southern California Institute for Research and Education
Metabolic Syndrome, HIV-1-infection
Effect of Berberine on Metabolic Syndrome, Efficacy and Safety in Combination With Antiretroviral Therapy in PLWH.
With current antiretroviral therapy, people living with HIV reach virological suppression faster, which in turn leads to a higher life expectancy.
- Conditions
- Metabolic Syndrome, HIV-1-infection, Glucose Intolerance, Dyslipidemias
- Trial name
- BERMESyH (NCT04860063)
- Testing
- Berberine
- Volunteers
- 40 people
- Sponsor
- Hospital Civil de Guadalajara
HIV-facial Lipoatrophy
Artefill for the Treatment of HIV-associated Facial Lipoatrophy
Artefill is an injectable facial filler device that is currently approved by the FDA for the correction of nasolabial folds. This study seeks to examine the use of Artefill in the treatment of HIV associated facial lipoatrophy.
- Trial name
- NCT02009462
- Testing
- Artefill dermal filler
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Gerald Pierone, Jr. M.D.
Hiv, HIV Infections
Changes in Weight, Body Composition and Metabolic Parameters After Discontinuing Dolutegravir or Tenofovir Disproxil
Randomized controlled parallel open-label study in persons living with HIV. The aim is to study weight changes in patients switching from a dolutegravir and tenofovir disoproxil containing regimen to either a dolutegravir or…
- Conditions
- Hiv, HIV Infections, HIV Lipodystrophy, Osteoporosis
- Trial name
- AVERTAS-2 (NCT04903847)
- Testing
- Dolutegravir/Lamivudine 50 MG-300 MG Oral Tablet [DOVATO], Doravirine/Lamivudine/Tenofovir Disoproxil Fumarate 100 MG-300 MG-300 MG Oral Tablet [DELSTRIGO]
- Where
- 5 sites in Denmark
- Volunteers
- 126 people
- Sponsor
- Thomas Benfield
HIV Infections
Metabolic Effects of Non-Thymidine Analogue Anti-HIV Medications
The purpose of this study is to observe the effects of certain anti-HIV medications on mitochondrial activity and fat cell death.
- Trial name
- NCT00433992
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections, Lipodystrophy-Syndrome
Role of the Autonomic Nervous System in HIV-Lipodystrophy
The study aims to characterise the influence of the autonomic nervous system activity on the development of the lipodystrophy syndrome in HIV-infected patients by measuring heart rate variability and various metabolic pathways in…
- Trial name
- NCT00149097
- Where
- Germany
- Volunteers
- 54 people
- Sponsor
- Hannover Medical School