Clinical trials: HIV Prevention
HIV
A Prospective, Observational Study of Individuals Who Seroconvert While Taking Truvada® for Pre-Exposure Prophylaxis (PrEP)
This study will evaluate HIV-1 RNA and the presence or absence of resistance at baseline and following seroconversion, assess the frequency of HIV-1 screening and screening method(s) used for evaluation of seroconverters, and…
- Trial name
- NCT01902472
- Where
- United States
- Volunteers
- 172 people
- Sponsor
- Gilead Sciences
HIV, Alcohol
GLP-1 Receptor Agonists to Decrease Ethanol and CVD Risk in HIV
The goal of this clinical trial is to learn if the drug semaglutide works to reduce alcohol intake among adults living with HIV. The main questions it aims to answer are: 1.
- Conditions
- HIV, Alcohol, Smoking Cigarette, Cardiovascular Disease Prevention
- Trial name
- GL1DER HIV RCT (NCT07221214)
- Testing
- Semaglutide (Rybelsus®)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Vanderbilt University Medical Center
HIV Infections
HIV Counseling and Testing and Linkage to Care in Uganda
This study will compare the effectiveness of brief versus detailed HIV counseling sessions, paired with referrals to either HIV-specific medical care or usual care, in reducing HIV risk behavior and in increasing treatment…
- Trial name
- NCT00648232
- Testing
- Voluntary brief HIV counseling and testing, Voluntary longer, more detailed HIV counseling and testing, Enhanced linkage to care
- Where
- Uganda
- Volunteers
- 3,415 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
HIV Pre-exposure Prophylaxis
Optimizing PrEP Uptake for African American Women in the South by Empowering Women to Make Informed HIV Prevention and Sexual Health Choices
Pilot testing of EMPOWER, a group sexual health intervention, to increase uptake and persistence of PrEP
- Trial name
- EMPOWER (NCT07173816)
- Testing
- EMPOWER
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Georgia
HIV Prevention, Primary Care
Clinic-based HIV Identification and Prevention Project Using Electronic Resources
Hybrid Type II effectiveness-implementation trial to investigate whether electronic medical and sexual history data collection with HIV risk categorization/scoring will increase pre-exposure prophylaxis (PrEP) uptake among…
- Conditions
- HIV Prevention, Primary Care, PrEP
- Trial name
- CHIPPER (NCT05412433)
- Testing
- Patient Level, Multilevel, Control
- Where
- United States
- Volunteers
- 1,170 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
HIV-1-infection, Unhealthy Alcohol Use
IGHID 12230 - An Implementation Trial of an Experiential Brief Alcohol Intervention for HIV Prevention
This study is a hybrid type 3, cluster randomized implementation trial to examine effective strategies to scale up the Brief Alcohol Intervention (BAI) in ART clinics in Vietnam.
- Trial name
- EBAI (NCT06358885)
- Testing
- Facilitation (FAC), Experiential Brief Alcohol Intervention (EBAI)
- Where
- Vietnam
- Volunteers
- 3,234 people
- Sponsor
- University of North Carolina, Chapel Hill
HIV/AIDS
Access to PrEP for MSM: Acceptability and Feasibility in Community-based Clinics in West Africa (CohMSM-PrEP)
This demonstration project will assess the acceptability and feasibility of pre-exposure prophylaxis (PrEP) for men who have sex with men (MSM) as part of a comprehensive HIV prevention package in community-based clinics in West…
- Trial name
- CohMSM-PrEP (NCT03459157)
- Testing
- HIV prevention package including PrEP
- Where
- 4 sites in Burkina Faso, Côte d’Ivoire and 2 more
- Volunteers
- 649 people, healthy volunteers welcome
- Sponsor
- ANRS, Emerging Infectious Diseases
HIV Infected Individuals, Osteopenia
Zoledronic Acid for the Prevention of TDF-sparing ART-induced Bone Mass Density Loss in Treatment-naive HIV Positive Individuals
The goal of this clinical trial is to learn if zolendric acid can prevent the anticipated deterioration of bone mass after antiviral treatment initiation for people that were recently diagnosed with HIV.
- Trial name
- NCT06762730
- Testing
- Zoledronic Acid 5 mg/Bag 100 ml Inj
- Where
- 3 sites in Israel
- Volunteers
- 110 people
- Sponsor
- Hadassah Medical Organization
HIV Infections
Backup With Combivir or Single Dose (SD) Truvada in Order to Avoid Non-nucleoside Reverse Transcriptase Inhibitor (NNRTI) Resistance After SD Nevirapine for the Prevention of Mother-to-child Transmission (PMTCT)
The aim of the study is to find short course alternatives to single dose (sd)nevirapine for the prevention of mother-to-child HIV-transmission with the same or better degree of transmission protection than sd nevirapine but with…
- Trial name
- NCT00346567
- Testing
- Zidovudine and Lamivudine (Combivir), Emtricitabine and Tenofovir (Truvada)
- Where
- Tanzania
- Volunteers
- 566 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
HIV Nonoccupational Post-exposure Prophylaxis in Men Who Have Sex With Men
Safety, Tolerability,and Adherence to Co-formulated Tenofovir-emtricitabine-rilpivirine Used as HIV Nonoccupational Post-exposure Prophylaxis in Men Who Have Sex With Men.
This study aims to describe the safety, tolerability and adherence to the coformulated anti-HIV drug tenofovir-emtricitabine-rilpivirine (eviplera) when given to men who have sex with men (MSM) following an actual or potential…
- Trial name
- EPEP (NCT01715636)
- Testing
- Eviplera = emtricitabine 200mg, rilpivirine 25mg, tenofovir 245mg
- Where
- 4 sites in Australia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Andrew Carr
HIV
Integrated Care Delivery of HIV Prevention and Treatment in AGYW in Zambia
The study team will test a multilevel package of interventions to connect adolescent girls and young women (AGYW) with a source of regular care to provide a sustainable platform for successful implementation of regular human…
- Trial name
- NCT03995953
- Testing
- SHIELD intervention (Support for HIV Integrated Education, Linkages to care, and Destigmatization), Integrated wellness care (IWC) clinics
- Where
- Zambia
- Volunteers
- 2,150 people
- Sponsor
- RTI International
HIV
CHWs, mHealth, and Combination HIV Prevention
Kasensero, a fishing community on Lake Victoria in Uganda, is a representative HIV "hotspot" with extremely high HIV prevalence (44.3%) and incidence (~3.9/100py), yet low HIV service utilization.
- Trial name
- mLAKE (NCT02556957)
- Testing
- HealthScouts, Standard of Care
- Where
- Uganda
- Volunteers
- 3,773 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Microbicide Delivery System Perceptibility and Acceptability
Developing Rectal USPE Measures
The purpose of this study is to: (a) adapt existing vaginal USPE items/instruments for evaluation of similar elements of rectal compartment use; (b) develop these scales using 3 distinct semi-solid formulations that represent a…
- Trial name
- Project DRUM (NCT02102867)
- Testing
- Gel, Cream, Liquid
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- The Miriam Hospital
HIV, Syphilis
Tenofovir/Emtricitabine With Doxycycline for Combination HIV and Syphilis Pre-exposure Prophylaxis in HIV-negative MSM
Men who have sex with men remain at high risk for HIV infection. Targeting prevention interventions to MSM at highest risk of seroconversion is an important goal of combination prevention interventions.
- Trial name
- DuDHS (NCT02844634)
- Testing
- Doxycycline 100mg PO daily x 12 months, Tenofovir/emtricitabine 200/300mg PO daily, Doxycycline 100mg PO daily x 6 months
- Where
- Canada
- Volunteers
- 52 people
- Sponsor
- British Columbia Centre for Disease Control
HIV, Alcohol; Harmful Use
Using CBPR to Engage Hazardous Drinking Women in the HIV Prevention and Care Continuum
Unhealthy alcohol use among women with and at risk for HIV can interrupt critical steps in the HIV prevention and care continuum, is associated with HIV transmission risk behaviors, and contributes to health disparities.
- Conditions
- HIV, Alcohol; Harmful Use, Mental Health Disorder
- Trial name
- NCT04090723
- Testing
- CBI-CC with peer navigation
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Johns Hopkins University
HIV Infections
A Network Intervention for Prevention of HIV Infection in Chennai, India - 1
The purpose of this study is to evaluate a peer-based HIV prevention intervention that targets active injection drug users and their drug and sex partners in Chennai India.
- Trial name
- NCT00218686
- Testing
- psychoeducational, control
- Where
- India
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
HIV Infections
Study of Tenofovir Disoproxil Fumarate (TDF) for Prevention of HIV
This Phase 2 study involving tenofovir disoproxil fumarate (TDF) will assess the extended safety of TDF 300 mg per day among young women who are not HIV-infected.
- Trial name
- NCT00122486
- Testing
- Tenofovir Disoproxil Fumarate
- Where
- 3 sites in Cameroon, Ghana and 1 more
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- FHI 360
HIV Infections
Improving Health Outcomes in Young Cisgender Men and Transgender Women (mLab App)
The mLab App combines HIV prevention information with push notifications/reminders to complete HIV testing and an automated image processing feature to provide real-time feedback on home-based HIV test results.
- Trial name
- NCT03803683
- Testing
- mLab App, HIV Prevention Information, HIV Home Tests
- Where
- 2 sites in United States
- Volunteers
- 525 people, healthy volunteers welcome
- Sponsor
- Rebecca Schnall, RN, MPH, PhD
HIV/AIDS Prevention, STI Prevention
Evaluating the Impact of Online Educator Microskill Training on Educator Knowledge and Skill
The goal of this clinical trial is to evaluate the efficacy of SkillTalk, a subscription-based microskills video training library designed to enhance the skills of high school sex educators to implement the frequently used core…
- Conditions
- HIV/AIDS Prevention, STI Prevention, Pregnancy Prevention
- Trial name
- NCT05950828
- Testing
- SkillTalk
- Where
- United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Philliber Research & Evaluation
HIV Prevention
Study for IFE4PrEP Intervention on PrEP Uptake by Southern African American Women
Purpose: This study is partnering with communities to identify the best ways to provide HIV prevention communication and services for women living in public housing who have been disproportionately affected by HIV but underserved…
- Trial name
- IFE4PrEP (NCT05087927)
- Testing
- Gain framing plus demographically targeted photos, Loss framing plus demographically targeted photos, Gain framing plus not demographically targeted photos
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill