Clinical trials: HIV Treatment Adherence
HIV
Treatment Advocacy Intervention for HIV-Positive African Americans
The investigators hypothesize that participants in the treatment advocacy intervention will show significantly better HIV treatment adherence than will participants in the no-treatment (wait-list) control group.
- Trial name
- TA (NCT01350544)
- Testing
- Treatment Advocacy
- Where
- United States
- Volunteers
- 216 people
- Sponsor
- Boston Children's Hospital
Depression
Comparative Trial of Antidepressant Treatment Models in HIV Care in Uganda
This study compares two models for implementing antidepressant treatment in 10 HIV clinics in Uganda. Using a cluster randomization, 5 clinics implement a task-shifting, protocolized model, and 5 others rely on clinical acumen.
- Trial name
- INDEPTH-Uganda (NCT02056106)
- Testing
- antidepressant therapy
- Where
- Uganda
- Volunteers
- 1,252 people
- Sponsor
- RAND
HIV
Emtricitabine/Tenofovir Alafenamide as Salvage ART
Background: HIV attacks the immune system. Antiretroviral therapy (ART) is a combination of drugs used for treating HIV infection. For some people, ART drugs stop working against their HIV.
- Trial name
- NCT02556333
- Testing
- FTC/TAF
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV/AIDS
Video-Intervention to Inspire Treatment Adherence for Life for Adolescents
This a two-arm randomized controlled trial whose objective is to explore the impact of VITAL Start for Adolescents (VS4A), a video-based antiretroviral treatment (ART) adherence intervention, on a range of implementation and…
- Trial name
- VS4A (NCT07064785)
- Testing
- Video-based ART adherence counseling, Standard of Care (SOC)
- Where
- 32 sites in Malawi
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Hepatitis C, HIV
A Peer-based Mobile-health Intervention to Increase Access & Adherence to Hepatitis C Treatment & HIV Viral Suppression
The purpose of this study is to test an intervention designed to train persons who inject drugs (PWID) and are infected with hepatitis C (HCV) and HIV in communication skills to 1) promote new HCV treatment and care 2) risk…
- Conditions
- Hepatitis C, HIV, Risk Reduction Behavior
- Trial name
- HCV-TTP (NCT02772328)
- Testing
- Peer Mentor
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
PrEP Uptake Experiences, PrEP Adherence Experiences
Trans STAIR: Implementing an Evidence Based Trauma Treatment With Community Led PrEP Navigation
This pilot trial will leverage "PrEP Well," an ongoing multi-level implementation strategy for providing PrEP in transgender/gender diverse (TGD)-serving contexts by integrating peer-led PrEP navigation with programming that…
- Conditions
- PrEP Uptake Experiences, PrEP Adherence Experiences, Mental Health Symptoms
- Trial name
- NCT06724965
- Testing
- Trans STAIR, PrEP Well
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- San Diego State University
HIV-1-infection, Medication Adherence
Implementing Cabenuva in Arkansas HIV Programs
This study seeks to address this gap by studying two Cabenuva delivery strategies conducted at six outpatient HIV clinics in Arkansas, a Southern state with a large population of rural, poor, and African-American residents.
- Conditions
- HIV-1-infection, Medication Adherence, Satisfaction, Patient
- Trial name
- NCT05096949
- Testing
- Home visit delivery strategy
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Arkansas
Adherence, Medication
Life-Steps Counseling to Enhance Adherence and Engagement in PrEP Care
The purpose of this study is to test how different types of interventions may affect how someone takes their pre-exposure prophylaxis (PrEP) medication.
- Trial name
- NCT04316715
- Testing
- Lifesteps for PrEP, Daily text message reminders
- Where
- 2 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Miami
HIV Infection
Typology of Adherence in Adolescents: Phase II
A number of factors influence HIV-positive adolescents' acceptance of and willingness to continue taking anti-HIV medicines. These factors include mental health and substance abuse issues, barriers such as lack of medical…
- Trial name
- NCT00106678
- Where
- 17 sites in United States, Puerto Rico
- Volunteers
- 1,200 people
- Sponsor
- University of North Carolina, Chapel Hill
Tuberculosis, HIV/AIDS
Alcohol Drinkers' Exposure to Preventive Therapy for TB (ADEPTT)
The Alcohol Drinkers' Exposure to Preventive Therapy for TB (ADEPTT) will examine the safety and tolerability of, and adherence to, 6 months of daily INH (6H) in 300 TB and HIV-infected persons (200 drinkers and 100 non-drinkers)…
- Conditions
- Tuberculosis, HIV/AIDS, Alcohol Abuse
- Trial name
- ADEPTT (NCT03302299)
- Testing
- Isoniazid 300 Mg ORAL TABLET, Pyridoxine 25 Mg Oral Tablet
- Where
- Uganda
- Volunteers
- 302 people
- Sponsor
- University of California, San Francisco
Malaria in Pregnancy, Adherence, Treatment
Acceptability and Feasibility in the Context of the IMPROVE Trial in Kenya
This multi-centre study will compare the acceptability, feasibility, cost and incremental cost-effectiveness of intermittent preventive treatment (IPTp) with dihydroartemisinin-piperaquine (DP) with or without azithromycin to the…
- Trial name
- NCT04160026
- Testing
- Monthly intermittent preventive treatment with dihydroartemisnin-piperaquine, Monthly intermittent preventive treatment with sulfadoxine-pyrimethamine, Monthly intermittent preventive treatment with dihydroartemisnin-piperaquine with targeted information transfer
- Where
- Kenya
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- Liverpool School of Tropical Medicine
HIV, Substance Abuse
Adherence to HIV Therapy in Heroin Addicts: Oral vs XR-NTX
Substance use, particularly the compulsive behaviors associated with addiction, lead to unhealthy behaviors including non-adherence to antiretroviral therapy (ART) and treatment failure.
- Conditions
- HIV, Substance Abuse, HIV Infections
- Trial name
- NCT01101815
- Testing
- Oral Naltrexone, Naltrexone Implant, Group Drug Counseling Manual Driven
- Where
- 2 sites in Russia
- Volunteers
- 200 people
- Sponsor
- University of Pennsylvania
HIV Treatment
Real-Life Outcomes of TAF/FTC/BIC in HIV Patients in Colombia
HIV remains a major global health issue, with 38 million people affected, and significant challenges in diagnosis and treatment due to stigma and socioeconomic factors.
- Trial name
- NCT06829082
- Testing
- BIKTARVY 50Mg-200Mg-25Mg Tablet
- Where
- Colombia
- Volunteers
- 161 people
- Sponsor
- Servicios de Salud IPS Suramericana S.A.S
HIV/AIDS
Positive Affect Promotion to Empower Optimal Adherence to HIV Therapy
This study assesses the feasibility and acceptability of the APPEAL program, a 3-session intervention designed to promote positive affect among men and women living with HIV infection.
- Trial name
- NCT04035759
- Testing
- APPEAL
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- State University of New York - Downstate Medical Center
Depression, Medication Adherence
Cognitive Behavioral Therapy on Adherence and Depression (CBT-AD) Among HIV/AIDS Patients
Depression is highly comorbid with HIV/ AIDS and is associated with worse poor adherence to antiretroviral therapy (ART), and potentially to long-term immune functioning. Cognitive behavioral therapy may solve these problem.
- Trial name
- NCT06109610
- Testing
- Cognitive Behavioral Therapy
- Where
- Ethiopia
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Mattu University
Human Immunodeficiency Virus, Depression
Support for Perinatal Adherence and Depression
The main aim was to conduct a pilot field test of a group-based depression and adherence counseling intervention with HIV-infected women in the perinatal period.
- Trial name
- INSPireD (NCT03069417)
- Testing
- Integrating Nuanced Support for Perinatal adherence and Depression
- Where
- 2 sites in United States, South Africa
- Volunteers
- 23 people
- Sponsor
- Massachusetts General Hospital
HIV Infections
Computerized Counseling to Promote Positive Prevention and HIV Health in Kenya
The purpose of this study is to see if a computerized counseling tool helps patients reduce their sexual transmission risk and improve their antiretroviral adherence.
- Trial name
- CARE+ Kenya (NCT01015989)
- Testing
- CARE+ Kenya brief computer risk assessment session, CARE+ Kenya computer counseling session
- Where
- 2 sites in Kenya
- Volunteers
- 236 people, healthy volunteers welcome
- Sponsor
- New York University
HIV-1-infection, Mental Health Issue
SYV: A Mental Health Intervention to Improve HIV Outcomes in Tanzanian Youth
The overall objectives of this proposal are to support positive coping strategies that bolster mental health and lead to improved HIV outcomes among Young People Living with HIV (YPLWH).
- Conditions
- HIV-1-infection, Mental Health Issue, Adherence, Medication
- Trial name
- NCT05374109
- Testing
- SYV: Sauti ya Vijana (The Voice of Youth intervention)
- Where
- 6 sites in Tanzania
- Volunteers
- 690 people
- Sponsor
- Duke University
HIV and Tuberculosis Co-infection
Nutritional Support for HIV-Tuberculosis Co-infected Adults in Senegal, West Africa
Food insecurity can contribute to poor adherence to both tuberculosis treatment and antiretroviral therapy (ART). Interventions that target food insecurity have the potential to improve treatment adherence and decrease mortality.
- Trial name
- NCT03711721
- Testing
- Food basket, Ready-to-Use Therapeutic Food
- Volunteers
- 26 people
- Sponsor
- University of Washington
Medication Adherence
China Adherence Through Technology Study
The CATS project is designed to increase understanding of interventions that are feasible and effective in helping injection drug users (IDU) or other patients at high risk of poor medication adherence who are HIV-positive to…
- Trial name
- CATS (NCT01722552)
- Testing
- adherence feedback, standard of care
- Where
- 2 sites in United States, China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Boston University