Clinical trials: HIV Treatment Adherence
Hiv, Transmission Vertical
Enhanced Mentor Mother Strategy for Pregnant and Postpartum Women Living With HIV
Mentor Mothers (MMs) are peer supporters who help pregnant and postpartum women living with HIV (WLHIV) as they receive prevention of mother-to-child transmission of HIV (PMTCT) services in resource-limited settings like Kenya.
- Conditions
- Hiv, Transmission Vertical, Viremia, Adherence, Treatment
- Trial name
- PIE-eMMs (NCT06999928)
- Testing
- Enhanced Mentor Mother Strategy
- Where
- Kenya
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Indiana University
HIV, Adherence
Evaluation of a Computer-Based System Using Cell Phones for HIV People in Peru
The investigators propose to develop and evaluate a computer-based intervention using cell phones to enhance adherence to antiretroviral treatment (ART) and support of HIV transmission risk-reduction among adult HIV-positive…
- Conditions
- HIV, Adherence, Sexual Behavior, HIV Infections
- Trial name
- Cell-POS (NCT01118767)
- Testing
- Cell phone intervention
- Where
- 2 sites in Peru
- Volunteers
- 210 people
- Sponsor
- Universidad Peruana Cayetano Heredia
HIV Infection, HIV Infections
Physician Focused Intervention to Improve Adherence With HIV Antiretrovirals
We hypothesized that providing physicians treating with HIV disease, at the time of a routine outpatient visit, with a detailed report describing patients' adherence with HIV antiretroviral medications, would improve the quality…
- Trial name
- MAP (NCT00870792)
- Testing
- Adherence report
- Where
- United States
- Volunteers
- 156 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Hiv, Adherence, Patient
Post-release Retention in HIV Care for Ex-inmates in South Africa
HIV remains the leading cause of death in South Africa as a result of a failure of people living with HIV to seek HIV treatment and be retained in care.
- Trial name
- NCT03340428
- Testing
- Transition Community Adherence Club (TCAC)
- Where
- South Africa
- Volunteers
- 176 people
- Sponsor
- Johns Hopkins University
HIV Infection Primary
Integrated Navigation Services for Treatment Adherence, Counseling, and Research
The goal of this research is to determine whether a Community Health Worker (CHW) intervention including a mobile telehealth (M-Health) component can help achieve long term viral suppression among Black people with poorly…
- Trial name
- INSTACARE (NCT04663152)
- Testing
- INSTACARE
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Miami
PreTerm Birth
Feasibility of Vaginal Progesterone to Reduce HIV-Associated Preterm Birth
More than 1.5 million HIV-infected women become pregnant each year. Approximately half have access to antiretroviral therapy (ART), but all are at increased risk of preterm birth (PTB).
- Trial name
- VP (NCT02970552)
- Testing
- Vaginal Progesterone
- Where
- Zambia
- Volunteers
- 140 people
- Sponsor
- University of North Carolina, Chapel Hill
HIV/AIDS
Youth Engagement Study: Intervention to Increase HIV Treatment Engagement and Adherence for Young People Living With HIV
This pragmatic adaptive clinical trial will test the effects of a Stigma-Motivational-Decision intervention designed to increase HIV treatment engagement, retention, and medication adherence for substance using adolescents and…
- Trial name
- YES (NCT03665532)
- Testing
- Youth Engagement in Services
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- University of Connecticut
HIV Infections
Adherence Interventions for HIV Youth Via Text & Cell Phone - Sequential Multiple Assignment Randomized Trial (SMART)
The purpose of this study is to test an adaptive adherence intervention, which utilizes two mobile health (mHealth) intervention designs, in an effort to promote adherence to antiretroviral therapy (ART) and achieve and maintain…
- Trial name
- SMART (NCT03535337)
- Testing
- CPS, SMS
- Where
- United States
- Volunteers
- 83 people
- Sponsor
- Florida State University
HIV Infections
Effect of Medication Diaries on Adherence to Highly Active Antiretroviral Drugs Among HIV-1 Infected Kenyan Children
Following significant reduction in antiretroviral drug prices over the past two years, more HIV-1 infected African adults and children are gaining access to treatment.
- Trial name
- NCT00194545
- Testing
- Medication diaries
- Where
- Kenya
- Volunteers
- 100 people
- Sponsor
- University of Washington
HIV
PRO 140 for Human Immunodeficiency Virus
PRO 140 2102 is a multicenter, randomized, double-blind, placebo-controlled, clinical trial of observed systemic, long-acting, anti-HIV treatment with a monoclonal CCR5 antibody (PRO 140) as an adjunct to a new, optimized, oral…
- Trial name
- NCT02438345
- Testing
- PRO 140
- Where
- United States
- Sponsor
- Drexel University
HIV/AIDS
International HIV Antiretroviral Adherence, Resistance and Survival
Real-time Wireless Adherence Monitoring to HIV Antiretroviral Therapy in Rural Uganda.
- Trial name
- UARTO (NCT01596322)
- Where
- Uganda
- Volunteers
- 750 people
- Sponsor
- Massachusetts General Hospital
HIV, Opiate Dependence
Project FIRST - Financial Incentives to Reduce Substance Use and Improve Treatment
This study will test whether contingency management (monetary vouchers contingent on abstinence from drugs) that reinforces one behavior (achieving abstinence from drugs) leads to improved outcomes in other related behaviors…
- Trial name
- Project FIRST (NCT01376570)
- Testing
- Abstinence-reinforcing contingency management intervention, Performance Feedback intervention
- Where
- 3 sites in United States
- Volunteers
- 242 people
- Sponsor
- Albert Einstein College of Medicine
HIV/AIDS
Behavioral Intervention to Enhance HIV Test/Treat
Prevention strategies that aim to test and treat people for HIV infection are undermined by HIV treatment non-adherence and sexually transmitted co-infections (STI).
- Trial name
- NCT01752777
- Testing
- Infectiousness Risk Reduction, General Health Improvement
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- University of Connecticut
Adherence, Patient
Promoting Engagement in the Drug Resistant TB-HIV Care Continuum in South Africa PRAXIS Study
The goal of the proposed study is to enhance adherence and retention in care for M/XDR-TB HIV patients through enhanced standard of care, targeted transition to outpatient medication self-administration prior to hospital…
- Trial name
- PRAXIS (NCT04032730)
- Testing
- Wisepill device
- Where
- South Africa
- Volunteers
- 171 people
- Sponsor
- Centre for the AIDS Programme of Research in South Africa
Stigma, Social, HIV/AIDS
Transgender Education for Affirmative and Competent HIV and Healthcare
Educational workshops are an efficacious strategy to increase healthcare providers' ability to provide gender-affirming care for transgender (trans) people.
- Conditions
- Stigma, Social, HIV/AIDS, Health Care Acceptability
- Trial name
- TEACHH (NCT04096053)
- Testing
- TEACHH
- Where
- Canada
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- University of Toronto
HIV, Depression
Therapy Targeting Depression and HIV Treatment Adherence (The TRIAD Study)
This study will test a therapy for both helping people adhere to their HIV medication regimens and treating them for depression.
- Conditions
- HIV, Depression, HIV Infections
- Trial name
- NCT00951028
- Testing
- Cognitive behavioral therapy (CBT) for adherence and depression (CBT-AD), Life-steps adherence treatment, Information and supportive psychotherapy (ISP) for adherence and depression (ISP-AD)
- Where
- 4 sites in United States
- Volunteers
- 240 people
- Sponsor
- Massachusetts General Hospital
HIV/AIDS
DuoPACT Pilot Intervention
The investigators will pilot test the intervention by randomizing 30 couples to one of three conditions: 1) DuoPACT, the newly-developed couples intervention; 2) Life Steps, a standardized antiretroviral adherence intervention…
- Trial name
- NCT02181881
- Testing
- DuoPACT, Life Steps
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of California, San Francisco
HIV Infection
Use of Incentives to Retain Drug Users in HIV Therapy
In many urban centres including Vancouver's Downtown Eastside, there is a high rate of HIV infection among users of illicit drugs.
- Trial name
- Incentives-2 (NCT01488942)
- Testing
- monetary reinforcer
- Where
- Canada
- Volunteers
- 139 people
- Sponsor
- University of British Columbia
HIV, Hypertension
INTEGRATE-RX: Integrating Clinical Pharmacists in HIV Care to Mitigate Last-Mile Challenges and Reduce Cardiovascular Disease Burden
The risk of heart attacks and stroke is two times higher among people living with HIV (PLWH), as compared to the general population.
- Conditions
- HIV, Hypertension, Cardiovascular Disease Prevention
- Trial name
- INTEGRATE-RX (NCT07711366)
- Testing
- INTEGRATE-RX
- Where
- 2 sites in Kenya
- Volunteers
- 450 people
- Sponsor
- Temple University
HIV Infections, Covid19
Bidirectional, Upbeat Communication and Differentiated, Distanced Care for Young People
Sub Saharan Africa is home to only 12% of the population, but accounts for approximately 70% of the global burden of HIV infection and 84% of infections among young people aged 10-24 years.
- Conditions
- HIV Infections, Covid19, Health Care Utilization, Gender-based Violence
- Trial name
- BUDDY (NCT04781400)
- Testing
- Mobile phone support, Remote service delivery model
- Where
- South Africa
- Volunteers
- 536 people, healthy volunteers welcome
- Sponsor
- Desmond Tutu HIV Foundation