Clinical trials: HIV Treatment Adherence
Patient Compliance, AIDS
Adherence, Improvement Measure (AIM) System
In this project, we will work directly with underserved patients in a safety-net setting to conduct a randomized clinical trial of standard-of-care adherence counseling versus a novel adherence intervention embedded in an…
- Trial name
- AIM (NCT01252212)
- Testing
- SMS medication adherence, No SMS adherence reminder
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- University of California, San Francisco
Acquired Immunodeficiency Syndrome
Longitudinal Study of HAART, Social Networks, & Adherence
Our study is a randomized controlled trial that aims to evaluate the effectiveness of modified directly observed therapy (mDOT) to (1) increase both short and long term adherence to HAART treatment, and (2) improve clinical…
- Trial name
- NCT00272220
- Testing
- modified directly observed therapy (mDOT)
- Where
- Mozambique
- Volunteers
- 350 people
- Sponsor
- University of Washington
HIV Infections, Men
Improving HIV Testing, Linkage, and Retention in Care for Men Through U=U Messaging
This study will evaluate the impact of U=U messaging and counseling on gaps in the HIV care cascade for men, including testing uptake and ART initiation (Aim 1), achieving viral suppression and retention in care (Aim 2) in two…
- Conditions
- HIV Infections, Men, Treatment Adherence
- Trial name
- NCT05602376
- Testing
- U=U testing messaging scripts, U=U adherence messaging scripts
- Where
- 2 sites in South Africa
- Volunteers
- 3,642 people, healthy volunteers welcome
- Sponsor
- Desmond Tutu HIV Foundation
HIV Prevention, HIV Risk
Evaluating an Interactive Digital Toolkit for Women's PrEP Implementation
The goal of this study is to test if a Digital PrEP Toolkit helps cisgender women learn about and access PrEP in Alabama and Mississippi. PrEP is a medication that prevents HIV infection.
- Conditions
- HIV Prevention, HIV Risk, Sexual and Reproductive Health
- Trial name
- NCT07292584
- Testing
- Interactive Digital PrEP Toolkit
- Where
- 4 sites in United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
HIV
Treatment Advocacy Intervention for HIV-Positive African Americans
The investigators hypothesize that participants in the treatment advocacy intervention will show significantly better HIV treatment adherence than will participants in the no-treatment (wait-list) control group.
- Trial name
- TA (NCT01350544)
- Testing
- Treatment Advocacy
- Where
- United States
- Volunteers
- 216 people
- Sponsor
- Boston Children's Hospital
HIV Infections
A Study to Prepare for Future HIV Vaccine Studies
The purpose of this study is to determine the ability of HVTN sites to recruit and retain people at risk for HIV infection for possible future HIV vaccine research studies.
- Trial name
- NCT00029744
- Where
- 2 sites in Haiti, Peru
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV/AIDS and Infections, Patient Preference
Patient-Reported Outcomes HIV BItherapy
HIV Treatment simplification strategies that involve switching cART regimens from four or three antiretrovirals to two in virologically suppressed patients living with HIV are now available in order to reduce long-term toxicity…
- Trial name
- PROBI (NCT04788784)
- Where
- 3 sites in France
- Volunteers
- 250 people
- Sponsor
- University Paris 7 - Denis Diderot
Hiv, Medication Adherence
Development of a Silica Microparticle Taggant System to Measure ART Adherence
Developing technologies to help measure and provide tools to support medication-taking behaviors (medication adherence) is an important step to ending the human immunodeficiency virus (HIV) epidemic.
- Conditions
- Hiv, Medication Adherence, Compliance, Medication
- Trial name
- TruTag (NCT06465862)
- Testing
- TruTag System, Biktarvy Pill
- Sponsor
- Brigham and Women's Hospital
Antiretroviral Therapy (ART) Adherence Among Adolescents Living With HIV
Adaptive Text Messaging and Non-Monetary Incentives to Sustain ART Adherence Among Adolescents Living With HIV in Ethiopia
Many adolescents living with HIV have difficulty taking their medicine on time, which can make it less effective and affect their health.
- Trial name
- NCT07377760
- Testing
- Non-adaptive reminder text messaging, Adaptive interventions, The control arm
- Where
- Ethiopia
- Volunteers
- 327 people
- Sponsor
- Arba Minch University
HIV
National Evaluation of PI-based 2nd Line Efficacy in Cambodia
Medium and long term efficacy of PI-based 2nd line antiretroviral (ARV) therapy in Cambodia is poorly documented when the numbers of patients on treatment and their duration are increasing.
- Trial name
- NCT01801618
- Where
- 13 sites in Cambodia
- Volunteers
- 15,001,351 people
- Sponsor
- ANRS, Emerging Infectious Diseases
HIV Infection
Enhanced Adherence Counselling, Pre-Post Study
Viral suppression among children and adolescents in Kenya is currently sub-optimal at 60% and 63% respectively. Under the current Kenya Ministry of Health Guidelines, clients with viral load of >1000 copies/ml, should receive a…
- Trial name
- NCT04915469
- Testing
- Standardized enhanced adherence counseling package
- Where
- Kenya
- Volunteers
- 741 people
- Sponsor
- Elizabeth Glaser Pediatric AIDS Foundation
HIV
Effectiveness of Mobile Phone Technology on Adherence and Treatment Outcomes Among HIV Positive Patients on ART
The objective of this study was to determine the effectiveness of mobile phone technology (SMS and telephone call reminders) in improving adherence and treatment outcomes among HIV positive patients on ART in Malaysia.
- Trial name
- NCT02677675
- Testing
- Intervention (reminder module)
- Volunteers
- 242 people
- Sponsor
- Universiti Putra Malaysia
Acquired Immunodeficiency Syndrome, HIV Infections
Computer-Assisted Adherence Program for Patients Taking Anti-HIV Drugs
The purpose of this study is to evaluate the effectiveness of a computer-assisted, self-administered adherence program for patients on complicated anti-HIV drug regimens.
- Trial name
- NCT00051766
- Testing
- Computer-based Intervention
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Antiretroviral Therapy (ART) Adherence, Alcohol Consumption
Pilot of an Intervention to Reduce Alcohol Use and Improve ART Adherence Among Men Living With HIV With Pregnant Partners in Uganda.
Hazardous alcohol use, which is common among men in Uganda, is a primary driver of both HIV risk and intimate partner violence (IPV) in this setting.
- Trial name
- Kisoboka Amaka (NCT06900634)
- Testing
- Kisoboka Amaka, Screening and Referral
- Where
- Uganda
- Volunteers
- 60 people
- Sponsor
- San Diego State University
HIV Infections
Adherence to Antiretroviral Therapy in HIV Infected Individuals in Assiut Governorate, Egypt
Egypt is a HIV low prevalence country but between 2010 and 2019 newly infected cases have more than quadrupled, and the rise continues at an alarming pace.
- Trial name
- NCT05953844
- Volunteers
- 278 people
- Sponsor
- Assiut University
Risk Behavior, Medication Adherence
Secondary HIV Prevention and Adherence Among HIV-infected Drug Users
This study will test whether 3H+ (Holistic Health for HIV) is comparable to the original HHRP+ (Holistic Health Recovery Program) in reducing HIV risk behaviors and improving ART (Antiretroviral Therapy) adherence in a randomized…
- Conditions
- Risk Behavior, Medication Adherence, HIV
- Trial name
- NCT01741311
- Testing
- 3H+ (Holistic Health for HIV), HHRP+ (Holistic Health Recovery Program)
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- University of Connecticut
HIV
Longitudinal Pediatric Palliative Care: Quality of Life & Spiritual Struggle
Our goal is to advance palliative care to adolescents and their families. We hope our study will decrease suffering (psychological, spiritual, physical) and increase quality of life (QOL).
- Trial name
- FACE (NCT01289444)
- Testing
- FAmily CEntered (FACE) ACP, Healthy Living Control
- Where
- 5 sites in United States
- Volunteers
- 216 people
- Sponsor
- Maureen Lyon
HIV Infections, Contraception
Kuwa Free! - Live Free!
The study investigators are conducting foundational pharmacokinetic (PK) and qualitative studies, among 15-24 years old (inclusive) adolescent girls and young women living with HIV (AGYWLHIV) already on oral antiretroviral…
- Conditions
- HIV Infections, Contraception, Drug-drug Interaction
- Trial name
- NCT05044962
- Testing
- Cabotegravir/ Rilpivirine, Etonogestrel (ETG) implant, Intramuscular depo-medroxyprogesterone acetate (IM DMPA)
- Where
- Kenya
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
HIV Infections, Substance Use
SmartSteps: A Context-Aware, PrEP Adherence Intervention for Individuals With Substance Use Disorder
This is a single-arm, observational study of HIV-negative MSM with substance use disorder. Those who meet pre-screening criteria will attend a Screening Visit (Visit 1), where the informed consent process will be conducted and…
- Conditions
- HIV Infections, Substance Use, Adherence, Medication, Adherence, Treatment
- Trial name
- SmartSteps (NCT05378399)
- Testing
- Descovy or Truvada, ID-Cap System, Beiwe
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Brigham and Women's Hospital
HIV
Youth mHealth Adherence Intervention for HIV+ YMSM
This study will help determine feasibility, acceptability, and preliminary efficacy of an app for HIV medication adherence over a 3-month period.
- Trial name
- NCT03092115
- Testing
- HIV medication adherence app
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia