Clinical trials: HIV Treatment Adherence
Hepatitis C, HIV Coinfection
Supporting Treatment Outcomes Among PWID
The goal of this study is to improve HCV care continuum outcomes for people who inject drugs (PWID), reduce potential onward transmission to others and improve HIV outcomes among those who are HIV/HCV coinfected.
- Trial name
- STOP-C (NCT04652804)
- Testing
- Low intensity HCV treatment adherence support, Medium intensity HCV treatment adherence support, High intensity HCV treatment adherence support
- Where
- India
- Volunteers
- 3,000 people
- Sponsor
- Johns Hopkins University
HIV Infections
HealthcAre sUppoRt fOr Remote HIV pAtients
Adherence to antiretroviral therapy (ART) is crucial for treatment success in HIV+ patients. This study proposes the use of a smartphone application, specifically developed for this project, to monitor ART adherence and assess…
- Trial name
- AURORA (NCT06563284)
- Testing
- AURORA Mobile App
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria
HIV Infections
Modified Directly Observed Therapy for Improving Antiretroviral Therapy Adherence in People With HIV
This study will evaluate the effectiveness of a modified directly observed therapy program in increasing antiretroviral therapy adherence in poor, HIV-infected residents of urban communities.
- Trial name
- NCT00339092
- Testing
- Modified Directly Observed Therapy, Standard Care
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Massachusetts General Hospital
HIV Infections
A Study of an Adherence Plan to Help HIV-Positive Patients Take Their First Anti-HIV Medications Correctly
The purpose of this study is to see if observed therapy can help HIV-positive patients stick to their anti-HIV medication schedule.
- Trial name
- NCT00001122
- Testing
- Nelfinavir mesylate, Efavirenz, Stavudine
- Where
- 2 sites in United States
- Volunteers
- 74 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Medication Adherence
Motivational Enhancement System for Adherence (MESA) for Youth Starting ART
This study is a multi-site (Detroit, MI; Los Angeles, CA; Philadelphia, PA, Washington, DC; Aurora, CO; Miami, FL; and Baltimore, MD), two-group randomized controlled trial testing a two-session intervention designed to increase…
- Trial name
- MESA (NCT02761746)
- Testing
- MESA
- Where
- 7 sites in United States
- Volunteers
- 155 people
- Sponsor
- Wayne State University
Behavioral Intervention, Viral Suppression of HIV Infection
Reactive Driven Support for Treatment, Adherence, Resilience, and Thriving (reSTART) Clinical Trial
Men who are living with HIV and use stimulants face many challenges and barriers that may interfere with remembering to take their HIV medication.
- Conditions
- Behavioral Intervention, Viral Suppression of HIV Infection, ART Adherence
- Trial name
- reSTART (NCT07125235)
- Testing
- reSTART Objective Adherence Self-Monitoring and Postive Affect mHealth Intervention, urine tenofovir point-of-care self-test
- Where
- United States
- Volunteers
- 270 people
- Sponsor
- University of California, San Francisco
HIV Infections, ART
Accelerated ART Initiation for PWHIV Who Are Out of Care
The main purpose of the study is to evaluate the effectiveness, of the ACCELERATE model of care to achieve HIV viral suppression at Week 24.
- Conditions
- HIV Infections, ART, Noncompliance, Patient
- Trial name
- ACCELERATE (NCT06374758)
- Testing
- The Accelerate model of care, bictegravir/emtricitabine/tenofovir alafenamide 50/200/25 mg
- Where
- 4 sites in United States
- Volunteers
- 120 people
- Sponsor
- University of Missouri-Columbia
mHealth, PMTCT
Mobile Strategies for Women's and Children's Health: Optimizing Adherence and Efficacy of PMTCT/ART
The investigators are conducting a 3-arm randomized trial comparing the effects of unidirectional SMS (ie: "push" messaging to participant) vs. bidirectional SMS dialogue between participant and provider vs.
- Conditions
- mHealth, PMTCT, Adherence, Medication, SMS
- Trial name
- Mobile WAChx (NCT02400671)
- Testing
- SMS messaging
- Where
- 6 sites in Kenya
- Volunteers
- 825 people, healthy volunteers welcome
- Sponsor
- University of Washington
HIV
Effectiveness of Mobile Phone Technology on Adherence and Treatment Outcomes Among HIV Positive Patients on ART
The objective of this study was to determine the effectiveness of mobile phone technology (SMS and telephone call reminders) in improving adherence and treatment outcomes among HIV positive patients on ART in Malaysia.
- Trial name
- NCT02677675
- Testing
- Intervention (reminder module)
- Volunteers
- 242 people
- Sponsor
- Universiti Putra Malaysia
HIV
Adherence to Dolutegravir and Outcome
The main assumption is that the dolutegravir can get virologic suppression to suboptimal adherence levels (between 80 and 95%, and after treatment interruptions) where other molecules are not capable, due to their…
- Trial name
- DOLUTECAPS (NCT02878642)
- Where
- France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Caen
HIV Infections
Durability of Adherence in Self-Management of HIV
Adherence to highly active antiretroviral therapy (HAART) is critical to successful treatment of HIV. This study tested an intervention that helps people infected with HIV take all their medications when and how they were…
- Trial name
- DASH (NCT00991302)
- Testing
- CAP-IT
- Where
- 2 sites in United States, Peru
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
HIV
IMplementation of CAB+RPV LA for People With HIV in Non-Metropolitan Areas
The goal of this implementation science study is to learn about the experience of receiving and providing cabotegravir + rilpivirine long-acting (CAB+RPV LA) injections as treatment for human immunodeficiency virus (HIV) for…
- Trial name
- IM-CAPABLE (NCT06451341)
- Testing
- Acceptability of Intervention Measure (AIM), Intervention Appropriateness Measure (IAM), Feasibility of Intervention Measure (FIM)
- Where
- 4 sites in United States
- Volunteers
- 75 people
- Sponsor
- University of Nebraska
Adherence, Medication, Risk Behavior
DOT Diary Optimization Pilot: A Pilot Study to Optimize the DOT Diary App to Measure PrEP Adherence
The researchers are working with a technology company, AiCure, to develop a smartphone app, DOT Diary, which combines two drug adherence strategies.
- Conditions
- Adherence, Medication, Risk Behavior, Pre-Exposure Prophylaxis, HIV Prevention
- Trial name
- NCT03387462
- Testing
- Emtricitabine / Tenofovir Disoproxil Oral Tablet, DOT Diary mobile app
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Public Health Foundation Enterprises, Inc.
Substance-Related Disorders, Mental Disorder
Community Health Worker Training to Reduce Depression and Substance Use Stigma in TB/HIV Care in South Africa
Poor engagement in care contributes to HIV- and TB-related morbidity and mortality in South Africa (SA). Community health workers (CHWs) are frontline lay health workers who work to re-engage patients who are lost to follow-up…
- Conditions
- Substance-Related Disorders, Mental Disorder, Social Stigma, Depression
- Trial name
- Siyakhana (NCT05282173)
- Testing
- Siyakhana CHW Training
- Where
- South Africa
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- University of Maryland, College Park
Tuberculosis, Pulmonary, HIV Coinfection
Pharmacist-Led Intervention to Improve TB Treatment Adherence
The goal of this clinical trial is to compare the adherence of co-morbid patients in control and experimental group The main question[s]it aims to answer are: 1.
- Trial name
- RA-15041995 (NCT06608069)
- Testing
- Educational counselling
- Where
- 2 sites in Malaysia
- Volunteers
- 383 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia
HIV Infections
A Waiting Room-Delivered Video to Enhance Clinical Outcomes Among Persons Living With HIV
The purpose of this project is to beta-test a brief waiting room video intervention that promotes early initiation of antiretroviral treatment among treatment-naïve HIV-positive patients, adherence to antiretroviral treatment and…
- Trial name
- TCOM (NCT03508310)
- Testing
- Taking Care of Me Video
- Volunteers
- 4,003 people
- Sponsor
- Centers for Disease Control and Prevention
Hiv, AIDS
ALHIV Smartphone Game Study
This is a cluster-randomized controlled trial that aims to conduct comprehensive feasibility testing of a smartphone game in a sample of 120 adolescents living with HIV (ALHIV) ages 15-21 in Kisumu, Kenya, to determine whether…
- Conditions
- Hiv, AIDS, Adolescent Behavior, Treatment Compliance
- Trial name
- NCT06913660
- Testing
- MyGoals, Standard of care
- Where
- Kenya
- Volunteers
- 120 people
- Sponsor
- Emory University
Acquired Immunodeficiency Syndrome, HIV Infections
A Pilot Study of Adherence to Oral Medication and Health Beliefs of Adolescents With HIV and Their Mothers
The proposed study has two specific aims 1) to gather data about treatment adherence levels among adolescents (11-21 years) with HIV and 2) to obtain information about the adolescents and mothers' health beliefs and examine their…
- Trial name
- NCT00001699
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- National Cancer Institute (NCI)
HIV, AIDS
Resistance Testing to Improve Management of Virologic Failure in Sub-Saharan Africa
The study design is an open-label, randomized controlled trial. The study will be conducted at study sites in Uganda and South Africa.
- Trial name
- REVAMP (NCT02787499)
- Testing
- HIV-1 RNA Resistance Testing
- Where
- 2 sites in South Africa, Uganda
- Volunteers
- 840 people
- Sponsor
- Massachusetts General Hospital
HIV Treatment Adherence
Piloting the Incentivized Text-Based Adherence Game Intervention.
This project will develop and test a novel intervention to improve HIV treatment adherence among young adults with HIV who attend an HIV clinic in Kumasi, Ghana.
- Trial name
- iTAG (NCT07115498)
- Testing
- iTAG
- Where
- Ghana
- Volunteers
- 21 people
- Sponsor
- Providence College