Clinical trials: HIV-infection/AIDS
HIV Infection
MK0518 in the Treatment of HIV-Infected Patients Switched From a Protease Inhibitor Regimen (0518-033)(TERMINATED)
The purpose of this study is to investigate the efficacy, safety, and tolerability of an investigational treatment for patients with Human Immunodeficiency Virus (HIV).
- Trial name
- NCT00443729
- Testing
- Comparator: raltegravir, Comparator: lopinavir (+) ritonavir
- Volunteers
- 355 people
- Sponsor
- Merck Sharp & Dohme LLC
HIV Infections
TMC114-TiDP3-C182 - A Study to Compare the Oral Bioavailability of a 800 mg Prototype Tablet Formulation of Darunivar (DRV) to That of the 400 mg Commercial Tablet Formulation in the Presence of Low Dose Ritonavir, Under Fasted and Fed Conditions
The purpose of this study is to compare the drug levels of darunavir obtained after administration of a single administration of the 800 mg tablet (new formulation) to that following administration of two 400 mg commercial…
- Trial name
- NCT01052883
- Testing
- DRV commercial formulation/ DRV new formulation/ rtv 100mg tab
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Tibotec Pharmaceuticals, Ireland
HIV Infections
Double Blind Study of Thymopentin Effects on Patients With HIV-1 Infection
Examine the ability of thymopentin (Timunox) to: Reduce the amount and/or frequency of virus isolation. Stimulate the immune system and alter the clinical findings in patients infected with HIV who do not yet have AIDS.
- Trial name
- NCT00002066
- Testing
- Thymopentin
- Where
- United States
- Sponsor
- Immunobiology Research Institute
Thyroid, HIV Infections
Prevalence of Thyroid Function Abnormalities in HIV-infected Patients
Review the evolution of thyroid function in HIV-infected patients, with sufficient follow-up.
- Trial name
- THYVI (NCT03149354)
- Testing
- Assay of TSH, FT3 and FT4 by immuno-radiometric method
- Where
- France
- Volunteers
- 154 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Human Immunodeficiency Virus
Mobile-health (mHealth) Intervention to Support HIV Self-testing and PrEP Uptake Among Young Men Who Have Sex With Men
The proposed study will involve adolescent (17-24 years old) men who have sex with men (described as YMSM hereafter) who meet eligibility criteria to participate.
- Trial name
- NCT04865341
- Testing
- IMB, Information-Only Control
- Where
- United States
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
HIV/AIDS
HIV Awal (Early) Testing & Treatment Indonesia Project Intervention Phase
This study will be one of the first to systematically evaluate strategies to improve the implementation of a T\&T strategy in a concentrated epidemic in Asia.
- Trial name
- NCT03659253
- Testing
- Oral Fluid Based Self Testing, Simplified ART Initiation, CBO AND BROTHEL-BASED ART SERVICE
- Where
- 4 sites in Indonesia
- Volunteers
- 827 people
- Sponsor
- Gadjah Mada University
HIV Infections, Hepatitis B
Treatment of Hepatitis B Virus (HBV) Before Beginning Anti-HIV Drugs in Patients With Both HBV and HIV
This study will evaluate the drug telbivudine (LdT) for treatment of hepatitis B virus (HBV) in HIV infected patients. Patients will take telbivudine alone for 24 weeks, add anti-HIV drugs for 24 weeks, then stop taking…
- Trial name
- NCT00051090
- Testing
- Telbivudine, Lamivudine, Efavirenz
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections
Same-day Antiretroviral Therapy With BIC/F/TAF
WHO had recommened rapid ART initiation, defined as starting ART within 7 days or on the same day after HIV diagnosis, to improve HIV care continuum.
- Trial name
- NCT04712058
- Testing
- Bictegravir / Emtricitabine / Tenofovir Alafenamide Oral Tablet [Biktarvy]
- Where
- Taiwan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Mental Health Issue, Hiv
Walk-in Therapy in Low Barrier Primary Care
The goals of the current research are to adapt an effective walk-in psychotherapy clinic intervention for the context of low-barrier primary care; and conduct a pilot implementation study in a low-barrier primary care clinic…
- Conditions
- Mental Health Issue, Hiv, Substance Use
- Trial name
- NCT06552325
- Testing
- Single Session Narrative Therapy
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Washington
HIV Infections
A Randomized, Comparative Trial of Zidovudine (AZT) Versus 2',3'-Didehydro-3'-Deoxythymidine (Stavudine; d4T) in Children With HIV Infection
PRIMARY: To compare the relative safety and tolerance of oral zidovudine (AZT) versus oral stavudine (d4T) in symptomatic HIV-infected children.
- Trial name
- NCT00000789
- Testing
- Stavudine, Zidovudine
- Where
- 54 sites in United States, Puerto Rico
- Volunteers
- 230 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections
Effects of Storage on Lactate in Blood Samples
The purpose of this study is to determine whether laboratory storage of samples affects the amount of lactate over 3 years. Lactate is a natural substance normally present in the body.
- Trial name
- NCT00011050
- Where
- 3 sites in United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Acquired Immunodeficiency Syndrome, HIV Infections
Computerized HIV/Sexually Transmitted Disease (STD) Prevention Program
The purpose of the current study is to test a computerized HIV/STD prevention program with heterosexual African Americans. The hypothesis is that those exposed to the program will increase their correct and consistent use of…
- Trial name
- TIPSS (NCT00947947)
- Testing
- Tailored Information Program for Safer Sex
- Where
- United States
- Volunteers
- 274 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
HIV Infection
Two Approaches to Providing HIV/AIDS Services in the Community to People Living With HIV/AIDS
This study will examine the effects of having a case manager help PHAs access and use health, social services and practical resources that are helpful to their needs as compared to the usual more PHA self-managed approach of…
- Trial name
- NCT00280449
- Testing
- strengths-based case managed proactive service model
- Where
- Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Hamilton Health Sciences Corporation
HIV Infections
Reducing HIV in Adolescents
The purpose of this study is to assess the impact of a cash-incentivised prevention intervention on reducing HIV incidence rates in high-school learners in rural KwaZulu-Natal.
- Trial name
- RHIVA (NCT01187979)
- Testing
- Cash incentives, Life skills curriculum
- Where
- South Africa
- Volunteers
- 3,217 people, healthy volunteers welcome
- Sponsor
- Centre for the AIDS Programme of Research in South Africa
HIV Infections
A Placebo-Controlled, Phase I, Pilot Clinical Trial to Evaluate the Safety and Immunogenicity of ENV 2-3, a Yeast-Derived Recombinant Envelope Protein of Human Immunodeficiency Virus-1, in Combination With MTP-PE/MF59 in Individuals With HIV Infection (Placebo Patients Receive MF59 Emulsion Only)
To determine the safety and immunogenicity of Env 2-3 in combination with MTP-PE/MF59 adjuvant in adult volunteers with HIV infection.
- Trial name
- NCT00000958
- Testing
- MTP-PE/MF59, Env 2-3
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections, Adolescent Behavior
Piloting a Smartphone App to Improve Treatment Adherence Among South African Adolescents Living With HIV
The overall goal of this pilot randomized-controlled trial (RCT) is to pilot MASI (MAsakhane Siphucule Impilo Yethu; Xhosa for "Let's empower each other and improve our health"), an ART adherence-supporting smartphone app with 50…
- Trial name
- NCT04661878
- Testing
- Social Support, Informational Resources, Self-Monitoring and habit formation
- Where
- South Africa
- Volunteers
- 50 people
- Sponsor
- Duke University
HIV Infections
Genotyping Directed Salvage Therapy in Children Who Have Failed Dual NRTIs
In HIV-NAT 013 phase I study, genotyping was performed in 95 children on dual NRTI which showed that almost all children had resistance to NRTi.
- Trial name
- NCT00477308
- Testing
- salvage therapy
- Where
- 3 sites in Thailand
- Volunteers
- 95 people
- Sponsor
- The HIV Netherlands Australia Thailand Research Collaboration
HIV Infections
Immune Responses to Pneumococcal Vaccination Among HIV-infected Subjects
The purpose of this study is to evaluate the best timing for administering pneumococcal vaccine (PV) to HIV-infected adults that have CD4 cell counts of more than 200 and are not yet receiving combination antiretroviral treatment…
- Trial name
- NCT00706550
- Testing
- (PV) 23-valent pneumococcal polysaccharide vaccine
- Where
- United States
- Volunteers
- 107 people
- Sponsor
- US Department of Veterans Affairs
Human Immunodeficiency Virus (HIV)
Comparison of Doravirine, Tenofovir, Lamivudine (MK-1439A) and ATRIPLA™ in Treatment-Naive Human Immunodeficiency Virus Type 1 (HIV-1)-Infected Participants (MK-1439A-021)
The purpose of this study is to compare the antiretroviral activity of doravirine, tenofovir, lamivudine (MK-1439A), a single-tablet, once-daily (q.d.) fixed-dose combination (FDC) containing doravirine (MK-1439A) 100 mg +…
- Trial name
- DRIVE-AHEAD (NCT02403674)
- Testing
- Doravirine, Tenofovir, Lamivudine, ATRIPLA™
- Volunteers
- 734 people
- Sponsor
- Merck Sharp & Dohme LLC
HIV Infections
Directly Observed Therapy for HIV Infected Adolescents
Adherence to a doctor-prescribed anti-HIV drug regimen is crucial in the management of HIV infection. In previous studies with tuberculosis patients, directly observed therapy (DOT), a strategy in which patients are observed…
- Trial name
- NCT00259389
- Testing
- Directly observed therapy (DOT)
- Where
- 6 sites in United States
- Volunteers
- 24 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
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