Clinical trials: HIV-infection/AIDS
HIV Infections
The Effect of Bacille Calmette Guerin (BCG) Vaccination on Immune Responses in HIV-Exposed and Unexposed Infants
Background: Each year, more than half a million babies are infected with HIV by mother-to child transmission in developing countries. Many of these babies get sick and develop HIV disease (AIDS) at a very young age.
- Trial name
- NCT00331474
- Testing
- BCG delayed
- Where
- South Africa
- Volunteers
- 180 people
- Sponsor
- University of Stellenbosch
HIV/AIDS
The PrEP (Pre-exposure Prophylaxis) SMART Study
The PrEP SMART study is testing a stepped model of scalable adherence support strategies in South African young women who initiate PrEP using a SMART (sequential multiple assignment randomized trial) design.
- Trial name
- NCT04038060
- Testing
- WhatsApp Group, 2-way SMS, Drug level feedback
- Where
- South Africa
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- University of Washington
HIV Infections
Evaluation of Therapeutic Drug Monitoring of Protease Inhibitors on Virologic Success and Tolerance of Highly Active Antiretroviral Therapy (HAART)
This Cophar2 study is a trial which evaluates repeated early therapeutic drug monitoring, from weeks 2 to 24, after the initiation of HAART including either indinavir/r, lopinavir/r or the new 625 mg formulation of nelfinavir…
- Trial name
- NCT00122590
- Testing
- nelfinavir, lopinavir/r, indinavir
- Where
- France
- Volunteers
- 115 people
- Sponsor
- French National Agency for Research on AIDS and Viral Hepatitis
Tuberculosis, HIV
Peer-led Implementation of TB-HIV Education and Adherence Counseling in Uganda
This cluster-randomized trial in Uganda will evaluate the effectiveness and implementation of a novel, peer-led TB education and counseling strategy to improve outcomes among persons with tuberculosis (TB) with and without…
- Trial name
- TEACH (NCT05917210)
- Testing
- Peer-Navigaton TB-EC Strategy, Usual TB-EC Strategy
- Where
- Uganda
- Volunteers
- 1,920 people
- Sponsor
- Yale University
HIV - Human Immunodeficiency Virus, Psychological Distress
Comparison of Acceptance and Commitment Therapy and Cognitive Behavior Therapy: Managing Psychological Distress and Its Multifaceted Impact on Stigmatization, Psychological Wellbeing, Social Support and Treatment Adherence in HIV/AIDS Patients
This is a randomized controlled trial comparing Acceptance and Commitment Therapy (ACT) and Cognitive Behavioral Therapy (CBT) for HIV/AIDS patients at Sheikh Zayed Hospital.
- Trial name
- HIV CBT ACT (NCT07652918)
- Testing
- CBT, ACT+ Standard Care
- Where
- Pakistan
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Sadia Batool
HIV Infections
Double-method Comparative Study in Order to Predict the Use of Co-receptors From Type 1 HIV: Phenotypic Study (Trofile ESTA®) and Virologic Response to a CCR5 Antagonist in the Short Term
The summary of the Study is to compare two methods in order to predict how the 1-HIV will use a co-receptor: the use of an accredited test (TROFILE ESTA®) and the viral response to a CCR5 antagonist in the short term.
- Trial name
- TROPISMVC (NCT01060618)
- Testing
- Maraviroc + Trofile ESTA® (diagnose test)
- Where
- 4 sites in Spain
- Volunteers
- 58 people
- Sponsor
- Asociacion para el Estudio de las Enfermedades Infecciosas
HIV Infections
Response to Standard HIV Treatment in Bamako, Mali
This study will evaluate the effectiveness of first-line HIV treatment (fixed-dose combination of the generic antiretroviral drugs nevirapine, stavudine and lamivudine) provided by the Malian National HIV Treatment Program.
- Trial name
- NCT00703404
- Where
- Mali
- Volunteers
- 76 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections, Kidney Failure, Chronic
Retrovir Capsules in the Treatment of HIV-Infected Patients in Renal Failure
To evaluate the safety, tolerance, and pharmacokinetics of Retrovir (AZT) administration in HIV-infected patients in renal failure receiving maintenance hemodialysis.
- Trial name
- NCT00002047
- Testing
- Zidovudine
- Where
- United States
- Sponsor
- Glaxo Wellcome
HIV/AIDS, Cervical Dysplasia
Factors Predicting Persistence of Oncogenic HPV and Cervical Dysplasia in HIV Infected Kenyan Women
This study will utilize a longitudinal study design to better understand the natural history of oncogenic Human Papillomavirus (HPV) infections in Human Immunodeficiency Virus (HIV)-infected and HIV-uninfected Kenyan women…
- Conditions
- HIV/AIDS, Cervical Dysplasia, HIV Infections
- Trial name
- NCT04045652
- Where
- 3 sites in United States, Kenya and 1 more
- Volunteers
- 223 people
- Sponsor
- Indiana University
Chronic Hepatitis C
Phase IV Study to Evaluate the Efficacy/Safety to Extend Treatment and High Dose of Ribavirin in co-Infected Patients
To compare the sustained virological response (SVR = ribonucleic acid (RNA) - hepatitis C virus (HCV) undetectable at week 24 before end the treatment) in chronic hepatitis C patients genotype 1-4 co-infected with HIV-HCV…
- Trial name
- PERICO (NCT00526448)
- Testing
- ribavirin, Peginterferon alfa-2a, epoetin beta
- Where
- 40 sites in Spain
- Volunteers
- 384 people
- Sponsor
- Hospital Carlos III, Madrid
High Triglyceride Level, HIV Infection
The Impact of Omega Three Fatty Acids on Vascular Function in HIV
The study seeks to determine if the use of omega three fatty acids in individuals infected with HIV and with high triglycerides leads to improved triglyceride levels, better blood vessel function and decrease in the amount of…
- Trial name
- HOST (NCT01041521)
- Testing
- Lovaza
- Where
- United States
- Volunteers
- 129 people
- Sponsor
- Tufts University
HIV Infections
Study of a Potential Preventive Vaccine Against HIV in Healthy Volunteers
This study will test the safety of a HIV DNA vaccine after it is injected into your muscle using an electroporation device (TriGrid™ Delivery System made by Ichor Medical Systems), and will test the ability of the vaccine to help…
- Trial name
- ADVAX-EP (NCT00545987)
- Testing
- TriGrid™ Delivery System, conventional intramuscular injection
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Rockefeller University
Chronic Kidney Disease, HIV Infections
Renal Function Assessment in HIV Patient
Recent progress in antiretroviral therapy has turned HIV infection into a chronic disease. Patients survival has dramatically improved but complications may occur that need to be prevented and monitored.
- Trial name
- HIVERS (NCT00821847)
- Testing
- DEXA scan
- Where
- France
- Volunteers
- 45 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Opioid-Related Disorders, HIV Infections
Buprenorphine and Integrated HIV Care Evaluation
The purpose of this study is to assess the feasibility, cost and effectiveness of interventions designed to integrate buprenorphine treatment for opioid dependence into HIV primary care in ten HIV care centers in the U.S.
- Conditions
- Opioid-Related Disorders, HIV Infections, AIDS
- Trial name
- NCT00124358
- Testing
- Buprenorphine, Integrated HIV care and office-based opioid dependence treatment
- Where
- 10 sites in United States
- Volunteers
- 1,350 people
- Sponsor
- The New York Academy of Medicine
HIV, Anal Dysplasia
Application of Oral Bacteriotherapy to Promote Anal HPV Clearance in HIV Positive Individuals
Published studies suggest that oral probiotic intake can promote the clearance of HPV genital infection and HPV related genital dysplasia in HIV negative women.
- Trial name
- HPVinHIV (NCT04099433)
- Testing
- Vivomixx
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Roma La Sapienza
Serologic Response of Syphilis, Early Syphilis
Comparisons of Serologic Response of Early Syphilis
Syphilis and HIV are prone to occur concomitantly and the two diseases share several modes of acquisition and risk factors such as men who have sex with men (MSM), sexual workers, intravenous drug users, previous history of…
- Conditions
- Serologic Response of Syphilis, Early Syphilis, High Risk Behavior
- Trial name
- NCT01944358
- Where
- 2 sites in Taiwan
- Volunteers
- 1,128 people
- Sponsor
- National Taiwan University Hospital
HIV
Immune-based Therapy Pilot Study for the Treatment of Primary HIV Infection (PHI-IMD).
Pilot study for the treatment of primary HIV infection with the objective to induce a strong specific HIV immune response able to control viral replication without HAART.
- Trial name
- PHI-IMD (NCT00979706)
- Testing
- HAART, HAART + Immunotherapy
- Where
- Spain
- Volunteers
- 22 people
- Sponsor
- Juan A. Arnaiz
HIV Infections
Pilot Study of High-Concentration Capsaicin Patches in the Treatment of Painful HIV-Associated Neuropathy
The purpose of the study is to gain initial information on the tolerability and feasibility of high-concentration capsaicin patches for the treatment of painful HIV-associated neuropathy, whether resulting from HIV disease and/or…
- Trial name
- NCT00061152
- Testing
- Capsaicin Dermal Patch
- Where
- 3 sites in United States
- Sponsor
- NeurogesX
Acquired Immunodeficiency Syndrome, HIV Infections
Treatment of Depression With Massage in HIV
The purpose of this study is to determine the effect of massage therapy on depression, quality of life and plasma cortisol levels in subjects with advanced HIV disease.
- Conditions
- Acquired Immunodeficiency Syndrome, HIV Infections, Depression
- Trial name
- NCT00033852
- Testing
- Massage Therapy
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
HIV Positive, Ageing
The Effects of Ageing on the 'Pharmacokinetic and Clinical Observations in People Over Fifty'
The purpose of this study is to identify medical conditions that may cause particular problems to individuals receiving care for HIV infection over the age of 50.
- Trial name
- POPPY (NCT01737047)
- Where
- 8 sites in Ireland, United Kingdom
- Volunteers
- 1,377 people, healthy volunteers welcome
- Sponsor
- Imperial College London
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