Clinical trials: HSV
High-risk Prostate Cancer, Prostate Cancer
Phase II High Risk Prostate Cancer Trial Using Gene & Androgen Deprivation Therapies, Radiotherapy, & Surgery
This is a prospective phase II study to assess the efficacy and toxicity of HSV-tk+ valacyclovir gene therapy in combination with androgen deprivation therapy, brachytherapy, external beam radiotherapy, and prostatectomy in…
- Trial name
- NCT03541928
- Testing
- HSV-Tk, Valacyclovir, Bicalutamide
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- The Methodist Hospital Research Institute
Multiple Sclerosis
Comparison Between Clinical and MRI Multiple Sclerosis Activity and Expression of Human Endogenous Retrovirus Type W and Herpesvirus
Multiple sclerosis is the most common autoimmune inflammatory disease of the central nervous system. It is known that your etiology has genetic and environmental causes.
- Trial name
- NCT02489877
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Faculdade de Ciências Médicas da Santa Casa de São Paulo
Herpes Simplex, HIV Infections
The Pilot Study of Foscarnet Cream in the Treatment of Mucocutaneous Herpes Simplex Virus Infections in Immunocompromised Patients Unresponsive to Acyclovir Treatment
PRIMARY: To evaluate the clinical activity of foscarnet cream on the index lesion of mucocutaneous herpes simplex virus (HSV) infections in immunocompromised patients previously unresponsive to acyclovir treatment.
- Trial name
- NCT00002144
- Testing
- Foscarnet sodium
- Where
- 8 sites in United States
- Volunteers
- 12 people
- Sponsor
- Astra USA
Herpes Zoster
Occlusion vs Standard Treatment for the Treatment of Herpes Zoster
This study evaluates the addition of occlusive dressings (hydrocolloids) or topical silicone gel in the treatment of shingles (herpes zoster).
- Trial name
- NCT04258930
- Testing
- Aluminum sulphate and calcium acetate drying soaks, Topical sterile silicone gel for wounds, Hydrocolloid dressing
- Where
- Mexico
- Volunteers
- 36 people
- Sponsor
- Fundación Nacional para la Enseñanza y la Investigación de la Dermatología A.C.
Herpes Simplex
Antiviral Prophylaxis in a Burn Population
A prospective, randomized trial to calculate incidence of Herpes Simplex Virus in an in-patient burn population and determine efficacy of prophylactic antiviral therapy to prevent viral infection and/or reactivation.
- Trial name
- NCT02349828
- Testing
- Acyclovir
- Where
- United States
- Sponsor
- Southern Illinois University
Herpes Simplex Keratitis, Corneal Neovascularization
Clinical Study of Intrastromal Anti-VEGF Injection for Corneal Neovascularization.
Corneal stromal injection is an emerging local drug delivery method, characterized by strong targeting, high drug concentration, and prolonged duration of action.
- Trial name
- NCT07329686
- Testing
- Intrastromal anti-VEGF injection and topical antiviral eye drops, Conventional antiviral topical ocular drops.
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Chronic Hepatitis C Infection
Herpes Simplex Type 1 Suppression in Hepatitis C
The purpose of this study is to examine the effects of valacyclovir in patients who have chronic hepatitis C, antibodies to herpes simplex type 1 infection but do not have antibodies to herpes simplex type 2 infection.
- Trial name
- HSV1/HCV (NCT01580995)
- Testing
- Valacyclovir
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Vaccine, Varicella-zoster Virus
Comparative Study of Two Vaccination Schedules for the Subunit Herpes Zoster Vaccine in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disease Patients Treated With Anti-CD20 Therapy: an Open-label Randomised Controlled Trial
Immunocompromised individuals, such as patients with multiple sclerosis (MS) or diseases of the neuromyelitis optica spectrum (NMOSD) treated with an anti-CD20 monoclonal antibody, present an increased risk of shingles.
- Conditions
- Vaccine, Varicella-zoster Virus, Multiple Sclerosis, Spectrum Disease Neuromyelitis Optica
- Trial name
- TACTIC (NCT07818356)
- Testing
- Two-dose M0-M2 vaccination schedule, Two-dose M0-M6 vaccination schedule
- Where
- 24 sites in France
- Volunteers
- 160 people
- Sponsor
- University Hospital, Toulouse
Herpes Zoster (HZ)
Safety and Immunogenicity of the Recombinant Zoster Vaccine, LYB004 in Adults Aged 40 Years and Older
This phase 1 study in China will evaluate the safety and immunogenicity of the Recombinant Zoster Vaccine, LYB004 in adults aged 40 years and older.
- Trial name
- NCT06874842
- Testing
- Low dose antigen and low dose adjuvant of LYB004, Low dose antigen and high dose adjuvant of LYB004, High dose antigen and low dose adjuvant of LYB004
- Where
- China
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Guangzhou Patronus Biotech Co., Ltd.
Postherpetic Neuralgia, Neuropathic Pain
Erector Spinae Plane Block Versus Transcutaneous Radiofrequency in Postherpetic Neuralgia
This observational study aims to compare the effectiveness of ultrasound-guided erector spinae plane (ESP) block and transcutaneous radiofrequency (RF) treatment in patients with postherpetic neuralgia.
- Conditions
- Postherpetic Neuralgia, Neuropathic Pain, Herpes Zoster
- Trial name
- NCT07400640
- Testing
- Erector Spinae Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Diskapi Teaching and Research Hospital
Acute Herpes Zoster
Efficacy of Electroacupuncture for Acute Herpes Zoster-Associated Pain and Biomarker Evaluation
Background: Herpes zoster (HZ) is an acute dermatological condition caused by the varicella-zoster virus. Its onset is characterized by severe pain, imposing significant physical and psychological burdens on patients.
- Trial name
- NCT07515885
- Testing
- Acupuncture, Valacyclovir, pregabalin and mecobalamin
- Where
- China
- Volunteers
- 228 people
- Sponsor
- Dexiong Han