Clinical trials: Haematologic Neoplasm
Preleukemia, Myelodysplastic Neoplasm
Repurposing Metformin As a Leukemia-preventive Drug in CCUS and LR-MDS
This is a single-arm pilot study of the feasibility and safety of metformin in patients with clonal cytopenia of undetermined significance (CCUS) or lower-risk myelodysplastic neoplasms (LR-MDS).
- Conditions
- Preleukemia, Myelodysplastic Neoplasm, Cytopenia, Preleukemic Anemia
- Trial name
- NCT04741945
- Testing
- Metformin
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Kirsten Grønbæk
Leukemia, Lymphoma
Comparing Fresh Random Platelets and Autologous Cryopreserved Thrombosol Treated Autologous Platelets
Objectives: Determine the corrected count increment of autologous transfused platelets that had been stored by cryopreservation with ThromboSol.
- Trial name
- NCT00074763
- Testing
- Platelet Transfusion
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Blood Cancer, Leukemia
Driving Inclusivity, Validity, and Equity in Research Through Strategic Engagement (DIVERSE)
The purpose of this research study is to enhance inclusion and diversity in clinical trial enrollment by training participants to perform and provide feedback through a community-based protocol review process, called DIVERSE.
- Trial name
- DIVERSE (NCT06469307)
- Testing
- DIVERSE Review Process
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Dana-Farber Cancer Institute
Influenza, SARS-CoV-2
Immunity to Infection in Healthy Participants and Participants With Cancer
Many cancer patients are highly susceptible to infection and respond poorly to vaccination. This observational study will determine molecular and cellular features of immunity to viral pathogens in participants with cancer and…
- Conditions
- Influenza, SARS-CoV-2, Hematologic Malignancy, Solid Tumor
- Trial name
- SYS01 (NCT05787964)
- Testing
- Biological sample collection
- Where
- Germany
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Acute Myeloid Leukemia, Myelodysplastic Syndrome
TevaGastrim for Stem Cell Mobilization Sibling Donors
The aim of this study is to evaluate the efficacy of TevaGastrim which is a biosimilar version of Filgrastim recombinant human G-CSF (G-CSF) in mobilizing sufficient number of stem cells from normal sibling donors for allogeneic…
- Trial name
- NCT01542944
- Testing
- TevaGastrim
- Where
- Israel
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Pediatric Solid Malignancies, Pediatric Hematological Malignancies
Neutrophil Extracellular Traps (NETs) Formation Following Chemotherapy and Their Role in Antitumor Activity
Examine neutrophil extracellular traps (NETs) formation, in relation to other neutrophil functions like chemotaxis, superoxide production, hydrogen peroxide production, and the presence of myeloperoxidase, in pediatric patients…
- Trial name
- NCT01533779
- Where
- Israel
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Monoclonal Gammopathy, Multiple Myeloma
Multi-center Screening for Serum M Protein
This study aims to utilize a highly sensitive method for detecting M protein in serum to examine the prevalence of M protein in various age groups of individuals aged over 30 who underwent physical examinations in different…
- Conditions
- Monoclonal Gammopathy, Multiple Myeloma, M-protein
- Trial name
- NCT06750965
- Testing
- Serum M protein screening
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
Solid and Hematological Malignancies
Study to Assess the Effect of Food and Acid Reducing Agents on the Absorption of Capivasertib in Healthy Participants
This is a two-part, open-label, randomized, crossover study in healthy subjects (vasectomized males and women of non-childbearing potential), performed at 2 study centers
- Trial name
- NCT04944771
- Testing
- Capivasertib, Rabeprazole
- Where
- Germany
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Pediatric ALL, Concussion, Mild
Concussion Active Rehabilitation
In this study, the investigator plans a randomized trial of active rehabilitation and standard care for acute concussion management.
- Conditions
- Pediatric ALL, Concussion, Mild, Concussion, Brain, Concussion, Intermediate
- Trial name
- NCT04248218
- Testing
- Active Rehabilitation Group/Case
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Children's National Research Institute
Breast Cancer, Gastrointestinal Cancer
Improving Comprehensive Care of Cancer Patients
Cancer survivors have unique healthcare needs, including managing serious late effects, ongoing surveillance, lifestyle modifications to reduce second cancer risk, and psychosocial support.
- Conditions
- Breast Cancer, Gastrointestinal Cancer, Hematologic Cancer
- Trial name
- NCT05323409
- Testing
- OPTIMISE
- Where
- United States
- Volunteers
- 340 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Eosinophilic Esophagitis, Barrett Esophagus
Imaging of the Esophagus Using a SECM Capsule
The goal of this validation study is to compare Spectrally Encoded Confocal Microscopy (SECM) Tethered Capsule Endoscopy (TCE) diagnosis of Eosinophilic Esophagitis to that of standard of care endoscopic biopsy.
- Trial name
- NCT03546660
- Testing
- SECM capsule
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia
Orca-T Following Chemotherapy and Total Marrow and Lymphoid Irradiation for the Treatment of Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia or Myelodysplastic Syndrome
This phase I trial tests the side effects and best dose of total marrow lymphoid irradiation along with chemotherapy, with fludarabine and melphalan, with or without thiotepa, in combination with Orca-T cells for patients with…
- Conditions
- Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia, Myelodysplastic Syndrome
- Trial name
- NCT06195891
- Testing
- Biospecimen Collection, Bone Marrow Aspiration, Bone Marrow Biopsy
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Leukemia, B-cell
INS19 CAR-T Cells for the Treatment of Relapsed or Refractory Acute B Lymphoblastic Leukemia
This study, a single-center, open, single-dose clinical study, was designed to evaluate the safety, tolerability, and pharmacokinetic profile of INS19 CAR-T cells for the treatment of patients with relapsed or refractory acute B…
- Trial name
- NCT06209671
- Testing
- INS19 CAR-T Cells
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Beijing Immunochina Medical Science & Technology Co., Ltd.
Myeloproliferative Neoplasm, Chronic Phase Chronic Myelogenous Leukemia
A Distress Reduction Intervention for Patients With BCR-ABL-Negative MPNs or CML on Tyrosine Kinase Inhibitors
This trial looks at how well a distress reduction intervention, called "Being Present", works to improve the quality of life of patients with BCR-ABL-negative myeloproliferative neoplasms (MPNs) or chronic phase chronic myeloid…
- Conditions
- Myeloproliferative Neoplasm, Chronic Phase Chronic Myelogenous Leukemia, Chronic Myeloid Leukemia
- Trial name
- NCT04605211
- Testing
- Online Mindfulness Meditation, Internet-Based Webinars
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Cardiopulmonary Arrest, Pediatric ALL
Impact of a mHealth Supportive Tool on Cardiopulmonary Resuscitation' Situational Awareness
This study will be a prospective, single-center, randomized controlled trial in a tertiary pediatric emergency department with two parallel groups of voluntary pediatric physicians and nurses.
- Conditions
- Cardiopulmonary Arrest, Pediatric ALL, Resuscitation
- Trial name
- InterFACE (NCT04464603)
- Testing
- InterFACE (mHealth tool), Conventional methods
- Where
- Switzerland
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Pediatric Clinical Research Platform
Hematological Malignancies
Mesenchymal Stem Cell Infusion as Prevention for Graft Rejection and Graft-versus-host Disease
Mesenchymal Stem Cell Infusion as Prevention for Graft Rejection and Graft-Versus-Host Disease After Allogeneic Hematopoietic Cell Transplantation With Nonmyeloablative Conditioning from HLA-mismatched PBSC or cord blood: a Pilot…
- Trial name
- NCT00504803
- Testing
- Mesenchymal stem cell infusion
- Where
- Belgium
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Liege
Multiple Myeloma
Study of KIR-Ligand Mismatched Haplo-Identical Natural Killer Cells Transfused Before Autologous Stem Cell Transplant
The purpose of this study is to induce anti-myeloma responses in patients with high risk or relapsed myeloma using combination chemo- and immunotherapy comprising sequentially: 1) lymphoid and myeloid suppressive conditioning, 2)…
- Trial name
- NCT00089453
- Testing
- Dexamethasone, Cyclophosphamide, Melphalan
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Childhood Acute Lymphoblastic Leukemia
Unravelling the Role of KCTD Protein Family in the Clinical Management of Childhood Acute Lymphoblastic Leukemias
A transcriptomic analysis of bone marrow from B-ALL patients was performed by our research group for identifying novel protein/factor with a putative role of disease biomarker.
- Trial name
- NCT05729178
- Testing
- observational study
- Where
- Italy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- IRCCS SYNLAB SDN
Depression, Hematopoietic and Lymphoid Cell Neoplasm
Using Technology to Optimize Collaborative Care Management of Depression in Urban and Rural Cancer Centers, SCOPE
This study compares the effectiveness of technology-enhanced collaborative care management (t-CoCM) to usual collaborative care management (u-CoCM) in achieving fidelity to processes of care and reducing depression symptoms in…
- Conditions
- Depression, Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm
- Trial name
- NCT05012124
- Testing
- Collaborative care, Interview or Focus Group, Media/technology Intervention with collaborative care
- Where
- 4 sites in United States
- Volunteers
- 297 people, healthy volunteers welcome
- Sponsor
- University of Washington
Neoplasms, Cancer
Cancer Experience Registry (CER) for Cancer Patients and Caregivers
The Cancer Experience Registry®: An Online Survey Research Study to Understand the Experiences of Those Impacted By a Cancer Diagnosis. The Registry is a web-based platform to distribute cross-sectional and longitudinal surveys.
- Conditions
- Neoplasms, Cancer, Caregiver
- Trial name
- CER (NCT02333604)
- Where
- United States
- Volunteers
- 15,000 people, healthy volunteers welcome
- Sponsor
- Cancer Support Community, Research and Training Institute, Philadelphia