Clinical trials: Haematology
Myelodysplastic Syndromes
Enhanced Palliative Care in MDS and AML
Objectives: The purpose of this study is to evaluate the impact of enhanced haematology palliative care services to the most symptomatic group of blood cancer patients, namely myelodysplastic syndrome (MDS) and acute myeloid…
- Trial name
- NCT04226768
- Testing
- Enhanced Haematology Palliative Care ("Fast-track") Group, Conventional Care
- Where
- Hong Kong
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Acute Lymphoblastic Leukemia
A Study Comparing the Blood Levels of Both Pegaspargase (S95014) Formulations (Liquid vs Lyophilized) in the Treatment of Paediatric Patients With Acute Lymphoblastic Leukemia (ALL)
The purpose of this study is to compare the pharmacokinetics (PK) of both lyophilized and liquid S95014 formulations during the induction phase after a single IV dose in newly diagnosed paediatric patients with ALL
- Trial name
- ALL (NCT04954326)
- Testing
- Lyophilized S95014, Liquid S95014
- Where
- 6 sites in Russia
- Volunteers
- 89 people
- Sponsor
- Institut de Recherches Internationales Servier
Chemotherapy-induced Symptomatic Anaemia, Solid Tumours
Biosimilar Retacrit™ (Epoetin Zeta) in the Treatment of Chemotherapy-Induced Symptomatic Anaemia in Haematology and Oncology
The purpose of this study is to observe correction of haemoglobin (Hb) levels in patients receiving chemotherapy as a consequence of a solid tumour, a malignant lymphoma or a multiple myeloma and who are treated with Retacrit™.
- Conditions
- Chemotherapy-induced Symptomatic Anaemia, Solid Tumours, Malignant Lymphomas, Multiple Myeloma
- Trial name
- NCT01626547
- Where
- 39 sites in Germany
- Volunteers
- 291 people
- Sponsor
- Hospira, now a wholly owned subsidiary of Pfizer
Pediatric Cancer
Mucositis and Infection Reduction With Liquid Probiotics in Children With Cancer
The aim of this study is to evaluate the feasibility of an randomised-controlled trial to investigate the efficacy of liquid probiotics to prevent or reduce mucositis and infection in children diagnosed with cancer who are…
- Trial name
- MaCROS (NCT03785938)
- Testing
- Probiotic
- Volunteers
- 40 people
- Sponsor
- University of Leeds
Covid19
PROphylaxis for paTiEnts at Risk of COVID-19 infecTion -V
COVID-19 (SARS-CoV2 virus) was declared a global pandemic by the WHO on 11th March 2020. Currently there are no drugs proven to prevent COVID-19 or to reduce the severity of illness if given as prophylaxis.
- Trial name
- PROTECT-V (NCT04870333)
- Testing
- Niclosamide, Ciclesonide, Sotrovimab
- Where
- 45 sites in United Kingdom
- Volunteers
- 2,240 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Invasive Aspergillosis
A Multicentre Randomised Controlled Trial Comparing Two Strategies for the Diagnosis of Invasive Aspergillosis in High-risk Haematology Patients
Aspergillus is a fungus found in soil, on farms and on construction sites. In those whose immune system is impaired it causes severe infection.
- Trial name
- NCT00163722
- Testing
- Culture and histology, Aspergillus galactomannan and PCR
- Where
- 6 sites in Australia
- Volunteers
- 240 people
- Sponsor
- Bayside Health
Myeloma, Non-Hodgkin's Lymphoma
Role of Antibiotic Therapy or Immunoglobulin On iNfections in hAematoLogy Platform Trial (RATIONAL-PT)
This is an adaptive platform study to find out how safe and effective different strategies are in comparison to each other, for preventing infection in patients with blood cancers.
- Conditions
- Myeloma, Non-Hodgkin's Lymphoma, Leukemia
- Trial name
- NCT07202052
- Testing
- Intravenous immunoglobulin, Trimethoprim / Sulfamethoxazole, Amoxicillin clavulanic acid
- Where
- 3 sites in Australia
- Volunteers
- 900 people
- Sponsor
- Monash University
Plasmapheresis, Haematology
Plasmapheresis: a Multi-modal Approach
Only very few studies have prospectively looked at the effect of repeated intensive plasma donation. In collaboration with the Rode Kruis Vlaanderen, we have recently found that repeated whole blood donation with a 3-month…
- Conditions
- Plasmapheresis, Haematology, Sport Performance, Body Composition
- Trial name
- NCT05815615
- Testing
- Plasmapheresis
- Where
- Belgium
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Université Catholique de Louvain
Acute Myeloid Leukemia (AML)
Study of Elacytarabine Versus Investigator's Choice in Patients With Late Stage Acute Myeloid Leukaemia (AML)
The purpose of the study is to assess the efficacy and safety of elacytarabine versus investigator's choice treatment in patients with relapsed or refractory acute myeloid leukemia (AML).
- Trial name
- CLAVELA (NCT01147939)
- Testing
- Elacytarabine, Investigator's Choice
- Where
- 73 sites in United States, Australia and 11 more
- Volunteers
- 381 people
- Sponsor
- Clavis Pharma
Hematological Diseases, Hematological Malignancies
Can Treatment With Bismuth Reduce Toxicity to Chemotherapy and Radiotherapy?
The purpose of this study is to determine whether treatment with Bismuth can reduce the toxicity of chemotherapy and radiotherapy in patients with malignant diseases of the blood.
- Conditions
- Hematological Diseases, Hematological Malignancies, Blood Diseases, Malignant Lymphoma
- Trial name
- Bismuth-PBH (NCT00892502)
- Testing
- Bismuth tablets
- Where
- Denmark
- Volunteers
- 50 people
- Sponsor
- Copenhagen University Hospital at Herlev
Chemotherapy Effect, G-CHOP Chemotherapy
Multidisciplinary Care Program to Secure MEdication Therapy for HematoLOgy Patients Receiving Injectable Anticancer Drugs
Several experiences of multidisciplinary care pathways associating oncologists, pharmacists and nurses have been reported for cancer patients, with positive results on medication management safety, reduction of Drug-Related…
- Conditions
- Chemotherapy Effect, G-CHOP Chemotherapy, R-CHOP Chemotherapy
- Trial name
- Melodia (NCT05350930)
- Testing
- Assessment of patient satisfaction regarding tele-consultation, Literacy questionnaire, Collection of socio-demographic characteristics
- Where
- France
- Volunteers
- 38 people
- Sponsor
- Hospices Civils de Lyon
MRSA Colonization, VRE Colonization
The Effect of Chlorhexidine Bathing on MRSA and VRE Colonization Among Haematology-Oncology ICU Patients
Hospital-acquired infections (HIs) are defined as an infection developed within 48-72 hours of admission to hospital in whom the infection was not incubating at the time of admission to the hospital or an infection acquired in…
- Trial name
- NCT04347057
- Testing
- Bed bathing with 2% CHG solution, Bed bathing with soap and water
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people
- Sponsor
- Hacettepe University
Haematological Malignancy
Concordance Between 2 Means of Temperature Measure in Neutropenic Patients Hospitalized in Intensive Hematology Care Units
Connected medicine "2.0" is a major challenge that will lead in the near future to profound changes in medical practices. Our study is part of this technological transformation, which is already taking the form of multiple…
- Trial name
- TEMPET (NCT04174053)
- Testing
- Enteric capsule
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre Henri Becquerel
Antifungal Prophylaxis, Haemopathy
Use of Micafungin (Mycamine®) as Antifungal Prophylaxis in Haematology and Onco-haematology
The purpose of this observational study is to describe the actual conditions of prescription of micafungin in antifungal prophylaxis in French haematological and onco-haematological units.
- Trial name
- OLYMPE (NCT02127788)
- Testing
- Micafungin
- Where
- 17 sites in France
- Volunteers
- 150 people
- Sponsor
- Astellas Pharma S.A.S.
Rash, Systemic Treatments
Telemedicine Rash Evaluation and Assessment of Toxicity in Skin in Acute Oncology and Haematology Care: A Pilot Study
This study is being done to find out if video consultations (telemedicine) can be used to safely and effectively assess and manage skin problems caused by cancer treatments.
- Conditions
- Rash, Systemic Treatments, Tele-assessment
- Trial name
- TREATS (NCT07476807)
- Testing
- telem healthassessment
- Where
- Ireland
- Volunteers
- 25 people
- Sponsor
- Sligo General Hospital
Aspergillosis
To Determine Whether Galactomannan Test Will Help to Detect Fungal Infections Early and Hence Start Treatment Early
Chemotherapy lowers the white blood cell count or weakens the immune system for a long time. This puts the patients at a high risk of getting a serious fungal infection of the internal organs or blood.
- Trial name
- NCT00361517
- Testing
- Galactomannan antigen monitoring, Aspergillus PCR, blood draws, blood draws for GM monitoring
- Where
- Singapore
- Volunteers
- 47 people
- Sponsor
- Singapore General Hospital
Fungal Infections
fungalAi for Fungal Surveillance & Antifungal Stewardship
This national Australian study will validate and implement an effective approach to real-time electronic surveillance of fungal infections in patients with blood cancers using technology based on artificial intelligence.
- Trial name
- fungalAi (NCT03793231)
- Testing
- fungalAi platform technology
- Where
- Australia
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Bayside Health
Well-being
Body Scan Meditations to Support Well-Being in Patients at Antwerp University Hospital.
INWARD is a pilot study designed to explore whether audio-guided body scan meditations can support well-being in adult patients receiving care in the haematology and oncology departments, including the day hospital, at Antwerp…
- Trial name
- INWARD (NCT07834021)
- Testing
- INWARD audio-guided body scan meditations
- Where
- Belgium
- Volunteers
- 29 people
- Sponsor
- Universiteit Antwerpen
Myeloma, Non Hodgkin's Lymphoma
Role of Antibiotic Therapy or Immunoglobulin On iNfections in hAematoLogy: Starting Immunoglobulin (Start Ig)
This study is being conducted to find out how safe and effective different strategies of infection prevention are in comparison to each other, for preventing infection in patients with blood cancers.
- Conditions
- Myeloma, Non Hodgkin's Lymphoma, Leukemia
- Trial name
- NCT07202078
- Testing
- Trimethoprim / Sulfamethoxazole, Immune Globulin Intravenous
- Where
- 3 sites in Australia
- Volunteers
- 900 people
- Sponsor
- Monash University
Haematological Malignancy
Economic Evaluation of Innovative Molecular Analyses in Onco-haematology
To evaluate the impact of innovative molecular diagnostics on the clinical management of patients with haematological malignancies via updated Appropriate-Prescribing-Guides including Next-Generation Sequencing (NGS) panels…
- Trial name
- NCT03750994
- Where
- 26 sites in France
- Volunteers
- 3,960 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris