Clinical trials: Hand Dermatitis
Chronic Hand Eczema
A 24 Week Trial to Compare the Efficacy and Safety of Delgocitinib Cream 20 mg/g Twice-daily With Alitretinoin Capsules Once-daily in Adult Participants With Severe Chronic Hand Eczema
This is a 24-week study in adult participants with severe chronic hand eczema (CHE) and with a documented inadequate response to treatment with topical corticosteroids (TCS) or for whom TCS are documented to be otherwise…
- Trial name
- DELTA FORCE (NCT05259722)
- Testing
- Delgocitinib, Toctino
- Where
- 102 sites in Austria, Canada and 8 more
- Volunteers
- 513 people
- Sponsor
- LEO Pharma
Hand Foot Syndrome, Palmar Plantar Erythrodysesthesia
Treatment of Palmar Plantar Erythrodysesthesia (PPE) With Topical Sildenafil
Hand-foot syndrome (HFS), also known as palmar-plantar erythrodysethesia (PPE), occurs in a 25%-50% of patients treated with several commonly used anti-cancer drugs including capecitabine and sunitinib.
- Trial name
- JADE (NCT01219023)
- Testing
- sildenafil citrate
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Duke University
Colorectal Cancer, Gastric Cancer (GC)
Topical Diclofenac for Hand-Foot Syndrome Prevention in Colorectal and Gastric Cancer on Capecitabine (DICLO-HFS)
Hand-foot syndrome (HFS) is a frequent adverse effect of capecitabine, presenting with redness, swelling, pain, and peeling of the skin on the palms and soles.
- Conditions
- Colorectal Cancer, Gastric Cancer (GC), Capecitabine, Hand Foot Syndrome
- Trial name
- DICLO-HFS (NCT07177560)
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 151 people
- Sponsor
- Gazi University
Hand-foot Syndrome
Acetylated Natural Nucleotides in Treating Hand-foot Syndrome
The clinical trial is planned to investigate the efficacy and safety of acetylated natural nucleotides in treating anti-cancer medications induced hand-foot syndrome (HFS).
- Trial name
- NCT04592731
- Testing
- Gel containing Acetylated Natural Nucleotides, Vehicle Gel
- Where
- China
- Volunteers
- 21 people
- Sponsor
- Nan xu
Hand Eczema
Dupilumab in Severe Chronic Hand Eczema
The purpose of this study is to investigate the efficacy of dupilumab in hand eczema patients with an inadequate response or intolerance to alitretinoin.
- Trial name
- DUPSHE (NCT04512339)
- Testing
- Dupilumab
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- University Medical Center Groningen
Chronic Hand Eczema
Efficacy and Safety of Dupilumab Chronic Hands Eczema Refractory to Highly Potent Topical Corticosteroids
Dupilumab has recently demonstrated high efficacy and good safety profile in the treatment of moderate-to-severe atopic dermatitis.
- Trial name
- DUPECZEMAIN (NCT03861455)
- Testing
- Dupilumab
- Where
- 4 sites in France
- Volunteers
- 94 people
- Sponsor
- University Hospital, Toulouse
Hand Eczema
Multicenter Clinical Study to Examine the Efficacy and Safety of Zarzenda in Patients With Hand Eczema
To show efficacy of Zarzenda in the treatment of hand eczema
- Trial name
- NCT00488241
- Testing
- Zarzenda
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Bayer
Hand Foot Syndrome
Treatment of Hand and Foot Syndrome With Traditional Chinese Medicine Formula LC09 in Patients Who Are Receiving Capecitabine for Colorectal and/or Breast Cancer
RATIONALE: Hand foot syndrome may be treated or reduced by soaking Traditional Chinese Medicine Formula LC09 in patients receiving capecitabine for colorectal and/or breast cancer.
- Trial name
- NCT02794493
- Testing
- Traditional Chinese Medicine Formula LC09
- Volunteers
- 156 people
- Sponsor
- China-Japan Friendship Hospital
Chronic Hand Dermatitis
Comparison Study With E-DO in Chronic Hand Dermatitis
The objective of this study is to evaluate the topical E-DO in patients with Chronic Hand Dermatitis (fu kuei shou).
- Trial name
- NCT00556855
- Testing
- E-DO
- Where
- Taiwan
- Volunteers
- 67 people
- Sponsor
- HenKan Pharmaceutical Co., Ltd.
Breast Cancer, Palmar-plantar Erythrodysesthesia
F511 Cream in Preventing Palmar-Plantar Erythrodysesthesia in Patients Receiving Doxorubicin Hydrochloride Liposome for Metastatic Breast Cancer
RATIONALE: F511 cream may prevent or reduce palmar-plantar erythrodysesthesia in women receiving doxorubicin hydrochloride liposome for metastatic breast cancer.
- Trial name
- NCT00992706
- Testing
- antiperspirant cream F511, pegylated liposomal doxorubicin hydrochloride
- Where
- 15 sites in Switzerland
- Volunteers
- 91 people
- Sponsor
- Swiss Cancer Institute
Atopic Dermatitis, Contact Dermatitis
Methotrexat to Hand Eczema in the BIOSKIN Cohort
Handeczema is a common chronic skin disease that markedly affect health and quality of life. Effective treatment is limited by the lack of biomarkers that can predict disease course, comorbidities and treatment response.
- Conditions
- Atopic Dermatitis, Contact Dermatitis, Hand Eczema
- Trial name
- BIOSKIN: MTX (NCT07338305)
- Where
- Denmark
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Lone Skov
Dermatitis, Psoriasis
Study to Compare Different Light Therapies (Narrowband Ultraviolet B vs PUVA) for Hand and Foot Skin Diseases.
Hand and foot skin diseases, such as dermatitis and psoriasis, that do not respond to topical creams can be treated with ultraviolet light therapy.
- Trial name
- NCT00217009
- Testing
- Narrowband Ultraviolet B (TL-01UVB) Therapy, Topical Psoralen plus ultraviolet A (PUVA)
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Mayo Clinic
Chronic Hand Eczema
PPDTM CorEvitasTM Chronic Hand Eczema (CHE) Drug Safety and Effectiveness Registry
The design is a prospective, observational registry for subjects with CHE under the care of dermatology or other qualified healthcare provider.
- Trial name
- NCT07598058
- Testing
- Observational (Non-Interventional) Registry
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- CorEvitas
Cancer
Prevention of Capecitabine Induced Hand and Foot Syndrome
Capecitabine is a common anti cancer drug. One of the most common side effects is a syndrome called hand and foot syndrome which comprises of hands and feet redness, swelling, dryness and painful sores.
- Trial name
- NCT01291628
- Testing
- socks containing copper-oxide fibers
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- Rabin Medical Center
Dermatitis Hand, Skin Abnormalities
Hand Sanitizer Effects on the Skin Barrier
Hand washing and the use of hand sanitizers are important interventions in disease prevention. Engaging in frequent hand washing is especially effective in preventing the spread of viruses, as this removes microbes and prevents…
- Conditions
- Dermatitis Hand, Skin Abnormalities, Atopic Dermatitis, Atopic Dermatitis Eczema
- Trial name
- NCT04525521
- Testing
- Hand sanitizer and hand washing
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- National Jewish Health
Henna, Hand-Foot Syndrome
Effectiveness of the Henna Application in Patients With Hand-Foot Syndrome: Nested Case-Control Study
Introduction: There is an explanation that there is a connection between the application of henna and the occurrence of hand-foot syndrome, and the purpose and progression of this interaction.
- Conditions
- Henna, Hand-Foot Syndrome, Case-Control Study
- Trial name
- [Henna] (NCT06832501)
- Testing
- Henna
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people
- Sponsor
- Hacettepe University
Psoriasis, Contact Dermatitis of Hand
An Open-label Controlled Trial: Effectiveness of Balneotherapy in Palmoplantar Psoriasis and Contact Dermatitis.
Patients who had an indication for phototherapy were included in this study. The treatment was used as a monotherapy protocol. The standard protocol for bathing PUVA involved applying 0.01% bath psoralen for 15 minutes, while the…
- Trial name
- NCT06458868
- Testing
- salt water or tap water before UVA
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Ankara University
Chronic Hand Eczema
Efficacy, Safety, and Tolerability of Abrocitinib in Subjects With Moderate to Severe Chronic Hand Eczema Refractory to Corticosteroid Therapy
This study aims to evaluate the safety, efficacy and tolerability of abrocitinib in subjects with moderate to severe chronic hand eczema, and its effects on skin biomarkers using a noninvasive method of tape stripping.
- Trial name
- NCT06283550
- Testing
- Abrocitinib 200 mg, Abrocitinib 100 mg
- Where
- 12 sites in Canada, Poland
- Volunteers
- 82 people
- Sponsor
- Innovaderm Research Inc.
Chronic Hand Eczema
Proof of Concept, Twice Daily Applications of LEO 124249 Ointment in the Treatment of Chronic Hand Eczema
To compare the efficacy of twice daily applications of LEO 124249 ointment with LEO 124249 ointment vehicle for up to 8 weeks in the treatment of subjects with chronic hand eczema.
- Trial name
- NCT02664805
- Testing
- LEO 124249 ointment, LEO 124249 ointment vehicle
- Where
- Germany
- Volunteers
- 91 people
- Sponsor
- LEO Pharma
Hand and Foot Skin Reaction, Hand and Foot Syndrome
Efficacy of Extra Virgin Olive Oil (EVOO) Supplementation on Hand-Foot Syndrome Incidence in Patients With Capecitabine
The study was aimed to evaluate the efficacy of extra virgin olive oil (EVOO) supplementation compared to placebo to prevent HFS by observing changes in serum COX 2, malondialdehyde (MDA), and TNF α levels in breast cancer and…
- Conditions
- Hand and Foot Skin Reaction, Hand and Foot Syndrome, Capecitabine
- Trial name
- EVOO (NCT06188000)
- Testing
- Extra Virgin Olive Oil, Olive Oil
- Where
- Indonesia
- Volunteers
- 60 people
- Sponsor
- Universitas Sriwijaya