Clinical trials: Hantavirus Infections
Hantavirus Pulmonary Infection, Immunisation
Andes Virus DNA Vaccine for the Prevention of Hantavirus Pulmonary Syndrome Using the PharmaJet Stratis(R) Needle-Free Injection Delivery Device
This is a Phase 1, randomized, placebo controlled, double-blind, dose escalation trial of 48 males and non-pregnant females, 18-49 years old, inclusive, who are in good health and meet all eligibility criteria.
- Trial name
- NCT03682107
- Testing
- Andes virus DNA vaccine
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Hemorrhagic Fever With Renal Syndrome
Study to Evaluate the Safety, Tolerability, and Immunogenicity of Hantaan and Puumala Virus DNA Vaccines
The purpose of this study is: To assess safety and tolerability of the HTNV and PUUV DNA vaccines, pWRG/HTN-M(x) and pWRG/PUUV-M(s2), administered intramuscularly using a TDS-IM electroporation device Secondary: To evaluate…
- Trial name
- HTNV/PUUV (NCT01502345)
- Testing
- Vaccine/device combination for prevention of HFRS
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- U.S. Army Medical Research and Development Command
Hantavirus Nephropathy, Hantavirus Infection
Hantavirus Nephropathy in North-Eastern France : Severity Risk Factors and Prognostic Tools
Hantaviruses are emerging pathogens responsible for hemorrhagic fever with renal syndrome. Severity risks factors aren't consensual in litterature, mostly related to scandinavian cohorts.
- Trial name
- HANTA-NE (NCT05415904)
- Testing
- HANTA-NE
- Where
- France
- Volunteers
- 101 people
- Sponsor
- Central Hospital, Nancy, France
Heart Failure
Integrated Diagnostic for Heart Failure
A prospective post-market study to evaluate the performance and clinic usability of heart failure risk status (HFRS) feature on CareLink.
- Trial name
- NCT01798797
- Where
- 3 sites in Canada
- Volunteers
- 100 people
- Sponsor
- Medtronic
Hantavirus Infections, Hemorrhagic Fever With Renal Syndrome
Hantavirus Registry - HantaReg
Hantavirus disease are zoonotic infections and remain a clinical challenge with globally increasing incidence and multiple serious outbreak situations in Europe within the last years.
- Conditions
- Hantavirus Infections, Hemorrhagic Fever With Renal Syndrome, Nephropathia Epidemica, Hantavirus Cardiopulmonary Syndrome
- Trial name
- HantaReg (NCT04323904)
- Testing
- Retrospective data collection
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- University of Cologne
Hemorrhagic Fever With Renal Syndrome
Ribavirin for Hemorrhagic Fever With Renal Syndrome
Hemorrhagic Fever with Renal Syndrome (HFRS) is caused by a virus acquired by contact with chronically infected rodent hosts. HFRS is present throughout Korea.
- Trial name
- NCT00623168
- Testing
- Ribavirin
- Where
- South Korea
- Sponsor
- U.S. Army Medical Research and Development Command
Hemorrhagic Fever With Renal Syndrome
Ribavirin for Hemorrhagic Fever With Renal Syndrome in Germany
This is a treatment protocol using IND Ribavirin-there is no control group. Hemorrhagic Fever with Renal Syndrome (HFRS) is caused by a virus acquired by contact with chronically infected rodent hosts.
- Trial name
- HFRS (NCT00868946)
- Testing
- Virazole (Ribavirin)
- Where
- Germany
- Sponsor
- U.S. Army Medical Research and Development Command
Hantaan Virus Nephropathy, Puumala Virus Nephropathy
Safety/Immunogenicity Hantaan Virus DNA Vaccine and Puumala Virus DNA Vaccine, For Prevention of HFRS
A randomized 4 cohort study that is comparing the data collected during the earlier phase study and to determine if immunogenicity can be retained with a 1 mg dose of Hantaan DNA vaccine.
- Trial name
- NCT04333459
- Testing
- Hantaan DNA Vaccine/Puumala DNA Vaccine
- Where
- 2 sites in United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- U.S. Army Medical Research and Development Command
Hantavirus Infections
Efficacy of Methylprednisolone for Hantavirus Cardiopulmonary Syndrome
The purpose of this study is to see if a drug, called methylprednisolone, is safe and effective in people with Hantavirus infection.
- Trial name
- NCT00128180
- Testing
- Methylprednisolone
- Where
- Chile
- Volunteers
- 66 people
- Sponsor
- University of New Mexico
HFRS
A Retrospective Cohort Study of HFRS
The goal of this retrospective cohort study is to learn about the clinial characteristics of HFRS patients, explore the risk factors of the occurrence and death of HFRS, and build a risk prediction model for HFRS.
- Trial name
- NCT06020326
- Where
- 8 sites in China
- Volunteers
- 500 people
- Sponsor
- Tongji Hospital
Hantaan Virus Disease, Puumala Virus
Combination HTNV and PUUV DNA Vaccine
To evaluate the safety and reactogenicity of the hantaan virus (HTNV), puumala virus (PUUV), and combination HTNV/PUUV DNA vaccine candidates delivered to healthy adults
- Trial name
- NCT03718130
- Testing
- Hantaan virus vaccine (HTNV) - Using TriGrid Delivery System (TDS) for Intradermal Delivery (ID), Hantaan virus vaccine (HTNV) - Using TriGrid Delivery System (TDS) for Intramuscular Delivery (IM), Puumala virus vaccine (PUUV) - Using the TriGrid Delivery System (TDS) for Intradermal Delivery (ID)
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- U.S. Army Medical Research and Development Command
Signs and Symptoms, Fever
Biomedical Signal Extraction From Symptom Descriptions: An Observational Registry Using the OpenGenome Platform
This registry prospectively collects anonymized free-text symptom descriptions submitted voluntarily by adults through the OpenGenome platform at opengenome.bio.
- Conditions
- Signs and Symptoms, Fever, Myalgia, Skin Diseases
- Trial name
- OGNOME-REG (NCT07578610)
- Testing
- OpenGenome AI Platform
- Where
- Germany
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- OpenGenome
Hemorrhagic Fever With Renal Syndrome
Phase 2a Immunogenicity Study of Hantaan/Puumala Virus DNA Vaccine for Prevention of Hemorrhagic Fever
The purpose of this study is to compare the immune responses of two different doses (1.0 mg and 2.0 mg) and two different dosing schedules (two doses or three doses) of a mixed Hantaan virus (HTNV) and Puumala virus (PUUV) DNA…
- Trial name
- NCT02116205
- Testing
- HTNV/PUUV DNA vaccine, TriGrid Delivery System (TDS)
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- U.S. Army Medical Research and Development Command
Dengue, Chikungunya
Risk Assessment of Community Spread of Multiple Endemic Infectious Diseases in a One Health Perspective
RACSMEI addresses the high burden of infectious diseases in low- and middle-income countries, including Cambodia, where limited surveillance and laboratory capacity often obscure etiologies and transmission dynamics.
- Conditions
- Dengue, Chikungunya, Zika Virus Infection, Japanese Encephalitis
- Trial name
- RACSMEI (NCT07358910)
- Where
- Cambodia
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur du Cambodge
Hemorrhagic Fever With Renal Syndrome
Study on the Relationship Between Neutrophil-mediated Thrombocytopenia and the Condition and the Course of Disease in Patients With HFRS
Thrombocytopenia is an important pathological feature of HFRS（Hemorrhagic Fever With Renal Syndrome, HFRS）. However, the cause of thrombocytopenia in HFRS is not yet fully understood.
- Trial name
- NCT04834713
- Testing
- clinical classification of HFRS
- Where
- China
- Volunteers
- 28 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
HFRS (Hemorrhagic Fever With Renal Syndrome)
Efficacy of Intravenous Immunoglobulin in Patients With Hemorrhagic Fever With Renal Syndrome: a Prospective Study
The goal of this randomized study to test the efficacy of different doses of IVIG (intravenous immunoglobulin) in the treatment of severe HFRS（hemorrhagic fever with renal syndrome）, and provide new clinical ideas for the…
- Trial name
- NCT06009042
- Testing
- IVIG 20g/d, IVIG 10g/d
- Where
- 9 sites in China
- Volunteers
- 100 people
- Sponsor
- Tongji Hospital
Andes Hantavirus
Natural History of Andes Virus Infection
This is a longitudinal observational cohort study enrolling individuals with a defined exposure to Andes Virus (ANDV) who are confined or quarantined.
- Trial name
- NAVIS (NCT07703579)
- Where
- 3 sites in France
- Volunteers
- 15 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hantavirus Pulmonary Syndrome
A Collaborative Double-Blind Placebo-Controlled Trial of Intravenous Ribavirin As a Treatment for Presumed Hantavirus Pulmonary Syndrome
The purpose is to test the safety and effectiveness of intravenous ribavirin therapy in persons with suspected and subsequently proven hantavirus infection.
- Trial name
- NCT00001123
- Testing
- Ribavirin
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Nephropathia Epidemica, Hemorrhagic Fever With Renal Syndrome
Diagnostic of Puumala Virus Infection in France
Routine Puumala virus (PUUV) infection diagnosis is performed using serological commercial kits of which performances have not been established in real life, which use recombinant protein from strains from Central or North…
- Trial name
- HANTADIAG (NCT02455375)
- Where
- 10 sites in France
- Volunteers
- 179 people
- Sponsor
- Centre Hospitalier de Charleville-Mézières
Hantavirus Infections
Hantavirus Transmission in Households in Chile
This study is designed to evaluate the transmission of hantavirus in Chile. It is an observational study that will look at close household contacts of people who have been diagnosed with hantavirus infections that result in a…
- Trial name
- NCT00533767
- Where
- Chile
- Volunteers
- 197 people
- Sponsor
- University of New Mexico