Clinical trials: Harm Reduction
Smoking Cessation, Harm Reduction
Assisting Smokers to Switch to a JUUL E-Cigarette by Devaluing Combustible Cigarettes
This study will evaluate a reward devaluation strategy in which smokers use the JUUL e-cigarette immediately before any combustible cigarettes (CCs) are smoked.
- Conditions
- Smoking Cessation, Harm Reduction, E-Cig Use, Cigarette Smoking
- Trial name
- RECON (NCT04188197)
- Testing
- JUUL
- Where
- 2 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Rose Research Center, LLC
Preterm Birth, Premature Birth
Exposure to Plasticisers in the Neonatal Intensive Care Unit
Neonatal intensive care relies on indwelling plastic medical devices fundamental in respiratory support, intravenous catheterization, and nutrition.
- Conditions
- Preterm Birth, Premature Birth, Neurodevelopmental Disorders, Pulmonary Disease
- Trial name
- PLASTIC-NICU (NCT05404815)
- Where
- Belgium
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Opioid Overdose
Preventing Opioid Overdose Mortality in the United States
This study aims to conduct a randomized controlled trial of 105 syringe services programs (SSPs) throughout the United States to understand the effectiveness of a multifaceted, facilitation-based strategy at advancing naloxone…
- Trial name
- NCT03924505
- Testing
- Organize and Mobilize for Implementation Effectiveness, Dissemination
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- RTI International
Alcohol Prevention, Harm Reduction
An Augmented Reality Videogame for Alcohol Use Prevention and Harm Reduction in Teens
The goal of this research study is to develop the AR-based alcohol use prevention and harm reduction intervention, "No Time Wasted", with the further aim of conducting a pre-post pilot study to assess whether the game reduce risk…
- Trial name
- NCT04351958
- Testing
- Experimental: Augmented Reality ("No Time Wasted")
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Yale University
Hiv, Tobacco Use
Trial of a Harm Reduction Strategy for People With HIV Who Smoke Cigarettes
Cigarette smoking is now the leading killer of people with HIV (PWH) in the US, and most cessation strategies tried to date have failed to increase long-term quit rates.
- Trial name
- NCT05642715
- Testing
- EX+, Varenicline, HR
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Anxiety, No Evidence of Disease
Video-Based Intervention in Reducing Anxiety in Patients Undergoing Lung Cancer Screening
This pilot trial studies a video-based intervention in reducing anxiety in patients undergoing lung cancer screening. Giving a video-based intervention to patients prior to lung cancer screening may reduce anxiety and improve the…
- Conditions
- Anxiety, No Evidence of Disease, Lung Carcinoma
- Trial name
- NCT02288416
- Testing
- educational intervention, questionnaire administration, quality-of-life assessment
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Drug Use Disorders, Hepatitis C
Community-Based, Client-Centered Prevention Homes to Address the Rural Opioid Epidemic- Aim 3
The goal of this study was to effectively use a client-centered community-based intervention to engage people who inject drugs (PWIDs) in healthcare that helps reduce risky behaviors and lower infectious disease risks.
- Conditions
- Drug Use Disorders, Hepatitis C, Harm Reduction, Opioid-use Disorder
- Trial name
- NCT04268173
- Testing
- Community-Based, Client-Centered Prevention Home
- Where
- 6 sites in United States
- Volunteers
- 343 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
HIV Prevention, Substance Use
Host Led Harm Reduction Approach Among Men Who Have Sex With Men Who Engaged in Chemsex in Bangkok, Thailand: A Pre-Implementation Study
This study evaluates the pre-implementation phase of a host-led harm reduction model for men who have sex with men (MSM) engaging in chemsex in Bangkok, Thailand, focusing on understanding harms, contexts, and needs to develop a…
- Conditions
- HIV Prevention, Substance Use, Mental Health, Sexually Transmitted Infections (STIs)
- Trial name
- HAMMOCK (NCT07512869)
- Testing
- Self-administered questionnaire assessment, Semi-structured in-depth interviews (IDIs), Development and refinement of harm reduction model
- Where
- Thailand
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Institute of HIV Research and Innovation Foundation, Thailand
Medication Abuse, Harm Reduction
Clinical Decision Support to Increase Use of Medications for Opioid Use Disorder
The objective of this study is to evaluate the impact of clinical decision support (CDS) in the form of an alert to identify patients who may be at risk of opioid use disorder (OUD) and a clinical care pathway helping providers…
- Conditions
- Medication Abuse, Harm Reduction, Opioid Use Disorder, Supportive Care
- Trial name
- NCT06526286
- Testing
- Medications for Opioid Use Disorder Pathway Clinical Decision Support (CDS)
- Where
- United States
- Volunteers
- 200,000 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Smoking, Cigarette
Switching to a Vaping Device: Evaluating Risk Reduction Among Quitline Treatment Failures
The overall aim of the study is to evaluate the provision of e-cigarette (EC) versus NRT on smoking behavior, product use patterns and continued use, and iCO, a biomarker of toxicant exposure, among a sample of recent QL…
- Trial name
- NCT03502200
- Testing
- JUUL, Treatment As Usual
- Where
- United States
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Tobacco Use Disorder
Efficacy of Oral Tobacco Products Compared to a Medicinal Nicotine
For the primary goals, we hypothesize that 1) the oral tobacco product will be more efficacious than the medicinal nicotine product in substituting for smoking cigarettes; 2) among non-abstainers, the oral tobacco product will…
- Trial name
- NCT00710034
- Testing
- Oral tobacco, Nicotine Gum
- Where
- 2 sites in United States
- Volunteers
- 391 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Gambling
Prevention Messages for EGMs: Effects on Behaviours and Cognitions
The goals of this randomized controlled trial are to test the manifold effects of prevention pop-up messages on participants' behaviours, cognitions and affects.
- Trial name
- NCT06341504
- Testing
- Prevention pop-up messages, Mandatory time limit, Responsible gambling information
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Benjamin Galipeau
Behavior
Interactive Program for Effective Playground Supervision
The goal of the Playground supervision clinical trial is to see if playground management skills are improved, after implementing the school-wide behavior management program.
- Trial name
- Playground_2 (NCT01094236)
- Testing
- On the Playground behavior management program
- Where
- United States
- Volunteers
- 2,316 people, healthy volunteers welcome
- Sponsor
- Oregon Center for Applied Science, Inc.
Cigarette Smoking, Addiction
Electronic Cigarettes as a Harm Reduction Strategy in Individuals With Substance Use Disorder
Patients in addiction treatment have exceptionally higher rate of cigarette smoking and very low quit rates compared to the general population.
- Conditions
- Cigarette Smoking, Addiction, E Cig Use
- Trial name
- NCT04063267
- Testing
- E cigarettes, Nicotine Replacement Therapy
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Tobacco Use Disorder, Smoking
Electronic Cigarettes (E-cigarettes) as a Harm Reduction Strategy
The purpose of this study is to examine the feasibility of using e-cigarettes as a method for harm reduction and the effects of providing e-cigarettes (or placebo e-cigarettes) on smoking outcomes.
- Trial name
- NCT02628964
- Testing
- e-cigarettes
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Opioid Overdose Prevention, People Who Use Opioids/People With Opioid Use Disorder (OUD)
Reducing Overdose and Substance Use-related Stigma by Training Non-substance-using Friends and Family Members of People Who Use Opioids to Be Harm Reduction Champions
Fatal opioid overdoses are more frequent among populations with low access to harm reduction (HR) services and with high substance use-related stigma (which is a major barrier to accessing HR services).
- Conditions
- Opioid Overdose Prevention, People Who Use Opioids/People With Opioid Use Disorder (OUD), Reduction of Substance Use-related Stigma, Non-substance-using People With a Friend or Family Member Who Uses Opioids
- Trial name
- NCT06823453
- Testing
- Peer Harm Reduction Support Champion Intervention
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Chicago
E-cigarette Use, Cigarette Smoking
Noncombustible Nicotine Delivery Systems as Potential Harm Reduction Tools for Persistent Cigarette Smokers
This between-subjects study aims to evaluate whether e-cigarettes (ECIGS) versus oral nicotine pouches (ONPS) more readily substitute for combustible cigarettes among 200 cigarette smokers.
- Conditions
- E-cigarette Use, Cigarette Smoking, Harm Reduction, Tobacco Use
- Trial name
- NCT06372899
- Testing
- E-cigarettes, Oral nicotine pouches
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Abramson Cancer Center at Penn Medicine
Cigarette Smoker
Validation of Biomarkers of Exposure and Host Response
This study will evaluate biomarkers measured in exhaled breath condensate (EBC) to assess clinical strategies of harm reduction.
- Trial name
- NCT00468234
- Testing
- nicotine polacrilex, nicotine transdermal system, nicotine inhaler
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Chronic Pain, Opioid Misuse
Integrative Psychosocial Group Treatment
A fundamental challenge for healthcare is to achieve a balance between decreasing the misuse of opioids and associated harms while optimizing patient care, including the provision of multidisciplinary treatments for chronic pain.
- Trial name
- NCT03648177
- Testing
- IPGT, Treatment as Usual
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Drug Abuse, Harm Reduction
Harm Reduction Intervention for Anabolic-androgenic Steroids Users: a Randomized Controlled Trial
This clinical trial aims to investigate the short and long-term efficacy of a harm reduction intervention in reducing the use of non-clinical anabolic-androgenic steroids (AAS) in abusive users of AAS.
- Conditions
- Drug Abuse, Harm Reduction, Minimization, Harm, Anabolic Steroids Adverse Events
- Trial name
- SOS-RCT-HR (NCT07039539)
- Testing
- harm reduction intervention in non-clinical anabolic-androgenic steroids users
- Where
- Brazil
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo