Clinical trials: Harm Reduction
Tobacco Use Disorder
Effectiveness of Using Tobacco Free Snuff in Reducing Negative Effects of Smokeless Tobacco Use
Though spit tobacco is smokeless, it still affects the cardiovascular system and may be associated with heart disease, stroke, and high blood pressure.
- Trial name
- NCT00218270
- Testing
- Tobacco free snuff
- Where
- United States
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Tobacco Use Disorder
Efficacy of Oral Tobacco Products Compared to a Medicinal Nicotine
For the primary goals, we hypothesize that 1) the oral tobacco product will be more efficacious than the medicinal nicotine product in substituting for smoking cigarettes; 2) among non-abstainers, the oral tobacco product will…
- Trial name
- NCT00710034
- Testing
- Oral tobacco, Nicotine Gum
- Where
- 2 sites in United States
- Volunteers
- 391 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Pregnancy Related, Sexual Behavior
Rigorous Evaluation of High School FLASH
High School FLASH is a 15-session comprehensive sexual health curriculum designed for classroom settings in grades 9 to 12. The basis of High School FLASH is a public health approach to behavior change.
- Conditions
- Pregnancy Related, Sexual Behavior, STD
- Trial name
- NCT04079608
- Testing
- FLASH curriculum, Sexual Health Education for Adolescents
- Where
- United States
- Volunteers
- 1,597 people, healthy volunteers welcome
- Sponsor
- ETR Associates
Alcohol Use, Alcohol Drinking
Smartphone Technology: Young Adult Drinking
Exploring technology based tools to reduce drinking is important. The purpose of this research study is to compare different BAC monitoring apps for their effects on alcohol drinking and ratings of usability among young…
- Conditions
- Alcohol Use, Alcohol Drinking, Drinking Behavior
- Trial name
- STEADY (NCT02963818)
- Testing
- Smartphone breathalyzer device/app use, BAC estimator app use, Text messaging procedure
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of Florida
Tobacco Use Disorder
Evaluation of Oral Tobacco as a Harm Reduction Method for Smokers
Recently, tobacco companies have developed new oral tobacco products that are purportedly less harmful than conventional tobacco products.
- Trial name
- NCT00711100
- Testing
- Camel Snus, Marlboro Snus, Stonewall
- Where
- 2 sites in United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Alcohol Use Disorder, Alcohol Drinking
TeleHealth Resources for IndiVidualizEd Goals (THRIVE) in Alcohol Recovery Study
This project will evaluate the effectiveness and mechanisms of mindfulness-based relapse prevention (MBRP) delivered via video conferencing, as compared to referral to online mutual support groups, in supporting long-term…
- Conditions
- Alcohol Use Disorder, Alcohol Drinking, Alcohol-Related Disorders
- Trial name
- THRIVE (NCT06074341)
- Testing
- Mindfulness-based relapse prevention, Online Mutual Support Groups
- Where
- United States
- Volunteers
- 470 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Cigarette Smoking
E-Cigarettes and Financial Incentives to Promote Tobacco Harm Reduction Among Adults Accessing Shelter Services
This randomized controlled trial evaluated the feasibility and potential efficacy of 1) e-cigarette switching (EC) or 2) e-cigarette switching + financial incentives for combustible cigarette cessation (EC+FI)
- Trial name
- EXCHANGE (NCT03743532)
- Testing
- E-cigarette Switching, Financial Incentives
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Substance Use, HIV Prevention
Pre-implementation Study to Develop Trans-tailored Services for Transgender Persons in Relation to chemsEX
The study is a pre-implementation cross-sectional study exploring chemsex behaviors among transgender persons and gathering perspectives from multiple stakeholders to inform the development of transgender-tailored harm reduction…
- Conditions
- Substance Use, HIV Prevention, Sexually Transmitted Infections (STIs)
- Trial name
- T-REX (NCT07505875)
- Testing
- Understanding of chemsex patterns, impacts, and service needs among transgender persons
- Where
- Thailand
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Institute of HIV Research and Innovation Foundation, Thailand
Anxiety, No Evidence of Disease
Video-Based Intervention in Reducing Anxiety in Patients Undergoing Lung Cancer Screening
This pilot trial studies a video-based intervention in reducing anxiety in patients undergoing lung cancer screening. Giving a video-based intervention to patients prior to lung cancer screening may reduce anxiety and improve the…
- Conditions
- Anxiety, No Evidence of Disease, Lung Carcinoma
- Trial name
- NCT02288416
- Testing
- educational intervention, questionnaire administration, quality-of-life assessment
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Smoking, Cigarette
Switching to a Vaping Device: Evaluating Risk Reduction Among Quitline Treatment Failures
The overall aim of the study is to evaluate the provision of e-cigarette (EC) versus NRT on smoking behavior, product use patterns and continued use, and iCO, a biomarker of toxicant exposure, among a sample of recent QL…
- Trial name
- NCT03502200
- Testing
- JUUL, Treatment As Usual
- Where
- United States
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Smoking, E-Cig Use
Clinical Alternatives for Reducing Harm Using E-cigarettes
For patients in cancer care, quitting smoking is critical, but a significant portion of patients in cancer care refuse all components of tobacco treatment, even when offered free of charge.
- Conditions
- Smoking, E-Cig Use, Oncology
- Trial name
- CARE (NCT07039292)
- Testing
- Harm Reduction (E-cigarette switching), Standard of Care
- Where
- United States
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Smoking, Cigarette
Heated Tobacco Products vs Electronic Cigarettes
This is a 12-weeks, open label, non-inferiority trial comparing HTPs vs ECs in terms of efficacy, adoption rate and acceptability, tolerability, and tobacco harm reduction in 220 healthy smokers, not motivated to quit, randomized…
- Trial name
- NCT03569748
- Testing
- IQOS, E-CIG
- Where
- Italy
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- University of Catania
Substance Abuse, Decision Making, Shared
Data2Action Oregon Project: Supporting Data-driven Decision-Making for Substance Use Services, Policy, and Overdose Prevention
Oregon's decision makers (e.g., community service providers, public health, justice, advocacy groups, payers) are calling for comprehensive, current, and trusted data to inform how they allocate resources to improve substance use…
- Conditions
- Substance Abuse, Decision Making, Shared, Implementation Science, Decision Making
- Trial name
- D2A Oregon (NCT06852170)
- Testing
- Co-Design Sessions (CDS), Data products
- Where
- United States
- Volunteers
- 341 people, healthy volunteers welcome
- Sponsor
- Chestnut Health Systems