Clinical trials: Head
Head and Neck Cancer
Prediction of Outcome After Chemoradiotherapy for Head and Neck Cancer Using Functional Imaging and Tumor Biology
Despite uniform histopathological definition the response of locally advanced squamous cell carcinomas of the head and neck (HNSCC) to ionizing radiation differs greatly with locoregional recurrences burdening this patient…
- Trial name
- NCT01829646
- Testing
- functional MRI, Hypoxia gene expression profile., Functional MRI before start of treatment.
- Where
- Belgium
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Brain Concussion, mTBI - Mild Traumatic Brain Injury
Screening Instruments for Measuring Visual Symptoms in Victims of Concussion
Visual dysfunction after mild traumatic brain injury (mTBI) is common but often remain undiscovered during longer periods of time. No valid, reliable and easy-to-use screening instrument for uncovering visual dysfunction exists.
- Trial name
- VisCom (NCT05862571)
- Where
- Denmark
- Volunteers
- 197 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Forward Head Posture
The Association of Telephone Head Tilt With Cervical, Thoracic, and Lumbar Spine Mobility and Disorders in Young Adults
To determine the relationship between telephone head tilt and cervical, thoracic, and lumbar spine mobility and disturbances in young adults.
- Trial name
- NCT05814289
- Testing
- To assess telephone head tilt and cervical, thoracic, and lumbar spine mobility and disturbances.
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Tokat Gaziosmanpasa University
Postoperative Hypoparathyroidism, Thyroid Disease
Assessing Benefits of NIRAF Detection for Identifying Parathyroid Glands During Total Thyroidectomy
This study describes a single center, randomized, single-blinded clinical trial to assess the clinical benefits of the use of near infrared autofluorescence (NIRAF) detection with an FDA-cleared device 'Parathyroid Eye (PTeye)'…
- Conditions
- Postoperative Hypoparathyroidism, Thyroid Disease, Thyroid Neoplasms, Thyroid Cancer
- Trial name
- NCT05579782
- Testing
- NIRAF Detection Technology
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Primary Generalized (Osteo)Arthritis, Post-traumatic Arthrosis of Other Joints, Upper Arm
Simpliciti IDE Trial; Replacing the Humeral Head in Total Shoulder Arthroplasty
The purpose of this study is to demonstrate safety and efficacy of the Simpliciti Shoulder System in total shoulder arthroplasty.
- Trial name
- NCT01390038
- Testing
- Simpliciti™ Shoulder System
- Where
- 14 sites in United States
- Volunteers
- 157 people, healthy volunteers welcome
- Sponsor
- Stryker Trauma and Extremities
Mild Traumatic Brain Injury, Traumatic Brain Injury
Advanced MRI Applications for Mild Traumatic Brain Injury
This feasibility study is being conducted to determine potential associations between a broad range of clinical neurological symptoms and magnetic resonance images (MRI), data, and clinical findings involved in mild traumatic…
- Trial name
- TBI (NCT02070588)
- Testing
- MRI
- Where
- United States
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- GE Healthcare
Healthy
Role of Endothelin-1 in Optic Nerve Head Blood Flow Regulation During Isometric Exercise in Healthy Humans
Autoregulation is defined as the ability of a vascular bed to adapt its vascular resistance to changes in perfusion pressure. In the eye, several studies have reported that retinal blood flow is autoregulated over a wide range of…
- Trial name
- NCT00915070
- Testing
- BQ-123, Physiological saline solution, Laser Doppler Flowmetry
- Where
- Austria
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Biomarkers
Role of Concentration of Biomarkers S100B and NSE in Serum in Mild and Moderate Head Trauma
In pediatric age groups communication difficulties very sometimes may present further obstacles in obtaining a detailed injury history and early identification of TBI symptoms.
- Trial name
- NCT02988102
- Testing
- Following S100B and NSE in head trauma
- Where
- Albania
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University Clinical Centre of Kosova
Head and Neck Cancer
Carcinologic Speech Severity Index
The hypothesis of the present study is that an automatic assessment technic can measure the impact of the speech disorders on the communication abilities giving a severity index of speech in patients treated for head and neck and…
- Trial name
- C2SI (NCT02875795)
- Testing
- automatic speech processing tool
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Sports Injury, Intermittent Fasting
The Effect of Intermittent Fasting on Acute Subconcussive Head Impacts
The purpose of this study is to examine the effect of intermittent fasting on the acute neural responses to subconcussive head impacts.
- Trial name
- NCT05236127
- Testing
- Soccer Heading, Intermittent Fasting
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Indiana University
Concussion, Mild
Australian University of California San Francisco (UCSF) Concussion in Athletes (AUSSIE-2)
Analysis of cardiac induced brain forces using cranial accelerometry has been shown to diagnose concussion in high school athletes.
- Trial name
- AUSSIE-2 (NCT05771051)
- Testing
- Headpulse measurements
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Lung Cancers, Liver Cancer
AI-Assisted Non-Contrast CT for Multi-Cancer Screening
Cancer poses a major public health challenge in China. Early detection can improve treatment outcomes and survival rates. In this study, we will conduct a large-scale, prospective, multi-center cohort study to evaluate the…
- Conditions
- Lung Cancers, Liver Cancer, Gastric Cancers, Colorectal, Cancer
- Trial name
- NCT06632886
- Testing
- AI-Assisted Non-Contrast CT for Multi-Cancer Screening
- Where
- China
- Volunteers
- 1,000,000 people, healthy volunteers welcome
- Sponsor
- Guo ShiWei
Brain Health Retired Elite Athletes
Long-term Brain Health of Retired Professional Rugby Players, With a History of Concussion/Head Impact Exposure
There has been significant recent interest on the issue of brain health in athletes. Participation in sports is generally viewed as extremely positive.
- Trial name
- NCT03544346
- Testing
- Exploratory brain and general health assessment
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Dublin, Trinity College
Head and Neck Cancer
Magnesium Sulphate and Rocuronium in Patients Over 60
The purpose of this study is to evaluate the effects of MgSO4 administration on the pharmacodynamics of rocuronium in patients with 60 or more years of age.
- Trial name
- NCT01804205
- Testing
- Magnesium Sulfate
- Where
- Brazil
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Pedro Rotava
Child Obesity
More Outside Your Door: a Diet/physical Activity Intervention to Decrease Risk of Obesity in Alaska Native Preschoolers
The preschool age is a crucial period of growth and an optimal time to begin to establish healthy eating and physical activity habits leading to better food and activity choices into adulthood, thereby minimizing risk for…
- Trial name
- MOYD (NCT06303544)
- Testing
- Wedge 1
- Where
- United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Alaska Native Tribal Health Consortium
Head Injury Trauma, Cognition Disorder
Assessment and Rehabilitation of Social Cognition in People With Traumatic Brain Injury
Patients who have suffered moderate to severe traumatic brain injury (TBI) frequently develop behavioural changes, which can have deleterious consequences on interpersonal relationships, social, family and professional…
- Trial name
- CogniSo-TC (NCT04562844)
- Testing
- sociale cognition
- Where
- 4 sites in France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Centre d'Investigation Clinique et Technologique 805
Cerebral Concussion
Concussion in French Amateur Rugby : Survey About the Management and Knowledge of Players
Rugby is a popular contact sport in France the majority of whom are amateur players. Concussion is one of the main risks given its potential severity and frequency (between 2.78 and 10 per 1,000 player hours).
- Trial name
- RUGBY-COM (NCT04760834)
- Testing
- Questionnaire
- Where
- France
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Cancer Diagnosis, LungCancer
Prospective Screening and Differentiating Common Cancers Using Peripheral Blood Cell-Free DNA Sequencing
The goal of this observational study is to screen and differentiate common cancers in participants with or without suspicious lesions.
- Conditions
- Cancer Diagnosis, LungCancer, Gastric Cancer, Liver Cancer
- Trial name
- NCT06036563
- Where
- 8 sites in China
- Volunteers
- 3,200 people, healthy volunteers welcome
- Sponsor
- Air Force Military Medical University, China
Pharynx Cancer, Larynx Cancer
Randomized Trial to Assess the Impact of a Screening Program on Upper Aerodigestive Tract Cancer Mortality in a High Risk Population
Randomized multicenter trial to assess the impact of a screening program for heavy alcohol drinkers and smokers treated in alcohol addiction clinics on upper aerodigestive tract cancer mortality.
- Conditions
- Pharynx Cancer, Larynx Cancer, Oral Cavity Cancer, Oesophageal Cancer
- Trial name
- NCT00359645
- Testing
- Screening by head and neck clinical examination with a fiberoptic nasolaryngoscopy and an oesopharyngeal brush biopsy annually during 3 years
- Where
- 35 sites in France
- Volunteers
- 1,993 people, healthy volunteers welcome
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Visual Field Defect, Peripheral
Establishing a Normative Database in Pediatric Population of the Head-mounted visuALL Field Analyzer
The goal of this study is to determine reference values of the VisuALL Field Test in pediatric population. Standard Automatic Perimetry (SAP) is the gold standard test for the evaluation of different diseases of the visual…
- Trial name
- NCT04175444
- Testing
- VisuALL Field Analyzer, Humphrey Field Analyzer
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
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